Current approaches in maxillary sinus traumatic and infectious injuries

Catedra Chirurgie Oro-Maxilo-Facială USMF „Nicolae Testemiţanu”This article represents a retrospective study that comprises statistical data according to traumatic and infectious lesions of the maxilary sinus, patients repartition by gender, place, attendance, aetiology, treatment, that were recorded during 2008 year in Republican Center of Oro-Maxilo-Facial Surgery from Chisinau. In this study contemporary diagnosis and treatment methods with traumatic and infectious lesions of maxillary sinus are presented. Acest articol reprezinta un studiu retrospectiv ce cuprinde date statistice referitoare la leziunile traumatice şi infecţioase ale sinusului maxilar, repartizarea bolnavilor dupa sex, localitate, adresabilitate, etiolodie, tratament, ce au fost înregistraţi pe parcursul anului 2008 în cadrul Centrului Republican de Chirurgie Oro-Maxilo-Facială din Chişinău. În lucrarea dată sunt prezentate metode contemporane de diagnostic şi tratament a bolnavilor cu leziuni traumatice şi infecţioase ale sinusului maxilar

Căile aeriene dificile în chirurgia maxilo-facială (Caz clinic)

Catedra Anesteziologie şi Reanimatologie Nr 1 „Valeriu Ghereg”, USMF „Nicolae Testemiţanu”, Centrul Naţional Ştiinţifico-Practic de Medicină de Urgenţă, Chişinău, Moldova, Catedra Chirurgie Orală şi Maxilo-Facială, USMF „Nicolae Testemiţanu”, Congresul II Internaţional al Societăţii Anesteziologie Reanimatologie din Republica Moldova 27-30 august 2009Confruntarea cu un pacient neventilat şi neintubat reprezintă o încercare serioasă pentru anestezist. Identificarea pacienţilor cu risc de intubare dificilă este un pas esenţial în examenul preanestezic ce poate reduce morbiditatea şi mortalitatea legată de căile aeriene dificile. Aplicarea anesteziei generale, a sedării intravenoase induce depresie respiratorie, care necesită asistenţă respiratorie cu protejarea căilor aeriene. Intubarea dificilă este definită ca necesitatea de a efectua mai mult de 3 încercări de intubare, sau mai mult de 10 minute, utilizând laringoscopie clasică. Laringoscopia dificilă este atunci, când nu este posibil de a vedea nici o porţiune a corzilor vocale prin laringoscopie clasică. În prezicerea căilor aeriene dificile sunt importante următoarele: anamnesticul, examinarea, măsurările, sistemele de scoruri, eşecurile

Diagrammatic analysis of the Hubbard model:Stationary property of the thermodynamic potential

Diagrammatic approach proposed many years ago for strong correlated Hubbard model is developed for analyzing of the thermodynamic potential properties. The new exact relation between such renormalized quantities as thermodynamic potential, one-particle propagator and correlation function is established. This relation contains additional integration of the one-particle propagator by the auxiliary constant. The vacuum skeleton diagrams constructed from irreducible Green's functions and tunneling propagator lines are determined and special functional is introduced. The properties of such functional are investigated and its relation to the thermodynamic potential is established. The stationary properties of this functional with respect to first order changing of the correlation function is demonstrated and as a consequence the stationary properties of the thermodynamic potential is proved.Comment: 6 pages, 4 figure

Decellularized tissue engineered pericardium as replacement for tricuspid valve in cardiac surgery

Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover Germany and Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School, Hannover, Germany, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: Tricuspid valve replacement is the last treatment choice in tricuspid valve pathology. The choice to insert mechanical or bioprosthetic valve remains controversial. Both prostheses have some limitations such as infection, risk of thromboembolism, need for life-long anticoagulation or limited durability. The following study aimed to develop a novel tissue-engineered tricuspid valve based on decellularized pericardium allograft. Materials and methods: Fresh ovine pericardium was harvested at the local slaughter house and decellularized using detergents. For disinfection all samples were treated for 24h with Phosphate Buffered Solution supplemented with 1% gentamicin and 1% streptomycin. The effectiveness of decellularization was evaluated by histological staining (hematoxylin-eosin, Movat’s Pentachrom and Van Gieson), Isolectin B4 staining (a-gal xenoantigen) and by DNA-quantification. Two valvular leaflets were manufactured out of decellularized pericardium and sutured ex-vivo into the tricuspid annulus of an ovine heart and suspended on papillary muscles. Hydraulic test were performed to prove valve competency. Discussion results: After detergent treatment pericardial tissue has been converted in a cell-free scaffold as proven by standard histological analysis. Immunofluorescent examinations revealed the absence of a-gal xenoantigens. DNA-quantification showed a substantial reduction in DNA content compared to the normal tissue. The alignment of collagenous fibers in decellularized scaffolds appeared well-preserved and was not affected by detergent decellularization procedure as proven by histological staining. Graft disinfection and storage in antibiotic solution after decellularization did not affect the texture of the scaffold. Furthermore, two leaflet structure created out of decellularized pericardium and surgically sutured in tricuspid position of ovine heart resulted in a competent valve prosthesis. Conclusion: The present results have shown successful decellularization of the ovine pericardium using detergents. Decellularized pericardial allograft can be used in cardiac surgery as a scaffold for valvular tissue engineering or for in-vivo guided tissue regeneration in tricuspid valve replacement

A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data\u2020

OBJECTIVES: Decellularized pulmonary homografts (DPH) have shown excellent results for pulmonary valve replacement. However, controlled multicentre studies are lacking to date.METHODS: Prospective European multicentre trial evaluating DPH for pulmonary valve replacement. Matched comparison of DPH to bovine jugular vein (BJV) conduits and cryopreserved homografts (CH) considering patient age, type of heart defect and previous procedures.RESULTS: In total, 121 patients (59 female) were prospectively enrolled (August 2014-December 2016), age 21.3 +/- 14.4 years, DPH diameter 24.4 +/- 2.8 mm. No adverse events occurred with respect to surgical handling; there were 2 early deaths (30 + 59 years) due to myocardial failure after multi-valve procedures and no late mortality (1.7% mortality). After a mean follow-up of 2.2 +/- 0.6 years, the primary efficacy end points mean peak gradient (16.1 +/- 12.1 mmHg) and regurgitation (mean 0.25 +/- 0.48, grade 0-3) were excellent. One reoperation was required for recurrent subvalvular stenosis caused by a pericardial patch and 1 balloon dilatation was performed on a previously stented LPA. 100% follow-up for DPH patients operated before or outside the trial (n = 114) included in the ESPOIR Registry, age 16.6 +/- 10.4 years, diameter 24.1 +/- 4.2 mm, follow-up 5.1 +/- 3.0 years. The combined DPH cohort, n = 235, comprising both Trial and Registry data showed significantly better freedom from explantation (DPH 96.7 +/- 2.1%, CH 84.4 +/- 3.2%, P = 0.029 and BJV 82.7 +/- 3.2%, P = 0.012) and less structural valve degeneration at 10 years when matched to CH, n = 235 and BJV, n = 235 (DPH 61.4 +/- 6.6%, CH 39.9 +/- 4.4%, n.s., BJV 47.5 +/- 4.5%, P = 0.029).CONCLUSIONS: Initial results of the prospective multicentre ESPOIR Trial showed DPH to be safe and efficient. Current DPH results including Registry data were superior to BJV and CH.Thoracic Surger

Evaluation of Suppressed Mite Reproduction (SMR) Reveals Potential for Varroa Resistance in European Honey Bees (Apis melliferaL.)

Simple Summary The miteVarroa destructorrepresents a great threat to honey bees and the beekeeping industry. The opportunity to select and breed honey bees that are naturally able to fight the mite stands a sustainable solution. This can be achieved by evaluation of the failure of mite reproduction (SMR, suppressed mite reproduction). We conducted a large European experiment to assess the SMR trait in different populations of honey bees spread over 13 different countries, and representing different honey bee populations. The first goal was to standardize and validate the SMR evaluation method, and then to compare the SMR trait between the different populations. Our results indicate that it is necessary to examine at least 35 brood cells infested by a single mite to reliably estimate the SMR score of any given colony. Several colonies from our dataset display high SMR scores, indicating that this trait is present within the European honey bee populations. No major differences could be identified between countries for a given population, or between populations in different countries. This study shows the potential to increase selection efforts to breedV. destructorhoney bee resistant populations. In the fight against theVarroa destructormite, selective breeding of honey bee (Apis melliferaL.) populations that are resistant to the parasitic mite stands as a sustainable solution. Selection initiatives indicate that using the suppressed mite reproduction (SMR) trait as a selection criterion is a suitable tool to breed such resistant bee populations. We conducted a large European experiment to evaluate the SMR trait in different populations of honey bees spread over 13 different countries, and representing different honey bee genotypes with their local mite parasites. The first goal was to standardize and validate the SMR evaluation method, and then to compare the SMR trait between the different populations. Simulation results indicate that it is necessary to examine at least 35 single-infested cells to reliably estimate the SMR score of any given colony. Several colonies from our dataset display high SMR scores indicating that this trait is present within the European honey bee populations. The trait is highly variable between colonies and some countries, but no major differences could be identified between countries for a given genotype, or between genotypes in different countries. This study shows the potential to increase selective breeding efforts ofV. destructorresistant populations

Vilnius Declaration on chronic respiratory diseases : multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

Correction: Volume: 10 Issue: 1 Article Number: 49 DOI: 10.1186/s13601-020-00357-4 Published: DEC 17 2020Background: Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD). The meeting resulted in the Vilnius Declaration that was developed by the participants of the EU Summit on chronic respiratory diseases under the leadership of Euforea. Conclusion: The Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge.Peer reviewe