8 research outputs found
Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2018
- Field of study
The antibacterial activity of 29 different polyoxometalates (POMs) against Moraxella catarrhalis was investigated by determination of the minimum inhibitory concentration (MIC). The Preyssler type polyoxotungstate (POT) [NaP5W30O110]14− demonstrates the highest activity against M. catarrhalis (MIC = 1 μg/ml) among all tested POMs. Moreover, we show that the Dawson type based anions, [P2W18O62]6−, [(P2O7)Mo18O54]4−, [As2Mo18O62]6−, [H3P2W15V3O62]6−, and [AsW18O60]7− are selective on M. catarrhalis (MIC range of 2-8 μg/ml). Among the six tested Keggin type based POTs ([PW12O40]3−, [H2PCoW11O40]5−, [H2CoTiW11O40]6−, [SiW10O36]8−, [SbW9O33]9−, [AsW9O33]9−), only the mono-substituted [H2CoTiW11O40]6− showed MIC value comparable to those of the Dawson type group. Polyoxovanadates (POVs) and Anderson type POMs were inactive against M. catarrhalis within the tested concentration range (1-256 μg/ml). Four Dawson type POMs [P2W18O62]6−, [(P2O7)Mo18O54]4−, [As2Mo18O62]6−, [H3P2W15V3O62]6− and the Preyssler POT [NaP5W30O110]14− showed promising antibacterial activity against M. catarrhalis (MICs < 8 μg/ml) and were therefore tested against three additional bacteria, namely S. aureus, E. faecalis, and E. coli. The most potent antibacterial agent was [NaP5W30O110]14−, exhibiting the lowest MIC values of 16 μg/ml against S. aureus and 8 μg/ml against E. faecalis. The three most active compounds ([NaP5W30O110]14−, [P2W18O62]6−, and [H3P2W15V3O62]6−) show bacteriostatic effects in killing kinetics study against M. catarrhalis. We demonstrate, that POM activity is mainly depending on composition, shape, and size, but in the case of medium-size POTs (charge is more than −12 and number of addenda atoms is not being higher than 22) its activity correlates with the total net charge
The P-type ATPase inhibiting potential of polyoxotungstates.
- Author
- Aleksandar Bijelic
- Annette Rompel
- Aureliano
- Aureliano
- Aureliano
- Bijelic
- Bijelic
- Bijelic
- Bijelic
- Blazevic
- Colović
- De Matteis
- de Meis
- Degnan
- Elias Tanuhadi
- Emir Al-Sayed
- Fraqueza
- Fraqueza
- Galani
- Gao
- Gerth
- Gil Fraqueza
- Hasenknopf
- Hua
- Joscha Breibeck
- Juan Fuentes
- Karnaky Jr
- Kortz
- Kraus
- Lee
- Lukáš Krivosudský
- Lv
- Manuel Aureliano
- Martos-Sitcha
- Mauracher
- Mauracher
- Miras
- Molitor
- Molitor
- Molitor
- Molitor
- Moussawi
- Nadiia Gumerova
- Papaconstantinou
- Pope
- Proust
- Raza
- Schmidt
- Stephan
- Tourné
- Toyoshima
- Treviño
- Turner
- Wang
- Yamase
- Yatime
- Zadunaisky
- Zhai
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2018
- Field of study
Polyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes. POMs are able to inhibit a series of biologically important enzymes, including phosphatases, and thus are able to affect many biochemical processes. In the present study, we analyzed and compared the inhibitory effects of nine different polyoxotungstates (POTs) on two P-type ATPases, Ca2+-ATPase from skeletal muscle and Na+/K+-ATPase from basal membrane of skin epithelia. For Ca2+-ATPase inhibition, an in vitro study was performed and the strongest inhibitors were determined to be the large heteropolytungstate K9(C2H8N)5[H10Se2W29O103] (Se2W29) and the Dawson-type POT K6[α-P2W18O62] (P2W18) exhibiting IC50 values of 0.3 and 0.6 μM, respectively. Promising results were also shown for the Keggin-based POTs K6H2[CoW11TiO40] (CoW11Ti, IC50 = 4 μM) and Na10[α-SiW9O34] (SiW9, IC50 = 16 μM), K14[As2W19O67(H2O)] (As2W19, IC50 = 28 μM) and the lacunary Dawson K12[α-H2P2W12O48] (P2W12, IC50 = 11 μM), whereas low inhibitory potencies were observed for the isopolytungstate Na12[H4W22O74] (W22, IC50 = 68 μM) and the Anderson-type Na6[TeW6O24] (TeW6, IC50 = 200 μM). Regarding the inhibition of Na+/K+-ATPase activity, for the first time an ex vivo study was conducted using the opercular epithelium of killifish in order to investigate the effects of POTs on the epithelial chloride secretion. Interestingly, 1 μM of the most potent Ca2+-ATPase inhibitor, Se2W29, showed only a minor inhibitory effect (14% inhibition) on Na+/K+-ATPase activity, whereas almost total inhibition (99% inhibition) was achieved using P2W18. The remaining POTs exhibited similar inhibition rates on both ATPases. These results reveal the high potential of some POTs to act as P-type ATPase inhibitors, with Se2W29 showing high selectivity towards Ca2+-ATPase.info:eu-repo/semantics/submittedVersio
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- Alcántara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso Verónica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Érika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-González Gabriela
- Ameh Emmanuel
- Amjad Muhammad Bin
- Amoabin Afua Amoabin
- Anatole Nzanzu
- Anatole Nzanzu Kipata
- Anaya Dominguez Marlene
- Anaya Firas
- Andrade Jerhy
- Andreussi Lorna
- Anicama Elias Rocio
- Annajjar Mohammad hasan
- Anntinea Jessmine
- Antunes Amanda
- Antunez-Mora Alexandra
- Anyomih Theophilus Teddy Kojo
- Anzelewicz Stefan
- Apaza Leon Jose Luis
- Appeadu-Mensah William
- Arabiat Esraa
- Arafa Mohamed Ahmed
- Arafat Hasan
- Aragão Liliana
- Arancibia Gutiérrez Elsa
- Aranda Sánchez Cristian Irela
- Arar Ahmad Samih
- Arauco Jenny
- Arbab Hana
- Arboleda Jenny
- Aremo Anuoluwapo
- Arnadóttir Helena
- Arnaud Alexis P
- Arnold Marion
- Arnoletto Lucia Beatriz
- Arrmali Saddam
- Arrmalli Lina Ali
- Arshad Muhammad
- Arthur Felicity
- Arul Suren
- Ashour Dina Ayman
- Ashour Yara shareef
- Aslan Yakup
- Aspirot Ann
- Assi Ahmadfateh
- Assi Muath Abdelrahem Fuad
- Astudillo Miguel
- Atatri Yazid yousef mahmoud
- Atta Ahmed
- Attia Alaa Mobarak
- Avile Romina
- Avolio Luigi
- Awad Hadeel
- Aydin Emrah
- Aykut Merve
- Ayque Rosas Fernando
- Aziz Dayang Anita Abdul
- Ba'baa' Basheer
- Badr Helmy
- Baertschiger Reto
- Bagbio Dominic
- Bah Abdoulie
- Bai Qiang
- Bai Yu Zuo
- Baistrocchi Valentina
- Bakar Ainal Huda Abu
- Baker Wisam
- Ballouhey Quentin
- Balousha Abrar ghassan
- Bamanga Ahmed
- Baniowda Muath A. M.
- Bao Xiaozhou
- Barauskas Vidmantas
- Barbosa Patricia Reis
- Baseggio Natalia
- Bashir Fatma
- Bashir Muhammad Kashif
- Bassan Gonçalves Paulo César
- Bataineh Ziad A.
- Batal Mohammad Mohannad
- Bazozi Hana Milad
- Beasley Spencer
- Becker Karin
- Belmino Gadelha Aluísio Augusto
- Benaskeur Yousra-Imane
- Beres Alana
- Berková Klára
- Bernaus Marianela
- Berrocal Anaya Waldo
- Berzanskis Mindaugas
- Beshtawi Doha mustafa saleh
- Beşir Ahmet
- Bianchin Ezequiel
- Bibas Fatma
- Biber Elna
- Bischoff Cristiano
- Bismarck Sylvester von
- Blain Otilia Eva
- Blanc Thomas
- Blazquez-Gomez Eva
- Bobadilla Morales Lucina
- Bode Christopher
- Bonnard Arnaud
- Boonthai Ampaipan
- Borbonet Daniel
- Bouhadiba Nordeen
- Bowder Alex
- Bracho Blanchet Eduardo
- Bradshaw Kate
- Bragagnini Paolo
- Brahmamdam Pavan
- Bravo Mauro Nicolas
- Bright Benedict Paul
- Brito Quevedo Luz Mery
- Broch Aline
- Brolin Santis Isolan Paola Maria
- Brunero Marco
- Bruxel Carla Luisa
- Bsisu Isam
- Bucaram Elena
- Bueno Mazzuca Rafael
- Bueno Motter Sarah
- Bujarimin Ahmad Shafiee bin
- Bulnes Mendizabal David
- Burks Stephen S.
- Burns Kate
- Butler Marilyn
- Bvulani Bruce
- C. Nwosu David
- Caamal Lorenzo Juvencio
- Calancea Calin
- Calderon Moore Antonio
- Calderón Arancibia José Alfredo
- Calistus Nwachukwu
- Cama Jitoko
- Camamra Kajali
- Cameron Fraser
- Camp Lauren
- Canözer Ali
- Caouette-Laberge Louise
- Cardenas Alva Loreley Raquel
- Cardenas Ruiz Velasco Juan Jose
- Carrasco Ana Lucia
- Carrasco-Ortega Cesar
- Carrillo Isabel
- Casado Francis Tanise
- Casal Beloy Isabel
- Caseb Paloma
- Casquero Victor
- Castañeda Espinosa Sergio
- Castaño Avila Daniela
- Castedo Camacho Fabiola Ruth
- Cavaiuolo Silvia
- Cañapataña Sahuanay Veronica Raquel
- Cepeda Rodrigo
- Cesur İlknur Banlı
- Chan Jonathan
- Chang Jeremy
- Charras Maria Delia
- Chaudary Ali Raza
- Chaudhry Muhammad Amjad
- Chauhan Nirav
- Chavez Galvez Patricia
- Chen Lulu
- Chen Rui
- Cheung Maija
- Chipalavela Rossana Francisco
- Chiriboga Elena
- Chitiavi Soita Wycliffe
- Chitnis Milind
- Cho Seok Hyeon
- Choo Candy SC
- Chukwu Isaac
- Chukwuemeka Anyanwu Lofty-John
- Chung Jae Hee
- Cletus Cyril
- Coghill Griffin
- Collins Nwokoro
- Colombo de Holanda Felipe
- Contreras Carla Sofia
- Coon John
- Cordonnier Annelien
- Cornelli Fabio
- Cornwall Hannah
- Corona C. Rivera Jorge Román
- Corona Rivera Alfredo
- Correa Leite Mila Torii
- Correa Armandou
- Correa Catalina
- Corrêa Costa Eduardo
- Cosoreanu Vlad
- Costas-Chavarri Ainhoa
- Cripovich Alejandrina
- Cunningham Aaron
- Czauderna Piotr
- Cáceres Aucatoma Freud
- Cárdenas Barón José de Jesús
- Cömert Hatice Sonay Yalçın
- da Silva Augusto Maria Lucia
- Dagilytė Rūta
- Dahman Nesrine Ben Hadj
- Dajia Wang
- Dalek Noor Fa'izatul Rahil Ambok
- Dallegre Maria Belen
- Dalloul Hisham
- Damiani Andrea
- Dammagh Nagham Mohammed Al
- Dania Bouguermouh
- Darras Osama Majed
- Darwish Ahmed S
- Darwish Ammar
- Dass Anthony
- Dassonville Martine
- Davenport Kate
- David Kuria
- Davies Justine
- Davis Jenna Kylene
- de Assis Silva Murilo
- de Azevedo Belesa Flavia
- de Campos Vieira Abib Simone
- de Deus Passos Leles Kamila
- de Guzman Johann
- de Souza Santos Ferreira Mariana
- Dedeke Florence
- Defago Victor Hugo
- Defert Coralie
- Delefortrie Thomas
- Delforge Xavier
- Delft Dirk von
- Delgado Malaga Florangel Patricia
- Delgado Quinteros Edgar Fernando
- Dellenmark Blom Michaela
- Dendusic Nejra
- Derbew Miliard
- Derks Terry
- Deya Corazone
- Deyab Abdelaziz
- Di Siervi Oscar
- Diaz Castañeda Flor de Maria
- Diaz Echegaray Marlene
- Diaz Gomez Jose Manuel
- Diaz Leon Cesar
- Dieudonné Lemfuka
- Dimatatac Doris Mae
- Djordjevic Ivona
- Dogar Sohail
- Doheim Mohamed Fahmy
- Dominguez Danny
- Donglai Hu
- Dornellas do Nascimento Suely
- dos Santos Dias André Iván Bradley
- Dosselman Luke J.
- Douiri Abdel
- Drah Weam
- Dube Andile Maqhawe
- Duchesne Camille
- Duggan Eileen
- Duote Cai
- Dure Carolina
- Dávila Perez Roberto
- Ebeido Annan
- Egbuchulem Ifeanyichukwu Kelvin
- Ejinkeonye Eze Chukwuemeka
- Ekenze Sebastian Okwuchukwu
- Ekwunife Okechukwu Hyginus
- El-Ghazaly Mohammed
- Elassall Gena Mohamed Hamed
- Elayeb Abdallah
- Elebute Olumide Abiodun
- Elewaily Mohamed
- Elfiky Mahmoud
- Elgammudi Mala
- Elghazaly Shrouk Mahmoud
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine Ali
- Elhattab Ahmad
- Elisante Joseph
- Elkaloush Abdullahn Abdousalam
- Elkhazmi Ebtesam Othman Abdulsalam
- Elmenam Mohamed Abd
- Elmzyyen Aya Mahmoud
- Elrais Safa Abdal
- Elsadek Menan Ahmed
- Elsaied Adham
- Elshaer Omar Adly
- Elsherbiny Mohamed
- Elsiraffy Omar Ossama
- Elstad Maria
- Elzohiri Mohamed
- Elzowawi Fathi
- Emam Omar Sameh
- Emil Sherif
- Enbaya Manal Ben
- Ensar Nicholas
- Erdem Melisa
- Eren Elif
- Ergenekon Ebru
- Eroğlu Egemen
- Erturk Nazile
- Erçin Seçil
- Eshkabilov Shukurali
- Espineda Beda
- Essa Tarek Mohamed
- Essamilghi Kamila Almabrouk Mohammed
- Ezidiegwu Ugochukwu S
- Ezomike Uchechukwu Obiora
- Faboya Omolara Moronkeji
- Fachin Camila
- Fadhle Muhamed Jassim
- Faks Vivian
- Falah Eyad Hassan
- Farag Eman mohamed
- Fares Jehad
- Farha Mervat Sufian Abu
- Farion-Aguiar Luiz
- Fawzy Omar Moustafa
- Fayez Mohamed
- Fazli Mohamad Rafi
- Feldens Leticia
- Felix Michael
- Ferdousi Tamanna
- Fernandes de Oliveira Darli
- Fernandes de Souza Rachel
- Fernandez Ferrer Marianelly
- Fernandez Portilla Emilio
- Fernandez Wilson Miriam Daniela
- Ferraz Schopf Luciano
- Flores Carbajal Lenny
- Ford Kat
- Forero Ladino Angelica Maria
- Fouda Mohamed Fayez
- Fouly Mariam Albatoul Nageh
- Fouquet-Languillat Virginie
- Fourcade Laurent
- Fowler Kathryn L
- Fox Sarah
- Franco Helena
- Furtado Meyer Karine
- Furtado Mariana
- Féliz Erick
- Gabriel Comba
- Gad Dalia
- Gadepalli Samir
- Gai A.
- Galdeano Marcelo
- Gall Caroline Le
- Gamage Tharanga
- Gamboa Kcomt Segundo
- Gao Zhigang
- Gao Zhou Chong
- Garcia Martinez Humberto
- Garcia Isidora
- Garcia Virginia
- Garcia-Aparicio Luis
- García Miriam
- Gargum Sondas Ali
- Garnier Hanna
- Garrett-Cox Robin
- Gasana Georges
- Gatzinsky Vladimir
- Gavrila Bogdan
- Gavrilovska-Brzanov Aleksandra
- Gee Oliver
- Gerus Sylwester
- Geze Şükran
- Ghabayen Amir Talat Sheda
- Ghallab Alaa
- Ghaly Khaled Abd elrahman
- Ghanem Waleed H.
- Ghayth Sumayyah
- Ghazzawi Ihsan
- Ghilardi Silva Ximena
- Ghorab Islam Abdelmonem
- Ghosh Dhruv
- Gilardi Jose
- Girão Tauffer Mariana
- Goddard Lucy
- Goebel Peter
- Gohil Hetal
- Gomes Adriano Luis
- Gomez Juanita
- Gomez Oscar
- Gondal Mudassir Fayaz
- Gonzales Brandy
- Gonzalez Cortez Luis Fernando
- Gonzalez Daniel Emilio
- Gonzalez Joann
- González Ojeda Alejandro
- Gonçalves Borges Carolina
- Gonçalves da Cunha
- Gonçalves Victor
- Gosain Ankush
- Grabowski Andrzej
- Granéli Christina
- Greenberg Jodie
- Grella Maria Giovanna
- Grosos Céline
- Grottling Emma
- Grynberg Lucie
- Guadagno Elena
- Guayelema Marisol
- Guazzotti Marinella
- Guerin Florent
- Guimarães Patricia
- Guinsburg Ruth
- Guisse Carmen
- Gurgel do Amaral Antonio Cipriano
- Gurskas Pranas
- Gutarra Palomino Andrea
- Gutierrez Maldonado Joan Elizabeth
- Habiba Alouani
- Hagander Lars
- Hagander Lars
- Haidari Sayed Aman
- Haider Naveed
- Hajajreh Ma'alem sameer
- Hakan Nilay
- Halabi Yasmeen Adly
- Hall Nigel
- Hall Timothy
- Hameed Soban
- Hamidi Nadia
- Hamidovic Ajla
- Hamill James
- Hamilton April
- Hammato Abdalkarim Yhya
- Hammond Philip
- Hammouri Ahmad G.
- Hamzah Siti Nur Aien binti Hamid
- Han Yijiang
- Hanifah Nur Atiqah binti Mohd
- Haraux Elodie
- Harilal Shamaman
- Harper Luke
- Hasan Samiul
- Hasan Samiul
- Hasanain Doaa Khalil
- Hashim Hidayah Hayati binti
- Hashim Imran
- Hashim Sophia
- Hassan Majd Yousef Mohammed
- Hassan Mohamed Abada
- Hassan Mohd Razin bin
- Hassan Zulfitri bin Md
- Herappe Mellado Dorihela
- Herdan Mohamed Omar
- Hernández Córdova Karina
- Herrera Pesara Luciana Martina
- Herrera Carina
- Herrera Laura
- Hery Géraldine
- Hinostroza Daniel
- Hisham Intisar
- Hodgman Erica
- Honhar Medhavi
- Horacio Bonavia
- Horozic Dzan
- Hospital Sonia Inamuco
- Huang Liuming
- Huang Shungen
- Huang Ting
- Huaytalla Quiroz Natalia
- Huespe Enrique
- Hukic Lamija
- Huq Umama
- Hussain Syeda Ra'ana
- Hussein Omar Ghazi
- Hussein Sara Al
- Hussien Muaad
- Hwang In ji
- Hyeon Cho Seok
- Hyman Gabriella
- Ibarra Daniel
- Ibrahim Eman Abouzeid Abouzeid
- Ibrahim Fowzia
- Ibrahim Mahmoud abdelshakour
- Ibukunolu Ogundele
- Igoche Matthias
- Ihediwa George
- İmamoğlu Mustafa
- Ionescu Sebastian
- Iracelay Susana
- Iriondo Martí
- Ishak Shareena
- Ismail Enas Musa
- Ismavel Vijay Anand
- Itangishaka Innocent
- Ivanov Monica
- Jabaiti Mohammad S.
- Jabang John N.
- Jaber Dania
- Jacobson Jillian
- Jain Sunil
- Jaiteh Musa
- Jallow Cherno S.
- Jalo Iliya
- Jamal Muhammad Umer
- Jamie Najlaa Abu
- Jamie Yasmin Mohammed Khalil Abu
- Jaramillo Martha
- Jauri Cesar
- Jayaratnam Sridharan
- Jayyab Mustafa abu
- Jester Ingo
- Jimenez Morejon Vinicio
- Joda Ali Egab
- Joharifard Shahrzad
- Johnson Stephanie
- Jones Brendan
- Jones Ceri
- Jones Matthew
- Jonuzi Asmir
- Jooma Uzair
- Joubeh Sharehan
- Jovcheski Laze
- Jr Acimar
- Juhasz Laszlo
- Julio Lapalma
- Junes Maria del Carmen
- Junjie Chen
- Junyi Wang
- Juricic Mélodie
- Jusabani Mubashir
- Jyun Keily Wong Yue
- Jáuregui Lorena
- Jérémie Niyonkuru
- Kader Şebnem
- Kalicińsk Piotr
- Kamel Tarek mohamed
- Kamilovski Marjan
- Kannessan Hemasutha a/p
- Kano Yar
- Kapihya Chisengo
- Karabulut Ramazan
- Karakus Suleyman Cuneyt
- Karamustafic Azra
- Karavdic Kenan
- Karim Sabbir
- Karim Safina
- Kaya Hatice
- Kayed Yara Imad Omar
- Kayibanda Emmanuel
- Kchiche Nahla
- Kelay Arun
- Keleş Elif
- Keshtgar Alireza
- Khaled Ala
- Khalel Wegden ibrahim almabrouk
- Khalid Hazlina Mohd.
- Khamag Omar
- Khatatba Lara Zahi Adel
- Khattak Muhammad Adnan Khan
- Khlevner Julie
- Khodor Cury Edson
- Khorana Jiraporn
- Kihiko David
- Kim Hyun-Young
- King Sebastian
- Knorr Brenner Nicole
- Knorr Christian
- Knurowska Agata
- Kohaut Jules
- Koipapi Sengua
- Korlacki Wojciech
- Kostic Ana
- Koszutski Tomasz
- Kowalewsk Grzegorz
- Krause Hardy
- Krayem Yousef
- Krisanova Dasha
- Krishnaswami Sanjay
- Kufeji Dorothy
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- Kumar Vijay
- Kumolalo Felix O.
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- Ugwunne Chuka A
- Ulasi Ikechukwu
- Ullrich Sarah
- Vacek Jonathan
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- Vanis Nedim
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- Vidal Cristian R. Zalles
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- Villalba Villalba Araceli
- Villegas Silva Raúl
- Vinskaite Asta
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- Vosoughi Armin
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- Wang Jinhu
- Wang Peng
- Waseem Basma
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- Wen Gang
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- Wester Tomas
- Wijekoon Naveen
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- Williams Regan
- Win Win Sabai Phyu
- Wishah Bisan D. M.
- Wishah Nidal
- Wissanji Hussein
- Wolak Przemyslaw
- Wolny Agnieszka
- Wong Janice
- Wong Marilyn
- Wright Naomi Jane
- Wu Guowei
- Wyrzykowski Dariusz
- Xiaodong Guo
- Xie Hua
- Yacoub Mina A.
- Yaghi Bashar
- Yaghi Dua Hasan
- Yalcinkaya Ali
- Yang Hee-Beom
- Yanis Ahmad H.
- Yanowsky Reyes Guillermo
- Yao Yang
- Yapo Benjamin
- Yarza Fernández Jessica
- Yeniay Aslı Öztürk
- Yola Mariya Mukhtar
- Yong Feng
- Youn Joong Kee
- Yousuf Hina
- Yu Mengnan
- Yu Raisa
- Yuen Quah Soong
- Yuldashev Rustam Z.
- Yunus Aayenah
- Za'nouneh Faris J. Abu
- Zaghlol Louay Y.
- Zahari Dato' Dr Zakaria bin
- Zain Mostafa
- Zaman Azrina SK
- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Çekiç Bahanur
- Çelik Müge
- Özçelik Zerrin
- Şeref Kıvanç
- Šafus Antonín
- Škvařil Jan
- Štichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
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- Shirazi Ahmed
- Shiwani Haaris
- Shmukler Daniel
- Shokor Muntaser Abu
- Sholadoye Tunde T.
- Shoukrie Shoukrie I. M.
- Shrestha Rashmit
- Siboe Mark
- Sica Giuseppe
- Siddig Esra
- Siddiqui M. Tayyab
- Sidiropoulos Theodoros
- Sievers Denise
- Sigamoney Kohila
- Silvestri Vania
- Simoes Joana
- Simon Natalie
- Simoncini Tommaso
- Simões Joana Filipa Ferreira
- Singer Georg
- Singh Abhinav
- Singh Baljit
- Singh Kathryn
- Singh Rajdeep
- Singh Tanveer
- Sinnerton Robert
- Siragusa Leandro
- Sivaprakasam Rajesh
- Skipworth Richard Je
- Slavchev Mihail
- Sleem Adham
- Smati Ismail
- Smelt Jeremy
- Smith A.
- Smolle-Juettner Freyja-Maria
- Sodhai Vivek
- Sofi Khalid
- Sohrabi Catrin
- Soibiharry Adaiah
- Sokolov Manol
- Solaini Leonardo
- Sole Oriol Martin
- Sole-Sedeno Josep M.
- Soljic Martina
- Solli Piergiorgio
- Soon Wai Cheong
- Sorbi Flavia
- Sotiropoulou Maria
- Sotudeh Mohadeseh
- Souadka Amine
- Soucheiron Maria Coronas
- Soytas Mustafa
- Sozzi Giulio
- Sparavigna Marco
- Spartalis Michael
- Spellar Kayleigh
- Spiers Harry V. M.
- Spina Alfio
- Spriano Giuseppe
- Squiers John
- Stabler Robert
- Stamatakis Emmanouil
- Stamatis Konstantinos
- Starr Nichole
- Stather Philip
- Stevens Sean
- Stevenson Andrew
- Stewart Grant D.
- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
- Stroumpoulis Konstantinos
- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
- Suresh Sreelakshmi
- Surya Ilham Utama
- Swed Sarya
- Syllaios Athanasios
- Symeonidis Dimitrios
- Szabómihályová Katarína
- Szakmany Tamas
- Szatmary Peter
- Sztipits Tamás
- Szyluk Karol
- Sá-Marta Eduarda
- Sánchez Alberto Cabañero
- Sánchez Rosa
- Sánchez-Guillén Luis
- Süleyman Marlen
- Tadic Boris
- Taha Anas
- Taha-Mehlitz Stephanie
- Tailor Bhavesh
- Taj Eldeen Samaher Taj Eldeen Hassan
- Takeda Flavio Roberto
- Takkenberg Marijn
- Talat Nabila
- Tallon-Aguilar Luis
- Talwar Rishi
- Tamayo Beatriz Villota
- Tamburello Sara
- Tamini Nicolò
- Tammo Ömer
- Tamoos Khalil
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Chih Ying
- Tan Shawn Jia Hwang
- Tanal Mert
- Tanas Yousef
- Tang Alethea
- Tang Yita
- Tani Sobhana Iftekhar
- Tantraworasin Apichat
- Tantri Aida Rosita
- Tapia-Herrero Ana-María
- Tarek Ahmed
- Tariq Aiman
- Tarle Marko
- Tarsitano Achille
- Tartaglia Dario
- Tartaglia Nicola
- Tashkandi Wail
- Taskiran Cagatay
- Tatar Cihad
- Tatsis Dimitris
- Tawalbeh Ra'Fat
- Tawiah Augustine
- Tebha Sameer
- Techapongsatorn Suphakarn
- Teixeira Pedro
- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
- Theivendran Kanthan
- Thekkinkattil Dinesh
- Theochari Nikoletta
- Theodoropoulos George
- Theophilidou Elena
- Thereska Dariel
- Thiruchandran Gajendiran
- Thomakos Nikolaos
- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
- Tirloni Luca
- Toia Francesca
- Tokidis Evripidis
- Tokocin Merve
- Tolani Musliu Adetola
- Toma Elena Adelina
- Tomasicchio Giovanni
- Tomlinson James
- Tonini Valeria
- Torre Beatrice
- Torregrosa Cristina
- Torun Bahar Canbay
- Tottman R.
- Tousidonis Manuel
- Trabulsi Nora
- Tranca Sebastian
- Trebol Jacobo
- Trejo-Avila Mario
- Triantafyllou Alexandra
- Triantafyllou Tania
- Trifunovski Aleksandar
- Tripathi Manjul
- Tripathi Prashant
- Tripathy Sujit
- Trivik-Barrientos Felipe
- Trostchansky Ivan
- Trulson Alexander
- Trungu Sokol
- Truss Adam
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsiantoula Paraskevi
- Tsironis Dimitrios
- Tsolakidis Alexandros
- Tsoulfas Georgios
- Tucker Olga
- Tuech Jean Jacques
- Turan Alparslan
- Turi Stefano
- Turna Akif
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
- Valadez Andrea Estefania Cueto
- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis
- Author
- Al-Sayed Emir (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Gumerova Nadiia I. (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Krivosudský Lukáš (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Rompel Annette (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Verbanac Donatella (Center for Translational and Clinical Research, Croatian Center of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb)
- Čipčić-Paljetak Hana (Center for Translational and Clinical Research, Croatian Center of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb)
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2018
- Field of study
The antibacterial activity of 29 different polyoxometalates (POMs) against Moraxella catarrhalis was investigated by determination of the minimum inhibitory concentration (MIC). The Preyssler type polyoxotungstate (POT) [NaP5W30O110]14− demonstrates the highest activity against M. catarrhalis (MIC = 1 μg/ml) among all tested POMs. Moreover, we show that the Dawson type based anions, [P2W18O62]6−, [(P2O7)Mo18O54]4−, [As2Mo18O62]6−, [H3P2W15V3O62]6−, and [AsW18O60]7− are selective on M. catarrhalis (MIC range of 2-8 μg/ml). Among the six tested Keggin type based POTs ([PW12O40]3−, [H2PCoW11O40]5−, [H2CoTiW11O40]6−, [SiW10O36]8−, [SbW9O33]9−, [AsW9O33]9−), only the mono-substituted [H2CoTiW11O40]6− showed MIC value comparable to those of the Dawson type group. Polyoxovanadates (POVs) and Anderson type POMs were inactive against M. catarrhalis within the tested concentration range (1-256 μg/ml). Four Dawson type POMs [P2W18O62]6−, [(P2O7)Mo18O54]4−, [As2Mo18O62]6−, [H3P2W15V3O62]6− and the Preyssler POT [NaP5W30O110]14− showed promising antibacterial activity against M. catarrhalis (MICs < 8 μg/ml) and were therefore tested against three additional bacteria, namely S. aureus, E. faecalis, and E. coli. The most potent antibacterial agent was [NaP5W30O110]14−, exhibiting the lowest MIC values of 16 μg/ml against S. aureus and 8 μg/ml against E. faecalis. The three most active compounds ([NaP5W30O110]14−, [P2W18O62]6−, and [H3P2W15V3O62]6−) show bacteriostatic effects in killing kinetics study against M. catarrhalis. We demonstrate, that POM activity is mainly depending on composition, shape, and size, but in the case of medium-size POTs (charge is more than −12 and number of addenda atoms is not being higher than 22) its activity correlates with the total net charge.© 2018 Gumerova, Al-Sayed, Krivosudský, Čipčić-Paljetak, Verbanac and Rompe
Total Synthesis, Stereochemical Assignment, and Divergent Enantioselective Enzymatic Recognition of Larreatricin
- Author
- Al-Sayed Emir (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Giester Gerald (Department of Mineralogy and Crystallography, Faculty of Earth Sciences, Geography and Astronomy, University of Vienna)
- Kampatsikas Ioannis (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Martin Harry J. (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
- Maulide Nuno (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
- Oost Rik (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
- Pretzler Matthias (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Roller Alexander (X-ray Structure Analysis Centre, Faculty of Chemistry, University of Vienna)
- Rompel Annette (Department of Biophysical Chemistry, Faculty of Chemistry, University of Vienna)
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
A concise and efficient total synthesis of the lignan natural product larreatricin as well as an unambiguous assignment of configuration of its enantiomers are reported, resolving a long‐held controversy. Enzyme kinetic studies revealed that different polyphenol oxidases show high and remarkably divergent enantioselective recognition of this secondary metabolite.© 2017 The Author
Global Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair
- Author
- Ali
- A. Rady Ahmed Hassan
- Aamir Faiqa B.
- Ababneh Hazim Sameer Mohammad
- Abaidalla Ahmed Faraj
- Abd Al-Fattah Mohammed
- Abd El-razik Sally Ahmed
- Abdelfattah Mohamed S.
- Abdelgalil Mahmoud Shaban
- Abdelhaleem Ibrahim A.
- Abdelmageed Abdelfatah A.
- Abdelwahid Elharith H.
- Abdulhamid Salaheddin M.
- Abdullah Areeba
- Abdullah Mohammad A.
- Abdullah Weaam M.
- Abdulmonem Aya Abdulilah
- Abdulwahed Eman A.
- Abelevich Alexander
- Abo Ghanima Shymaa M.
- Abotaleb Khadega
- Abozid Anwaar
- Abu Jayyab Mustafa A.
- Abu Reyash Tamara K.
- Abu-Arish Hamdoon
- Abu-Ismail Luai
- Abubakr Muhammad
- Abufaraj Mohammad
- Abuleil Amro
- Abuzeid Issa A.
- Adesunkanmi Abdul Hafiz O.
- Adeyeye Ademola Adetoyese
- Adinolfi Elvira
- Adwin Zainal Z.
- Afeikhena Ehis
- Agalianos Christos
- Ahmad Abrar
- Ahmad Hasan Y.
- Ahmad Shahzaib
- Ahmad Sharifa
- Ahmed Fathil Ida Nadiah
- Ahmed Samar G.
- Ahmed Shaheer
- Ahonkhai Irele Ifijeh
- Aimon Sibgha
- Aiolfi Alberto
- Ajekwu Samuel Chibuzo
- Aketch Martin Safari
- Akhtar Aamena
- Akhtar Hamza
- Akram Muhammad U.
- Aktas Ahmed
- Al Bastaki Aysha
- AL Hamoud Mohammad A.
- Al Sagheir Eman
- Al Shareeda Mohamad
- Al-Aydi Tala
- Al-Dhaheri Manal Jamal
- Al-Eryani Fatima
- Al-Eryani Salwa
- Al-Hajj Al-Fakih Wadhah Ahmed
- Al-Juaifari Maytham A.
- Al-Kubaisy Manolia
- Al-Nagdy Mohamed
- Al-Naggar Hamza
- Al-Saba'a Yousef K.
- Al-Shami Khayry
- Al-Shehari Mohammed
- AL-Wajeeh Ghadeer
- Alaa Sherif
- Alabad Madian
- Alabd Husayn M.
- Alahmad Ziad
- Alam Mansoor
- Alameen Hind
- Alaniz Alday Maria Jimena
- Alannaz Omar
- Alansary Marwa N.
- Alarabi Rehab
- Alasawdeh Hadeel
- Albaraesi Mohammed N.
- Alberca Páramo Ana
- Alberich Prats Marta
- Aldawoody Hogir I. R.
- Aldressi Wafa
- Alemad Shada
- Alfa Yakubu
- Alghareeb Rafah
- Alhaj Ahmad
- Alharazin Mohammed
- Alhasan Hasan
- Ali Ali
- Ali Ebrahim M.
- Ali Farjad
- Ali Wasaq
- Aliskander Fater
- Aljaber Ahmad
- Aljamal Sarah
- Alkahlout Dana M.
- Alkaseek Akram Mohammed
- Alkomi Saja
- Allen-Brough Chelsea
- Almasarweh Sami A.
- Almokdad Fares Kh.
- Almugaddami Ayman
- Aloulou Mohammad
- Alozai Muhammad Ilyas
- Alqassab Mohammed K.
- AlQatta Wail M.
- Alrayes Bourhan M. H.
- Alsayadi Ramzi
- Alshaikh Bushra Hussein
- Alshareea Entisar
- Alsmail Mohamed H.
- Alsori Mohamed
- Alvarado-Hurtado Ricardo
- Alvarez Cuiñas Ana
- Alvarez-Lozada Luis Adrian
- Alwis Weerakkodige Mithun Chamindaka
- Amer Fatima M.
- Amnaina Mohamed G.
- Anastasi Alessandro
- Andreuccetti Jacopo
- Andrews Emmet
- Anele Christopher Obinna
- Antonaya Rubia Eva
- Antonopoulou Maria Ioanna
- Antropoli Carmine
- Anwar Muhammad Idrees
- Apelian Shant N.
- Aprea Giovanni
- Arbi Fawad M.
- Arnaout Ahmad Y.
- Arnaout Khaled
- Arrambide-Garza Francisco J.
- Arthur Thomas
- Asghar Tofique
- Ashfersh Mohamed
- Asif Aiza
- Askar Aamal
- Asla Amir F.
- Asla Amir Fathi
- Atatra Khalil O.
- Attiya Omar
- Auchterlonie Rowan
- Avellaneda Nicolás L.
- Awad Ahmed K.
- Awadi Sajeda
- Awwad Amjad H.
- Ayaz Ali Amrat
- Azzam Muayad
- Bagaglini Giulia
- Bagrjancev Maxim
- Bahroun Sumayyah G.
- Baili Efstratia
- Bakeer Hibah Bileid
- Bakhtiar Mahnoor
- Balasubramanian Ishwarya
- Baldini Edoardo
- Balla Andrea
- Balluerca Alba María
- Balogun Simon Adewale
- Bandara Ginimal Bandaralage Kavinda Deshapriya
- Bani Hani Mohammad
- Barka Sharf
- Barnes Tracey
- Barry Kevin
- Bashir Muhammed
- Bazaev Andrey
- Bean Orlagh
- Bennett Kathleen E.
- Biala Marwa
- Biancafarina Alessia
- Biel Arrufat Alex
- Bissett Ian P.
- Boccia Olivia
- Boland Michael R.
- Bolger Jarlath C.
- Bona Davide
- Booth Alexander
- Borreca Riccardo
- Botes Azel
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Brachini Gioia
- Brady Aaron M. J.
- Breen Kieran J.
- Bsisu Isam
- Butt Adam U. A.
- Cagigal Ortega Elima
- Calabrò Marcello
- Camuera González Maite
- Can Şahin Melike Zeynep
- Canonico Giuseppe
- Cantürk Nuh Zafer
- Capolupo Gabriella T.
- Carannante Filippo
- Carganico Giacomo
- Caricato Marco
- Carmignani Francesco
- Carrara Giulia
- Carroll Paul
- Castaldi Antonio
- Cavaliere Davide
- Cervera Celdrán Iria
- Chan Kin Yik
- Charalabopoulos Alexandros
- Chatzimavroudis Grigorios
- Chavarrías Torija Nuria
- Chawla Tabish
- Chong Nicole
- Chrysos Emmanuel
- Chua Irene
- Chubukova Natalia
- Clancy Cillian
- Clarizia Guglielmo
- Clementé Gastón A.
- Coello-González Alejandro
- Coffey Calvin
- Colás-Ruiz Enrique
- Conlon Eoin
- Conneely John B.
- Connelly Tara M.
- Constantine Ezeme
- Cook Holly
- Cooke Fiachra
- Corcione Francesco
- Creavin Ben
- Croghan Stefanie M.
- Dal Nawaz A.
- Daniyan Muhammad
- Danzi Michele
- Dar Kamran H.
- Daradkeh Hamza
- Dardour Mohammad
- Daula Muhammad I. H.
- Davey Matthew G.
- Davis Niall F.
- de la O-Escamilla Manuel E.
- De Luca Marcello
- De Marco Paolino
- De Palma Giovanni Domenico
- De Prizio Marco
- Dean Yomna
- Deeknah Abdulqudus
- Deiana Selene
- Del Castillo Díez Federico
- Demirli Atici Semra
- Dhannoon Amenah
- Di Franco Gregorio
- Diaz Peña Patricia
- Dillon Patrick
- Dominguez Carla M
- Dorovinis Panagiotis
- Durán-Castro Daniela G.
- Durrani Ahmed M.
- Dweik Raghad
- Earley Helen
- Ebada Mahmoud A.
- Edgerton Colston
- Egbuchulem Ifeanyichukwu Kelvin
- Egdeer Amin
- Ekhmaj Reyad
- El Assaad Yousra
- El Azzazi Hind
- El kady Abd Elrahman S.
- El Sherpiny Mohamed A.
- El Tahier Abdalla Omer Mohammad
- El-Deeb Amr M.
- El-Mansoury Tarek M.
- El-Taher Ahmed K.
- Elbadawy Merihan A.
- Eldeghedi Maher
- Elfeki Hossam
- Elgadi Tahani
- Elghadban Hosam
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras A. D.
- Elliott Jessie A.
- Elliott Jessie A.
- Elsaadany Reem
- Elsadek Menan A.
- Elsayed Ahmed
- Elshami Mohamedraed
- Eltaeb Khalid F.
- Eltagani Eltahir
- Enjuto Martínez Diego T.
- Erman Myyas N.
- Estraviz- Mateos Begoña
- Ewedah Moataz
- Fabbri Nicolò
- Fahey Brian
- Fakhar Samra
- Fakoya Adegbolahan
- Farag Marina
- Farahat Sherif
- Farhan Emaan
- Farinelli Pablo Alberto
- Farooqui Fareeha
- Fayed Laila
- Fayed Notaila M.
- Fazal Mishaal
- Fazal Talha bin
- Feo Carlo V.
- Fernández-Vega Laura
- Fleming Christina A.
- Fleres Francesco
- Foley Niamh M.
- Fradelos Evangelos
- Frank Amy
- Fullard Anna
- Fullard Anna C.
- Furbetta Niccolò
- Galal-Eldin Sami
- Gallo Gaetano
- Galun Danijel
- García Domínguez Antonio
- García López de Goicoechea David
- Garrahy Darragh
- Garvin Joseph
- Ghaith Hazem S.
- Ghamri Nusr
- Ghanem Maha
- Ghannam Mohammad Maen
- Ghatwary Ahmed M.
- Ghazal Ahmad
- Ghmagh Reem
- Giacaman Yazan
- Gidiem Doaa
- Gil Barrionuevo Marta
- Gil Gomez Vicente
- Gill Sonia
- Ginestal Mariana
- Girardi Martina
- Giraudo Giorgio
- Gjam Fatima Z.
- Gomaty Jamal M.
- Gonzalez Guerreiro Judit
- Gonzalez-De Miguel Melania
- Gortázar de las Casas Sara
- Goya María M.
- Grande Michele
- Grassia Michele
- Grimaldi Luciano
- Grinlinton Megan
- Guadagni Simone
- Guboug Ali
- Guevara Martínez Jenny
- Guldogan Cem E.
- Gundogdu Emre
- Güler Sertaç Ata
- Güner 
- Hai Arrham
- Haider Sohaib
- Haij Manal Zain Mohammed
- Halwani M. Yasser
- Hamdan Alaa
- Hameed Fahd Mudassar
- Hamid Hytham K. S.
- Hanly Ann
- Hannigan Amy
- Hardy Niall P.
- Harmston Christopher
- Hasan Wisam A.
- Hasiata Vilingatoni
- Hassaan Mohamad
- Hassan Bassam
- Hassan Luden Saif Aldawla
- Hassan Ramy A.
- Hasson Hussain
- Hasson Mohammad
- Hechtl Daniel
- Hegazy Mohammed G.
- Helguera Martínez Pablo
- Helles Ameer A.
- Helmy Salma Tarek
- Heras Garceau María
- Herdan Mohamed O.
- Herrero López Imanol
- Hesham Yousef
- Hevia Falú Ramiro
- Hill Arnold D. K.
- Himi Ahmed A.
- Hokenek Ummahan Dalkilinc
- Hoti Emir
- Huang Dora
- Huilca Luis F
- Hussain Akbar
- Hussein Reema A.
- Ibraheem Fadwa F.
- Ibrahim Ahmed M.
- Ibrahim Hamza
- Idris Alhaj O.
- Ijaz Muhammad Tayyab
- Ikechukwu Ulasi Bartholomew
- Il Haddad Haifaa
- Ioannidis Argyrios
- Iqbal Aqsa
- Iruthayanathar Andru Nitharasan
- Isik Arda
- Ismail Ruba S.
- Jabbar Naveed
- Jacob Prem Thomas
- Jamal Muhammad Asad
- Jamaluddin Muhammad
- Jamel Wael
- Jamil Soomal
- Jamous Hussam
- Jaralla Nasir
- Jarkas Bakri T.
- Jarullah Furqan A.
- Javaid Amna
- Javed Arwa
- Javed Farhan
- Javeed Muhammad Hassan
- Jayarajah Umesh
- Jiang Shuwen
- Johnston Sean M.
- Joseph Nejo
- Joshi Prabesh
- Joyce William P.
- Juma Isam
- Kalfountzos Christos
- Kamour Khaula
- Kanna Sanad
- Kantola Venla
- Karim Muhammad Qaisar
- Karunarathne Rathnayake Mudhiyanselage Dulanee
- Kavalieratos George
- Kayali Ahmad Amir H.
- Kayali Hasan F.
- Kazzaz Ranim
- Kearns Emma C.
- Kelly Orlaith
- Kennedy Czara
- Kersik Alessia
- Khader Abdellatif
- Khalafalla Ashraf
- Khalid Noor
- Khalid Rizwan
- Khalil El Sharif F.
- Khaliq Fatima
- Khamaj Malak
- Khamees Almu'atasim
- Khamis Areej A.
- Khan Adel
- Khan Hashim
- Khan Muhammad Sarfraz
- Khan Rehan A.
- Khan Zartaj A.
- Khogaly Amer M. A.
- Khrais Oweiss
- Killeen Shane
- Konaizeh Dani S.
- Konstantinidis Michael
- Konstantinidou Sofia
- Korkolis Dimitrios
- Kotoreni Georgia
- Koukou Mouad
- Koukoulis Georgios
- Kozadinos Alexandros
- Krad Khaled
- Kudra Danial Aghyad
- Kumar Yash
- Kykalos Stylianos
- Ladoukakis Aristeidis
- Laghari Sundas
- Laila Aya A. N.
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Lasithiotakis Konstantinos
- Latif Javed
- Lederhuber Hans
- Lepiane Pasquale
- Liakakos Theodore
- Lim Sean T.
- Lin Anthony
- Lincango Naranjo Eddy P
- Lionetti Ruggero
- Lisi Giorgio
- Lonergan Peter E.
- Longhini Alessandro
- Lopez Juan Cruz
- López Borao Jaime
- Lucchi Andrea
- Luffarelli Paolo
- Mabrouk Laila Raafat
- Machairas Nikolaos
- Madrazo González Zoilo
- Maguire Donal
- Mahfouz Shaimaa M.
- Mahmoud Mai D.
- Mahmoud Mohamed K.
- Makhluf Hawazen A.
- Malick Daniya S.
- Malik Abdur R.
- Malik Bilal M.
- Manasra Mahmoud
- Manatakis Dimitrios K.
- Manigrasso Michele
- Mansoor Maheen
- Mansoor Shabhaz
- Mansour Hanan
- Mariani Nicolo
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- Martin Santos Silvia
- Martin Sean T.
- Marwan Abdulrhman
- Masri Ruqaya
- Masroor Layiba
- Massobrio Andrea
- Matías-García Belén
- Mazza Marcodomenico
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- McCormick Paul
- McCoubrey Alison
- McCullough Peter W.
- McDermott Frank
- McDermott Frank
- McGovern Ruth
- McGuinness Matthew
- McInerney Niall J.
- McLaughlin Ray P.
- Mehraj Asif
- Meldon Aengus
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- Menditto Rosa
- Mendoza Moreno Fernando
- Menzulin Ruslan
- Milanesi Maria
- Milone Marco
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- Mini Emanuele
- Mitchell Josh
- Mohamed Esraa E.
- Mohamed Islam M.
- Mohammad Mazen
- Mohammed Sabir Fatima
- Mohammed Alaa M. E.
- Mohan Helen M.
- Molony Emily
- Montuori Mauro
- Morelli Luca
- Morgan Fatma M.
- Mostafa Mohamed
- Mostafa Omar
- Mrissa Yassine
- Msameh Renad
- Mulita Francesk
- Muñoz-Maldonado Gerardo E.
- Murgese Alessandra
- Musa Keffi Mubarak
- Muse Samantha
- Naana Reyam
- Nabi Nauman
- Nader Mohamed
- Nafea Ahmed
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- Nasani Mohannad
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- Nassar Mahmoud A.
- Nastah Samer
- Nasto Aurelio
- Neary Peter
- Negoi Ionut
- Negoita Valentina M.
- Negrete Ocampo Jose R
- Nelli Tommaso
- Ng Kin Cheung
- Nigri Giuseppe
- Nikolouzakis Taxiarchis K.
- Novikova Anastastia
- Nugent Emmeline
- null null
- O' Leary Peter D.
- O'Brien Stephen J.
- O'Riordain Michael
- Ogundoyin Olakoyode O
- Olagunju Naomi
- Olaisheh Habib
- Olayinka Mohammed Taofiq
- Omar Mohammed A.
- Omar Osama
- Omon Henry Ehidiamen
- Oqdeh Yahya F.
- Ortiz Rodriguez Carles
- Osman Osama S.
- Otaky Mohammad Baraa
- Otero de Pablos Jaime
- Ozmen Mahir M.
- Pace Marco
- Pagès-Valle Naila
- Palomba Giuseppe
- Palumbo Alessio
- Pantea Stelian
- Pata Francesco
- Pata Francesco
- Patrone Renato
- Paunero Vázquez Patricia
- Peirce Colin
- Pellino Gianluca
- Pertile Davide
- Petrocca Sergio
- Petrucciani Niccolò
- Picardi Biagio
- Pinotti Enrico
- Pipitone Federico Nicoletta Sveva
- Pîrvu Cătălin-Alexandru
- Porcelli Francesco
- Povo Ana
- Prieto La Noire Fernando
- Proud David
- Puccioni Caterina
- Putortì Antonella
- Quinlan David M.
- Quiroga-Garza Alejandro
- Raftery Nicola
- Rajput Akram
- Ramos Bonilla Antonio
- Ranucci Maria Chiara
- Rashdan Mohammad
- Rashid Haroon
- Ratnayake Milidu V. B.
- Rehman Kiran
- Reynolds Ian S.
- Riboni Cristiana
- Ridgway Paul F.
- Ripetti Valter
- Robb William B.
- Rodrigo Vitharanage Srimantha Dewsiri
- Rodriguez-Leon Gerardo
- Rodríguez Cano María A.
- Rodríguez Gómez Lorena
- Romanzi Andrea
- Rossi Stefano
- Rostum Zuhair
- Roy Dorina
- Ruíz Frías Piedad
- Ryabkov Maxim
- Ryan Eanna
- Ryan Jessica M.
- Ryan Odhran K.
- Saad Aalaa
- Saad Ahmad
- Saad Reem J.
- Sadek Kareem
- Saeed Abdullah B.
- Saeed Reham J. M.
- Sainz-Lete Aitor
- Sakr Ahmad
- Sakr Yara
- Salih Mugahid A.
- Salih Saniye
- Saracoglu Kemal Tolga
- Sarwar Muhammad Zeeshan
- Sasia Diego
- Sawas Fatima
- Sayed Hafez Somaya Z. E
- Sánchez-Rubio María
- Scabini Stefano
- Schimera Antonio
- Schizas Dimitrios
- Scolaro Roberta
- Scorsi Alessandro
- Selvaggi Francesco
- Selvaggi Lucio
- Senhuri Alrayah E.
- Serrano-Navidad Monica
- Shaaban Abdelrahman
- Shafi Mahnoor
- Shah Syed Faraz Ali
- Shahab Tooba
- Shahbaz Usama
- Shaheen Ahmed
- Shalaby Mostafa
- Shami Sarah M.
- Shams Marvi
- Shanahan Ben
- Sharifa Mohammad
- Shehata Eslam S. A. M.
- Shetiwy Mohamed
- Shream Sarah
- Shuayb Ahlam M.
- Shulman Natassia
- Shumrakh Saeed K.
- Siggins Lauren
- Silva Cláudio
- Skroubis Georgios
- Soeda Seminario Isami
- Solaini Leonardo
- Soldevila-Verdeguer Carla
- Soriero Domenico
- Soto-Schütte Sonia
- Sountoulides Petros
- Spoletini Domenico
- Srinivasan Madhu
- Stafford Anthony T.
- Sueiras Gil Albert
- Swindon Daisy
- Syllaios Athanasios
- Şahin Enes
- Şimşek Turgay
- Taha Sandy A.
- Tahir Izza
- Taktuk Salah S.
- Talpai Tamás
- Tammo Shergal
- Tanas Yousef
- Tarky Alhashash Ahmad
- Tasis Nikolaos
- Tatar Ozan Can
- Teker Kenan
- Telha Ghassan K.
- Telha Khaled A.
- Teng Roy
- Teoh Jeremy Y. C.
- Thompson-Fawcett Mark W.
- Tolani Musliu Adetola
- Toomey Desmond
- Torchiaro Marco
- Toubasi Ahmad A.
- Toum Fthelrahman M.
- Ukrani Ronika Devi
- ul Haq Syed Atif
- Umer Farooq
- Uprak Tevfik Kıvılcım
- Ur Rehman Sheeraz
- Vailas Michail
- Valderrabano Gonzalez Santiago
- Vallet Fernandez Josep
- Vannelli Alberto
- Varghese Chris
- Vázquez-Melero Alba
- Vignati Barbara
- Vigutto Gabriele
- Wang Huaxi
- Waqar Usama
- Weeratunga George
- Winter Des C.
- Winter Des C.
- Wong Benjamin Ngie Xiong
- Xenaki Sofia
- Xu William
- Y. Aljabarein Osama
- Yaghoub Ali Abdulhafiz
- Yang Wah
- Yanishev Alexey
- Yaqoob Sadia
- Yaqub Aimen
- Yasin Fawzi Hesham
- Younes Eman
- Youssef Hadeer M. S.
- Zahid Muhammad
- Zahid Sufian M.
- Zahran Ahmed A. A. A
- Zalf Kamal
- Zarin Mohammad
- Zawahra Aya
- Zayat Hussein
- Zayat Mohammed A.
- Zevallos-Quiroz Julio
- Zheng Helen
- Zivanovic Marko
- Zwain Yasir A.
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Importance Postoperative urinary retention (POUR) is a well-recognized complication of inguinal hernia repair (IHR). A variable incidence of POUR has previously been reported in this context, and contradictory evidence surrounds potential risk factors.Objective To ascertain the incidence of, explore risk factors for, and determine the health service outcomes of POUR following elective IHR.Design, Setting, and Participants The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) study, an international, prospective cohort study, recruited participants between March 1 and October 31, 2021. This study was conducted across 209 centers in 32 countries in a consecutive sample of adult patients undergoing elective IHR.Exposure Open or minimally invasive IHR by any surgical technique, under local, neuraxial regional, or general anesthesia.Main Outcomes and Measures The primary outcome was the incidence of POUR following elective IHR. Secondary outcomes were perioperative risk factors, management, clinical consequences, and health service outcomes of POUR. A preoperative International Prostate Symptom Score was measured in male patients.Results In total, 4151 patients (3882 male and 269 female; median [IQR] age, 56 [43-68] years) were studied. Inguinal hernia repair was commenced via an open surgical approach in 82.2% of patients (n = 3414) and minimally invasive surgery in 17.8% (n = 737). The primary form of anesthesia was general in 40.9% of patients (n = 1696), neuraxial regional in 45.8% (n = 1902), and local in 10.7% (n = 446). Postoperative urinary retention occurred in 5.8% of male patients (n = 224), 2.97% of female patients (n = 8), and 9.5% (119 of 1252) of male patients aged 65 years or older. Risk factors for POUR after adjusted analyses included increasing age, anticholinergic medication, history of urinary retention, constipation, out-of-hours surgery, involvement of urinary bladder within the hernia, temporary intraoperative urethral catheterization, and increasing operative duration. Postoperative urinary retention was the primary reason for 27.8% of unplanned day-case surgery admissions (n = 74) and 51.8% of 30-day readmissions (n = 72).Conclusions The findings of this cohort study suggest that 1 in 17 male patients, 1 in 11 male patients aged 65 years or older, and 1 in 34 female patients may develop POUR following IHR. These findings could inform preoperative patient counseling. In addition, awareness of modifiable risk factors may help to identify patients at increased risk of POUR who may benefit from perioperative risk mitigation strategies
[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
- Author
- Abbey Ianthe
- Abdel Rehim Marwa
- Abdel Rehim Marwa
- Abdul Rahman A
- Abduljawwad Emad
- Abduljawwad Emad
- Abe Emuri
- Abe Ryuzo
- Aboab Jerome
- Aboab Jerome
- Acevedo Juan
- Acharya Anand
- Acquarolo Annamaria
- Acquarolo Annamaria
- Adamzik Michael
- Adamzik Michael
- Adembri Chiara
- Adrie Christophe
- Adrie Christophe
- Afessa Bekele
- Ainoda Yusuke
- Aiyar S
- Al Dabbagh Tarek
- Al Dabbagh Tarek
- Al Knawy Bandar A
- Al Knawy Bandar A
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Arabi Rida
- Al-Dorzi Hasan M
- Al-Dorzi Hasan M
- Al-Muhamadi Ali
- Al-Naeeb Yasseen
- Al-Naeeb Yasseen
- Al-Shaer Mohammad
- Al-Shaer Mohammad
- Al-Tamimi Waleed
- Al-Tamimi Waleed
- Alaniz Cesar
- Alevizaki Maria
- Alevizaki Maria
- Alinejad Faranak
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- Allolio Bruno
- AlNajjar Taghreed
- AlNajjar Taghreed
- Altintas M A
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Amano Kosaku
- Amano Kosaku
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Ambriz-Plascencia Ana Rosa
- Ameen Abdelbadee
- Ameen Abdelbadee
- Amini Amir
- Amini Amir
- Amini Amir
- Amos Taryn
- Amour Julien
- Anderegg Brent A
- Anderegg Brent A
- Andersson Liane
- Andersson Liane
- Andrade Bertha Coelho
- Androulakis Ioannis P
- Aneja Rajesh
- Angus Derek C
- Angus Derek C
- Anjum Aisha
- Anjum Aisha
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annetta M
- Antonelli M
- Antonopoulou Anastasia N
- Antonopoulou Anastasia N
- Antonucci E
- Apollonatou Sofia
- Apollonatou Sofia
- Apostolidou Efterpi N
- Apostolidou Efterpi N
- Apostolou K
- Apostolou K
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
- Araujo Leonardo V
- Aravinthan Aloysious
- Aravinthan Aloysious
- Arbor Ann
- Arlt Wiebke
- Arlt Wiebke
- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Aronowitz Paul
- Arriagada S Daniela
- Arroyo Vicente
- Arroyo Vicente
- Asahata Sayaka
- Asehnoune Karim
- Asehnoune Karim
- Asfar Pierre
- Asfar Pierre
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Atay Suleyman
- Atrash Jawad
- Atrash Jawad
- Aufort Sophie
- Aufort Sophie
- Augustatou Callirhoe
- Avidan Alexander
- Awasthi Shally
- Aya Hollmann D
- Aya Hollmann D
- Ayestaran Ignacio
- Ayestaran Ignacio
- Ayestaran Jose I
- Ayestaran Jose I
- Azoulay Elie
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- Baker Tim
- Bander Joseph
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- Barel Remy
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- Barnett Adrian G
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- Beishuizen Albertus
- Beishuizen Albertus
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- Beishuizen Albertus
- Beishuizen Albertus
- Belkouchi Abdelkader
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellomo Rinaldo
- Bellomo Rinaldo
- Bellomo Rinaldo
- Bellomo Rinaldo
- Benbenishty Julie
- Bendel Stepani
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- Bennett Stephanie
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- Bijkerk Ronald M
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- Bissell Brittany D
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- Blanchard Anne
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- Bloomfield Roxanna
- Blum Claudine A
- Boden L A
- Bogatsch Holger
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- Bohe Julien
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- Bokhari Faran
- Bollaert Pierre Edouard
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- Boney Charlotte M
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- Bornstein Stefan R
- Bosman Rob J
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- Botoula E
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- Boudou Philippe
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- Boutron Carole M
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- Briassouli E
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- Briassoulis G
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- Briegel Josef
- Briegel Josef
- Briegel Josef
- Briegel Josef
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- Briegel Josef
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- Briegel Josef
- Briegel Josef
- Briegel Josef
- Briegel Josef
- Brierley Joe
- Brindley Peter G
- Brito Vinicius Nahime
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- Brits Riette
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- Britt L D
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- Brockmeier Diane
- Broux Christophe
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- Brown Glen
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- Brunkhorst Frank M
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- Buchele Gustavo Luiz
- Buchman Timothy G
- Buisson Christian Brun
- Buno Antonio
- Burkitt Jamie M
- Burroughs Andrew Kenneth
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- Burry Lisa
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- Busch K H
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- Butschkau Antje
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- Cakir E
- Calandra Thierry
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- Caldera Maria V
- Caldwell Ellen
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- Calvano Steve E
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- Candido-Vitto Cristina
- Caputo C
- Carcillo Joseph A
- Carcillo Joseph A
- Cariou Alain
- Cariou Alain
- Cariou Alain
- Cariou Alain
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- Carlier Robert
- Carlier Robert
- Carmean Amanda
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- Carori Giampiero
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- Carr Julie
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- Carson Stephanie J
- Casanova Bonaventura
- Casanova Elena
- Casanova-Cardiel Luis Javier
- Cassar Charmaine
- Casserly Brian
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- Castanon-Gonzalez Jorge Alberto
- Castel Muriel
- Catravas John
- Cavaliere F
- Cazalis Marie-Angelique
- Cecconi Maurizio
- Cecconi Maurizio
- Cepkova Magda
- Cepkova Magda
- Cesari-Giordani Jean Francois
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- Cha Stephen S
- Chabre Olivier
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- Chagnon Frederic
- Chagnon Frederic
- Chagnon Jean-Luc
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- Chaney Whitney
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- Chang Xiao
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- Chappuis Philippe
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- Chastre Jean
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- Chaudhury Prosanto
- Chaudry Irshad H
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- Chew Victoria W
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- Chia Wai-Kit
- Chiolero Rene
- Chiriac Stefan
- Chittawatanarat Kaweesak
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- Cho Kiho
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- Chouinard Lucie
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- D'honneur Gilles
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- Dizier Stephanie
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- Douglas Ivor S
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- Kocak Mehmet
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- Koch Susanne
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- Koh Won-Jung
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- Koivula Irma
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- Kon Alexander
- Konstandelou Evangellia
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- Kopterides Petros
- Kotanidou Anastasia
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- Mazzuco Tania Longo
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- Meduri G Umberto
- Meersseman Philippe
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- Mehta Sangeeta K
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- Meier-Hellmann Andreas
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- Meng Xinke
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- Mentzelopoulos Spyros
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- Mercier Gregoire
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- Nenke M A
- Nesseler Nicolas
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- Wright Robert
- Wu Cheng-Shyong
- Wu Huang-Pin
- Wu Huang-Pin
- Wu Ling-Yi
- Wu Ta-Wei
- Wynn James L
- Xirouchakis Elias
- Xu Jun
- Xu Mujuan
- Xu Mujuan
- Yamamoto Masakazu
- Yamamoto Masakazu
- Yamashita Kiyohiko
- Yang Chunli
- Yang Chunli
- Yee Kristen S
- Yee Kristen S
- Yeh Timothy
- Yu Chung-Chieh
- Yu Chung-Chieh
- Yu Jihion
- Yu Teng-Jen
- Yu Teng-Jen
- Yu Xuezhong
- Yu Yuan-Bin
- Yu Zhui
- Yu Zhui
- Yuan Ying
- Zabalza Michel
- Zakynthinos Spyros
- Zakynthinos Spyros
- Zaloga Gary
- Zaman Muhammad
- Zampieri Fernando Godinho
- Zamri-Saad M
- Zandstra Durk F
- Zandstra Durk F
- Zaritsky Arno
- Zeni Fabrice
- Zervou Maria
- Zhang Fengmin
- Zhang Fengmin
- Zhang Haibo
- Zhang Haibo
- Zhang Qian
- Zhang Qian
- Zhang Yang
- Zhang Yang
- Zhang Zhong
- Zhang Zhong
- Zhao Xin
- Zhao Xin
- Zheng Juanjuan
- Zheng Juanjuan
- Zheng Liangliang
- Zhou Qing
- Zhou Qing
- Zhu Huadong
- Ziegenfuss Marc
- Ziegenfuss Marc
- Zijlstra J G
- Zimmerman Jerry J
- Zimmerman Jerry J
- Zuckerberg Aaron
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2007
- Field of study