The Role of String Similarity Metrics in Ontology Alignment

Tim Berners-Lee originally envisioned a much different world wide web than the one we have today - one that computers as well as humans could search for the information they need [3]. There are currently a wide variety of research efforts towards achieving this goal, one of which is ontology alignment

Novel Insights into the Roles of Rho Kinase in Cancer

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in the organization of the actin cytoskeleton, and is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, proliferation, and apoptosis. Since the discovery of effective inhibitors such as fasudil and Y27632, the biological roles of ROCK have been extensively explored in numerous diseases, including cancer. Accumulating evidence supports the concept that ROCK plays important roles in tumor development and progression through regulating many key cellular functions associated with malignancy, including tumorigenicity, tumor growth, metastasis, angiogenesis, tumor cell apoptosis/survival and chemoresistance as well. This review focuses on the new advances of the most recent 5 years from the studies on the roles of ROCK in cancer development and progression; the discussion is mainly focused on the potential value of ROCK inhibitors in cancer therapy

Special issue on ontology and linked data matching

cheatham2017bEditorial, Semantic web journal 8(2):183-18

Ontology Matching: OM-2018: Proceedings of the ISWC Workshop

International audienceno abstrac

OM-2017: Proceedings of the Twelfth International Workshop on Ontology Matching

shvaiko2017aInternational audienceOntology matching is a key interoperability enabler for the semantic web, as well as auseful tactic in some classical data integration tasks dealing with the semantic heterogeneityproblem. It takes ontologies as input and determines as output an alignment,that is, a set of correspondences between the semantically related entities of those ontologies.These correspondences can be used for various tasks, such as ontology merging,data translation, query answering or navigation on the web of data. Thus, matchingontologies enables the knowledge and data expressed with the matched ontologies tointeroperate

Proceedings of The Tenth International Workshop on Ontology Matching (OM-2015)

shvaiko2016aInternational audienceno abstrac

An Ontology Pattern for Oceanographic Cruises: Towards an Oceanographer\u27s Dream of Integrated Knowledge Discovery

EarthCube is a major effort of the National Science Foundation to establish a next-generation knowledge architecture for the broader geosciences. Data storage, retrieval, access, and reuse are central parts of this new effort. Currently, EarthCube is organized around several building blocks and research coordination networks. OceanLink is a semantics enabled building block that aims at improving data retrieval and reuse via ontologies, Semantic Web technologies, and Linked Data for the ocean sciences. Cruises, in the sense of research expeditions, are central events for ocean scientists. Consequently, information about these cruises and the involved vessels has to be shared and made retrievable. For example, the ability to find cruises in the vicinity of physiographic features of interest, e.g., a hydrothermal vent field or a fracture zone, is of primary interest for oceanographers. In this paper, we use a design pattern-centric strategy to engineer ontologies for OceanLink. We provide a formal axiomatization of the introduced patterns and ontologies using the Web Ontology Language, explain design choices, discuss the re-usability of our models, and provide lessons learned for the future geo-ontologies

Results of the Ontology Alignment Evaluation Initiative 2015

cheatham2016aInternational audienceOntology matching consists of finding correspondences between semantically related entities of two ontologies. OAEI campaigns aim at comparing ontology matching systems on precisely defined test cases. These test cases can use ontologies of different nature (from simple thesauri to expressive OWL ontologies) and use different modalities, e.g., blind evaluation, open evaluation and consensus. OAEI 2015 offered 8 tracks with 15 test cases followed by 22 participants. Since 2011, the campaign has been using a new evaluation modality which provides more automation to the evaluation. This paper is an overall presentation of the OAEI 2015 campaign

Intelligent Systems for Geosciences: An Essential Research Agenda

A research agenda for intelligent systems that will result in fundamental new capabilities for understanding the Earth system. Many aspects of geosciences pose novel problems for intelligent systems research. Geoscience data is challenging because it tends to be uncertain, intermittent, sparse, multiresolution, and multiscale. Geosciences processes and objects often have amorphous spatiotemporal boundaries. The lack of ground truth makes model evaluation, testing, and comparison difficult. Overcoming these challenges requires breakthroughs that would significantly transform intelligent systems, while greatly benefitting the geosciences in turn

Differential protein phosphorylation in 3T3-L1 adipocytes in response to insulin versus platelet-derived growth factor

Insulin regulates glucose metabolism in adipocytes via a phosphatidylinositide 3-kinase (PI3K)-dependent pathway that appears to involve protein phosphorylation. However, the generation of phosphoinositides is not sufficient for insulin action, and it has been suggested that insulin regulation of glucose metabolism may involve both PI3K-dependent and -independent pathways, the latter being insulin specific. To test this hypothesis, we have designed a phosphoprotein screen to study insulin-specific phosphoproteins that may be either downstream or in parallel to PI3K. Nineteen insulin-regulated phosphospots were detected in the cytosol and high speed pellet fractions, only six of which were significantly regulated by platelet-derived growth factor. Importantly, almost all (92%) of the insulin-specific phosphoproteins identified using this approach were sensitive to the PI3K inhibitor wortmannin. Thus, we obtained no evidence for an insulin-specific, PI3K-independent signaling pathway. A large proportion (62%) of the insulin-specific phosphoproteins were enriched in the same high speed pellet fraction to which PI3K was recruited in response to insulin. Thus, our data suggest that insulin specifically stimulates the phosphorylation of a novel subset of downstream targets and this may in part be because of the unique localization of PI3K in response to insulin in adipocytes