Explaining the outcome of knowledge-based systems; a discussion-based approach

Many inferences made in everyday life are only valid in the absence of explicit counter information. This has led to the development of nonmonotonic logics. The kind of reasoning performed by these logics can be difficult to explain to the average end-user of a knowledge based system that implements them. Although the system can still give advice, it is hard for the user to assess the rationale be- hind this advice. In this paper we propose an argumentation approach that enables the advice to be assessed through an interactive dialogue with the system much like the discussion one might have with a col- league. The aim of thie dialogue is for the system to convince the user that the advice is well-founded

Trifluoroacetylation of Oxygenated Naphthalenes. Synthesis of some Naphtho[2,3 c]pyran 5,10 quinones

Trifluoroacetic anhydride is shown to acylate 1,4,5-tri- and 1.4.5.7-tetramethoxynaphthalene, the former at C(3) or C(8), and the latter at C(8) exclusively. The same reagent also acylates 1-napththol and its 4,8-dialkoxy- and 4,6,8-triatkoxyderivatives to give ortto-trifluoroacetylnaphthols tn good yield. Cerium(IV) ammonium nitrate oxidation of the alkoxynaphthols gives the corresponding 2(1,1-dihydroxy-2- trifluoroethyl)-1 Anaphthoquinones. These quinones undergo hydroxypentylation of the quinonoid nucleus with 3- hydroxyhexanoic acid to give naphthol[2,3-c]pyran-5,10- quinones

Arithmetically Cohen-Macaulay Bundles on complete intersection varieties of sufficiently high multidegree

Recently it has been proved that any arithmetically Cohen-Macaulay (ACM) bundle of rank two on a general, smooth hypersurface of degree at least three and dimension at least four is a sum of line bundles. When the dimension of the hypersurface is three, a similar result is true provided the degree of the hypersurface is at least six. We extend these results to complete intersection subvarieties by proving that any ACM bundle of rank two on a general, smooth complete intersection subvariety of sufficiently high multi-degree and dimension at least four splits. We also obtain partial results in the case of threefolds.Comment: 15 page

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effectors of RIPK3-dependent cell death. Here, we directly test this idea by employing a method for the specific removal of mitochondria via mitophagy. Mitochondria-deficient cells were resistant to the mitochondrial pathway of apoptosis, but efficiently died via tumor necrosis factor (TNF)-induced, RIPK3-dependent programmed necrosis or as a result of direct oligomerization of RIPK3. Although the ROS scavenger butylated hydroxyanisole (BHA) delayed TNF-induced necroptosis, it had no effect on necroptosis induced by RIPK3 oligomerization. Furthermore, although TNF-induced ROS production was dependent on mitochondria, the inhibition of TNF-induced necroptosis by BHA was observed in mitochondria-depleted cells. Our data indicate that mitochondrial ROS production accompanies, but does not cause, RIPK3-dependent necroptotic cell death

Cooling and the SU(2) Instanton Vaccuum

We present results of an investigation into the nature of instantons in 4-dimensional pure gauge lattice $SU(2)$\ obtained from configurations which have been cooled using an under-relaxed cooling algorithm. We discuss ways of calibrating the cooling and the effects of different degrees of cooling, and compare our data for the shapes, sizes and locations of instantons with continuum results. In this paper we extend the ideas and techniques developed by us for use in $O(3)$, and compare the results with those obtained by other groups.Comment: 22 pages, LaTeX, uuencoded compressed tarfile of figures sent separately. Full (compressed) postscript version (118k)available from ftp://rock.helsinki.fi/pub/preprints/tft/Year1995/HU-TFT-95-21/paper.ps.

The Effect of Student-Directed Transition Planning With a Computer-Based Reading Support Program on the Self-Determination of Students With Disabilities

The purpose of this study was to investigate the impact of student-directed transition planning instruction (Whose Future Is It Anyway? curriculum) with a computer-based reading support program (Rocket Reader) on the self-determination, self-efficacy and outcome expectancy, and transition planning knowledge of students with disabilities. This study employed a pre- and postmeasure design with 168 middle school students with disabilities who were assigned to an experimental group (n = 86) and control group (n = 82). The results of the study demonstrated that self-determination, self-efficacy, and outcome expectancy for education planning improved through the application of Rocket Reader . Avenues are discussed for promoting middle school students’ self-determination in their transition planning, as are implications for future research.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

The magnetic field topology associated to two M flares

On 27 October, 2003, two GOES M-class flares occurred in the lapse of three hours in active region NOAA 10486. The two flares were confined and their associated brightenings appeared at the same location, displaying a very similar shape both at the chromospheric and coronal levels. We focus on the analysis of magnetic field (SOHO/MDI), chromospheric (HASTA, Kanzelhoehe Solar Observatory, TRACE) and coronal (TRACE) observations. By combining our data analysis with a model of the coronal magnetic field, we compute the magnetic field topology associated to the two M flares. We find that both events can be explained in terms of a localized magnetic reconnection process occurring at a coronal magnetic null point. This null point is also present at the same location one day later, on 28 October, 2003. Magnetic energy release at this null point was proposed as the origin of a localized event that occurred independently with a large X17 flare on 28 October, 2003, at 11:01 UT. The three events, those on 27 October and the one on 28 October, are homologous. Our results show that coronal null points can be stable topological structures where energy release via magnetic reconnection can happen, as proposed by classical magnetic reconnection models.Comment: 14 pages, 7 figure

Search for a Standard Model Higgs Boson in CMS via Vector Boson Fusion in the H->WW->l\nu l\nu Channel

We present the potential for discovering the Standard Model Higgs boson produced by the vector-boson fusion mechanism. We considered the decay of Higgs bosons into the W+W- final state, with both W-bosons subsequently decaying leptonically. The main background is ttbar with one or more jets produced. This study is based on a full simulation of the CMS detector, and up-to-date reconstruction codes. The result is that a signal of 5 sigma significance can be obtained with an integrated luminosity of 12-72 1/fb for Higgs boson masses between 130-200 GeV. In addition, the major background can be measured directly to 7% from the data with an integrated luminosity of 30 1/fb. In this study, we also suggested a method to obtain information in Higgs mass using the transverse mass distributions.Comment: 26 pages, 22 figure

Penetration into limestone targets with ogive-nose steel projectiles

We conducted depth of penetration experiments into limestone targets with 3.0 caliber-radius-head, 4340 Rc 45 steel projectiles. Powder guns launched two projectiles with length-to-diameter ratios of ten to striking velocities between 0.4 and 1.5 km/s. Projectiles had diameters and masses of 12.7 mm, 0. 117 kg and 25.4 mm, 0.610 kg. Based on data sets with these two projectile scales, we proposed an empirical penetration equation that described the target by its density and an empirical strength constant determined from penetration depth versus striking velocity data

The combined expression of solute carriers is associated with a poor prognosis in highly proliferative ER+ breast cancer

Purpose: Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity, and patient outcome. Glutamine availability for growth and progression of BC is important in several BC subtypes. This study aimed to evaluate the biological and prognostic role of the combined expression of key glutamine transporters, SLC1A5, SLC7A5 and SLC3A2 in BC with emphasis on the intrinsic molecular subtypes. Methods: SLC1A5, SLC7A5 and SLC3A2 were assessed at the protein level, using immunohistochemistry on tissue microarrays constructed from a large well characterised BC cohort (n=2,248). Patients were stratified into accredited clusters based on protein expression and correlated with clinicopathological parameters, molecular subtypes, and patient outcome. Results: Clustering analysis of SLC1A5, SLC7A5 and SLC3A2 identified three clusters Low SLCs (SLC1A5-/SLC7A5-/SLC3A2-), High SLC1A5 (SLC1A5+/SLC7A5-/SLC3A2-) and High SLCs (SLC1A5+/SLC7A5+/SLC3A2+) which had distinct correlations to known prognostic factors and patient outcome (p<0.001). The key regulator of tumour cell metabolism, c-MYC, was significantly expressed in tumours in the High SLCs cluster (p<0.001). When different BC subtypes were considered, the association with the poor outcome was observed in the ER+ high proliferation/luminal B class only (p= 0.003). In multivariate analysis, SLC clusters were independent risk factor for shorter breast cancer specific survival (p= 0.001). Conclusion: The co-operative expression of SLC1A5, SLC7A5 and SLC3A2 appears to play a role in the aggressive subclass of ER+ high proliferation/ luminal BC, driven by c-MYC, and therefore have the potential to act as therapeutic targets, particularly in synergism