Avaliação do conhecimento e das percepções da população a partir de similaridade de grupos em relação ao consumo do pinhão, sistema produtivo e conservação da araucária.

O uso racional de bens e serviços da natureza tem se mostrado cada vez mais importante para as atividades humanas devido as grandes pressões ambientais ocasionadas pelo consumo desenfreado. A Araucaria angustifolia (Bertol.) Kuntze é uma espécie arbórea pertencente floresta ombrófila mista, sua semente é consumida em diversas regiões do país. Porém é uma espécie ameaçada de extinção. O objetivo do trabalho foi avaliar o conhecimento da população sobre a cadeia produtiva do pinhão. Para este estudo foi realizada pesquisa online com 1000 participantes, os resultados agrupados por similaridade e a produção de clusters de análise. Foi possível perceber que grande parte das pessoas que conhecem o pinhão se encontra na região sul e são mulheres. Seu consumo está relacionado com rendas mais altas e maior escolaridade. A maioria dos consumidores não conhece o manejo produtivo.Anais da Reunião Técnica sobre Agroecologia: Agroecologia, Resiliência e Bem Viver, 2021, Pelotas

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

The essential mitotic kinase Aurora A (AURKA) is controlled during cell cycle progression via two distinct mechanisms. Following activation loop autophosphorylation early in mitosis when it localizes to centrosomes, AURKA is allosterically activated on the mitotic spindle via binding to the microtubule-associated protein, TPX2. Here, we report the discovery of AurkinA, a novel chemical inhibitor of the AURKA-TPX2 interaction, which acts via an unexpected structural mechanism to inhibit AURKA activity and mitotic localization. In crystal structures, AurkinA binds to a hydrophobic pocket (the 'Y pocket') that normally accommodates a conserved Tyr-Ser-Tyr motif from TPX2, blocking the AURKA-TPX2 interaction. AurkinA binding to the Y- pocket induces structural changes in AURKA that inhibit catalytic activity in vitro and in cells, without affecting ATP binding to the active site, defining a novel mechanism of allosteric inhibition. Consistent with this mechanism, cells exposed to AurkinA mislocalise AURKA from mitotic spindle microtubules. Thus, our findings provide fresh insight into the catalytic mechanism of AURKA, and identify a key structural feature as the target for a new class of dual-mode AURKA inhibitors, with implications for the chemical biology and selective therapeutic targeting of structurally related kinases.We are grateful for the access and support at beamlines i02, i03 and i04-1 at Diamond Light Source at Harwell, UK (proposal MX9007 and MX9537) and at beamline Proxima1 at the SOLEIL Synchrotron, Gif-sur-Yvette, France. We are grateful for access and support from the X-ray and biophysics facilities (Dept. of Biochemistry) and the screening/imaging facility (MRC Cancer Unit). M.J. was supported by a Cancer Research UK studentship held in the labs of DS and ARV, PS and MR by a Wellcome Trust Strategic Award to ARV and MH, and DJH, BH, AJN and GM by grants from the UK Medical Research Council to ARV.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/srep2852

An update on site search activities for SWGO

The Southern Wide-field Gamma-ray Observatory (SWGO) is a project by scientists and engineers from 14 countries and 78 institutions to design and build the first wide-field, ground-based gamma-ray observatory in the Southern Hemisphere, with high duty cycle and covering an energy range rom hundreds of GeV to the PeV scale. The observatory will cover the Southern sky and aims to map the Galaxy's large-scale emission, as well as detecting transient and variable phenomena. The host sites under consideration are at a minimum altitude of 4400 m.a.s.l. and comprise two types: flat plateaus of at least 1 km$^{2}$ for the installation of an array of tank-based water Cherenkov detectors (WCD), or large natural lakes for the direct deployment of WCD units. Four South American countries proposed excellent sites to host the observatory meeting these requirements. Argentina proposed two locations in the Salta province, Bolivia presented one site in Chacaltaya, Chile two locations within the Atacama Astronomical Park, and Peru two ground-based locations in the Arequipa district as well as lakes in the Cuzco region. The SWGO collaboration is currently conducting a site characterization study, gathering all the necessary information for site shortlisting and final site selection by the end of 2023. The process has reached the shortlisting phase, in which primary and backup sites for each country have been identified. The primary sites were visited by a team of experts from the collaboration, to investigate and validate the proposed site characteristics. Here we present an update on these site selection activities.Comment: In Proceedings of the 2023 ICRC, Nagoya, Japa

MARTA: A high-energy cosmic-ray detector concept with high-accuracy muon measurement

A new concept for the direct measurement of muons in air showers is presented. The concept is based on resistive plate chambers (RPCs), which can directly measure muons with very good space and time resolution. The muon detector is shielded by placing it under another detector able to absorb and measure the electromagnetic component of the showers such as a water-Cherenkov detector, commonly used in air shower arrays. The combination of the two detectors in a single, compact detector unit provides a unique measurement that opens rich possibilities in the study of air showers.Comment: 11 page

Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV

We describe the measurement of the depth of maximum, Xmax, of the longitudinal development of air showers induced by cosmic rays. Almost four thousand events above 10^18 eV observed by the fluorescence detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selected for the analysis. The average shower maximum was found to evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/- 0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The interpretation of these results in terms of the cosmic ray mass composition is briefly discussed.Comment: Accepted for publication by PR

The Pierre Auger Observatory III: Other Astrophysical Observations

Astrophysical observations of ultra-high-energy cosmic rays with the Pierre Auger ObservatoryComment: Contributions to the 32nd International Cosmic Ray Conference, Beijing, China, August 201

Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200

Highlights from the Pierre Auger Observatory

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 201