8 research outputs found
Author Correction:The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
Correction to: Nature Communications https://doi.org/10.1038/s41467-019-09441-1; published online 29 March 201
Molecular Detection of Microorganisms Associated with Small Mammals and Their Ectoparasites in Mali
International audienc
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Parasite density data for each study and positivity by microscopy or RDT. Used for figures 1,2,
Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings
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Gametocyte and asexual parasite density data. Used for figure 6
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Infectivity data and asexual parasite density. Used for figures 7,8
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Longitudinal data with positivity by PCR and microscopy. Used for figure 4
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Data on probability of being slide-positive in the future. Used for figure 5