294 research outputs found
Mindful Parenting, Parenting Cognitions, and Parent-Youth Communication: Bidirectional Linkages and Mediational Processes
Objectives: Mindful parenting and parenting cognitions likely have important linkages to each other and to parent-child communication, but these linkages have not been tested. In this article, we test the bidirectional linkages between mindful parenting and parenting cognitions (sense of competence, parent-centered attributions) and the underlying mediational processes that link them to parent-child communication (parental solicitation and youth disclosure). Methods: Longitudinal, autoregressive cross-lagged models were run within a longitudinal sample of rural and suburban early adolescents and their mothers (n = 421; mean adolescent age = 12.14, 46% male, 73% white). Results: Significant bidirectional linkages were found between mindful parenting and parenting cognitions across Time 1 and Time 2. Greater mindful parenting at Time 1 was associated with more positive parenting cognitions (e.g., greater perceptions of parental competence and fewer negative parent-centered attributions or self-blame) at Time 2. More positive parenting cognitions at Time 1 were also associated with greater levels of mindful parenting at Time 2. Mindful parenting at Time 2 mediated the association between parenting cognitions (both parent-centered attributions and sense of competence) at Time 1 and parental solicitation at Time 3. Conclusions: Mindful parenting and parenting cognitions influence each other over time. Parenting cognitions can affect parental solicitation via increases in mindful parenting. The discussion focuses on potential underlying processes
The contemporary distribution of grasses in Australia:a process of immigration, dispersal and shifting dominance
Motion of rotatory molecular motor and chemical reaction rate
We examine the dependence of the physical quantities of the rotatory
molecular motor, such as the rotation velocity and the proton translocation
rate, on the chemical reaction rate using the model based only on diffusion
process. A peculiar behavior of proton translocation is found and the energy
transduction efficiency of the motor protein is enhanced by this behavior. We
give a natural explanation that this behavior is universal when certain
inequalities between chemical reaction rates hold. That may give a clue to
examine whether the motion of the molecular motor is dominated by diffusion
process or not.Comment: 12 pages, 8 figure
Stuffed Rare Earth Pyrochlore Solid Solutions
Synthesis and crystal structures are described for the compounds
Ln2(Ti2-xLnx)O7-x/2, where Ln = Tb, Dy, Ho, Er, Tm, Yb, Lu, and x ranges from 0
to 0.67. Rietveld refinements on X-ray powder diffraction data indicate that in
Tb and Dy titanate pyrochlores, extra Ln3+ cations mix mainly on the Ti4+ site
with little disorder on the original Ln3+ site. For the smaller rare earths
(Ho-Lu), stuffing additional lanthanide ions results in a pyrochlore to defect
fluorite transition, where the Ln3+ and Ti4+ ions become completely randomized
at the maximum (x=0.67). In all of these Ln-Ti-O pyrochlores, the addition of
magnetic Ln3+ in place of nonmagnetic Ti4+ adds edge sharing tetrahedral spin
interactions to a normally corner sharing tetrahedral network of spins. The
increase in spin connectivity in this family of solid solutions represents a
new avenue for investigating geometrical magnetic frustration in the rare earth
titanate pyrochlores.Comment: 25 pages, 7 figures, submitted to J. Solid State Che
Phenomenology of non-standard Z couplings in exclusive semileptonic b -> s transitions
The rare decays , and
are analyzed in a generic scenario where New Physics effects
enter predominantly via penguin contributions. We show that this
possibility is well motivated on theoretical grounds, as the vertex
is particularly susceptible to non-standard dynamics. In addition, such a
framework is also interesting phenomenologically since the coupling
is rather poorly constrained by present data. The characteristic features of
this scenario for the relevant decay rates and distributions are investigated.
We emphasize that both sign and magnitude of the forward-backward asymmetry of
the decay leptons in , , carry sensitive information on New Physics. The observable is proposed as a useful probe of
non-standard CP violation in couplings.Comment: Minor modifications; version to appear in Phys. Rev.
Study into the Role of Nickel Vapor on Surface Modification of a Third-Generation Single-Crystal Superalloy
b -> s gamma in the left-right supersymmetric model
The rare decay is studied in the left-right supersymmetric
model. We give explicit expressions for all the amplitudes associated with the
supersymmetric contributions coming from gluinos, charginos and neutralinos in
the model to one-loop level. The branching ratio is enhanced significantly
compared to the standard model and minimal supersymmetric standard model values
by contributions from the right-handed gaugino and squark sector. We give
numerical results coming from the leading order contributions. If the only
source of flavor violation comes from the CKM matrix, we constrain the scalar
fermion-gaugino sector. If intergenerational mixings are allowed in the squark
mass matrix, we constrain such supersymmetric sources of flavor violation. The
decay sets constraints on the parameters of the model and
provides distinguishing signs from other supersymmetric scenarios.Comment: 12 figure
'Education, education, education' : legal, moral and clinical
This article brings together Professor Donald Nicolson's intellectual interest in professional legal ethics and his long-standing involvement with law clinics both as an advisor at the University of Cape Town and Director of the University of Bristol Law Clinic and the University of Strathclyde Law Clinic. In this article he looks at how legal education may help start this process of character development, arguing that the best means is through student involvement in voluntary law clinics. And here he builds upon his recent article which argues for voluntary, community service oriented law clinics over those which emphasise the education of students
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic phenotype remains unknown. Approximately one half of individuals with FMD have no identified mutation in FLNA and are phenotypically very similar to individuals with FLNA mutations, except for an increased tendency to form keloid scars. Using whole-exome sequencing and targeted Sanger sequencing in 19 FMD-affected individuals with no identifiable FLNA mutation, we identified mutations in two genes-MAP3K7, encoding transforming growth factor β (TGF-β)-activated kinase (TAK1), and TAB2, encoding TAK1-associated binding protein 2 (TAB2). Four mutations were found in MAP3K7, including one highly recurrent (n = 15) de novo mutation (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations affecting the kinase domain (c.208G>C [p.Glu70Gln], c.299T>A [p.Val100Glu], and c.502G>C [p.Gly168Arg]). Notably, the subjects with the latter three mutations had a milder FMD phenotype. An additional de novo mutation was found in TAB2 (c.1705G>A, p.Glu569Lys). The recurrent mutation does not destabilize TAK1, or impair its ability to homodimerize or bind TAB2, but it does increase TAK1 autophosphorylation and alter the activity of more than one signaling pathway regulated by the TAK1 kinase complex. These findings show that dysregulation of the TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations. Furthermore, they suggest that the pathogenesis of some of the filaminopathies caused by FLNA mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin toxin
The catechin, epigallocatechin gallate (eGCG), found in green tea, has inhibitory activity against a number of protein toxins and was investigated in relation to its impact upon ricin toxin (RT) in vitro. The IC50 for RT was 0.08 ± 0.004 ng/mL whereas the IC50 for RT + 100 μM eGCG was 3.02 ± 0.572 ng/mL, indicating that eGCG mediated a significant (p < 0.0001) reduction in ricin toxicity. This experiment was repeated in the human macrophage cell line THP-1 and IC50 values were obtained for RT (0.54 ± 0.024 ng/mL) and RT + 100 μM eGCG (0.68 ± 0.235 ng/mL) again using 100 μM eGCG and was significant (p = 0.0013). The documented reduction in ricin toxicity mediated by eGCG was found to be eGCG concentration dependent, with 80 and 100 μg/mL (i.e. 178 and 223 μM respectively) of eGCG mediating a significant (p = 0.0472 and 0.0232) reduction in ricin toxicity at 20 and 4 ng/ml of RT in Vero and THP-1 cells (respectively). When viability was measured in THP-1 cells by propidium iodide exclusion (as opposed to the MTT assays used previously) 10 ng/mL and 5 ng/mL of RT was used. The addition of 1000 μM and 100 μM eGCG mediated a significant (p = 0.0015 and < 0.0001 respectively) reduction in ricin toxicity relative to an identical concentration of ricin with 1 μg eGCG. Further, eGCG (100 μM) was found to reduce the binding of RT B chain to lactose-conjugated Sepharose as well as significantly (p = 0.0039) reduce the uptake of RT B chain in Vero cells. This data suggests that eGCG may provide a starting point to refine biocompatible substances that can reduce the lethality of ricin
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