El Departamento de Expresión Gráfica y el ámbito de Análisis de Formas, desde una experiencia docente

Junta de Andalucía-Consejería de Política TerritorialExcmo. Ayuntamiento de SevillaEscuela Técnica Superior de Arquitectura de la Universidad de SevillaColegio Oficial de Arquitectos de Andalucía Occidenta

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff’s spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained.ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed.ConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL

Estrés laboral en prestadores de servicio social de enfermería en hospitales de Michoacán

Introduction. Worldwide stress is considered one of the causes of greater depression in the population. It is intensified by the lifestyles that people wear, a daily routine with a lot of work, in which there is pressure, anguish and fatigue. Objective. To analyze the level of work stress presented by the Nursing Social Service Providers in Hospitals of Michoacán. Method. Non-experimental, descriptive, correlational, cross-sectional study; sample 150 participants, applying self-administered KEZKAK questionnaire: Bilingual questionnaire of stressors of nursing students in clinical practices with Likert scale, with 11 Dimensions and 67 items, reliability with Crombach's alpha 0.975. Results 55.3% (83) are between 23-25 years old, 43.3% (65) perform the social service in Hospitals of the Ministry of Health; in the "contact with suffering" dimension, the level of stress was slight in 45.3% (68); the dimension "relationship with tutors and partners" stress is slight in 67.3% (101); the dimension psychological manifestations a slight stress in 75.3% (113). Conclusion. There is stress in the PSSE, from the academic training we must provide coping and stress control strategies and prevent their effects.Introducción. A nivel mundial el estrés se considera una de las causas de mayor depresión en la población. Este se ve intensificado por los estilos de vida que llevan las personas, una rutina diaria con mucho trabajo,en el cual se presenta presión, angustia y cansancio. Objetivo. Analizar el nivel de estrés laboral que presentan los Prestadores de Servicio Social de Enfermería en Hospitales de Michoacán. Método. Estudio no experimental, descriptivo, correlacional, transversal; muestra 150 participantes, aplicando cuestionario autoadministrado KEZKAK: cuestionario bilingüe de estresores de los estudiantes de enfermería en las prácticas clínicas con escala tipo Likert, con 11 Dimensiones y 67 ítems, confiabilidad con alfa de Crombach 0.975. Resultados. El 55.3% (83) tienen entre 23-25 años, el 43.3% (65) realiza el servicio social en Hospitales de la Secretaria de Salud; en la dimensión “contacto con el sufrimiento” el nivel de estrés fue leve en el 45.3% (68); la dimensión “relación con tutores y compañeros” el estrés es leve en el 67.3% (101); la dimensión manifestaciones psicológica un estrés leve en el 75.3% (113). Conclusión. Existe estrés en los PSSE, desde la formación académica debemos facilitar estrategias de afrontamiento y control del estrés y prevenir sus efectos

DataSheet_1_NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia.pdf

NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell function may result from an aberrant expression of such receptors, a condition often seen in patients with hematological cancers. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer worldwide and NK cells have emerged as crucial targets for developing immunotherapies. However, there are important gaps concerning the phenotype and behavior of NK cells during emergence of ALL. In this study we analyze the phenotype and function of NK cells from peripheral blood in pediatric patients with ALL at diagnosis. Our results showed that NK cells exhibited an altered phenotype highlighted by a significant reduction in the overall expression and percent representation of activating receptors compared to age-matched controls. No significant differences were found for the expression of inhibitory receptors. Moreover, NK cells with a concurrent reduced expression in various activating receptors, was the dominant phenotype among patients. An alteration in the relative frequencies of NK cells expressing NKG2A and CD57 within the mature NK cell pool was also observed. In addition, NK cells from patients displayed a significant reduction in the ability to sustain antibody-dependent cellular cytotoxicity (ADCC). Finally, an aberrant expression of activating receptors is associated with the phenomenon of leukemia during childhood.</p

DataSheet_2_NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia.docx

NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell function may result from an aberrant expression of such receptors, a condition often seen in patients with hematological cancers. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer worldwide and NK cells have emerged as crucial targets for developing immunotherapies. However, there are important gaps concerning the phenotype and behavior of NK cells during emergence of ALL. In this study we analyze the phenotype and function of NK cells from peripheral blood in pediatric patients with ALL at diagnosis. Our results showed that NK cells exhibited an altered phenotype highlighted by a significant reduction in the overall expression and percent representation of activating receptors compared to age-matched controls. No significant differences were found for the expression of inhibitory receptors. Moreover, NK cells with a concurrent reduced expression in various activating receptors, was the dominant phenotype among patients. An alteration in the relative frequencies of NK cells expressing NKG2A and CD57 within the mature NK cell pool was also observed. In addition, NK cells from patients displayed a significant reduction in the ability to sustain antibody-dependent cellular cytotoxicity (ADCC). Finally, an aberrant expression of activating receptors is associated with the phenomenon of leukemia during childhood.</p

Table_1_Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.xlsx

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (pConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL.</p