The missing complexity in seismically imaged normal faults: What are the implications for geometry and production response?

The impact of geometric uncertainty on across-fault flow behaviour at the scale of individual intra-reservoir faults is investigated in this study. A high resolution digital elevation model (DEM) of a faulted outcrop is used to construct an outcrop-scale geocellular grid capturing high-resolution fault geometries (5 m scale). Seismic forward modelling of this grid allows generation of a 3D synthetic seismic cube, which reveals the corresponding seismically resolvable fault geometries (12.5 m scale). Construction of a second geocellular model, based upon the seismically resolvable fault geometries, allows comparison with the original outcrop geometries. Running fluid flow simulations across both models enables us to assess quantitatively the impact of outcrop resolution versus seismic resolution fault geometries upon across-fault flow. The results suggest that seismically resolvable fault geometries significantly underestimate the area of across-fault juxtaposition relative to realistic fault geometries. In turn this leads to overestimates in the sealing ability of faults, and inaccurate calculation of fault plane properties such as transmissibility multipliers (TMs)

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utilizes to escape drug control. Armed with this knowledge, strategies to limit the expansion of HIVDR are proposed

A parallel multigrid solver for multi-patch Isogeometric Analysis

Isogeometric Analysis (IgA) is a framework for setting up spline-based discretizations of partial differential equations, which has been introduced around a decade ago and has gained much attention since then. If large spline degrees are considered, one obtains the approximation power of a high-order method, but the number of degrees of freedom behaves like for a low-order method. One important ingredient to use a discretization with large spline degree, is a robust and preferably parallelizable solver. While numerical evidence shows that multigrid solvers with standard smoothers (like Gauss Seidel) does not perform well if the spline degree is increased, the multigrid solvers proposed by the authors and their co-workers proved to behave optimal both in the grid size and the spline degree. In the present paper, the authors want to show that those solvers are parallelizable and that they scale well in a parallel environment.Comment: The first author would like to thank the Austrian Science Fund (FWF) for the financial support through the DK W1214-04, while the second author was supported by the FWF grant NFN S117-0

Normal fault growth in continental rifting: insights from changes in displacement and length fault populations due to increasing extension in the Central Kenya Rift

This study examines the scaling relationship between fault length and displacement for the purpose of gaining a better understanding of the evolution of normal faults within the central Kenya Rift. 620 normal faults were manually mapped from a digital elevation model (DEM), with 30 m2 resolution and an estimated maximum displacement of ~40–~6030 m and fault lengths of 1270 ‐ 60,600 m. To assess the contribution of fault populations to the strain accommodation from south to north, the study area has been divided into three zones of fault populations based upon their average fault orientations; zone 1 in the north is dominated by NNE striking faults, zone 2 in the centre of the rift is characterised by NNW to NNE fault trends, whereas zone 3 in the south is characterised by NNW striking fault systems. Extensional strain was estimated by summing fault heaves across six transects along the rift, which showed a progressive increase of strain from south to north. The fault length and displacement data in the three zones fit to a power law distribution. The cumulative distributions of fault length populations showed similar fractal dimension (D) in the three zones. The cumulative displacement distributions for the three zones showed a decrease in the Power-law fractal dimension with increasing strain, which implies that the strain is increasingly localized onto larger faults as the fault system becomes more evolved from south to north. Increasing displacement with increasing strain while the fault length remains almost constant may indicate that the fault system could be evolving in accordance with a constant length fault growth model, where faults lengthen quickly and then accrue displacement. Results of this study suggest that the process of progressively increasing fault system maturity and strain localization onto large faults can be observed even over a relatively small area (240 × 150 km) within the rift system. It is also suggested that patterns of fault growth can be deduced from the fractal dimension of cumulative distribution of fault size populations

Educação física na promoção da saúde : estratégias de ensino não formal para fortalecer o ensino formal

O presente trabalho resgata uma discussão teórica e crítica da atuação dos professores de educação física no âmbito da promoção da saúde. Nosso objetivo foi buscar respostas para a seguinte questão norteadora: Como as práticas educativas em saúde podem ser construídas através de processos participativos compartilhados, enriquecendo a troca de saberes populares e científicos, para a compreensão do processo saúde-doença e cidadania? Apresentamos uma proposta de atividade pedagógica baseada na construção de conhecimento em saúde, operacionalizada em um espaço não formal de ensino. Essa atividade proporcionou uma vivência corporal que partiu da demanda coletiva, possibilitando maior integração dos participantes. A estratégia enriqueceu a troca de saberes entre os diversos atores sociais e resgatou alguns conceitos do processo saúde-doença e cidadania

A Search for Star-Disk Interaction Among the Strongest X-ray Flaring Stars in the Orion Nebula Cluster

The Chandra Orion Ultradeep Project observed hundreds of young, low-mass stars undergoing highly energetic X-ray flare events. The 32 most powerful cases have been modeled with the result that the magnetic structures responsible for these flares can be many stellar radii in extent. In this paper, we model the observed spectral energy distributions of these 32 stars in order to determine, in detail for each star, whether there is circumstellar disk material situated in sufficient proximity to the stellar surface for interaction with the large magnetic loops inferred from the observed X-ray flares. Our spectral energy distributions span the wavelength range 0.3-8 um (plus 24 um for some stars), allowing us to constrain the presence of dusty circumstellar material out to >10 AU from the stellar surface in most cases. For 24 of the 32 stars in our sample the available data are sufficient to constrain the location of the inner edge of the dusty disks. Six of these (25%) have spectral energy distributions consistent with inner disks within reach of the observed magnetic loops. Another four stars may have gas disks interior to the dust disk and extending within reach of the magnetic loops, but we cannot confirm this with the available data. The remaining 14 stars (58%) appear to have no significant disk material within reach of the large flaring loops. Thus, up to ~40% of the sample stars exhibit energetic X-ray flares that possibly arise from a magnetic star-disk interaction, and the remainder are evidently associated with extremely large, free-standing magnetic loops anchored only to the stellar surface.Comment: Accepted to the ApJ; 26 pages, 6 tables, 6 figure

Diffuse White Matter Signal Abnormalities on Magnetic Resonance Imaging Are Associated With Human Immunodeficiency Virus Type 1 Viral Escape in the Central Nervous System Among Patients With Neurological Symptoms

Background: Human immunodeficiency virus type 1 (HIV-1) can replicate independently in extravascular compartments such as the central nervous system, resulting in either cerebrospinal fluid (CSF) discordance (viral load [VL] in CSF 0.5 log10 copies HIV-1 RNA greater than plasma VL) or escape (detection of HIV VL >50 copies/mL in CSF in patients with suppressed plasma VL <50 copies/mL). Both discordance and escape may be associated with neurological symptoms. We explored risk factors for CSF discordance and escape in patients presenting with diverse neurological problems. Methods: HIV-infected adult patients undergoing diagnostic lumbar puncture (LP) at a single center between 2011 and 2015 were included in the analysis. Clinical and neuroimaging variables associated with CSF discordance/escape were identified using multivariate logistic regression. Results: One hundred forty-six patients with a median age of 45.3 (interquartile range [IQR], 39.6–51.5) years underwent 163 LPs. Median CD4 count was 430 (IQR, 190–620) cells/µL. Twenty-four (14.7%) LPs in 22 patients showed CSF discordance, of which 10 (6.1%) LPs in 9 patients represented CSF escape. In multivariate analysis, both CSF discordance and escape were associated with diffuse white matter signal abnormalities (DWMSAs) on cranial magnetic resonance imaging (adjusted odds ratio, 10.3 [95% confidence interval {CI}, 2.3–45.0], P = .007 and 56.9 [95% CI, 4.0–882.8], P = .01, respectively). All 7 patients with CSF escape (10 LPs) had been diagnosed with HIV >7 years prior to LP, and 6 of 6 patients with resistance data had documented evidence of drug-resistant virus in plasma. Conclusions: Among patients presenting with diverse neurological problems, CSF discordance or escape was observed in 15%, with treatment-experienced patients dominating the escape group. DWMSAs in HIV-infected individuals presenting with neurological problems should raise suspicion of possible CSF discordance/escape

Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency

© 2016 The Author(s).The gag gene is highly polymorphic across HIV-1 subtypes and contributes to susceptibility to protease inhibitors (PI), a critical class of antiretrovirals that will be used in up to 2 million individuals as second-line therapy in sub Saharan Africa by 2020. Given subtype C represents around half of all HIV-1 infections globally, we examined PI susceptibility in subtype C viruses from treatment-naïve individuals. PI susceptibility was measured in a single round infection assay of full-length, replication competent MJ4/gag chimeric viruses, encoding the gag gene and 142 nucleotides of pro derived from viruses in 20 patients in the Zambia-Emory HIV Research Project acute infection cohort. Ten-fold variation in susceptibility to PIs atazanavir and lopinavir was observed across 20 viruses, with EC50 s ranging 0.71-6.95 nM for atazanvir and 0.64-8.54 nM for lopinavir. Ten amino acid residues in Gag correlated with lopinavir EC50 (p < 0.01), of which 380 K and 389I showed modest impacts on in vitro drug susceptibility. Finally a significant relationship between drug susceptibility and replication capacity was observed for atazanavir and lopinavir but not darunavir. Our findings demonstrate large variation in susceptibility of PI-naïve subtype C viruses that appears to correlate with replication efficiency and could impact clinical outcomes

Desenvolvimento de leguminosas herbáceas perenes, semeadas na época das águas no sul do Tocantins.

O objetivo deste trabalho foi avaliar o desenvolvimento de leguminosas herbáceas perenes semeadas na época das águas no sul do Tocantins, onde foram utilizadas: cudzu tropical (Pueraria phaseoloides), siratro (Macroptilium atropurpureum) e centrosema (Centrosema pubescens). O estudo foi conduzido na Universidade Federal do Tocantins, no município de Gurupi-TO, com delineamento experimental em blocos casualizados com quatro repetições avaliando: velocidade de emergência; capacidade de cobertura do solo; supressão sobre as plantas invasoras; decomposição e acúmulo de nutrientes na parte aérea. O siratro apresentou maior velocidade de emergência, enquanto o cudzu tropical obteve crescimento mais lento, porém reduziu maior número de plantas invasoras. Não foi observada diferença significativa entre os tratamentos na decomposição dos resíduos. A centrosema proporcionou maior aporte de N e P, e quanto aos demais macronutrientes, não foi observada diferença estatística

RACE-OC Project: Rotation and variability in the epsilon Chamaeleontis, Octans, and Argus stellar associations

We aim at determining the rotational and magnetic-related activity properties of stars at different stages of evolution. We focus our attention primarily on members of young stellar associations of known ages. Specifically, we extend our previous analysis in Paper I (Messina et al. 2010, A&A 520, A15) to 3 additional young stellar associations beyond 100 pc and with ages in the range 6-40 Myr: epsilon Chamaeleontis (~6 Myr), Octans (~20 Myr), and Argus (~40 Myr). Additional rotational data of eta Chamaeleontis and IC2391 clusters are also considered. Rotational periods were determined from photometric time-series data obtained by the All Sky Automated Survey (ASAS) and the Wide Angle Search for Planets (SuperWASP) archives. With the present study we have completed the analysis of the rotational properties of the late-type members of all known young loose associations in the solar neighborhood. Considering also the results of Paper I, we have derived the rotation periods of 241 targets: 171 confirmed, 44 likely, 26 uncertain. The period of the remaining 50 stars known to be part of loose associations still remains unknown. This rotation period catalogue, and specifically the new information presented in this paper at ~6, 20, and 40 Myr, contributes significantly to a better observational description of the angular momentum evolution of young stars.Comment: Accepted by Astronomy & Astrophysics. Onlines figures will be available at CD