Incorporating grape seed antioxidants into a functional food model

Gemstone Team IMMUNE (Innovative Medicines for Maladies Utilizing Nutraceutical Enhancements)Consumption of foods rich in natural antioxidants may potentially reduce the risk of chronic illnesses. This study examined feasibility and consumer acceptability of creating a functional food rich in natural antioxidants from cold-pressed grape seed oil and flour. The first study investigated and compared five grape seed varieties, and found Chardonnay grape seeds contained the highest quantity of health-beneficial properties. Consequently, addition of Chardonnay grape seed flour and oil to bread significantly increased health-beneficial properties. Baking conditions influenced antioxidant properties of bread, indicating processing conditions may affect antioxidant activity in finished food products. In addition, the consumer sensory evaluation study found control bread was preferred over bread containing grape seed flour and oil; however, grape seed containing bread had an overall positive reception. Incorporation of grape seeds into bread may be effective in incorporating health-beneficial compounds into the diet; however, further studies on long term health effects should be conducted

The Benefits of Frequent Positive Affect: Does Happiness Lead to Success?

Numerous studies show that happy individuals are successful across multiple life domains, including marriage, friendship, income, work performance, and health. The authors suggest a conceptual model to account for these findings, arguing that the happiness–success link exists not only because success makes people happy, but also because positive affect engenders success. Three classes of evidence—crosssectional, longitudinal, and experimental—are documented to test their model. Relevant studies are described and their effect sizes combined meta-analytically. The results reveal that happiness is associated with and precedes numerous successful outcomes, as well as behaviors paralleling success. Furthermore, the evidence suggests that positive affect—the hallmark of well-being—may be the cause of many of the desirable characteristics, resources, and successes correlated with happiness. Limitations, empirical issues, and important future research questions are discussed

TP63 and TP73 in cancer, an unresolved “family” puzzle of complexity, redundancy and hierarchy

AbstractTP53 belongs to a small gene family that includes, in mammals, two additional paralogs, TP63 and TP73. The p63 and p73 proteins are structurally and functionally similar to p53 and their activity as transcription factors is regulated by a wide repertoire of shared and unique post-translational modifications and interactions with regulatory cofactors. p63 and p73 have important functions in embryonic development and differentiation but are also involved in tumor suppression. The biology of p63 and p73 is complex since both TP63 and TP73 genes are transcribed into a variety of different isoforms that give rise to proteins with antagonistic properties, the TA-isoforms that act as tumor-suppressors and DN-isoforms that behave as proto-oncogenes. The p53 family as a whole behaves as a signaling “network” that integrates developmental, metabolic and stress signals to control cell metabolism, differentiation, longevity, proliferation and death. Despite the progress of our knowledge, the unresolved puzzle of complexity, redundancy and hierarchy in the p53 family continues to represent a formidable challenge

Contextualising Apartheid at the End of Empire: Repression, ‘Development’ and the Bantustans

This article examines the global dynamics of late colonialism and how these informed South African apartheid. More specifically, it locates the programmes of mass relocation and bantustan ‘self-government’ that characterised apartheid after 1959 in relation to three key dimensions. Firstly, the article explores the global circulation of idioms of ‘development’ and trusteeship in the first half of the twentieth century and its significance in shaping segregationist policy; secondly, it situates bantustan ‘selfgovernment’ in relation to the history of decolonisation and the partitions and federations that emerged as late colonial solutions; and, thirdly, it locates the tightening of rural village planning in the bantustans after 1960 in relation to the elaboration of anti-colonial liberation struggles, repressive southern African settler politics and the Cold War. It argues that, far from developing policies that were at odds with the global ‘wind of change’, South African apartheid during the 1960s and 1970s reflected much that was characteristic about late colonial strategy

Optimised off-line SPE-GC-FID method for the determination of mineral oil saturated hydrocarbons (MOSH) in vegetable oils

4siAn optimised off-line SPE–GC–FID method based on the use of silver-silica gel was developed for the determination of mineral oil saturated hydrocarbons (MOSH) in vegetable oils, including olive pomace oil. The method is specific in not including the aromatic hydrocarbons. The performance of different silica gels (untreated, activated and treated with silver nitrate) was compared in terms of capacity to retain fat and retention of interfering olefins present in particularly large amounts in refined olive oils. A coefficient of variation of 9% was obtained performing six replicate analyses of an extra virgin olive oil fortified with an amount of MOSH near the estimated LOQ (15 mg/kg). Recoveries were close to 100%. The use of activated aluminium oxide as an additional tool to eliminate interference by endogenous long-chain n-alkanes, is discussed.reservedmixedMoret, Sabrina; Barp, Laura; Grob, Konrad; Conte, LanfrancoMoret, Sabrina; Barp, Laura; Grob, Konrad; Conte, Lanfranc

Mineral oil in human tissues, Part II: Characterization of the accumulated hydrocarbons by comprehensive two-dimensional gas chromatography

Mineral oil hydrocarbons are by far the largest contaminant in the human body. Their composition differs from that in the mineral oils humans are exposed to, and varies also between different tissues of the same individual. Using the presently best technique for characterizing the composition of mineral oil hydrocarbons, comprehensive two-dimensional gas chromatography (GC 7 GC), the hydrocarbons in human tissues were compared to those of various mineral oils. This provided information about the strongly accumulated species and might give hints on the flow path through the human body. The selectivity of accumulation is probably also of interest for the risk assessment of synthetic hydrocarbons (polyolefins). GC 7 GC grouped the MOSH into classes of n-alkanes, paraffins with a low degree of branching, multibranched paraffins and naphthenes (alkylated cyclic hydrocarbons) with 1\u20134 rings. Metabolic elimination was observed for constituents of all these classes, but was selective within each class. The MOSH in the subcutaneous abdominal fat tissues and the mesenteric lymph nodes (MLN) had almost the same composition and included the distinct signals observed in mineral oil, though in reduced amounts relative to the cloud of unresolved hydrocarbons. The MOSH in the liver and the spleen were different from those in the MLN and fat tissue, but again with largely identical composition for a given individual. Virtually all constituents forming distinct signals were eliminated, leaving an unresolved residue of highly isomerized hydrocarbons. [ABSTRACT FROM AUTHOR

MD2036: UFO Dynamics Studies and UFO Fast Detection

UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 um

Analysis of Loss Signatures of Unidentified Falling Objects in the LHC

Particulates in the LHC beam pipes can interact with the proton beams and cause significant beam losses. The "UFOs" (unidentified falling objects) hypothesis describes a particle falling into the beam, creating particle showers, being ionized and repelled. Though the signals of the beam loss monitors support this, many aspects remain unknown. Neither the source of the dust nor the release mechanism from the beam pipe are understood. The same holds for the forces involved in the interaction and the observed UFO rate reduction over the years. These open questions are approached from different angles. Firstly, a new data analysis tool was established featuring advanced raw data selection and statistical analysis. Results of this analysis will be presented. Secondly, dust samples were extracted from LHC components and analyzed to gain insight into the size distribution and material composition of the contamination. The performed observations and analysis lead to a better modelling of the UFO events and helped to understand the physics involved. The validated UFO models will be crucial in view of the high luminosity upgrade of the LHC (HL-LHC) and the Future Circular Collider (FCC).Macroparticles in the LHC beam pipes can interact with the proton beams and cause significant beam losses. The "UFO" (Unidentified Falling Objects) hypothesis describes a macroparticle falling into the beam, creating particle show- ers, being ionized and repelled. Though the signals of the beam loss monitors support this, many aspects remain un- known. Neither the source of the dust nor the release mech- anism from the beam pipe are understood. The same holds for the forces involved in the interaction and the observed UFO rate reduction over the years. These open questions are approached from different angles. Firstly, a new data analysis tool was established which allowed advanced stud- ies of the post-mortem data. Secondly, dust samples were extracted from LHC components and are being analyzed to gain insight into the size distribution and material compo- sition of the contamination. The results from direct LHC observations lead to a better modeling of the UFO events and question the initial UFO model. Updated and validated UFO models will be crucial in view of the high luminosity project of the LHC and the Future Circular Collider