Avoiding deontic explosion by contextually restricting aggregation

In this paper, we present an adaptive logic for deontic conflicts, called P2.1(r), that is based on Goble's logic SDLaPe-a bimodal extension of Goble's logic P that invalidates aggregation for all prima facie obligations. The logic P2.1(r) has several advantages with respect to SDLaPe. For consistent sets of obligations it yields the same results as Standard Deontic Logic and for inconsistent sets of obligations, it validates aggregation "as much as possible". It thus leads to a richer consequence set than SDLaPe. The logic P2.1(r) avoids Goble's criticisms against other non-adjunctive systems of deontic logic. Moreover, it can handle all the 'toy examples' from the literature as well as more complex ones

Regression modeling weather and biolsolids effects on dryland wheat yields in Eastern Colorado, 2001-2012

In the western Great Plains, climate dictates dryland wheat (Triticum aestivum, L) productivity. Producers use inorganic N fertilizers to improve crop yields in this region, while municipalities recycle sewage biosolids in the area. Will biosolids (from the Littleton/Englewood, CO Wastewater Treatment Plant) applications to western Great Plains dryland agroecosystems interact with weather to affect wheat production? To this end, we regressed crop yields on weather variables from 2000 through 2011 at a site about 40 km (approximately 25 miles) east of Byers, CO (Byers). We used SAS (Proc Reg) to develop several multiple regression models to predict crop yields. Our model of choice included four weather parameters for Byers wheat production. Regression variables included September and May precipitation and October and May monthly mean temperatures. Biosolids or nitrogen fertilizer application did not appear in our chosen model. We validated the wheat models using weather data and yields from the Colorado State University (CSU) Crops Testing Program from Akron, Burlington, Lamar, and Yuma, CO. According to t-tests comparing mean observed and predicted yields, the Byers model predicted yields from 2000-2011 at these locations with a +5.3% mean absolute error. A positive result of these analyses is that biosolids produced the same crop yields as commercial N fertilizer from 2001 through 2011

Regression modeling weather and biolsolids effects on dryland wheat yields in Eastern Colorado, 2001-2012

In the western Great Plains, climate dictates dryland wheat (Triticum aestivum, L) productivity. Producers use inorganic N fertilizers to improve crop yields in this region, while municipalities recycle sewage biosolids in the area. Will biosolids (from the Littleton/Englewood, CO Wastewater Treatment Plant) applications to western Great Plains dryland agroecosystems interact with weather to affect wheat production? To this end, we regressed crop yields on weather variables from 2000 through 2011 at a site about 40 km (approximately 25 miles) east of Byers, CO (Byers). We used SAS (Proc Reg) to develop several multiple regression models to predict crop yields. Our model of choice included four weather parameters for Byers wheat production. Regression variables included September and May precipitation and October and May monthly mean temperatures. Biosolids or nitrogen fertilizer application did not appear in our chosen model. We validated the wheat models using weather data and yields from the Colorado State University (CSU) Crops Testing Program from Akron, Burlington, Lamar, and Yuma, CO. According to t-tests comparing mean observed and predicted yields, the Byers model predicted yields from 2000-2011 at these locations with a +5.3% mean absolute error. A positive result of these analyses is that biosolids produced the same crop yields as commercial N fertilizer from 2001 through 2011

Cosmological Implications of Neutrinos

The lectures describe several cosmological effects produced by neutrinos. Upper and lower cosmological limits on neutrino mass are derived. The role that neutrinos may play in formation of large scale structure of the universe is described and neutrino mass limits are presented. Effects of neutrinos on cosmological background radiation and on big bang nucleosynthesis are discussed. Limits on the number of neutrino flavors and mass/mixing are given.Comment: 41 page, 7 figures; lectures presented at ITEP Winter School, February, 2002; to be published in the Proceeding

Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV

The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5’-triphosphate pyrophosphohydrolase (ITPase). Here, we investigated the association of ITPase activity and ITPA genotype with the occurrence of adverse events (AEs) during combination antiretroviral therapy (cART) for human immunodeficiency virus (HIV) infection. In 393 adult HIV-seropositive patients, AEs were defined as events that led to stop of cART regimen. ITPase activity 4 mmol IMP/mmol Hb/hour was considered as normal. ITPA genotype was determined by testing two ITPA polymorphisms: c.94C>A (p. Pro32Thr, rs1127354) and c.124+21A>C (rs7270101). Logistic regression analysis determined odds ratios for developing AEs. In tenofovir-containing regimens decreased ITPase activity was associated with less AEs (p = 0.01) and longer regimen duration (p = 0.001). In contrast, in abacavir-containing regimens decreased ITPase activity was associated with more AEs (crude p = 0.02) and increased switching of medication due to AEs (p = 0.03). ITPA genotype wt/wt was significantly associated with an increase in the occurrence of AEs in tenofovir-containing regimens. Decreased ITPase activity seems to be protective against occurrence of AEs in tenofovir-containing cART, while it is associated with an increase in AEs in abacavir-containing regimens

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes

Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding disease progression and remission. We investigated longitudinally circulating concentrations of CCR5 ligands of 256 newly diagnosed patients with type 1 diabetes. CCR5 ligands were differentially associated with beta-cell function and clinical remission. CCL5 was decreased in remitters and positively associated with HbA1c suggestive of a Th1 associated progression of the disease. Likewise, CCL3 was negatively related to C-peptide and positively associated with the beta-cell stress marker proinsulin but increased in remitters. CCL4 associated with decreased beta-cell stress shown by negative association with proinsulin. Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes

Breakup reaction models for two- and three-cluster projectiles

Breakup reactions are one of the main tools for the study of exotic nuclei, and in particular of their continuum. In order to get valuable information from measurements, a precise reaction model coupled to a fair description of the projectile is needed. We assume that the projectile initially possesses a cluster structure, which is revealed by the dissociation process. This structure is described by a few-body Hamiltonian involving effective forces between the clusters. Within this assumption, we review various reaction models. In semiclassical models, the projectile-target relative motion is described by a classical trajectory and the reaction properties are deduced by solving a time-dependent Schroedinger equation. We then describe the principle and variants of the eikonal approximation: the dynamical eikonal approximation, the standard eikonal approximation, and a corrected version avoiding Coulomb divergence. Finally, we present the continuum-discretized coupled-channel method (CDCC), in which the Schroedinger equation is solved with the projectile continuum approximated by square-integrable states. These models are first illustrated by applications to two-cluster projectiles for studies of nuclei far from stability and of reactions useful in astrophysics. Recent extensions to three-cluster projectiles, like two-neutron halo nuclei, are then presented and discussed. We end this review with some views of the future in breakup-reaction theory.Comment: Will constitute a chapter of "Clusters in Nuclei - Vol.2." to be published as a volume of "Lecture Notes in Physics" (Springer

Light propagation in statistically homogeneous and isotropic universes with general matter content

We derive the relationship of the redshift and the angular diameter distance to the average expansion rate for universes which are statistically homogeneous and isotropic and where the distribution evolves slowly, but which have otherwise arbitrary geometry and matter content. The relevant average expansion rate is selected by the observable redshift and the assumed symmetry properties of the spacetime. We show why light deflection and shear remain small. We write down the evolution equations for the average expansion rate and discuss the validity of the dust approximation.Comment: 42 pages, no figures. v2: Corrected one detail about the angular diameter distance and two typos. No change in result

Oscillation effects on neutrino decoupling in the early universe

In the early universe, neutrinos decouple from equilibrium with the electromagnetic plasma at a temperature which is only slightly higher than the temperature where electrons and positrons annihilate. Therefore neutrinos to some extent share in the entropy transfer from e^+e^- to other species, and their final temperature is slightly higher than the canonical value T_nu = (4/11)^{1/3} T_gamma. We study neutrino decoupling in the early universe with effects of neutrino oscillations included, and find that the change in neutrino energy density from e^+ e^- annihilations can be about 2-3% higher if oscillation are included. The primordial helium abundance can be changed by as much as 1.5 x 10^-4 by neutrino oscillations.Comment: minor changes, matches version to appear in PR

Measurement of νˉμ\bar{\nu}_{\mu} and νμ\nu_{\mu} charged current inclusive cross sections and their ratio with the T2K off-axis near detector

We report a measurement of cross section $\sigma(\nu_{\mu}+{\rm nucleus}\rightarrow\mu^{-}+X)$ and the first measurements of the cross section $\sigma(\bar{\nu}_{\mu}+{\rm nucleus}\rightarrow\mu^{+}+X)$ and their ratio $R(\frac{\sigma(\bar \nu)}{\sigma(\nu)})$ at (anti-)neutrino energies below 1.5 GeV. We determine the single momentum bin cross section measurements, averaged over the T2K $\bar{\nu}/\nu$-flux, for the detector target material (mainly Carbon, Oxygen, Hydrogen and Copper) with phase space restricted laboratory frame kinematics of $\theta_{\mu}$500 MeV/c. The results are $\sigma(\bar{\nu})=\left( 0.900\pm0.029{\rm (stat.)}\pm0.088{\rm (syst.)}\right)\times10^{-39}$ and $\sigma(\nu)=\left( 2.41\ \pm0.022{\rm{(stat.)}}\pm0.231{\rm (syst.)}\ \right)\times10^{-39}$in units of cm$^{2}$/nucleon and$R\left(\frac{\sigma(\bar{\nu})}{\sigma(\nu)}\right)= 0.373\pm0.012{\rm (stat.)}\pm0.015{\rm (syst.)}$.Comment: 18 pages, 8 figure