3,703 research outputs found
Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland.
A comparison has been made between the carcinogenic activities of benzo(a)pyrene and the proposed proximate carcinogen, benzo(a)pyrene 7,8-dihydrodiol, in the adult C57BL mouse submandibular salivary gland. In preliminary studies using a range of doses, the dihydrodiol was slightly less active than the parent hydrocarbon in this system. There was a difference in the type of tumour induced by the 2 compounds. Benzo(a)pyrene induced tumours of the salivary glands at the site of injection, whereas the dihydrodiol induced malignant lymphosarcomas, particularly of the thymus, which were often metastatic to other orgnas. Possible reasons for the different sites of action of the 2 compounds are discussed
Emerging importance of molecular pathogenesis of vascular malformations in clinical practice and classifications
Introduction: Vascular malformations occur during early vascular development
resulting in abnormally formed vessels that can manifest as arterial,
venous, capillary or lymphatic lesions or in combination, and include
local tissue overdevelopment. Vascular malformations are largely caused
by sporadic somatic gene mutations. This article aims to review and
discuss current molecular signaling pathways and therapeutic targets for
vascular malformations and to classify vascular malformations according
to the molecular pathways involved. /
Methods: A literature review was performed using Embase and Medline. Different
MeSH terms were combined for the search strategy, with the aim of
encompassing all studies describing the classification, pathogenesis and
treatment of vascular malformations. /
Results: Major pathways involved in the pathogenesis of vascular malformations
are VEGF, Ras/Raf/MEK/ERK, Angiopoietin-TIE2, TGF- β and
PI3K/AKT/mTOR. These pathways are involved in controlling cellular
growth, apoptosis, differentiation and proliferation, and play a central
role in endothelial cell signaling and angiogenesis. Many vascular
malformations share similar aberrant molecular signaling pathways with
cancers and inflammatory disorders. Therefore, selective anti-cancer
agents and immunosuppressants may be beneficial in treating vascular
malformations of specific mutations. The current classification systems of
vascular malformations including the ISSVA classification are primarily
observational and clinical, and are not based on the molecular pathways
involved in the pathogenesis of the condition. /
Conclusions: Several molecular pathways with potential therapeutic targets have been
demonstrated to contribute to the development of various vascular
anomalies. Classifying vascular malformations based on their molecular
pathogenesis may improve treatment by determining the underlying
nature of the condition and their potential therapeutic target
Hole-depletion of ladders in SrCuO induced by correlation effects
The hole distribution in SrCuO is studied by low
temperature polarization dependent O K Near-Edge X-ray Absorption Fine
Structure measurements and state of the art electronic structure calculations
that include core-hole and correlation effects in a mean-field approach.
Contrary to all previous analysis, based on semi-empirical models, we show that
correlations and antiferromagnetic ordering favor the strong chain
hole-attraction. For the remaining small number of holes accommodated on
ladders, leg-sites are preferred to rung-sites. The small hole affinity of
rung-sites explains naturally the 1D - 2D cross-over in the phase diagram of
(La,Y,Sr,Ca)CuOComment: 6 pages, 8 figure
Heights of one- and two-sided congruence lattices of semigroups
The height of a poset is the supremum of the cardinalities of chains in
. The exact formula for the height of the subgroup lattice of the symmetric
group is known, as is an accurate asymptotic formula for the
height of the subsemigroup lattice of the full transformation monoid
. Motivated by the related question of determining the heights
of the lattices of left- and right congruences of , we develop a
general method for computing the heights of lattices of both one- and two-sided
congruences for semigroups. We apply this theory to obtain exact height
formulae for several monoids of transformations, matrices and partitions,
including: the full transformation monoid , the partial
transformation monoid , the symmetric inverse monoid
, the monoid of order-preserving transformations
, the full matrix monoid , the partition
monoid , the Brauer monoid and the
Temperley-Lieb monoid
Sperm morphology, adenosine triphosphate (ATP) concentration and swimming velocity: unexpected relationships in a passerine bird.
The relationship between sperm energetics and sperm function is poorly known, but is central to our understanding of the evolution of sperm traits. The aim of this study was to examine how sperm morphology and ATP content affect sperm swimming velocity in the zebra finch Taeniopygia guttata We exploited the high inter-male variation in this species and created extra experimental power by increasing the number of individuals with very long or short sperm through artificial selection. We found a pronounced quadratic relationship between total sperm length and swimming velocity, with velocity increasing with length up to a point, but declining in the very longest sperm. We also found an unexpected negative association between midpiece length and ATP content: sperm with a short midpiece generally contained the highest concentration of ATP. Low intracellular ATP is therefore unlikely to explain reduced swimming velocity among the very longest sperm (which tend to have a shorter midpiece)
Exchange bias in GeMn nanocolumns: the role of surface oxidation
We report on the exchange biasing of self-assembled ferromagnetic GeMn
nanocolumns by GeMn-oxide caps. The x-ray absorption spectroscopy analysis of
this surface oxide shows a multiplet fine structure that is typical of the Mn2+
valence state in MnO. A magnetization hysteresis shift |HE|~100 Oe and a
coercivity enhancement of about 70 Oe have been obtained upon cooling (300-5 K)
in a magnetic field as low as 0.25 T. This exchange bias is attributed to the
interface coupling between the ferromagnetic nanocolumns and the
antiferromagnetic MnO-like caps. The effect enhancement is achieved by
depositing a MnO layer on the GeMn nanocolumns.Comment: 7 pages, 5 figure
The spin state transition in LaCoO; revising a revision
Using soft x-ray absorption spectroscopy and magnetic circular dichroism at
the Co- edge we reveal that the spin state transition in LaCoO
can be well described by a low-spin ground state and a triply-degenerate
high-spin first excited state. From the temperature dependence of the spectral
lineshapes we find that LaCoO at finite temperatures is an inhomogeneous
mixed-spin-state system. Crucial is that the magnetic circular dichroism signal
in the paramagnetic state carries a large orbital momentum. This directly shows
that the currently accepted low-/intermediate-spin picture is at variance.
Parameters derived from these spectroscopies fully explain existing magnetic
susceptibility, electron spin resonance and inelastic neutron data
Ising magnetism and ferroelectricity in CaCoMnO
The origin of both the Ising chain magnetism and ferroelectricity in
CaCoMnO is studied by electronic structure calculations
and x-ray absorption spectroscopy. We find that CaCoMnO has the
alternate trigonal prismatic Co and octahedral Mn sites in the
spin chain. Both the Co and Mn are in the high spin state. In
addition, the Co has a huge orbital moment of 1.7 which is
responsible for the significant Ising magnetism. The centrosymmetric crystal
structure known so far is calculated to be unstable with respect to exchange
striction in the experimentally observed
antiferromagnetic structure for the Ising chain. The calculated inequivalence
of the Co-Mn distances accounts for the ferroelectricity.Comment: 4 pages, 3 figures, PRL in press (changes made upon referees
comments
- …