The Cretaceous-Paleogene boundary and its 405-kyr eccentricity cycle phase: a new constraint on radiometric dating and astrochronology

Radiometric dating and astrochronologic dating still suffer discrepancies without knowing which one gives the most reliable results. A new tool is proposed to constrain both the approaches. The phase of the 405-kyr signal with respect to the Cretaceous - Paleogene boundary event has been determined in the Ain Settara section (Kalaat Senan, central Tunisia). We use this phase value (Option 2), as well as an average of phase values obtained from the literature (Option 1), to examine the relationship linking both the radiometric (absolute) age assigned to the K-Pg boundary and the Cenozoic average-value of the similar to 405-kyr eccentricity period. A new useful constraint emerges: to any absolute age assumed for the K-Pg boundary corresponds a value of the mean Cenozoic 405-kyr period, and vice versa. Supposing a K-Pg boundary radiometric age in the vicinity of 66.0 Ma, then the number of entire cycles (comprised between two minima of the 405-kyr eccentricity signal) within the Cenozoic Period could only be equal to 163. When adding to this figure the parts of the cycles preceding and following these 163 entire cycles the total duration of the Cenozoic Era becomes equal to 163.168 cycles (Option 1) or 163.081 cycles (Option 2). We propose to grant a special interest to the determination of the 405-kyr cycle phase at stratigraphically well documented levels, particularly those that correspond to world-wide, sudden and catastrophic events, that are well located in time by reliable radiometric dates

Temporal integration for robust detection of distant moving objects observed by a mobile camera

The detection of moving objects in an outdoor and disturbed scene observed by a mobile camera is a difficult problem, whos e solution requires to take into account more than two successive images to achieve robustness . In this paper we present two ways to carry out this temporal integration in the motion detection process : first, the use of long temporal observations for the decisio n criteria, secondly the implementation of a prediction module . These observations are usually get from temporal filtering at differen t temporal scales . Prediction of mobile objects is iteratively updated using current detection results, but also controls the detectio n process of the following instant . When using a static sensor, we have only to consider successive images, but if the sensor itself i s moving, we need previously to compensate the apparent motion of the image . The methods that we have developped are teste d on various real images, and their interest is evaluated .La détection d'objets mobiles dans une scène extérieure perturbée à partir d'une caméra embarquée est un problème difficile, dont la solution ne peut être robuste qu'avec un intervalle temporel d'analyse supérieur à deux images consécutives. on envisage ici deux façons d'intégrer le temps dans le processus de détection : d'une part l'utilisation d'observations temporelles longues pour la décision, d'autre part la mise en oeuvre d'un module de prédiction. Ces observations sont typiquement construites à partir d'un filtrage temporel de la séquence d'images à différentes échelles de temps. La prédiction, qui concerne les objets détectés, est mise à jour incrémentalement à l'aide des résultats de la détection à l'instant courant, mais elle permet aussi de guider la détection lors de l'instant suivant. Quand la caméra est fixe, il suffit de considérer les images successives, mais dans le cas d'une caméra mobile, il est nécessaire de compenser préalablement le mouvement apparent de l'image. Les méthodes présentées dans cet article sont validées sur plusieurs séquences réelles et l'apport des différentes solutions est évalué

Occurrence and fate of antimony in plastics

Antimony (Sb) is a technology critical element whose presence is ubiquitous in manufactured products, and in particular in plastics where it is used extensively as a flame retardant synergist for brominated compounds, as a catalyst for polyethylene terephthalate production, and as a pigment for colour. This study reviews the usage, regulations and fate of Sb in plastics by examining primary data on its production, applications, contents in and migration from manufactured objects, and presence in and release from waste, including the disposal and recycling routes for this material (i.e., non-controlled disposal, incineration, landfilling and recycling). Consumption of Sb and the relative apportioning of the metalloid between different uses in plastics change continuously and are largely driven by dynamic economic factors; accordingly, reference to secondary data or sources can be misleading. Since Sb is not recovered from plastics, its fate is entirely linked to the fate of plastics themselves which, as far as disposal and recycling are concerned, might be dictated by the presence of co-associated regulated substances such as brominated flame retardants. Significantly, because of the high leachability of Sb from bottom incineration ashes, the EU considers the metalloid as the most problematic substance regarding the potential reuse of this material

Luxembourg

The 2018 political year was dominated by the parliamentary elections on 14 October2018. The general expectation was that the Christian Democrats (CSV), who had been inopposition since 2013,would win the election and return to government.In the end,they lostvotes and the incumbent coalition of Liberals (DP), Social Democrats (LSAP) and Greens(Déi Gréng) could maintain its majority, allowing the three parties to continue for a secondterm. These elections also led to the rise of the Pirate Party.On the legislative front, several bills on the government’s legislative agenda were votedon by Parliament

The structural and chemical basis of temporary adhesion in the sea star Asterina gibbosa

Background: Marine biological adhesives are a promising source of inspiration for biomedical and industrial applications. Nevertheless, natural adhesives and especially temporary adhesion systems are mostly unexplored. Sea stars are able to repeatedly attach and detach their hydraulic tube feet. This ability is based on a duo-gland system and, upon detachment, the adhesive material stays behind on the substrate as a 'footprint'. In recent years, characterization of sea star temporary adhesion has been focussed on the forcipulatid species Asterias rubens. Results: We investigated the temporary adhesion system in the distantly related valvatid species Asterina gibbosa. The morphology of tube feet was described using histological sections, transmission-, and scanning electron microscopy. Ultrastructural investigations revealed two adhesive gland cell types that both form electron-dense secretory granules with a more lucid outer rim and one de-adhesive gland cell type with homogenous granules. The footprints comprised a meshwork on top of a thin layer. This topography was consistently observed using various methods like scanning electron microscopy, 3D confocal interference microscopy, atomic force microscopy, and light microscopy with crystal violet staining. Additionally, we tested 24 commercially available lectins and two antibodies for their ability to label the adhesive epidermis and footprints. Out of 15 lectins labelling structures in the area of the duo-gland adhesive system, only one also labelled footprints indicating the presence of glycoconjugates with α-linked mannose in the secreted material. Conclusion: Despite the distant relationship between the two sea star species, the morphology of tube feet and topography of footprints in A. gibbosa shared many features with the previously described findings in A. rubens. These similarities might be due to the adaptation to a benthic life on rocky intertidal areas. Lectin- and immuno-labelling indicated similarities but also some differences in adhesive composition between the two species. Further research on the temporary adhesive of A. gibbosa will allow the identification of conserved motifs in sea star adhesion and might facilitate the development of biomimetic, reversible glues.</p

11β-Hydroxysteroid Dehydrogenase-1 Is a Novel Regulator of Skin Homeostasis and a Candidate Target for Promoting Tissue Repair

11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the interconversion of cortisone and cortisol within the endoplasmic reticulum. 11β-HSD1 is expressed widely, most notably in the liver, adipose tissue, and central nervous system. It has been studied intensely over the last 10 years because its activity is reported to be increased in visceral adipose tissue of obese people. Epidermal keratinocytes and dermal fibroblasts also express 11β-HSD1. However, the function of the enzymatic activity 11β-HSD1 in skin is not known. We found that 11β-HSD1 was expressed in human and murine epidermis, and this expression increased as keratinocytes differentiate. The expression of 11β-HSD1 by normal human epidermal keratinocytes (NHEKs) was increased by starvation or calcium-induced differentiation in vitro. A selective inhibitor of 11β-HSD1 promoted proliferation of NHEKs and normal human dermal fibroblasts, but did not alter the differentiation of NHEKs. Topical application of selective 11β-HSD1 inhibitor to the dorsal skin of hairless mice caused proliferation of keratinocytes. Taken together, these data suggest that 11β-HSD1 is involved in tissue remodeling of the skin. This hypothesis was further supported by the observation that topical application of the selective 11β-HSD1 inhibitor enhanced cutaneous wound healing in C57BL/6 mice and ob/ob mice. Collectively, we conclude that 11β-HSD1 is negatively regulating the proliferation of keratinocytes and fibroblasts, and cutaneous wound healing. Hence, 11β-HSD1 might maintain skin homeostasis by regulating the proliferation of keratinocytes and dermal fibroblasts. Thus 11β-HSD1 is a novel candidate target for the design of skin disease treatments

Sugary interfaces mitigate contact damage where stiff meets soft

The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3(+)-DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA-and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices

The Multiscenario Multienvironment BioSecure Multimodal Database (BMDB)

A new multimodal biometric database designed and acquired within the framework of the European BioSecure Network of Excellence is presented. It is comprised of more than 600 individuals acquired simultaneously in three scenarios: 1) over the Internet, 2) in an office environment with desktop PC, and 3) in indoor/outdoor environments with mobile portable hardware. The three scenarios include a common part of audio/video data. Also, signature and fingerprint data have been acquired both with desktop PC and mobile portable hardware. Additionally, hand and iris data were acquired in the second scenario using desktop PC. Acquisition has been conducted by 11 European institutions. Additional features of the BioSecure Multimodal Database (BMDB) are: two acquisition sessions, several sensors in certain modalities, balanced gender and age distributions, multimodal realistic scenarios with simple and quick tasks per modality, cross-European diversity, availability of demographic data, and compatibility with other multimodal databases. The novel acquisition conditions of the BMDB allow us to perform new challenging research and evaluation of either monomodal or multimodal biometric systems, as in the recent BioSecure Multimodal Evaluation campaign. A description of this campaign including baseline results of individual modalities from the new database is also given. The database is expected to be available for research purposes through the BioSecure Association during 2008Comment: Published at IEEE Transactions on Pattern Analysis and Machine Intelligence journa

Mechanical properties of the compass depressors of the sea-urchin Paracentrotus lividus (Echinodermata, Echinoidea) and the effects of enzymes, neurotransmitters and synthetic tensilin-like protein

The compass depressors (CDs) of the sea-urchin lantern are ligaments consisting mainly of discontinuous collagen fibrils associated with a small population of myocytes. They are mutable collagenous structures, which can change their mechanical properties rapidly and reversibly under nervous control. The aims of this investigation were to characterise the baseline (i.e. unmanipulated) static mechanical properties of the CDs of Paracentrotus lividus by means of creep tests and incremental force-extension tests, and to determine the effects on their mechanical behaviour of a range of agents. Under constant load the CDs exhibited a three-phase creep curve, the mean coefficient of viscosity being 561±365 MPa.s. The stress-strain curve showed toe, linear and yield regions; the mean strain at the toe-linear inflection was 0.86±0.61; the mean Young's modulus was 18.62±10.30 MPa; and the mean tensile strength was 8.14±5.73 MPa. Hyaluronidase from Streptomyces hyalurolyticus had no effect on creep behaviour, whilst chondroitinase ABC prolonged primary creep but had no effect on secondary creep or on any force-extension parameters; it thus appears that neither hyaluronic acid nor sulphated glycosaminoglycans have an interfibrillar load transfer function in the CD. Acetylcholine, the muscarinic agonists arecoline and methacholine, and the nicotinic agonists nicotine and 1-[1-(3,4-dimethyl-phenyl)-ethyl]-piperazine produced an abrupt increase in CD viscosity; the CDs were not differentially sensitive to muscarinic or nicotinic agonists. CDs showed either no, or no consistent, response to adrenaline, L-glutamic acid, 5-hydroxytryptamine and γ-aminobutyric acid. Synthetic echinoid tensilin-like protein had a weak and inconsistent stiffening effect, indicating that, in contrast to holothurian tensilins, the echinoid molecule may not be involved in the regulation of collagenous tissue tensility. We compare in detail the mechanical behaviour of the CD with that of mammalian tendon and highlight its potential as a model system for investigating poorly understood aspects of the ontogeny and phylogeny of vertebrate collagenous tissues.(undefined)info:eu-repo/semantics/publishedVersio

De novo assembly of a transcriptome from the eggs and early embryos of Astropecten aranciacus

Starfish have been instrumental in many fields of biological and ecological research. Oocytes of Astropecten aranciacus, a common species native to the Mediterranean Sea and the East Atlantic, have long been used as an experimental model to study meiotic maturation, fertilization, intracellular Ca2+ signaling, and cell cycle controls. However, investigation of the underlying molecular mechanisms has often been hampered by the overall lack of DNA or protein sequences for the species. In this study, we have assembled a transcriptome for this species from the oocytes, eggs, zygotes, and early embryos, which are known to have the highest RNA sequence complexity. Annotation of the transcriptome identified over 32,000 transcripts including the ones that encode 13 distinct cyclins and as many cyclin-dependent kinases (CDK), as well as the expected components of intracellular Ca2+ signaling toolkit. Although the mRNAs of cyclin and CDK families did not undergo significant abundance changes through the stages from oocyte to early embryo, as judged by real-time PCR, the transcript encoding Mos, a negative regulator of mitotic cell cycle, was drastically reduced during the period of rapid cleavages. Molecular phylogenetic analysis using the homologous amino acid sequences of cytochrome oxidase subunit I from A. aranciacus and 30 other starfish species indicated that Paxillosida, to which A. aranciacus belongs, is not likely to be the most basal order in Asteroidea. Taken together, the first transcriptome we assembled in this species is expected to enable us to perform comparative studies and to design gene-specific molecular tools with which to tackle long-standing biological questions