On Barrier Graphs of Sensor Networks

The study of sensor networks begins with a model, which usually has a geometric component. This thesis focuses on networks of sensors modeled as collections of rays in the plane whose use is to detect intruders, and in particular a graph derived from this geometry, called the barrier graph of the network, which captures information about the network\u27s coverage. Every such ray-barrier sensor network corresponds to a barrier graph, but not every graph is the barrier graph of some network. We show that any barrier graph is not just tripartite, but perfect. We describe how to find networks which have certain designated graphs as their barrier graphs. We show that the size of a minimum vertex cover (in this context called the resilience) of a given graph can yield information about whether and how one can find a sensor network whose barrier graph is the given graph. Finally, we demonstrate that barrier graphs have certain strong structural properties, as a result of the geometry of ray-barrier networks, which represent progress towards a full characterization of barrier graphs

Barrier Graphs and Extremal Questions on Line, Ray, Segment, and Hyperplane Sensor Networks

A sensor network is typically modeled as a collection of spatially distributed objects with the same shape, generally for the purpose of surveilling or protecting areas and locations. In this dissertation we address several questions relating to sensors with linear shapes: line, line segment, and rays in the plane, and hyperplanes in higher dimensions. First we explore ray sensor networks in the plane, whose resilience is the number of sensors that must be crossed by an agent traveling between two known locations. The coverage of such a network is described by a particular tripartite graph, the barrier graph of the network. We show that barrier graphs are perfect (Berge) graphs and have a rigid neighborhood structure due to the rays\u27 geometry. We introduce two extremal problems for networks in the plane made of line sensors, line segment sensors, or ray sensors, which informally ask how well it is possible to simultaneously protect k locations with n (line/ray/segment)-shaped sensors from intruders. The first question allows any number of intruders, while the second assumes there is a lone intruder. We show these are questions to be answered separately, and provide complete answers for k = 2 in both cases. We provide asymptotically tight answers for question (1) when k = 3, 4 and the locations are in convex position. We also provide asymptotic lower bounds for question (1) for any k. Finally, we generalize these extremal problems to d dimensions. For the d-dimensional version of question (1) we provide asymptotic lower and upper bounds for any combination of k and d, though these bounds do not meet

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival