Fra visibile e invisibile: il paesaggio nelle fonti cartografico-storiche

This work, which summarises the results of prolonged archival research, deals with the role that historical cartography can have in a territorialist perspective. The works carried out by French topographers in Piedmont and Liguria, between the late eighteenth and the early nineteenth century, exemplifies the capabilities of displaying territorial phenomena of these figures and therefore their current ‘value in use’. Heirs of the Enlightenment’s advances in astronomy, mathematics and geometry, from a topographic point of view they are indeed witnesses of the pictorial paradigm of imitation of nature. During the nineteenth century, the growing trend towards standardisation, objectiveness and abstraction, would have defined the almost complete disappearance of landscape from maps

Emilio Sereni e la cartografia. Un incontro mancato?

The originality of Emilio Sereni's new use of pictorial images in his most known work, have drawn the attention of many scholars. Regardless of positive or negative opinions, an underestimated evaluation of the countless types of sources used by the author for his argumentation about italian rural landscapes, has occurred. In particular, this work analyses the approach of Sereni towards historic and thematic cartography

Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study

Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodegenerative motor neuron disorders characterized by progressive age-dependent loss of corticospinal motor tract function, lower limb spasticity, and weakness. Recent clinical use of next generation sequencing (NGS) methodologies suggests that they facilitate the diagnostic approach to HSP, but the power of NGS as a first-tier diagnostic procedure is unclear. The larger-than-expected genetic heterogeneity-there are over 80 potential disease-associated genes-and frequent overlap with other clinical conditions affecting the motor system make a molecular diagnosis in HSP cumbersome and time consuming. In a single-center, cross-sectional study, spanning 4 years, 239 subjects with a clinical diagnosis of HSP underwent molecular screening of a large set of genes, using two different customized NGS panels. The latest version of our targeted sequencing panel (SpastiSure3.0) comprises 118 genes known to be associated with HSP. Using an in-house validated bioinformatics pipeline and several in silico tools to predict mutation pathogenicity, we obtained a positive diagnostic yield of 29% (70/239), whereas variants of unknown significance (VUS) were found in 86 patients (36%), and 83 cases remained unsolved. This study is among the largest screenings of consecutive HSP index cases enrolled in real-life clinical-diagnostic settings. Its results corroborate NGS as a modern, first-step procedure for molecular diagnosis of HSP. It also disclosed a significant number of new mutations in ultra-rare genes, expanding the clinical spectrum, and genetic landscape of HSP, at least in Italy

A pandemic recap : lessons we have learned

On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.Non peer reviewe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Sulle tracce di Emilio Sereni in Val Polcevera (Liguria). Fonti iconografiche e osservazioni di terreno per la storia ambientale

On the trail of Emilio Sereni in Val Polcevera (Genoa). Iconographic sources and fieldwork for environmental history. This work is inspired by some photographs taken in Val Polcevera (Liguria, Italy) in September 1951 by Emilio Sereni (1907-1977), a scholar whose contribution to the foundation of historical landscape studies in Italy is well known. In Sereni's fundamentally “continuist” interpretation, the images had to document a landscape typology (the “marrelo”) due to ancient techniques. Today, in the light of more recent studies, these images take on a new role once they are inserted into a wider network of iconographic, textual and field sources. In fact, the preliminary results of this research show how a historical-geographical micro-analysis that begins with the identification of the photographed sites can better document the environmental processes that have crossed the ecology of the rural landscapes documented by Sereni himself and their resources. All this in order to guide the actions of environmental planning and enhancement of local productions in a context that is currently at the center of various urban regeneration projects

Il pensiero critico fra geografia e scienza del territorio. Scritti su Massimo Quaini

Massimo Quaini (1941-2017) è stato uno dei protagonisti della geografia. Un gruppo di studiosi gli dedica questo libro per continuare a dipanare, nel labirinto del mondo, il filo delle sue riflessioni, che hanno collocato la geografia tra le scienze del territorio per farne oggetto di impegno civile. Il suo pensiero critico, transdisciplinare, non ha mai riconosciuto confini ma solo feconde differenze di prospettiva: la sua più alta eredità sta forse in questo impulso a integrare competenze diverse (di storici, poeti, archeologi, ecologi, pianificatori…) per rimettere in valore i luoghi del mondo. Questo non è quindi il classico libro ‘in memoria’ sui temi di Quaini ma, oseremmo dire, un libro con Quaini. Robert

Cartografia e patrimonio militare. Il caso dell’Arsenale Militare Marittimo della Spezia

L’11 e il 12 febbraio 2016 il Dipartimento di Lettere, Arti, Storia e Società dell’Università di Parma e il Centro Italiano per gli Studi Storico-Geografici hanno organizzato nella città emiliana il seminario di studio Officina cartografica: materiali per lo studio della cartografia. Due grandi campi di ricerca hanno dato fondamento all’incontro: la storia della cartografia come evoluzione nel lungo periodo della rappresentazione dello spazio; la cartografia storica quale fonte primaria per la storia del territorio, del paesaggio e dei centri urbani. L’articolato ventaglio di approcci che gli studiosi hanno messo in gioco – e che bene si riflette nei saggi qui raccolti, frutto dell’approfondimento e della rielaborazione dei temi affrontati nel corso del seminario – rivela il desiderio di conoscenza che, attorno alla cartografia storica e nell’orbita della galassia relazionale che fa capo al cosiddetto spatialturn, da qualche anno accomuna geografi, storici (dell’ambiente, della città, dell’amministrazione, della cultura ecc.), sociologi, urbanisti, storici dell’arte e della letteratura. Il lettore interessato potrà quindi trovare – frutto del lavoro di nomi affermati del panorama scientifico italiano e internazionale e di giovani studiosi – contributi metodologici e riflessioni sui recenti cambiamenti epistemologici nella ricerca storico-cartografica (Mangani, Rombai, Siniscalchi), proposte di scambio scientifico, di formazione archivisitica e aperture a nuove piste di ricerca (Guarducci, Pressenda e Sturani, M. Rossi); ricerche d’archivio e casi di studio dalla forte ricaduta applicativa (Quaini, De Santi, Gemignani-Cervellini-Rossi L., Sacco, Masetti, D’Ascenzo, Spagnoli, Piastra, Scanu e Podda, Dai Prà e Mastronunzio, Masotti, Berti, Rizzo) e una finale riflessione sul recente e fortunato romanzo di Vittorio Giacopini La mappa (Iacoli) che, riprendendo una tradizione illustrata da Borges, Calvino e tanti altri, chiama in causa il dispositivo apparentemente tecnico e astratto della carta per proporre al pubblico degli appassionati di letteratura una vicenda declinata fra storia e immaginazione