Osteocondritis disecante de la cabeza del 2º metacarpiano en un niño: a propósito de un caso

La osteocondritis disecante en articulaciones de la mano es un proceso muy raro, sólo existen dos casos previos publicados en la literatura. Presentamos un paciente de 10 años de edad con dolor e impotencia funcional de la articulación metacarpofalángica de la mano izquierda de semanas de evolución. Con el diagnós - tico final de osteocondritis disecante realizamos una resección del fragmento libre asociadas a perforaciones con aguja fina. Tras el primer año de seguimiento el paciente se encuentra asintomático y se observa remodelación casi completa de la superficie articular.Ostheocondritis in the hand is a rare process. Only two cases were reported in the previous litera - ture. In this report we present a 10 years old boy with pain and a few functional limitation in second metacarpal phalangeal joint for weeks. With the final diagnosis of osteochondritis dissecans we performed surgery. Intraope - ratively the cartilage flap was removed and some drilling was realized. Before one year the patient was asympto - matic and we observed an improvement of articular surface

A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma

Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses\u27 Health Study (NHS) and Health Professionals Follow-up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0, and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis

Waveguide manufacturing technologies for next-generation millimeter-wave antennas

Some recent waveguide-based antennas are presented in this paper, designed for the next generation of communication systems operating at the millimeter-wave band. The presented prototypes have been conceived to be manufactured using different state-of-the-art techniques, involving subtractive and additive approaches. All the designs have used the latest developments in the field of manufacturing to guarantee the required accuracy for operation at millimeter-wave frequencies, where tolerances are extremely tight. Different designs will be presented, including a monopulse antenna combining a comparator network, a mode converter, and a spline profile horn; a tunable phase shifter that is integrated into an array to implement reconfigurability of the main lobe direction; and a conformal array antenna. These prototypes were manufactured by diverse approaches taking into account the waveguide configuration, combining parts with high-precision milling, electrical discharge machining, direct metal laser sintering, or stereolithography with spray metallization, showing very competitive performances at the millimeter-wave band till 40 GHzThis work was supported by the Spanish Government under Grant TEC2016-76070- C3-1/2-R (ADDMATE); in part under Grant PID2020-116968RB-C32/33 (DEWICOM), Agencia Estatal de Investigación MCIN/AEI/10.13039/501100011033, Fondo Europeo de Desarrollo Regional: AEI/FEDER, UE. This work was also partially supported under Grant S2013/ICE3000 (SPADERADARCM), Madrid Regional Governmen

Prevalencia de secuelas en pacientes con diabetes mellitus tipo 2 sobrevivientes al COVID-19

Objective: To assess whether there is an association between the prevalence of sequelae due to COVID-19 and type 2 diabetes mellitus. Material and methods: Cross-sectional analytical design. A structured questionnaire, validated by experts, was applied by telephone to patients who had been discharged for at least three months, and clinical data was obtained from their medical records. An informed consent was applied. Results: 52% were male (p=0,5); the median age was 57 years (IQR: 21), and the time between discharge and interview was 9 months. The severity of COVID-19 was: moderate 51%, severe 38%, critical 9%; diabetics 23,75% (p<0,05). An association was found between general sequelae and diabetes (OR=3,04, CI95%: 1,51-6,13, p: 0,001, RPa: 2,4), followed by cardiovascular sequelae (OR=2,91, CI95%: 1,57-5,38, p: 0,000, RPa: 2,1). Of the 57 diabetics, 85,9% had sequelae due to COVID-19; and of the 183 non-diabetics, 68,3% (p: 0,009, OR: 2,84, 95% CI: 1,26-6,38, PRc: 2,32). Conclusions: The prevalence of sequelae due to COVID-19 was higher in diabetic patients than in non-diabetic patients; the most frequent type of sequelae was fatigue.Objetivo: Evaluar si existe asociación entre la prevalencia de secuelas por COVID-19 y diabetes mellitus tipo 2. Material y métodos: Diseño analítico trasversal. Se aplicó por teléfono un cuestionario estructurado, validado por expertos, a pacientes con al menos tres meses de alta y se obtuvieron datos clínicos de sus historias clínicas. Se aplicó un consentimiento informado. Resultados: El 52% fueron varones (p=0,5); la mediana de edad 57 años(RIC:21), y el tiempo entre alta y entrevista fue 9 meses. La severidad de COVID-19 fue: moderado 51%, grave 38%, critico 9%; diabéticos 23,75% (p<0,05). Se halló asociación entre secuelas generales y diabetes (OR=3,04, IC95%: 1,51-6,13, p:0,001, RPa:2,4), seguida por secuelas cardiovasculares (OR=2,91, IC95%: 1,57-5,38, p:0,000, RPa:2,1). De los 57 diabéticos, 85,9% hicieron secuelas por COVID-19; y de los 183 no diabéticos, el 68,3% (p: 0,009, OR:2,84, IC95%:1,26-6,38, RPc:2,32). Conclusiones: La prevalencia de secuelas por COVID-19 fue mayor en pacientes diabéticos que en los no diabéticos; el tipo de secuelas más frecuente fue fatiga

Modulation of argon pressure as an option to control transmittance and resistivity of ZnO:Al films deposited by DC magnetron sputtering: on the dark yellow films at 10^-7 Torr base pressures

In a previous paper, we reported that thin films of ZnO:Al [aluminum-zinc oxide (AZO)] deposited after achieving a very low base pressure [from 4.0×10-7 Torr (5.6×10-5 Pa) to 5.7×10-7 Torr (7.6×10-5 Pa)] result dark yellow in color and are resistive. These are undesirable characteristics for the application of AZO thin films as front electrodes in solar cells. However, given the increasingly tendency in the acquisition of equipment that allow us to reach excellent vacuum levels, it is necessary to find the deposition conditions that lead to an improving of transmittance without greatly impacting the electrical properties of materials deposited after achieving these levels of vacuum. In this way, the present work is focused on AZO thin films deposited after achieving a very low base pressure value: 4.2×10-7 Torr (5.6×10-5 Pa). For this, we studied the effect of the variation of the oxygen volume percent in the argon/oxygen mixture (by maintaining the deposition pressure constant) and the effect of deposition pressure with only argon gas on the main properties of AZO thin films. The depositions were done at room temperature on glass substrates by direct-current magnetron sputtering with a power of 120 W (corresponding to a power density of 2.63 W/cm2). As results, we found that the variation of deposition pressure with only argon gas is a good option for the control of optical and electrical properties, since the addition of oxygen, although improves transmittance, greatly impacts on the electrical properties. Furthermore, an interesting correlation was found between the optical and electrical properties and the chemical composition of the AZO films, the latter depending on the argon pressure (for this, a careful X-ray photoelectron spectroscopy analysis was performed). Also, the inverse relationship between crystallinity and deposition rate was confirmed, in which deposition rate inversely depends on argon pressure

Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity

An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3[alpha]-hydroxy- and 3[alpha],21-dihydroxy-5[alpha]-pregnanolones. Using testosterone as starting material, a new short synthesis of an aromatase inhibitor, 4-OHA, has been achieved through hydroboration/oxidation followed by a Swern type oxidation and epimerization. Another aromatase inhibitor, androst-4-ene-3,6-17-trione, has been efficiently prepared using PCC on montmorillonite K10, under ultrasonic irradiation.http://www.sciencedirect.com/science/article/B6THR-3WC46V7-8/1/5f915790e78df65f4c988ab78bf4f17

State estimation of a dehydration process by interval analysis

This article presents a general methodology of state estimation by interval analysis in a dynamic system modeled by difference equations. The methodology is applied to a pineapple osmotic dehydration process, in order to predict the behavior of the process within a range of allowed perturbation. The paper presents simulations and validations

Correlation of recist, computed tomography morphological response, and pathological regression in hepatic metastasis secondary to colorectal cancer : The avamet study

The prospective phase IV AVAMET study was undertaken to correlate response evaluation criteria in solid tumors (RECIST)-defined response rates with computed tomography-based morphological criteria (CTMC) and pathological response after liver resection of colorectal cancer metastases. Eligible patients were aged ≥18 years, with Eastern Cooperative Oncology Group (ECOG) performance status 0/1 and histologically-confirmed colon or rectal adenocarcinoma with measurable liver metastases. Preoperative treatment was bevacizumab (7.5 mg on day 1) + XELOX (oxaliplatin 130 mg/m, capecitabine 1000 mg/m bid on days 1-14 q3w). After three cycles, response was evaluated by a multidisciplinary team. Patients who were progression-free and metastasectomy candidates received one cycle of XELOX before undergoing surgery 3-5 weeks later, followed by four cycles of bevacizumab + XELOX. A total of 83 patients entered the study; 68 were eligible for RECIST, 67 for CTMC, and 51 for pathological response evaluation. Of these patients, 49% had a complete or partial RECIST response, 91% had an optimal or incomplete CTMC response, and 81% had a complete or major pathological response. CTMC response predicted 37 of 41 pathological responses versus 23 of 41 responses predicted using RECIST (p = 0.008). Kappa coefficients indicated a lack of correlation between the results of RECIST and morphological responses and between morphological and pathological response rates. CTMC may represent a better marker of pathological response to bevacizumab + XELOX than RECIST in patients with potentially-resectable CRC liver metastases