43 research outputs found
Skeletal muscle transcriptional coactivator PGC-1alpha mediates mitochondrial, but not metabolic, changes during calorie restriction
Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1alpha is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. Consequently, many of the mitochondrial and metabolic benefits of CR are attributed to increased PGC-1alpha activity. To test this model, we examined the metabolic and mitochondrial response to CR in mice lacking skeletal muscle PGC-1alpha (MKO). Surprisingly, MKO mice demonstrated a normal improvement in glucose homeostasis in response to CR, indicating that skeletal muscle PGC-1alpha is dispensable for the whole-body benefits of CR. In contrast, gene expression profiling and electron microscopy (EM) demonstrated that PGC-1alpha is required for the full CR-induced increases in mitochondrial gene expression and mitochondrial density in skeletal muscle. These results demonstrate that PGC-1alpha is a major regulator of the mitochondrial response to CR in skeletal muscle, but surprisingly show that neither PGC-1alpha nor mitochondrial biogenesis in skeletal muscle are required for the whole-body metabolic benefits of CR
Self-consistent Coulomb effects and charge distribution of quantum dot arrays
This paper considers the self-consistent Coulomb interaction within arrays of
self-assembled InAs quantum dots (QDs) which are embedded in a pn structure.
Strong emphasis is being put on the statistical occupation of the electronic QD
states which has to be solved self-consistently with the actual
three-dimensional potential distribution. A model which is based on a Green's
function formalism including screening effects is used to calculate the
interaction of QD carriers within an array of QDs, where screening due to the
inhomogeneous bulk charge distribution is taken into acount. We apply our model
to simulate capacitance-voltage (CV) characteristics of a pn structure with
embedded QDs. Different size distributions of QDs and ensembles of spatially
perodic and randomly distributed arrays of QDs are investigated.Comment: submitted to pr
Instant preheating mechanism and UHECR
Top-down models assume that the still unexplained Ultra High Energy Cosmic
Rays (UHECR's) are the decay products of superheavy particles. Such particles
may have been produced by one of the post-inflationary reheating mechanisms and
may account for a fraction of the cold dark matter. In this paper, we assess
the phenomenological applicability of the simplest instant preheating framework
not to describe a reheating process, but as a mechanism to generate relic
supermassive particles as possible sources of UHECR's. We use cosmic ray flux
and cold dark matter observational data to constrain the parameters of the
model.Comment: 7 pages, 2 figures, submitted to PR
A Measurement of Time-Averaged Aerosol Optical Depth using Air-Showers Observed in Stereo by HiRes
Air fluorescence measurements of cosmic ray energy must be corrected for
attenuation of the atmosphere. In this paper we show that the air-showers
themselves can yield a measurement of the aerosol attenuation in terms of
optical depth, time-averaged over extended periods. Although the technique
lacks statistical power to make the critical hourly measurements that only
specialized active instruments can achieve, we note the technique does not
depend on absolute calibration of the detector hardware, and requires no
additional equipment beyond the fluorescence detectors that observe the air
showers. This paper describes the technique, and presents results based on
analysis of 1258 air-showers observed in stereo by the High Resolution Fly's
Eye over a four year span.Comment: 7 pages, 3 figures, accepted for publication by Astroparticle Physics
Journa
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
Observation of the gamma-ray binary HESS J0632+057 with the HESS, MAGIC, and VERITAS telescopes
The results of gamma-ray observations of the binary system HESS J0632 + 057 collected during 450 hr over 15 yr, between 2004 and 2019, are presented. Data taken with the atmospheric Cherenkov telescopes H.E.S.S., MAGIC, and VERITAS at energies above 350 GeV were used together with observations at X-ray energies obtained with Swift-XRT, Chandra, XMM-Newton, NuSTAR, and Suzaku. Some of these observations were accompanied by measurements of the Hα emission line. A significant detection of the modulation of the very high-energy gamma-ray fluxes with a period of 316.7 ± 4.4 days is reported, consistent with the period of 317.3 ± 0.7 days obtained with a refined analysis of X-ray data. The analysis of data from four orbital cycles with dense observational coverage reveals short-timescale variability, with flux-decay timescales of less than 20 days at very high energies. Flux variations observed over a timescale of several years indicate orbit-to-orbit variability. The analysis confirms the previously reported correlation of X-ray and gamma-ray emission from the system at very high significance, but cannot find any correlation of optical Hα parameters with fluxes at X-ray or gamma-ray energies in simultaneous observations. The key finding is that the emission of HESS J0632 + 057 in the X-ray and gamma-ray energy bands is highly variable on different timescales. The ratio of gamma-ray to X-ray flux shows the equality or even dominance of the gamma-ray energy range. This wealth of new data is interpreted taking into account the insufficient knowledge of the ephemeris of the system, and discussed in the context of results reported on other gamma-ray binary systems.C. B. Adams, W. Benbow, A. Brill, J. H. Buckley, M. Capasso, A. J. Chromey ... et al
DES13S2cmm: the first superluminous supernova from the Dark Energy Survey
We present DES13S2cmm, the first spectroscopically-confirmed superluminous
supernova (SLSN) from the Dark Energy Survey (DES). We briefly discuss the data
and search algorithm used to find this event in the first year of DES
operations, and outline the spectroscopic data obtained from the European
Southern Observatory (ESO) Very Large Telescope to confirm its redshift (z =
0.663 +/- 0.001 based on the host-galaxy emission lines) and likely spectral
type (type I). Using this redshift, we find M_U_peak = -21.05 +0.10 -0.09 for
the peak, rest-frame U-band absolute magnitude, and find DES13S2cmm to be
located in a faint, low metallicity (sub-solar), low stellar-mass host galaxy
(log(M/M_sun) = 9.3 +/- 0.3); consistent with what is seen for other SLSNe-I.
We compare the bolometric light curve of DES13S2cmm to fourteen similarly
well-observed SLSNe-I in the literature and find it possesses one of the
slowest declining tails (beyond +30 days rest frame past peak), and is the
faintest at peak. Moreover, we find the bolometric light curves of all SLSNe-I
studied herein possess a dispersion of only 0.2-0.3 magnitudes between +25 and
+30 days after peak (rest frame) depending on redshift range studied; this
could be important for 'standardising' such supernovae, as is done with the
more common type Ia. We fit the bolometric light curve of DES13S2cmm with two
competing models for SLSNe-I - the radioactive decay of 56Ni, and a magnetar -
and find that while the magnetar is formally a better fit, neither model
provides a compelling match to the data. Although we are unable to conclusively
differentiate between these two physical models for this particular SLSN-I,
further DES observations of more SLSNe-I should break this degeneracy,
especially if the light curves of SLSNe-I can be observed beyond 100 days in
the rest frame of the supernova.Comment: Accepted by MNRAS (2015 January 23), 13 pages, 6 figures, 2 table
DES15E2mlf: a spectroscopically confirmed superluminous supernova that exploded 3.5 Gyr after the big bang
We present the Dark Energy Survey (DES) discovery of DES15E2mlf, the most distant superluminous supernova (SLSN) spectroscopically confirmed to date. The light curves and Gemini spectroscopy of DES15E2mlf indicate that it is a Type I superluminous supernova (SLSN-I) at z = 1.861 (a lookback time of ∼10 Gyr) and peaking at MAB = −22.3 ± 0.1 mag. Given the high redshift, our data probe the rest-frame ultraviolet (1400–3500 Å) properties of the SN, finding velocity of the C III feature changes by ∼5600 km s−1 over 14 d around maximum light. We find the host galaxy of DES15E2mlf has a stellar mass of 3.5+3.6 −2.4 × 109 M, which is more massive than the typical SLSN-I host galaxy
A Likelihood Method for Measuring the Ultrahigh Energy Cosmic Ray Composition
Air fluorescence detectors traditionally determine the dominant chemical
composit ion of the ultrahigh energy cosmic ray flux by comparing the averaged
slant depth of the shower maximum, , as a function of energy to the
slant depths expect ed for various hypothesized primaries. In this paper, we
present a method to make a direct measurement of the expected mean number of
protons and iron by comparing the shap es of the expected
distributions to the distribution for data. The advantages of this method
includes the use of information of the full distribution and its ability to
calculate a flux for various cosmic ray compositi ons. The same method can be
expanded to marginalize uncertainties due to choice of spectra, hadronic models
and atmospheric parameters. We demonstrate the technique with independent
simulated data samples from a parent sample of protons and iron. We accurately
predict the number of protons and iron in the parent sample and show that the
uncertainties are meaningful.Comment: 11 figures, 22 pages, accepted by Astroparticle Physic
Alternative Methods to Finding Patterns in HiRes Stereo Data
In this paper Ultra High Energy Cosmic Rays UHECRs data observed by the HiRes
fluorescence detector in stereo mode is analyzed to search for events in the
sky with an arrival direction lying on a great circle. Such structure is known
as the arc structure. The arc structure is expected when the charged cosmic
rays pass through the galactic magnetic field. The arcs searched for could
represent a broad or a small scale anisotropy depending on the proposed source
model for the UHECRs. The Arcs in this paper are looked for using Hough
transform were Hough transform is a technique used to looking for patterns in
images. No statistically significant arcs were found in this study