Clinical Characteristics, Patient-Reported Outcomes, and Previous Therapeutic Management of Patients with Uncontrolled Neuropathic Pain Referred to Pain Clinics

Background. The aim of this report was to evaluate the clinical profile and previous management of patients with uncontrolled neuropathic pain who were referred to pain clinics. Methods. We included adult patients with uncontrolled pain who had a score of ≥4 in the DN4 questionnaire. In addition to sociodemographic and clinical data, we evaluated pain levels using a visual analog scale as well as anxiety, depression, sleep, disability, and treatment satisfaction employing validated tools. Results. A total of 755 patients were included in the study. The patients were predominantly referred to pain clinics by traumatologists (34.3%) and primary care physicians (16.7%). The most common diagnoses were radiculopathy (43%) and pain of oncological origin (14.3%). The major cause for uncontrolled pain was suboptimal treatment (88%). Fifty-three percent of the patients were depressed, 43% had clinical anxiety, 50% rated their overall health as bad or very bad, and 45% noted that their disease was severely or extremely interfering with their daily activities. Conclusions. Our results showed that uncontrolled neuropathic pain is a common phenomenon among the specialties that address these clinical entities and, regardless of its etiology, uncontrolled pain is associated with a dramatic impact on patient well-being

Metamorfosis del paisaje almeriense. Antropología e historia de una alteración

Within a historical and environmental perspective, market values imposed from state power or distant centers of power, have fiercely altered the Mediterranean landscape and Almería in particular. With the extraction of raw materials for processing industries and the gradual clearing of forests, an intense process of desertification Anthropic occurs. Interviews our fieldwork shows that agricultural practices on highs and middle Mountain, maintain a conflict over access to natural resources within a limiting process mechanisms for purchase.Dentro de una perspectiva histórico-medioambiental, los valores del mercado impuestos desde el poder estatal o lejanos centros de poder, han alterado ferozmente el paisaje mediterráneo y el almeriense en particular. Con la extracción de materia prima para industrias de transformación y la progresiva roturación de los montes, se produce un intenso proceso de desertificación Antrópica. Las entrevistas realizadas en nuestro trabajo de campo demuestran que en la actualidad, las prácticas agrícolas de media y alta montaña, mantienen un conflicto por el acceso a los recursos naturales, dentro de un proceso de limitación de los mecanismos para su adquisición

Time Series on Functional Service Life of Buildings using Fuzzy Delphi Method

The functional service life of heritage buildings, defined as the time period during which the building fulfils the requirements for which it was designed, is a complex system that has still not been fully resolved and continues to be the object of research regarding its social, economic and cultural importance. This paper presents an application for analysing time series that reflect the state of building performance over time. To this end, historical time records are used that provided data that could be interpreted by experts in the field. The latter can then evaluate the input variables (vulnerability and risk) using the expert system for predicting the service life of buildings, Fuzzy Building Service Life (FBSL), this methodology put together the fuzzy logic tools and Delphi method. This model provides output data on the state of functionality or performance of each buildings at each moment in time whenever information records are available. The Delphi Method is used to eliminate expert subjectivity, establishing an FDM-type assessment methodology that effectively quantifies the service life of buildings over time. The application is able to provide significant data when generating future preventive maintenance programmes in architectural-cultural heritage buildings. It can also be used to optimise the resources invested in the conservation of heritage buildings. In order to validate this system, the FDM methodology is applied to some specific building examples.Ministerio de Economía y Competitividad de España, Project ART-RISK - BIA2015-64878-RMinisterio de Economía y Competitividad de España MTM 2015-65397-

Protocolo terapéutico multidisciplinar del tratamiento del dolor en pacientes con úlceras cutáneas dolorosas

Una ulcera cutanea es una perdida de sustancia que afecta a la epidermis, la dermis y, en ocasiones a planos mas profundos, con extension, forma y profundidad variable. Hablamos de Ulcera cutánea crónica cuando existe una evolucion en la cicatrizacion mayor de 6 semanas. La cicatrizacion o curacion de las heridas es un proceso fisiologico de gran complejidad que tiene la finalidad de restaurar la integridad de la piel y evitar asi, cualquier anomalía en su funcion barrera, lo cual resulta fundamental para mantener la homeostasis y el bienestar general de cualquier individuo”. (1,2,3)Las ulceras cutáneas, se consideran una patología de gran importancia por su prevalencia en constante aumento, la necesidad de cuidados que genera y la carga económica que conlleva ya que incide especialmente sobre grupos de población con enfermedades crónicas de riesgo como son los pacientes encamados, con alteraciones arteriales o venosas periféricas, los diabéticos, e individuos pertenecientes al grupo de la tercera edad.Existen distintos tipos de úlceras cutáneas, por lo que diferenciar un tipo de úlcera de otro es importante a la hora de elaborar un diagnóstico, un tratamiento y un plan de cuidados.Enfermerí

Preventive Conservation and Restoration Monitoring of Heritage Buildings Based on Fuzzy Logic

This article discusses the usability of the Art-Risk 3.0 software for research on the conservation of heritage buildings. It is a new and free software based on fuzzy logic, which enables the assessment of preventive conservation and surveillance of the restoration of heritage buildings over a period of time. This artificial intelligence-based tool considers the vulnerability of buildings, their environ ments, and their management to evaluate the necessity of their restoration or preventive con servation. To validate the Art-Risk 3.0, 500 theoretical case studies were analyzed, and a 14th century Mudejar-Gothic-style Church in Seville, Spain was studied both before and after its restora tion to identify post-restoration changes. This proof of concept demonstrates the capability of the Art-Risk 3.0 software to analyze environmental impacts on the vulnerability, risk, and functional service life of buildings, and assess the effectiveness of restoration activities. Additionally, this software identifies the most problematic factors and the necessity of restoration.Ministerio de Economía y Competitividad BIA2015- 64878-R (RETOS)Ministerio de Ciencia e Innovación PID2019-107257RB-I00 (FENIX)Ministerio de Ciencia, Innovación y Universidades EQC2019-005780-P (Ambulab-LAB)Junta de Andalucía PYC20 RE 034 UPO RESILIENT-TOURISMMinisterio de Ciencia e Innovación PTA2019-01688

Triglycerides and Residual Atherosclerotic Risk.

Even when low-density lipoprotein-cholesterol (LDL-C) levels are lower than guideline thresholds, a residual risk of atherosclerosis remains. It is unknown whether triglyceride (TG) levels are associated with subclinical atherosclerosis and vascular inflammation regardless of LDL-C. This study sought to assess the association between serum TG levels and early atherosclerosis and vascular inflammation in apparently healthy individuals. An observational, longitudinal, and prospective cohort study, including 3,754 middle-aged individuals with low to moderate cardiovascular risk from the PESA (Progression of Early Subclinical Atherosclerosis) study who were consecutively recruited between June 2010 and February 2014, was conducted. Peripheral atherosclerotic plaques were assessed by 2-dimensional vascular ultrasound, and coronary artery calcification (CAC) was assessed by noncontrast computed tomography, whereas vascular inflammation was assessed by fluorine-18 fluorodeoxyglucose uptake on positron emission tomography. Atherosclerotic plaques and CAC were observed in 58.0% and 16.8% of participants, respectively, whereas vascular inflammation was evident in 46.7% of evaluated participants. After multivariate adjustment, TG levels ≥150 mg/dl showed an association with subclinical noncoronary atherosclerosis (odds ratio [OR]: 1.35; 95% confidence interval [CI]: 1.08 to 1.68; p = 0.008). This association was significant for groups with high LDL-C (OR: 1.42; 95% CI: 1.11 to 1.80; p = 0.005) and normal LDL-C (OR: 1.85; 95% CI: 1.08 to 3.18; p = 0.008). No association was found between TG level and CAC score. TG levels ≥150 mg/dl were significantly associated with the presence of arterial inflammation (OR: 2.09; 95% CI: 1.29 to 3.40; p = 0.003). In individuals with low to moderate cardiovascular risk, hypertriglyceridemia was associated with subclinical atherosclerosis and vascular inflammation, even in participants with normal LDL-C levels. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318).The PESA study is funded by the National Center for Cardiovascular Research (CNIC) and Santander Bank. The study also has received funding from the Carlos III Health Institute (ISCIII; PI15/02019, PI17/ 00590, and PI20/00819) and the European Regional Development Fund. The CNIC is supported by the ISCIII, the Ministry of Science and Innovation, and the Pro CNIC Foundation. CNIC is a Severo Ochoa Center of Excellence (SEV-2015-0505). The funders had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. Dr. Ibáñez is the recipient of a European Research Council grant MATRIX (ERC-COG-2018-ID: 819775). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.S

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder

Background: Oral erythroplakia has been classically considered as the potentially malignant disorder with the highest rate of malignant development into squamous cell carcinoma. This critical systematic review and meta-analysis aim to estimate the malignant development rate of oral erythroplakia and identify the associated risk factors. Methods: We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and LILACS, with keywords “erythroplakia,” “erythroplasia,” “malignant transformation,” “malignant development,” “malignization,” “carcinogenesis,” “oral cancer,” “oral squamous cell carcinoma,” “mouth neoplasm,” and “prognosis.” Meta-analysis was conducted using a random-effects model. Results: Ten observational studies with 441 patients met the inclusion criteria, whose mean malignant development rate was 12.7% and with a mean follow-up period of patients of 6.66 years. In the initial biopsy, 42.8% of oral erythroplakia were already squamous cell carcinoma. The buccal mucosa was the most frequent location of oral erythroplakia, but the floor of the mouth was the most common site of malignant development. All patients who underwent malignant development showed epithelial dysplasia on the initial diagnostic biopsy. Conclusion: Overall malignant development rate of OE in the meta-analysis was 19.9%. We could not associate any specific clinicopathological feature with the malignant development. The presence of epithelial dysplasia in the initial biopsy remains the worst prognostic factor. Further observational studies on OE are needed, with well-established diagnostic criteria and good clinical follow-up, in order to identify the true risk of malignant development of oral erythroplakia and the related risk factorsS

Revista de Vertebrados de la Estación Biológica de Doñana

Captura de Petromyzon marinus lo en las Marismas del GuadalquivirEstudio sobre la Lagartiia de Valverde Algyroides marchi (Reptilia, Lacertidae)Dimorfismo sexual en Psammodromuus algirus (Reptilia, Lacertidae)Mecanismos de parasitización por Clamator glandarius y defensa por Pica pica.Nidificación de Cyanopica cyana en Doñana.Reproducción de la Urraca (P.pica) en DoñanaNesting relationship between Columba palambus and Milvus migransBiometría y dimorfismo sexual en el Calamón (Polphyrio porphyrio).Sobre sexo, mecanismos y proceso de reproducciónen el Buitre Leonado (Gyps fulvus)Aves anilladas por la Estación Biológica de Doñana. Informe Nº 1. (Años 1964 a 1971)Dimorfismo sexual y diferenciación de edades en Sturnus unicolor Temm.Contribución al estudio de la biología y ecología del Lirón Careto, Eliomys quercinus Linnaeus 1766, en Iberia Central, Parte 1: Crecimiento, Reproducción y Nidificación.Sobre el Lobo (Canis lupus) ibérico:1. Dimorfismo sexual en cráneosMorfología y dimorfismo sexual de la pelvis de Pitymys duodecimcostatusAlgunos aspectos del diformismo sexual en el cráneo de las Ginetas españolas, (Genetta genetta) (L.) 1758Peer reviewe

Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.ISCIII and European Regional Funds (Grants PI17/01644 and PI20/01126)Andalusian Health Government (Grant PE-0356-2018).Andalusian Health Government (Grant PI-0027-2020)

Recerca i tecnologia en enginyeria gràfica i disseny a la Universitat Politècnica de Catalunya

Els temps canvien cada vegada més ràpidament, i a la universitat això encara es nota més. L’històric departament d‘Expressió Gràfica a l’Enginyeria (EGE) de la Universitat Politècnica de Catalunya, garant d’una docència de Grau, Màster i Doctorat de qualitat i adaptada a les necessitats de la societat, emprèn l’any 2020 amb una proposta de canvi de nom per adaptar-se al nous coneixements que estan esdevenint la seva matèria principal, al voltant de l’enginyeria gràfica i el disseny. Les àrees de recerca del centenar de professors que formen el departament són àmplies i variades, i sempre en col·laboració en diversos grups tant de la pròpia UPC com d’altres universitats. Una recerca avançada, de caràcter pluridisciplinari, on s'apliquen creativitat i innovació com a eines de coneixement, implicats en un territori ampli, i situats als diferents campus de la UPC. En els capítols d’aquest llibre podeu veure una petita mostra d’aquesta recerca tecnològica en camps ben variats.Postprint (published version