683 research outputs found
Exact Constructions in the (Non-linear) Planar Theory of Elasticity: From Elastic Crystals to Nematic Elastomers
In this article we deduce necessary and sufficient conditions for the presence of âConti-typeâ, highly symmetric, exactly stress-free constructions in the geometrically non-linear, planar n-well problem, generalising results of Conti et al. (Proc R Soc A 73(2203):20170235, 2017). Passing to the limit , this allows us to treat solid crystals and nematic elastomer differential inclusions simultaneously. In particular, we recover and generalise (non-linear) planar tripole star type deformations which were experimentally observed in Kitano and Kifune (Ultramicroscopy 39(1â4):279â286, 1991), Manolikas and Amelinckx (Physica Status Solidi (A) 60(2):607â617, 1980; Physica Status Solidi (A) 61(1):179â188, 1980). Furthermore, we discuss the corresponding geometrically linearised problem
Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium
Background: Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A1c (HbA1c) is used to monitor the quality of diabetes treatment. Its strength of association with cardiovascular outcomes in the general population remains uncertain. This study aims to assess the association of HbA1c with cardiovascular outcomes in the general population. Methods: Data from six prospective population-based cohort studies across Europe comprising 36,180 participants were analyzed. HbA1c was evaluated in conjunction with classical cardiovascular risk factors (CVRFs) for association with cardiovascular mortality, cardiovascular disease (CVD) incidence, and overall mortality in subjects without diabetes (N = 32,496) and with diabetes (N = 3684). Results: Kaplan\u2013Meier curves showed higher event rates with increasing HbA1c levels (log-rank-test: p < 0.001). Cox regression analysis revealed significant associations between HbA1c (in mmol/mol) in the total study population and the examined outcomes. Thus, a hazard ratio (HR) of 1.16 (95% confidence interval (CI) 1.02\u20131.31, p = 0.02) for cardiovascular mortality, 1.13 (95% CI 1.03\u20131.24, p = 0.01) for CVD incidence, and 1.09 (95% CI 1.02\u20131.17, p = 0.01) for overall mortality was observed per 10 mmol/mol increase in HbA1c. The association with CVD incidence and overall mortality was also observed in study participants without diabetes with increased HbA1c levels (HR 1.12; 95% CI 1.01\u20131.25, p = 0.04) and HR 1.10; 95% CI 1.01\u20131.20, p = 0.02) respectively. HbA1c cut-off values of 39.9 mmol/mol (5.8%), 36.6 mmol/mol (5.5%), and 38.8 mmol/mol (5.7%) for cardiovascular mortality, CVD incidence, and overall mortality, showed also an increased risk. Conclusions: HbA1c is independently associated with cardiovascular mortality, overall mortality and cardiovascular disease in the general European population. A mostly monotonically increasing relationship was observed between HbA1c levels and outcomes. Elevated HbA1c levels were associated with cardiovascular disease incidence and overall mortality in participants without diabetes underlining the importance of HbA1c levels in the overall population
Precise 3D track reconstruction algorithm for the ICARUS T600 liquid argon time projection chamber detector
Liquid Argon Time Projection Chamber (LAr TPC) detectors offer charged
particle imaging capability with remarkable spatial resolution. Precise event
reconstruction procedures are critical in order to fully exploit the potential
of this technology. In this paper we present a new, general approach of
three-dimensional reconstruction for the LAr TPC with a practical application
to track reconstruction. The efficiency of the method is evaluated on a sample
of simulated tracks. We present also the application of the method to the
analysis of real data tracks collected during the ICARUS T600 detector
operation with the CNGS neutrino beam.Comment: Submitted to Advances in High Energy Physic
Search for anomalies in the {\nu}e appearance from a {\nu}{\mu} beam
We report an updated result from the ICARUS experiment on the search for
{\nu}{\mu} ->{\nu}e anomalies with the CNGS beam, produced at CERN with an
average energy of 20 GeV and travelling 730 km to the Gran Sasso Laboratory.
The present analysis is based on a total sample of 1995 events of CNGS neutrino
interactions, which corresponds to an almost doubled sample with respect to the
previously published result. Four clear {\nu}e events have been visually
identified over the full sample, compared with an expectation of 6.4 +- 0.9
events from conventional sources. The result is compatible with the absence of
additional anomalous contributions. At 90% and 99% confidence levels the limits
to possible oscillated events are 3.7 and 8.3 respectively. The corresponding
limit to oscillation probability becomes consequently 3.4 x 10-3 and 7.6 x 10-3
respectively. The present result confirms, with an improved sensitivity, the
early result already published by the ICARUS collaboration
Responsive glyco-poly(2-oxazoline)s: synthesis, cloud point tuning, and lectin binding
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well as 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers with the possibility to tune the properties by thiol-ene "click" reactions, is described. Extensive solubility studies on the corresponding glycocopolymers demonstrated that the lower critical solution temperature behavior and pH-responsiveness of these copolymers can be adjusted in water and phosphate-buffered saline (PBS) depending on the choice of the thiol. By conjugation of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose and subsequent deprotection of the sugar moieties, the hydrophilicity of the copolymer could be increased significantly, allowing a cloud-point tuning in the physiological range. Furthermore, the binding capability of the glycosylated copoly(2-oxazoline) to concanavalin A was investigated
Experimental search for the LSND anomaly with the ICARUS detector in the CNGS neutrino beam
We report an early result from the ICARUS experiment on the search for nu_mu
to nu_e signal due to the LSND anomaly. The search was performed with the
ICARUS T600 detector located at the Gran Sasso Laboratory, receiving CNGS
neutrinos from CERN at an average energy of about 20 GeV, after a flight path
of about 730 km. The LSND anomaly would manifest as an excess of nu_e events,
characterized by a fast energy oscillation averaging approximately to
sin^2(1.27 Dm^2_new L/ E_nu) = 1/2. The present analysis is based on 1091
neutrino events, which are about 50% of the ICARUS data collected in 2010-2011.
Two clear nu_e events have been found, compared with the expectation of 3.7 +/-
0.6 events from conventional sources. Within the range of our observations,
this result is compatible with the absence of a LSND anomaly. At 90% and 99%
confidence levels the limits of 3.4 and 7.3 events corresponding to oscillation
probabilities of 5.4 10^-3 and 1.1 10^-2 are set respectively. The result
strongly limits the window of open options for the LSND anomaly to a narrow
region around (Dm^2, sin^2(2 theta))_new = (0.5 eV^2, 0.005), where there is an
overall agreement (90% CL) between the present ICARUS limit, the published
limits of KARMEN and the published positive signals of LSND and MiniBooNE
Collaborations.Comment: 10 pages, 7 figure
Precision measurement of the neutrino velocity with the ICARUS detector in the CNGS beam
During May 2012, the CERN-CNGS neutrino beam has been operated for two weeks
for a total of 1.8 10^17 pot in bunched mode, with a 3 ns narrow width proton
beam bunches, separated by 100 ns. This tightly bunched beam structure allows a
very accurate time of flight measurement of neutrinos from CERN to LNGS on an
event-by-event basis. Both the ICARUS-T600 PMT-DAQ and the CERN-LNGS timing
synchronization have been substantially improved for this campaign, taking
ad-vantage of additional independent GPS receivers, both at CERN and LNGS as
well as of the deployment of the "White Rabbit" protocol both at CERN and LNGS.
The ICARUS-T600 detector has collected 25 beam-associated events; the
corresponding time of flight has been accurately evaluated, using all different
time synchronization paths. The measured neutrino time of flight is compatible
with the arrival of all events with speed equivalent to the one of light: the
difference between the expected value based on the speed of light and the
measured value is tof_c - tof_nu = (0.10 \pm 0.67stat. \pm 2.39syst.) ns. This
result is in agreement with the value previously reported by the ICARUS
collaboration, tof_c - tof_nu = (0.3 \pm 4.9stat. \pm 9.0syst.) ns, but with
improved statistical and systematic errors.Comment: 21 pages, 13 figures, 1 tabl
Underground operation of the ICARUS T600 LAr-TPC: first results
Open questions are still present in fundamental Physics and Cosmology, like
the nature of Dark Matter, the matter-antimatter asymmetry and the validity of
the particle interaction Standard Model. Addressing these questions requires a
new generation of massive particle detectors exploring the subatomic and
astrophysical worlds. ICARUS T600 is the first large mass (760 ton) example of
a novel detector generation able to combine the imaging capabilities of the old
famous "bubble chamber" with an excellent energy measurement in huge electronic
detectors. ICARUS T600 now operates at the Gran Sasso underground laboratory,
studying cosmic rays, neutrino oscillation and proton decay. Physical
potentialities of this novel telescope are presented through few examples of
neutrino interactions reconstructed with unprecedented details. Detector design
and early operation are also reported.Comment: 14 pages, 8 figures, 2 tables. Submitted to Jins
Performance Of A Liquid Argon Time Projection Chamber Exposed To The WANF Neutrino Beam
We present the results of the first exposure of a Liquid Argon TPC to a
multi-GeV neutrino beam. The data have been collected with a 50 liters
ICARUS-like chamber located between the CHORUS and NOMAD experiments at the
CERN West Area Neutrino Facility (WANF). We discuss both the instrumental
performance of the detector and its capability to identify and reconstruct low
multiplicity neutrino interactions.Comment: 14 pages, 12 figures. Submitted for publication to Physical Review
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