Arrow ribbon graphs

We introduce an additional structure on ribbon graphs, arrow structure. We extend the Bollob\'as-Riordan polynomial to ribbon graph with this structure. The extended polynomial satisfies the contraction-deletion relations and naturally behaves with respect to the partial duality of ribbon graphs. We construct an arrow ribbon graph from a virtual link whose extended Bollob\'as-Riordan polynomial specializes to the arrow polynomial of the virtual link recently introduced by H.Dye and L.Kauffman. This result generalizes the classical Thistlethwaite theorem to the arrow polynomial of virtual links.Comment: to appear in Journal of Knot Theory and Its Ramification

Strategic toolkits: seniority, usage and performance in the German SME machinery and equipment sector

This paper examines the strategic tool kit, from a human resource management (HRM) perspective, in terms of usage and impact. Research to date has tended to consider usage, assuming to a certain extent that knowledge and understanding of particular tools suggest that practitioners value them. The research on which this paper is based builds upon the idea that usage indicates satisfaction, but develops the usage theme to investigate which decision-makers are actually engaged in both tool appliance and the strategic process. Of particular interest to the researchers are the educational background, age and seniority of the decision-makers. In addition, potential links with HRM and organizational performance are also explored. The context of the research, the German machinery and equipment sector, provides an insight into the industry's ability to sustain growth in face of increasing international competition. The paper calls for a greater awareness, from a human resource perspective, and utilization of strategic management practice and associated decision-making aids

Structural basis for complement factor H-linked age-related macular degeneration

This is the final version of the article. Available from the publisher via the DOI in this record.Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to approximately 50% of attributable risks for AMD. We present the crystal structure of the region of FH containing the polymorphic amino acid His402 in complex with an analogue of the glycosaminoglycans (GAGs) that localize the complement regulator on the cell surface. The structure demonstrates direct coordination of ligand by the disease-associated polymorphic residue, providing a molecular explanation of the genetic observation. This glycan-binding site occupies the center of an extended interaction groove on the regulator's surface, implying multivalent binding of sulfated GAGs. This finding is confirmed by structure-based site-directed mutagenesis, nuclear magnetic resonance-monitored binding experiments performed for both H402 and Y402 variants with this and another model GAG, and analysis of an extended GAG-FH complex.B. Prosser is funded by the Wellcome Trust Structural Biology Training Program (075415/Z/04/Z). S. Johnson and P. Roversi were funded by grants to S.M. Lea from the Medical Research Council (MRC) of the United Kingdom (grants G0400389 and G0400775). D. Uhrin and P.N. Barlow were funded by the Wellcome Trust (078780/ Z/05/Z). S.J. Clark was funded by an MRC Doctoral Training Account (G78/7925), and R.B. Sim and A.J. Day were funded by MRC core funding to the MRC Immunochemistry Unit

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

Background: Inflammasome-mediated neuroinflammation may cause secondary injury following traumatic brain injury (TBI) in children. The pattern recognition receptors NACHT domain-, Leucine-rich repeat-, and PYD-containing Protein 1 (NLRP1) and NLRP3 are essential components of their respective inflammasome complexes. We sought to investigate whether NLRP1 and/or NLRP3 abundance is altered in children with severe TBI. Methods: Cerebrospinal fluid (CSF) from children (n = 34) with severe TBI (Glasgow coma scale score [GCS] ≤8) who had externalized ventricular drains (EVD) placed for routine care was evaluated for NLRP1 and NLRP3 at 0-24, 25-48, 49-72, and >72 h post-TBI and was compared to infection-free controls that underwent lumbar puncture to rule out CNS infection (n = 8). Patient age, sex, initial GCS, mechanism of injury, treatment with therapeutic hypothermia, and 6-month Glasgow outcome score were collected. Results: CSF NLRP1 was undetectable in controls and detected in 2 TBI patients at only 4 (15.50 [3.65-25.71] vs. 3.04 [1.52-8.87] ng/mL, respectively; p = 0.048). Controlling for initial GCS in multivariate analysis, peak NLRP3 >6.63 ng/mL was independently associated with poor outcome at 6 months. Conclusions: In the first report of NLRP1 and NLRP3 in childhood neurotrauma, we found that CSF NLRP3 is elevated in children with severe TBI and independently associated with younger age and poor outcome. Future studies correlating NLRP3 with other markers of inflammation and response to therapy are warranted

Visible Light Photo-oxidation of Model Pollutants Using CaCu3Ti4O12: An Experimental and Theoretical Study of Optical Properties, Electronic Structure, and Selectivity

[Image: see text] Charge transfer between metal ions occupying distinct crystallographic sublattices in an ordered material is a strategy to confer visible light absorption on complex oxides to generate potentially catalytically active electron and hole charge carriers. CaCu(3)Ti(4)O(12) has distinct octahedral Ti(4+) and square planar Cu(2+) sites and is thus a candidate material for this approach. The sol−gel synthesis of high surface area CaCu(3)Ti(4)O(12) and investigation of its optical absorption and photocatalytic reactivity with model pollutants are reported. Two gaps of 2.21 and 1.39 eV are observed in the visible region. These absorptions are explained by LSDA+U electronic structure calculations, including electron correlation on the Cu sites, as arising from transitions from a Cu-hybridized O 2p-derived valence band to localized empty states on Cu (attributed to the isolation of CuO(4) units within the structure of CaCu(3)Ti(4)O(12)) and to a Ti-based conduction band. The resulting charge carriers produce selective visible light photodegradation of 4-chlorophenol (monitored by mass spectrometry) by Pt-loaded CaCu(3)Ti(4)O(12) which is attributed to the chemical nature of the photogenerated charge carriers and has a quantum yield comparable with commercial visible light photocatalysts

Effects of PepSoyGen processing method on nursery pig growth performance

Swine Industry Day, 2014 is known as Swine Day, 2014A total of 292 weanling pigs (PIC 327 × 1050; 13.3 ± 2.4 lb BW and 21 d of age) were used in a 31-d experiment evaluating the effects of alternative PepSoyGen processing methods for nursery pig diets. There were 11 replicate pens per treatment and 6 or 7 pigs per pen. At weaning, pigs were allotted to pens by initial weight to 1 of 4 treatments in a completely randomized design. A 3-phase diet series was used with treatment diets fed during Phase 1 (d 0 to 7) and Phase 2 (d 7 to 21), with a common diet fed from d 21 to 31. Diets were: (1) negative control (corn, soybean meal, and dried whey), (2) positive control (4% DPS 50 + 1% PepSoyGen), (3) PepSoyGen processing method 1 (PSG1; 5%), and (4) PepSoyGen processing method 2 (PSG2; 5%). The alternative PepSoyGen processing methods incorporated increasing levels of a proprietary additive post-fermentation (PSG2 > PSG1) aimed at further breakdown of anti-nutritional factors associated with soybean meal. Nutrient analyses generally matched formulated levels for negative and positive control diets, but for both PSG1 and PSG2, CP and amino acid concentrations were lower than formulated, with PSG1 generally 10% lower than PSG2. In Phase 1, pigs fed the positive control diet had improved (P < 0.01) ADG and feed efficiency compared with pigs fed the negative control, whereas pigs fed PSG1 and PSG2 diets were intermediate for feed efficiency but tended (P < 0.07) to have increased ADG compared with those fed the negative control. For Phase 2, there were no significant differences in growth performance between treatment diets. For the overall experimental period (d 0 to 21), pigs fed the positive control diet and PSG2 diet had improved ADG (P < 0.05), whereas pigs fed the positive control, PSG1, and PSG2 diets had improved feed efficiency (P < 0.05) compared with pigs fed the negative control diet. Also, pigs fed PSG1 tended (P < 0.06) to have lower ADG compared with pigs fed the positive control diet. During the Phase 3 common period, no difference in growth performance was observed. Overall (d 0 to 31), ADG was greater (P < 0.01) for pigs fed the positive control diet and tended to be greater (P < 0.07) for pigs fed diets containing PSG2 than the negative control diet, with pigs fed PSG1 intermediate. In conclusion, pigs fed the PSG1 or PSG2 diets had similar performance to pigs fed the positive control diet. Numerically, the PSG2 diet elicited greater performance than the PSG1 diet, but it is unclear whether this response is reflective of the reduced CP and amino acid content in the PSG1 diet or if the differences in processing method affected growth response

Effects of creep feed pellet diameter on suckling and nursery pig performance

Citation: Clark, A. B., De Jong, J. A., DeRouchey, J. M., Tokach, M. D., Dritz, S. S., Goodband, R. D., & Woodworth, J. C. (2016). Effects of creep feed pellet diameter on suckling and nursery pig performance. Journal of Animal Science, 94, 100-101. doi:10.2527/msasas2016-213A total of 26 litters of pigs (PIC 327 × 1050; initially 3.2 kg BW and 10-d of age) were used to evaluate the effects of creep feed pellet diameter on suckling pig and nursery growth performance. On d 10 of suckling, litters were allotted to 1 of 2 dietary treatments by parity and BW in a randomized complete block design with 13 replications per treatment. Starting on d 10 of lactation, pigs were fed common pelleted creep feed processed using either a 3.2 mm (small) or a 12.7 mm (large) die. Chromic oxide was included as a fecal marker and fecal swabs were taken on d 14, 17, and 21 to determine percentage of pigs consuming creep feed. On d 21, pigs were weaned and re-allotted to nursery treatments for 21-d and fed in 2 phases. Phase 1 (d 0 to 7 postweaning) treatment diets were the same diets fed during the suckling period with 50% of the pigs remaining on their previously allotted pellet diameter treatment and the other 50% of pigs were re-allotted to the opposite pellet diameter treatment in the nursery. A common meal form diet was fed from d 7 to 21 postweaning. During the suckling phase (d 10 to 21), litters of pigs fed the large creep pellet had decreased (P < 0.03) pre-weaning mortality (0 vs. 2.54%; SEM = 0.008) and increased (P < 0.05) ADFI from d 17 to 21 (30.8 vs. 17.6 g; SEM = 4.41). There were no significant differences in suckling pig BW gain (3.21 vs. 3.25 kg; SEM = 0.107, for small and large pellet treatments, respectively) or percentage of pigs consuming creep feed (58 vs. 59%; SEM = 0.008, for small and large pellet treatments, respectively). During the nursery phase, pigs fed a large nursery pellet, regardless of creep feed treatment, had increased (P < 0.01) ADFI from d 0 to 7 (138 vs. 153 g; SEM = 3.6). Pigs fed the large creep feed pellet, regardless of nursery pellet diameter, had improved (P < 0.03) ADG (67 vs. 50 g; SEM = 5.0) and G:F (0.452 vs. 0.334; SEM = 0.0349) from d 0 to 7 postweaning, as well as improved G:F overall (0.828 vs. 0.779; SEM = 0.0129). There were no significant differences in ADG or ADFI during the common or overall period. In summary, feeding a large creep feed pellet improved late suckling creep ADFI and nursery G:F, while feeding a large nursery pellet increased ADFI during the first week in the nursery

Supernova Remnants in the Fossil Starburst in M82

We report the discovery of ten compact H-alpha-bright sources in the post-starburst region northeast of the center of M82, ``M82 B.'' These objects have H alpha luminosities and sizes consistent with Type II supernova remnants (SNRs). They fall on the same H alpha surface brightness-diameter (Sigma-D) relation defined by SNRs in other nearby star-forming galaxies, with the M82 candidates lying preferentially at the small diameter end. These are the first candidates for optically-visible SNRs in M82 outside the heavily obscured central starburst within ~250 pc from the galactic center. If these sources are SNRs, they set an upper limit to the end of the starburst in region ``B2,'' about 500 pc from the galaxy's core, of ~50 Myr. Region ``B1,'' about 1000 pc from the core, lacks good SNR candidates and is evidently somewhat older. This suggests star formation in the galaxy has propagated inward toward the present-day intense starburst core.Comment: Re-submitted to AJ, referee's comments taken into account, 15 pages LaTeX preprint style, 4 postscript figures; full-resolution figures available from http://www.astro.virginia.edu/~rd7a/snrs/ Changes: minor textual changes and orientation/axes of Fig.

Spitzer Imaging and Spectral Mapping of the Oxygen-Rich Supernova Remnant G292.0+1.8

We present mid-infrared continuum and emission line images of the Galactic oxygen-rich supernova remnant (SNR) G292.0+1.8, acquired using the MIPS and IRS instruments on the Spitzer Space Telescope. The MIPS 24 micron and 70 micron images of G292.0+1.8 are dominated by continuum emission from a network of filaments encircling the SNR. The morphology of the SNR, as seen in the mid-infrared, resembles that seen in X-rays with the Chandra X-ray Observatory. Most of the mid-infrared emission in the MIPS images is produced by circumstellar dust heated in the non-radiative shocks around G292.0+1.8, confirming the results of earlier mid-IR observations with AKARI. In addition to emission from hot dust, we have also mapped atomic line emission between 14 micron and 36 micron using IRS spectral maps. The line emission is primarily associated with the bright oxygen-rich optical knots, but is also detected from fast-moving knots of ejecta. We confirm our earlier detection of 15-25 micron emission characteristic of magnesium silicate dust in spectra of the radiatively shocked ejecta. We do not detect silicon line emission from any of the radiatively shocked ejecta in the southeast of the SNR, possibly because that the reverse shock has not yet penetrated most of the Si-rich ejecta in that region. This may indicate that G292.0+1.8 is less evolved in the southeast than the rest of the SNR, and may be further evidence in favor of an asymmetric SN explosion as proposed in recent X-ray studies of G292.0+1.8.Comment: 16 pages, 1 table, 7 figures, accepted for publication in Ap