530 research outputs found
Exo-Ï€-bonding to an ortho-carborane hypercarbon atom: systematic icosahedral cage distortions reflected in the structures of the fluoro-, hydroxy- and amino-carboranes, 1-X-2-Ph-1,2-C2B10H10 (X = F, OH or NH2) and related anions
The structures of derivatives of phenyl-ortho-carborane bearing on the second cage hypercarbon atom a pi-donor substituent (F, OH, O-, NH2, NH- and CH2-) were investigated by NMR, X-ray crystallography and computational studies. The molecular structures of these compounds, notably their cage C1-C2 distances and the orientations of their pi-donor substituents (OH, NH2, NH- and CH2-) show remarkable and systematic variations with the degree of exo pi-bonding, which varies as expected with the pi-donor characteristics of the substituent
Optimal imaging of remote bodies using quantum detectors
We implement a general imaging method by measuring the complex degree of coherence using linear optics and photon number resolving detectors. In the absence of collective or entanglement-assisted measurements, our method is optimal over a large range of practically relevant values of the complex degree of coherence. We measure the size and position of a small distant source of pseudothermal light, and show that our method outperforms the traditional imaging method by an order of magnitude in precision. Finally, we show that a lack of photon-number resolution in the detectors has only a modest detrimental effect on measurement precision and simulate imaging using the new and traditional methods with an array of detectors, showing that the new method improves both image clarity and contrast
Transport by molecular motors in the presence of static defects
The transport by molecular motors along cytoskeletal filaments is studied
theoretically in the presence of static defects. The movements of single motors
are described as biased random walks along the filament as well as binding to
and unbinding from the filament. Three basic types of defects are
distinguished, which differ from normal filament sites only in one of the
motors' transition probabilities. Both stepping defects with a reduced
probability for forward steps and unbinding defects with an increased
probability for motor unbinding strongly reduce the velocities and the run
lengths of the motors with increasing defect density. For transport by single
motors, binding defects with a reduced probability for motor binding have a
relatively small effect on the transport properties. For cargo transport by
motors teams, binding defects also change the effective unbinding rate of the
cargo particles and are expected to have a stronger effect.Comment: 20 pages, latex, 7 figures, 1 tabl
Adjoint "quarks" on coarse anisotropic lattices: Implications for string breaking in full QCD
A detailed study is made of four dimensional SU(2) gauge theory with static
adjoint ``quarks'' in the context of string breaking. A tadpole-improved action
is used to do simulations on lattices with coarse spatial spacings ,
allowing the static potential to be probed at large separations at a
dramatically reduced computational cost. Highly anisotropic lattices are used,
with fine temporal spacings , in order to assess the behavior of the
time-dependent effective potentials. The lattice spacings are determined from
the potentials for quarks in the fundamental representation. Simulations of the
Wilson loop in the adjoint representation are done, and the energies of
magnetic and electric ``gluelumps'' (adjoint quark-gluon bound states) are
calculated, which set the energy scale for string breaking. Correlators of
gauge-fixed static quark propagators, without a connecting string of spatial
links, are analyzed. Correlation functions of gluelump pairs are also
considered; similar correlators have recently been proposed for observing
string breaking in full QCD and other models. A thorough discussion of the
relevance of Wilson loops over other operators for studies of string breaking
is presented, using the simulation results presented here to support a number
of new arguments.Comment: 22 pages, 14 figure
4pi Models of CMEs and ICMEs
Coronal mass ejections (CMEs), which dynamically connect the solar surface to
the far reaches of interplanetary space, represent a major anifestation of
solar activity. They are not only of principal interest but also play a pivotal
role in the context of space weather predictions. The steady improvement of
both numerical methods and computational resources during recent years has
allowed for the creation of increasingly realistic models of interplanetary
CMEs (ICMEs), which can now be compared to high-quality observational data from
various space-bound missions. This review discusses existing models of CMEs,
characterizing them by scientific aim and scope, CME initiation method, and
physical effects included, thereby stressing the importance of fully 3-D
('4pi') spatial coverage.Comment: 14 pages plus references. Comments welcome. Accepted for publication
in Solar Physics (SUN-360 topical issue
On the structure and evolution of a polar crown prominence/filament system
Polar crown prominences are made of chromospheric plasma partially circling
the Suns poles between 60 and 70 degree latitude. We aim to diagnose the 3D
dynamics of a polar crown prominence using high cadence EUV images from the
Solar Dynamics Observatory (SDO)/AIA at 304 and 171A and the Ahead spacecraft
of the Solar Terrestrial Relations Observatory (STEREO-A)/EUVI at 195A. Using
time series across specific structures we compare flows across the disk in 195A
with the prominence dynamics seen on the limb. The densest prominence material
forms vertical columns which are separated by many tens of Mm and connected by
dynamic bridges of plasma that are clearly visible in 304/171A two-color
images. We also observe intermittent but repetitious flows with velocity 15
km/s in the prominence that appear to be associated with EUV bright points on
the solar disk. The boundary between the prominence and the overlying cavity
appears as a sharp edge. We discuss the structure of the coronal cavity seen
both above and around the prominence. SDO/HMI and GONG magnetograms are used to
infer the underlying magnetic topology. The evolution and structure of the
prominence with respect to the magnetic field seems to agree with the filament
linkage model.Comment: 24 pages, 14 figures, Accepted for publication in Solar Physics
Journal, Movies can be found at http://www2.mps.mpg.de/data/outgoing/panesar
Immuno-fluorescence staining patterns of leukocyte subsets in the skin of taurine and indicine cattle
The immuno-staining patterns of skin leukocytes were investigated in three breeds of cattle: Holstein-Friesian, Brahman and Santa Gertrudis of similar age before and after tick infestation. The antibodies specific for CD45 and CD45RO reacted with cells in the skin of all Holstein-Friesian cattle but did not react with cells in the skin of any Brahman cattle. The same antibodies reacted with cells from the skin of four (CD45) and seven (CD45RO) of twelve Santa Gertrudis cattle. The antibodies specific for T cells and γδ subset of T cells recognized cells from all three breeds of cattle. The antibody specific for MHC class II molecules labelled cells of mostly irregular shape, presumably dermal dendritic cells and/or macrophages and Langerhans cells. The antibody specific for granulocytes (mAb CH138) reacted with cells only in sections cut from skin with lesions. The antibody specific for CD25+ cells labelled regularly shaped cells that showed a wide range of intensities of staining
Kepler-22b: A 2.4 Earth-radius Planet in the Habitable Zone of a Sun-like Star
A search of the time-series photometry from NASA's Kepler spacecraft reveals
a transiting planet candidate orbiting the 11th magnitude G5 dwarf KIC 10593626
with a period of 290 days. The characteristics of the host star are well
constrained by high-resolution spectroscopy combined with an asteroseismic
analysis of the Kepler photometry, leading to an estimated mass and radius of
0.970 +/- 0.060 MSun and 0.979 +/- 0.020 RSun. The depth of 492 +/- 10ppm for
the three observed transits yields a radius of 2.38 +/- 0.13 REarth for the
planet. The system passes a battery of tests for false positives, including
reconnaissance spectroscopy, high-resolution imaging, and centroid motion. A
full BLENDER analysis provides further validation of the planet interpretation
by showing that contamination of the target by an eclipsing system would rarely
mimic the observed shape of the transits. The final validation of the planet is
provided by 16 radial velocities obtained with HIRES on Keck 1 over a one year
span. Although the velocities do not lead to a reliable orbit and mass
determination, they are able to constrain the mass to a 3{\sigma} upper limit
of 124 MEarth, safely in the regime of planetary masses, thus earning the
designation Kepler-22b. The radiative equilibrium temperature is 262K for a
planet in Kepler-22b's orbit. Although there is no evidence that Kepler-22b is
a rocky planet, it is the first confirmed planet with a measured radius to
orbit in the Habitable Zone of any star other than the Sun.Comment: Accepted to Ap
The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder
Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to ‘over-’ or ‘under-report’ child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD
Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development
The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype—a set of sub-clinical characteristics of autism spectrum disorder—on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30–68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research
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