Constraints on gamma-ray burst and supernova progenitors through circumstellar absorption lines. (II): Post-LBV Wolf-Rayet stars

Van Marle et al. (2005) showed that circumstellar absorption lines in early Type Ib/c supernova and gamma-ray burst afterglow spectra may reveal the progenitor evolution of the exploding Wolf-Rayet star. While the quoted paper deals with Wolf-Rayet stars which evolved through a red supergiant stage, we investigate here the initially more massive Wolf-Rayet stars which are thought to evolve through a Luminous Blue Variable (LBV) stage. We perform hydrodynamic simulations of the evolution of the circumstellar medium around a 60 Msol star, from the main sequence through the LBV and Wolf-Rayet stages, up to core collapse. We then compute the column density of the circumstellar matter as a function of radial velocity, time and angle. This allows a comparison with the number and blue-shifts, of absorption components in the spectra of LBVs, Wolf-Rayet stars, Type Ib/c supernovae and gamma-ray burst afterglows. Our simulation for the post-LBV stage shows the formation of various absorption components, which are, however, rather short lived; they dissipate on time scales shorter than 50,000yr. As the LBV stage is thought to occur at the beginning of core helium burning, the remaining Wolf-Rayet life time is expected to be one order of magnitude larger. When interpreting the absorption components in the afterglow spectrum of GRB-021004 as circumstellar, it can be concluded that the progenitor of this source did most likely not evolve through an LBV stage. However, a close binary with late common-envelope phase (Case C) may produce a circumstellar medium that closely resembles the LBV to Wolf-Rayet evolution, but with a much shorter Wolf-Rayet period.Comment: accepted for publication by A&

Forming a constant density medium close to long gamma-ray bursts

The progenitor stars of long Gamma-Ray Bursts (GRBs) are thought to be Wolf-Rayet stars, which generate a massive and energetic wind. Nevertheless, about 25 percent of all GRB afterglows light curves indicate a constant density medium close to the exploding star. We explore various ways to produce this, by creating situations where the wind termination shock arrives very close to the star, as the shocked wind material has a nearly constant density. Typically, the distance between a Wolf-Rayet star and the wind termination shock is too large to allow afterglow formation in the shocked wind material. Here, we investigate possible causes allowing for a smaller distance: A high density or a high pressure in the surrounding interstellar medium (ISM), a weak Wolf-Rayet star wind, the presence of a binary companion, and fast motion of the Wolf-Rayet star relative to the ISM. We find that all four scenarios are possible in a limited parameter space, but that none of them is by itself likely to explain the large fraction of constant density afterglows. A low GRB progenitor metallicity, and a high GRB energy make the occurrence of a GRB afterglow in a constant density medium more likely. This may be consistent with constant densities beingpreferentially found for energetic, high redshift GRBs.Comment: 13 pages, 13 figures, new version: as accepted by Astronomy & Astrophysic

The origin of blue-shifted absorption lines in a gamma-ray burst afterglow

The afterglow spectrum of GRB 021004 shows a system of blueshifted absorption lines, indicating the presence of matter moving towards us at discrete velocities in the range from 0 to more than 2000 km/s. We propose that these lines are the result of absorption by circumstellar matter, which was ejected by gamma-ray burst progenitor (a massive star) during its evolution. We have simulated the evolution of the circumstellar medium around such a star and find that the evolutionary sequence: main-sequence, Red Supergiant, Wolf-Rayet star can qualitatively reproduce the various absorption lines systems

Vascular disease in HIV/AIDS patients

Objectives. An ongoing prospective clinical survey to determine the spectrum of vascular disease in HIV/AIDS patients and the risk factors affecting clinical outcome in order to formulate a management protocol for future use. Methods. Comprehensive screening for risk factors for vascular disease as well as HIV/AIDS-related conditions. Disease pattern and presentation are noted and patients treated accordingly. Vascular emergencies are managed regardless of HIV status because this information is usually not available at the time of presentation. Elective management is based on immune status and risk stratification. Results. 42 patients tested positive for HIV. The majority of patients presented with occlusive disease (57%), followed by anearysms (21%) and vascular trauma (19%). A variety of vascular surgical procedures were performed on 36 patients. There was no surgical mortality and 10 patients developed complications, including 2 amputations and 7 cases of minor wound sepsis. The 3 patients who received preoperative antiretroviral therapy showed a marked reduction in viral count and a significant improvement in CD4 T-cell count. Conclusion. Surgery can be safe and effective in HIV-positive patients provided the necessary precautions are taken to reduce surgical morbidity. (South African Medical Journal: 2002 92(12): 974-977

A randomized controlled trial of the efficacy and cost-effectiveness of a brief intensified cognitive behavioral therapy and/or pharmacotherapy for mood and anxiety disorders: Design and methods

Background: Anxiety and mood disorders involve a high disease burden and are associated with high economic costs. A stepped-care approach intervention and abbreviated diagnostic method are assumed to increase effectiveness and efficiency of the mental healthcare and are expected to reduce economic costs. Methods: Presented are the rationale, design, and methods of a two-armed randomized controlled trial comparing \u27treatment as usual\u27 (TAU) with a brief intensified cognitive behavioral therapy (CBT) and/or pharmacotherapy. Eligible participants (N =500) of five Dutch outpatient Mental Healthcare Centers are randomly assigned to either TAU or to the experimental condition (brief CBT and/or pharmacotherapy). Data on patients\u27 progress and clinical effectiveness of treatment are assessed at baseline, post-treatment (3. months after baseline), and at 6 and 12. months post-treatment by Routine Outcome Monitoring (ROM). Cost analysis is performed on the obtained data. Discussion: Since few studies have investigated both the clinical and cost effectiveness of a stepped-care approach intervention and a shortened diagnostic ROM method in both anxiety and/or mood disorders within secondary mental health care, the results of this study might contribute to the improvement of (cost)-effective treatment options and diagnostic methods for these disorders

Gamma-Ray Bursts from tidally spun-up Wolf-Rayet stars?

The collapsar model requires rapidly rotating Wolf-Rayet stars as progenitors of long gamma-ray bursts. However, Galactic Wolf-Rayet stars rapidly lose angular momentum due to their intense stellar winds. We investigate whether the tidal interaction of a Wolf-Rayet star with a compact object in a binary system can spin up the Wolf-Rayet star enough to produce a collapsar. We compute the evolution of close Wolf-Rayet binaries, including tidal angular momentum exchange, differential rotation of the Wolf-Rayet star, internal magnetic fields, stellar wind mass loss, and mass transfer. The Wolf-Rayet companion is approximated as a point mass. We then employ a population synthesis code to infer the occurrence rates of the various relevant binary evolution channels. We find that the simple scenario -- i.e., the Wolf-Rayet star being tidally spun up and producing a collapsar -- does not occur at solar metallicity and may only occur with low probability at low metallicity. It is limited by the widening of the binary orbit induced by the strong Wolf-Rayet wind or by the radius evolution of the Wolf-Rayet star that most often leads to a binary merger. The tidal effects enhance the merger rate of Wolf-Rayet stars with black holes such that it becomes comparable to the occurrence rate of long gamma-ray bursts.Comment: 9 pages, 11 figures, accepted for publication in A&

Morphology and function of dog arterial grafts preserved in UW-solution

Objectives:To assess the function of arterial grafts after prolonged preservation in the University of Wisconsin solution (UW), in vitro and in vivo.Methods:Carotid arteries were harvested from dogs and stored for 1–21 days at 4°C in UW (n = 10) or in PBS (0.9% NaCl, pH 7.4), (PBS) (n = 10). Slices were examined by lightmicroscopy (LM) and scanning electron microscopy (SEM). For viability testing, specimens were connected to an isometric force transducer (2 × n = 9). Contractile and relaxation responses were examined by adding phenylephrine (200μM) and metacholine (200μM), respectively. For in vivo studies (n = 41), 2.5cm carotid artery segments were implanted orthotopically, as autografts and allografts, after 14 days of storage in UW or in PBS. Autologous veins were used as controls. After 28 days or 56 days, arteriography was performed and the grafts were excised for LM and SEM.Results:The arterial endothelial layer remained intact after up to 14 days of storage in UW. In PBS, the endothelium was lost after 3 days. The functional response after 14 days storage in UW was approximately 50% vs. 0% after 14 days in PBS. In the autografts, total patencies (28 days + 56 days) were 100% (8/8) and 63% (5/8) for UW and PBS stored grafts, respectively. In the allografts, the UW and PBS preserved grafts showed total patencies of 86% (12/14) and 83% (5/6), respectively. Microscopically, the allografts showed fibrotic degeneration.Conclusions:Arteries are well preserved in UW up to 14 days of storage. Arterial autografts preserved in UW showed good patency and better integrity of the vessel wall after implantation, than grafts stored in PBS or allografts (without immunosuppressive therapy)