13 research outputs found
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/04/2024
- Field of study
Get PDFOne in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants â„3âmonths following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brainâgut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials
Recubrimientos bioactivos de base hidroxiapatita sobre titanio y sus aleaciones para aplicaciones biomédicas
- Author
- Publication venue
- Academia de Ciencias de Cuba
- Publication date
- 20/03/2020
- Field of study
No full textPremios de la Academia de Ciencias de Cuba 2018
Las soluciones que la medicina moderna brinda ante las enfermedades Ăłseas han propiciado que las ciencias contemporĂĄneas dediquen cada vez mĂĄs esfuerzos al desarrollo de biomateriales que mejoraren la capacidad funcional del individuo y su calidad de vida. Uno de los puntos crĂticos que se requiere superar es conseguir la fijaciĂłn satisfactoria entre implante y tejido Ăłseo. Sobre esta base, el objetivo del trabajo consistiĂł en el desarrollo de una tecnologĂa novedosa para obtener recubrimientos cerĂĄmicos de hidroxiapatita sobre titanio (Ti) y su aleaciĂłn Ti6Al4V, utilizada en cirugĂa osteoarticular, combinando el mĂ©todo de sol-gel con una cristalizaciĂłn por tratamiento tĂ©rmico a presiĂłn reducida, a bajas temperaturas. Los resultados del trabajo demostraron que con estos mĂ©todos se obtienen recubrimientos uniformes de hidroxiapatita con caracterĂsticas texturales de porosidad controlada, mejor adherencia y efecto protector al fenĂłmeno de la corrosiĂłn, propiedades requeridas para su uso en implantes Ăłseos. AdemĂĄs, los ensayos de citocompatibilidad in vitro demostraron que los materiales obtenidos no son citotĂłxicos. Por otra parte, la obtenciĂłn de piezas de titanio poroso recubiertas con hidroxiapatita, garantiza el equilibrio biomecĂĄnico y biofuncional, asĂ como la obtenciĂłn de la porosidad de tamaño adecuado (Âż100 Âżm, 40-50 %vol) de tipo interconectada, permitirĂĄ el crecimiento del hueso hacia el interior del implante y el transporte del fluido fisiolĂłgico. Sobre la base de los resultados de caracterizaciĂłn quĂmico-fĂsica, la morfologĂa, la adherencia y la impedancia de los sistemas obtenidos, los recubrimientos de hidroxiapatita, ademĂĄs de sus propiedades de biocompabilidad, sirven como capa protectora al fenĂłmeno de la corrosiĂłn haciendo promisorio el sistema para posibles aplicaciones biomĂ©dicas como prĂłtesis ortopĂ©dicas
Aumento na quantidade de alunos em disciplinas bĂĄsicas: Como obter vantagens dessa realidade universitĂĄria
- Author
- Ahlfeldt S.
- Almeida M.A.T. de
- Alvarenga B.
- Azevedo A.E.G. de
- Baker F.B.
- Barbeta V.B.
- Barros J.A.
- Bates S.
- Casey M.M.
- Cheng K.K.
- Cruz E.
- Dehaan R.L.
- Gerab F.
- Goldmberg J.
- Hake R.R.
- Halloun I.A.
- Hazari Z.
- Hudson H.T.
- Julian E.R.
- JuliĂŁo J.F.
- Kuh G.D.
- Kuh G.D.
- Kuh G.D.
- Kuncel N.R.
- Moscati G.
- Pinho A.G. de
- Pinho A.G. de
- Prado F.D.
- Ribeiro D.
- Richards-Babb M.
- Sadler P.M.
- Silveira F.L. da
- Silveira F.L. da
- Soares V.L.L.
- Soares V.L.L.
- Tai R.H.
- Telles A.P.
- Waltenberg F.D.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
No full textStructural Features of Niobium Carbide Disperse Particles in the Structure of Heat-Resistant Alloys Based on Feâ25Crâ35Ni System
- Author
- A. Formenti
- A. Talis
- A.A. Kaya
- A.A. Kaya
- A.I. Gusev
- A.I. Rudskoi
- A.I. Rudskoy
- A.I. Rudskoy
- A.I. Rudskoy
- A.I. Rudskoy
- B. Piekarski
- C. Monachon
- E.A. Kenik
- F.C. Nunes
- F.C. Nunes
- F.G. Caballero
- G.D. De Almeida Soares
- H. M. Tawancy
- I.A. Sustaita-Torres
- I.G. Rodionova
- J. Billingham
- J. Yan
- J.P. Landesman
- K.G. Buchanan
- K.G. Buchanan
- L. Bonaccorsi
- L.H. De Almeida
- L.S. Monobe
- M. Garbiak
- M.N. Ilman
- R. Kesri
- R.A.P. Ibanez
- S. Borjali
- S.Yu. Kondratâev
- S.Yu. Kondratâev
- T. Sourmail
- T.J. Konno
- W.F. Brizes
- W.Z. Wang
- Z. Mao
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
No full textGuava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications
- Author
- Ana Melero
- ASHRAF A.
- AYALA-ZAVALA J.F.
- BEECHER G.R.
- Bruna Galdorfini Chiari-Andréo
- CHEN H.-Y.
- CHIARI B.G.
- CHYAU C.C.
- CLIFFORD M.N.
- DE ARAĂJO A.A.
- DE SOUSA E.
- DE VRIES J.H.
- DHALLA N.S.
- DREHER F.
- DRISSI A.
- DUNCAN S.H.
- EL KHARRASSI Y.
- EL-AHMADY S.H.
- Eliane Trovatti
- GUTIĂRREZ R.M.P.
- HATANO T.
- Helena Ribeiro
- IDSTEIN H.
- IHA S.M.
- IWATSUKI K.
- JAIARJ P.
- JAISWAL R.
- JIMĂNEZ-ESCRIG A.
- Joana Marto
- KAHRAMAN A.
- KANEKO T.
- LEE J.
- Leila Aparecida Chiavacci
- LI S.
- LOPEZ-TORRES M.
- LUTTERODT G.D.
- Marcos Antonio CorrĂȘa
- Maria Gabriela José de Almeida-Cincotto
- MEINKE M.C.
- OH W.K.
- OLTHOF M.R.
- OSAWA T.
- PALOMBO P.
- PARK J.S.
- PINNELL S.R.
- RAHMAN M.S.
- RAPOSO S.
- RUFINO M.S.M.
- SANDER C.S.
- SOARES F.D.
- Teresa Garrigues
- THAIPONG K.
- TOREL J.
- UKEDA H.
- Vera Lucia Borges Isaac
- WANG C.J.
- WILLIAMS J.T.
- ZHAO D.-L.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2017
- Field of study
No full textMethodologies and Applications of Proteomics for Study of Yeast Strains: An Update
- Author
- Addis M.F.
- Aguilar-Pontes M.V.
- Ahmad S.
- Ahmad Y.
- Alspaugh J.A.
- Ana Marisa Fusco-Almeida
- Anand S.
- Anderson N.L.
- Aoki W.
- Arentz G.
- Aslam B.
- Bader G.D.
- Bader O.
- Basso L.C.
- Beck S.
- Berezovsky I.N.
- Bhosale S.D.
- Bianco L.
- Blasco L.
- Bond U.
- Bozhkov P.V.
- Brilhante R.S.N.
- Bubis J.A.
- Caetano-Anolles G.
- Campbell K.
- Capusoni C.
- Casey T.M.
- Caspi R.
- Chalupova J.
- Chandra J.
- Chen B.
- Chen C.
- Chen L.
- Chong Y.T.
- Ciani M.
- Coelho C.
- Colangelo C.M.
- Cox J.
- Cristoni S.
- Crowgey E.L.
- Culibrk L.
- Dack R.E.
- de Godoy L.M.
- De la Torre Gonzalez F.J.
- Desiere F.
- Dong S.J.
- Edwil A. Gattas
- Elkon R.
- Farrell A.E.
- Fasoli E.
- Fazekas D.
- Fenyo D.
- Feret R.
- Fredens J.
- Frost D.C.
- Garcia-Santamarina S.
- GarcĂa J.M.
- Gavin A.C.
- Geddes J.M.
- Geddes J.M.
- Geddes-McAlister J.
- Ghezzi P.
- Ghiaci P.
- Gil-Bona A.
- Gnad F.
- Goeminne L.J.
- Gonneaud A.
- Graumann J.
- Greening D.W.
- Group B.D.W.
- Gruhler A.
- Gygi S.P.
- Hamzeiy H.
- Hao X.C.
- Hebert A.S.
- Hsu J.L.
- Hsu J.L.
- Jang W.E.
- Jewison T.
- Jia S.
- Joshi-Tope G.
- Kandasamy K.
- Kanehisa M.
- Kaneva I.N.
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- Kobi D.
- Kohl F.J.
- Kolkman A.
- Koppel I.
- Koppram R.
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- Landels A.
- Laskay U.A.
- Latimer L.N.
- Lauterbach A.
- Lee P.Y.
- Leger T.
- Legras J.L.
- Lereim R.R.
- Li H.
- Liu H.
- Liu H.
- Liu Y.
- Liu Z.H.
- Lv Y.J.
- Lyutvinskiy Y.
- Macedo N.
- Magdeldin S.
- Mann M.
- Maria José Soares Mendes-Giannini
- Maria Priscila F. Lacerda
- Marinach C.
- Marinach-Patrice C.
- Matallana E.
- Miah S.
- Mirzaei M.
- Moreno-GarcĂa J.
- Mostert T.T.
- Munoz-Bernal E.
- MĂŽnica Yonashiro Marcelino
- Nagaraj N.
- NatĂĄlia M.S. Lourencetti
- Neilson K.A.
- Nikitin A.
- Noberini R.
- Oliveira B.M.
- Olshina M.A.
- Papagianni M.
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- Passoth V.
- Paulo J.A.
- Paulo J.A.
- Petruzzi L.
- Picariello G.
- Pico A.R.
- Picotti P.
- Pillich R.T.
- Pomastowski P.
- Posteraro B.
- Pretorius I.S.
- Qi F.
- Qin L.
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- Renvoise M.
- Renvoise M.
- Rice C.J.
- Rodicio R.
- Romanos M.A.
- Salvado Z.
- Salvado Z.
- Santi L.
- Santos R.M.
- Sato T.K.
- Schaefer C.F.
- Schmidt A.
- Schulte F.
- Schulz B.L.
- Searle B.C.
- Seidel G.
- Selevsek N.
- Sharma N.K.
- Sheng J.
- Sherman F.
- Shui W.
- Smeekens J.M.
- Spanos C.
- Stefaniuk E.
- Strimbu K.
- Szklarczyk D.
- Szopinska A.
- Tang X.
- The M.
- Tokpohozin S.E.
- Truong T.
- Turvey M.E.
- Vadia S.
- Van Oudenhove L.
- Van Sluyter S.C.
- Vialas V.
- Vialas V.
- Vitali A.
- Vizcaino J.A.
- Vu K.
- Wang T-Y.
- Washburn M.P.
- Washburn M.P.
- Webb K.J.
- Westman J.O.
- Wilkins M.
- Winter M.B.
- Wright E.P.
- Xiao W.
- Xu J.
- Xu K.
- Xu W.
- Yofe I.
- Zhao X.
- Zheng D.
- Ălvaro Baptista Neto
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
No full textErratum to: Measurement of exclusive ΄ photoproduction from protons in pPb collisions at s NN = 5.02 TeV (The European Physical Journal C, (2019), 79, 3, (277), 10.1140/epjc/s10052-019-6774-8)
- Publication venue
- Publication date
- 01/01/2022
- Field of study
No full textIn this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022
Measurement of single-diffractive dijet production in protonâproton collisions at âs=8Te with the CMS and TOTEM experiments
- Publication venue
- Publication date
- 01/01/2020
- Field of study
No full textMeasurements are presented of the single-diffractive dijet cross section and the diffractive cross section as a function of the proton fractional momentum loss Ο and the four-momentum transfer squared t. Both processes ppâpX and ppâXp, i.e. with the proton scattering to either side of the interaction point, are measured, where X includes at least two jets; the results of the two processes are averaged. The analyses are based on data collected simultaneously with the CMS and TOTEM detectors at the LHC in protonâproton collisions at s=8Te during a dedicated run with ÎČâ=90m at low instantaneous luminosity and correspond to an integrated luminosity of 37.5nb-1. The single-diffractive dijet cross section ÏjjpX, in the kinematic region Ο< 0.1 , 0.03<|t|<1Ge2, with at least two jets with transverse momentum pT>40Ge, and pseudorapidity | η| < 4.4 , is 21.7±0.9(stat)-3.3+3.0(syst)±0.9(lumi)nb. The ratio of the single-diffractive to inclusive dijet yields, normalised per unit of Ο, is presented as a function of x, the longitudinal momentum fraction of the proton carried by the struck parton. The ratio in the kinematic region defined above, for x values in the range - 2.9 †log 10x†- 1.6 , is R=(ÏjjpX/ÎΟ)/Ïjj=0.025±0.001(stat)±0.003(syst), where ÏjjpX and Ïjj are the single-diffractive and inclusive dijet cross sections, respectively. The results are compared with predictions from models of diffractive and nondiffractive interactions. Monte Carlo predictions based on the HERA diffractive parton distribution functions agree well with the data when corrected for the effect of soft rescattering between the spectator partons. © 2020, CERN for the benefit of the CMS and TOTEM collaborations
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
- Publication venue
- Publication date
- 01/01/2020
- Field of study
No full textWe describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in protonâproton collisions at an energy of s=13TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb-1. A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ÂŻ. © 2020, The Author(s)
Outcomes from elective colorectal cancer surgery during the SARSâCoVâ2 pandemic
- Author
- 6\u11f\ufcc\ufc H
- 6fner D
- 6hlberger L
- \u106oza I
- \uc2ngelo M
- \uc4lg\ue5 A
- \uc7elebi F
- \uc7olak E
- Aawsaj Y
- Abad Gurumeta A
- Abad\u2010Motos A
- Abate E
- Abbott D
- Abdalla M
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarim M
- Abdur\u2010Rahman L
- Abel MK
- Aboelkassem Ibrahim A
- Abou Chaar MK
- Abou Chaar Mohamad K.
- Abreu da Silva A
- Abubakar A
- Acebes Garc\ueda F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Afonso J
- Agapov M
- Agarwal Arnav
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguilera Lorena Maria
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aim\ue9 A
- Akalin M
- Akaydin E
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Get PDFAim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58â14.06), postoperative SARS-CoV-2 (16.90, 7.86â36.38), male sex (2.46, 1.01â5.93), age >70 years (2.87, 1.32â6.20) and advanced cancer stage (3.43, 1.16â10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks
