On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events

Therapy by human immunoglobulin G (IgG) concentrates is a success story ongoing for decades with an ever increasing demand for this plasma product. The success of IgG concentrates on a clinical level is documented by the slowly increasing number of registered indication and the more rapid increase of the off-label uses, a topic dealt with in another contribution to this special issue of Frontiers in Immunology. A part of the success is the adverse event (AE) profile of IgG concentrates which is, even at life-long need for therapy, excellent. Transmission of pathogens in the last decade could be entirely controlled through the antecedent introduction by authorities of a regulatory network and installing quality standards by the plasma fractionation industry. The cornerstone of the regulatory network is current good manufacturing practice. Non-infectious AEs occur rarely and mainly are mild to moderate. However, in recent times, the increase in frequency of hemolytic and thrombotic AEs raised worrying questions on the possible background for these AEs. Below, we review elements of non-infectious AEs, and particularly focus on hemolysis and thrombosis. We discuss how the introduction of plasma fractionation by ion-exchange chromatography and polishing by immunoaffinity chromatographic steps might alter repertoire of specificities and influence AE profiles and efficacy of IgG concentrates

L’actualité scientifique de ce début 2022 vue par les étudiants de l’AMPS

L’AMPS rassemble les étudiants en santé qui, en plus de suivre une formation clinique, se forment à la recherche scientifique dans le but de devenir soignant-chercheurs. Elle promeut les interactions multidisciplinaires entre la santé et les sciences, et permet une émulation scientifique entre les étudiants des différentes facultés, aux profils, compétences et idées variés

Management of patients with inherited bleeding disorders in oral surgery: A 13-year experience

International audienc

Laserterapia transcongiuntivale nella correzione della eversione esclusiva del puntino lacrimale inferiore sintomatico (E.e.P.i.S.). Nostra esperienza

Gli autori descrivono una tecnica di correzione parachirurgica dell'eversione sintomatica ed esclusiva del puntino lacrimale inferior

CONSIDERAZIONI CLINICO STATISTICHE SULLE VARIAZIONI DELLA PRESSIONE INTRAOCULARE IN RAPPORTO AL SESSO E ALL'ETA'

Gli Autori si sono proposti in questo studio di valutare statisticamente l'andamento della pressione oculare in relazione al sesso ed all'età. La popolazione in esame (modalità di raccolta dei dati e metodi statistici usati sono già stati riferiti), è stata divisa in 3 gruppi di età per ogni sesso, 25-35 anni, 35-45 anni età fertile - oltre 50 anni - menopausa. Il confronto dei valori medi del tono oculare dei vari gruppi ha messo in evidenza una notevole variazione pressoria nel sesso femminile all'età della menopausa. I risultati statistici suggeriscono una correlazione tra l'influenza ormonale sessuale e la pressione oculare.This study analyzes with statistical criteria, the behaviour of ocular pressure in relation to sex and age. The tested population has been divided into three groups according to age and sex as follows: 25-35 years, 35-45 years - fertile age, above 50 years - menopause (Modality of collecting data and statistical methodology have been already presented). The comparison of the average values of the ocular pressure among the various groups shows a noticeable variation in pressure in the menopause age group. The results of the statistical study suggests relationship between the influence of sex hormones and ocular pressure