Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

The Iso2k database: a global compilation of paleo-δ18O and δ2H records to aid understanding of common era climate

Reconstructions of global hydroclimate during the Common Era (CE; the past ~2,000 years) are important for providing context for current and future global environmental change. Stable isotope ratios in water are quantitative indicators of hydroclimate on regional to global scales, and these signals are encoded in a wide range of natural geologic archives. Here we present the Iso2k database, a global compilation of previously published datasets from a variety of natural archives that record the stable oxygen (δ18O) or hydrogen (δ²H) isotopic composition of environmental waters, which reflect hydroclimate changes over the CE. The Iso2k database contains 756 isotope records from the terrestrial and marine realms, including: glacier and ground ice (205); speleothems (68); corals, sclerosponges, and mollusks (145); wood (81); lake sediments and other terrestrial sediments (e.g., loess) (158); and marine sediments (99). Individual datasets have temporal resolutions ranging from sub-annual to centennial, and include chronological data where available. A fundamental feature of the database is its comprehensive metadata, which will assist both experts and non-experts in the interpretation of each record and in data synthesis. Key metadata fields have standardized vocabularies to facilitate comparisons across diverse archives and with climate model simulated fields. This is the first global-scale collection of water isotope proxy records from multiple types of geological and biological archives. It is suitable for evaluating hydroclimate processes through time and space using large-scale synthesis, model-data intercomparison and (paleo)data assimilation. The Iso2k database is available for download at: https://doi.org/10.25921/57j8-vs18 (Konecky and McKay, 2020) and is also accessible via through the NOAA/WDS Paleo Data landing page: https://www.ncdc.noaa.gov/paleo/study/29593

Analecta Paracelsica. Studien zum Nachleben Theophrast von Hohenheims im deutschen Kulturgebiet der frühen Neuzeit. Heidelberger Studien zur Naturkunde der frühen Neuzeit, 4. Stuttgart, 1994

Braun Lucien. Analecta Paracelsica. Studien zum Nachleben Theophrast von Hohenheims im deutschen Kulturgebiet der frühen Neuzeit. Heidelberger Studien zur Naturkunde der frühen Neuzeit, 4. Stuttgart, 1994. In: Revue d'histoire et de philosophie religieuses, 76e année n°1, Janvier-mars 1996. pp. 92-94

Periodica Philosophica. Eine internationale Bibliographie philosophischer Zeitschriften von den Anfängen bis zur Gegenwart, von Hogrebe, Kamp und König. Düsseldorf, Philosophia Verlag, 1972

Braun Lucien. Periodica Philosophica. Eine internationale Bibliographie philosophischer Zeitschriften von den Anfängen bis zur Gegenwart, von Hogrebe, Kamp und König. Düsseldorf, Philosophia Verlag, 1972. In: Revue d'histoire et de philosophie religieuses, 54e année n°4,1974. p. 555

Paracelsus (Theophrastus Bombastus von Hohenheim), Vita beata. Vom seligen Leben. Herausgegeben von Urs Leo Gantenbein, unter Mitarbeit von Michael Baumann und Detlef Roth, (Neue Paracelsus-Edition. Theologische Werke, 1), Berlin – New York, de Gruyter, 2008

Braun Lucien. Paracelsus (Theophrastus Bombastus von Hohenheim), Vita beata. Vom seligen Leben. Herausgegeben von Urs Leo Gantenbein, unter Mitarbeit von Michael Baumann und Detlef Roth, (Neue Paracelsus-Edition. Theologische Werke, 1), Berlin – New York, de Gruyter, 2008. In: Revue d'histoire et de philosophie religieuses, 91e année n°4, Octobre-Décembre 2011. pp. 582-583

Historiographie et iconographie philosophiques

The history of philosophy, a discipline intensively practised since the 18th Century, has until recently been based exclusively on ancient philosophical texts The question is asked whether this discipline should also address the images that have accompanied philosophy in its historical development. Philosophical inconography, a fledgling discipline, tries to establish a correspondence between a text and the multiple representations, allegorical and symbolic, that philosophy has evoked throughout the ages. The questions of the specificity of the two disciplines and of their possible cross-fertilization are here examined.L'histoire de la philosophie, discipline intensément cultivée depuis le XVIIIe siècle, s'est jusqu'ici fondée exclusivement sur les textes passés des philosophes. La question de savoir si elle doit se référer aussi aux images qui ont accompagné la philosophie dans son développement historique est posée. L'iconographie philosophique, discipline naissante, s'efforce défaire correspondre un texte aux multiples représentations, allégoriques et symboliques, que la philosophie a suscitées à travers les siècles. La question de la spécificité des deux disciplines et de leur possible fécondation réciproque fait l'objet du présent examen.Braun Lucien. Historiographie et iconographie philosophiques. In: Revue d'histoire et de philosophie religieuses, 78e année n°1, Janvier-mars 1998. pp. 3-14

Periodica Philosophica. Eine internationale Bibliographie philosophischer Zeitschriften von den Anfängen bis zur Gegenwart, von Hogrebe, Kamp und König. Düsseldorf, Philosophia Verlag, 1972

Braun Lucien. Periodica Philosophica. Eine internationale Bibliographie philosophischer Zeitschriften von den Anfängen bis zur Gegenwart, von Hogrebe, Kamp und König. Düsseldorf, Philosophia Verlag, 1972. In: Revue d'histoire et de philosophie religieuses, 54e année n°4,1974. p. 555

Ces jours auvergnats où la liberté fut victime

The memorial tablet at the entrance of the Strasbourg University (Palais universitaire) serves, thanks to the names listed on it, to preserve a memory that has taken on various forms, in the course of the years, although these forms do not necessarily exclude each other. The following lines describe the crucial moments of this metamorphosis.La table du souvenir, installée à l’entrée du Palais universitaire, constitue, grâce aux noms qui s’y trouvent inscrits, le point d’appui d’une mémoire qui n’a cessé, au cours du temps, de revêtir des formes successives, non exclusives les unes des autres. Les lignes qui suivent essaient de rappeler des moments de cette métamorphose.Braun Lucien. Ces jours auvergnats où la liberté fut victime. In: Revue d'histoire et de philosophie religieuses, 91e année n°3, Juillet-Septembre 2011. pp. 331-337

Analecta Paracelsica. Studien zum Nachleben Theophrast von Hohenheims im deutschen Kulturgebiet der frühen Neuzeit. Heidelberger Studien zur Naturkunde der frühen Neuzeit, 4. Stuttgart, 1994

Braun Lucien. Analecta Paracelsica. Studien zum Nachleben Theophrast von Hohenheims im deutschen Kulturgebiet der frühen Neuzeit. Heidelberger Studien zur Naturkunde der frühen Neuzeit, 4. Stuttgart, 1994. In: Revue d'histoire et de philosophie religieuses, 76e année n°1, Janvier-mars 1996. pp. 92-94