A Successful Component Architecture for Interoperable and Evolvable Ground Data Systems

The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) has adopted an open architecture approach for satellite control centers and is now realizing benefits beyond those originally envisioned. The Goddard Mission Services Evolution Center (GMSEC) architecture utilizes standardized interfaces and a middleware software bus to allow functional components to be easily integrated. This paper presents the GMSEC architectural goals and concepts, the capabilities enabled and the benefits realized by adopting this framework approach. NASA experiences with applying the GMSEC architecture on multiple missions are discussed. The paper concludes with a summary of lessons learned, future directions for GMSEC and the possible applications beyond NASA GSFC

Mission Services Evolution Center Message Bus

The Goddard Mission Services Evolution Center (GMSEC) Message Bus is a robust, lightweight, fault-tolerant middleware implementation that supports all messaging capabilities of the GMSEC API. This architecture is a distributed software system that routes messages based on message subject names and knowledge of the locations in the network of the interested software components

Moyo Vol. I N 1

JDB, Greek to Me . 1. Hood, Richard. Hood Advocates Off-Campus Living . 3. Rinehart, Dawn. Beta Press Biggio on Plan B . 10. Boyden, Ode on a Grecian Turn: An Interview with President Michele T. Myers . 6. Rogers, Kirstin. The Social Auction . 11. Bosari, David. Bosari on Brotherhood . 13. Mason, Amy. A Pledge in a Sea of Screaming Girls . 13. Kruse, Kristina. Kruse, Urges Thinking Hard . 14. O\u27Hare, Kimberly. Never Uncertain . 15. Howard, Tressie. D.U.\u27s New Face from Bucknell . 15. Pryor, Derrick. AΦA: A Fraternity of a Different Color . 16. Norpell, Bradley F. The Year of 1950: Looking Back on Fraternity Life . 18. Rogers, Kirstin. Freshman Lambert Co-Authors Book . 19. Bergstrom, Ida. Defending the System . 20. Bristow, Vernall. Meding D.U.\u27s Broken Reputation . 20

Planetary Candidates from K2 Campaign 16

Given that Campaign 16 of the K2 mission is one of just two K2 campaigns observed so far in "forward-facing" mode, which enables immediate follow-up observations from the ground, we present a catalog of interesting targets identified through photometry alone. Our catalog includes 30 high-quality planet candidates (showing no signs of being non-planetary in nature), 48 more ambiguous events that may be either planets or false positives, 164 eclipsing binaries, and 231 other regularly periodic variable sources. We have released light curves for all targets in C16, and have also released system parameters and transit vetting plots for all interesting candidates identified in this paper. Of particular interest is a candidate planet orbiting the bright F dwarf HD 73344 (V=6.9, K=5.6) with an orbital period of 15 days. If confirmed, this object would correspond to a $2.56 \pm 0.18 \ R_\oplus$ planet and would likely be a favorable target for radial velocity characterization. This paper is intended as a rapid release of planet candidates, eclipsing binaries and other interesting periodic variables to maximize the scientific yield of this campaign, and as a test run for the upcoming TESS mission, whose frequent data releases call for similarly rapid candidate identification and efficient follow-up.Comment: 19 pages, 7 figures, 5 tables, accepted for publication in A

Nuggets, Pearls, and Vignettes of Master Heart Failure Clinicians

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73696/1/j.1527-5299.2001.00307.x.pd

Planetary Candidates from K2 Campaign 16

Given that Campaign 16 of the K2 mission is one of just two K2 campaigns observed so far in "forward-facing" mode, which enables immediate follow-up observations from the ground, we present a catalog of interesting targets identified through photometry alone. Our catalog includes 30 high-quality planet candidates (showing no signs of being non-planetary in nature), 48 more ambiguous events that may be either planets or false positives, 164 eclipsing binaries, and 231 other regularly periodic variable sources. We have released light curves for all targets in C16 and have also released system parameters and transit vetting plots for all interesting candidates identified in this paper. Of particular interest is a candidate planet orbiting the bright F dwarf HD 73344 (V = 6.9, K = 5.6) with an orbital period of 15 days. If confirmed, this object would correspond to a 2.56 ± 0.18 R_⊕ planet and would likely be a favorable target for radial velocity characterization. This paper is intended as a rapid release of planet candidates, eclipsing binaries, and other interesting periodic variables to maximize the scientific yield of this campaign, and as a test run for the upcoming TESS mission, whose frequent data releases call for similarly rapid candidate identification and efficient follow up

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts