428 research outputs found
ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
- Author
- Publication venue
- Biomed Res Int
- Publication date
- 01/01/2015
- Field of study
TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four siblings. A consanguineous family of Roma (Gipsy) ethnic origin gave birth to 6 children of which 4 were affected presenting with dysmorphic features, failure to thrive, cardiomyopathy, metabolic crises, and 3-methylglutaconic aciduria as clinical symptoms. Genetic testing revealed a homozygous mutation (c.317-2A>G) in the TMEM70 gene. While light microscopy was unremarkable, ultrastructural investigation of muscle tissue revealed accumulation of swollen degenerated mitochondria with lipid crystalloid inclusions, cristae aggregation, and exocytosis of mitochondrial material. Biochemical analysis of mitochondrial complexes showed an almost complete ATP synthase deficiency. Despite harbouring the same mutation, the clinical outcome in the four siblings was different. Two children died within 60 h after birth; the other two had recurrent life-threatening metabolic crises but were successfully managed with supplementation of anaplerotic amino acids, lipids, and symptomatic treatment during metabolic crisis. In summary, TMEM70 mutations can cause distinct ultrastructural mitochondrial degeneration and almost complete deficiency of ATP synthase but are still amenable to treatment
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
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- Bhatnagar Priya
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- Walford Jamie
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- Walstow Deborah
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- Walters Ashleigh
- Wani Mushtaq
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- Wardlaw Joanna M
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- Waterfield Kelly
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- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Benchmarking whole exome sequencing in the German Network for Personalized Medicine
- Author
- Adam Eugen
- Appenzeller Silke
- Armeanu-Ebinger Sorin
- Auber Bernd
- Aust Daniela
- Ball Markus
- Banan Rouzbeh
- Bartels Stephan
- Basitta Patrick
- Begemann Matthias
- Benary Manuela
- Beule Dieter
- Blanc Eric
- Blank Cornelia
- Borkhardt Arndt
- Budczies Jan
- Carta Maria Giulia
- Claus Rainer
- Dietmaier Wolfgang
- Dikow Nicola
- Dintner Sebastian
- Doll Julia
- Dönitz Jürgen
- Eberhardt Timo
- Elbracht Miriam
- Evert Matthias
- Falkenberg Kim
- Ferrazzi Fulvia
- Fink Annette
- Fürstberger Axel
- Gaisa Nadine T.
- Gerstenmaier Uwe
- Goering Wolfgang
- Goldschmid Hannah
- Greif Phillip
- Groß Thomas
- Göbel Kirsten
- Haack Tobias
- Hamelmann Stefan
- Hartmann Nils
- Hirsch Daniela
- Hirsch Steffen
- Hofmann Winfried
- Horny Kai
- Horst David
- Hölscher Florian
- Immel Alexander
- Jacob Anne
- Jelting Yvonne
- Jonigk Danny
- Joosten Maria
- Jung Andreas
- Junk Stefanie
- Jurmeister Phillip
- Kazdal Daniel
- Kirmse Santina
- Klauschen Frederick
- Kloth Michael
- Kumbrink Jörg
- Kutz Oliver
- Lassmann Silke
- Lehmann Kjong-Van
- Lehmann Ulrich
- Malek Nisar
- Marienfeld Ralf
- Martis-Thiele Mihaela
- Matysiak Uta
- Maurer Angela
- Maurus Katja
- Mayr Eva-Maria
- Meier-Kolthoff Jan
- Menzel Michael
- Merkelbach-Bruse Sabine
- Meyer Robert
- Mock Andreas
- Moskalev Evgeny A.
- Murtagh Justin
- Märkl Bruno
- Möbs Markus
- Neumann Olaf
- Niewöhner Jakob
- Ortiz Brüchle Nadina
- Ossowski Stephan
- Ott Alexander
- Pfarr Nicole
- Prause Rebecca
- Rehker Jan
- Reuter-Jessen Kirsten
- Romanovsky Eva
- Rosenthal Tessa
- Roth Wilfried
- Ruckert Christian
- Sahm Felix
- Schaaf Christian P.
- Schirmacher Peter
- Schmidt Gunnar
- Schroeder Christopher
- Seillier Lancelot
- Siebolts Udo
- Siemanowski-Hrach Janna
- Sivalingam Sugirthan
- Stenzinger Albrecht
- Ströbel Philipp
- Tischler Verena
- Trautmann Marcel
- Tögel Lars
- Weichert Wilko
- Werner Martin
- William Doreen
- Wolter Steffen
- Wulf Anna-Lena
- Yasin Layal
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Introduction
Whole Exome Sequencing (WES) has emerged as an efficient tool in clinical cancer diagnostics to broaden the scope from panel-based diagnostics to screening of all genes and enabling robust determination of complex biomarkers in a single analysis.
Methods
To assess concordance, six formalin-fixed paraffin-embedded (FFPE) tissue specimens and four commercial reference standards were analyzed by WES as matched tumor-normal DNA at 21 NGS centers in Germany, each employing local wet-lab and bioinformatics investigating somatic and germline variants, copy-number alteration (CNA), and different complex biomarkers. Somatic variant calling was performed in 494 diagnostically relevant cancer genes. In addition, all raw data were re-analyzed with a central bioinformatic pipeline to separate wet- and dry-lab variability.
Results
The mean positive percentage agreement (PPA) of somatic variant calling was 76% and positive predictive value (PPV) 89% compared a consensus list of variants found by at least five centers. Variant filtering was identified as the main cause for divergent variant calls. Adjusting filter criteria and re-analysis increased the PPA to 88% for all and 97% for clinically relevant variants. CNA calls were concordant for 82% of genomic regions. Calls of homologous recombination deficiency (HRD), tumor mutational burden (TMB), and microsatellite instability (MSI) status were concordant for 94%, 93%, and 93% respectively. Variability of CNAs and complex biomarkers did not increase considerably using the central pipeline and was hence attributed to wet-lab differences.
Conclusion
Continuous optimization of bioinformatic workflows and participating in round robin tests are recommend
Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial
- Author
- Aktas Bahriye
- Anderson Charles
- Barretina Pilar
- Baurain Jean-francois
- Bednarek Wieslawa
- Berman Tara
- Blank Stephanie
- Blank Stephanie V.
- Bourhaba Maryam
- Bradley William
- Brasiuniene Birute
- Brasiuniene Birute
- Bruchim Ilan
- Burke James
- Cabrera Luviano Jesus Elvis
- Camargo Vanessa Rosas
- Cappuccini Fabio
- Carney Michael
- Chambers Setsuko
- Chang Suk-joon
- Chen Lee-may
- Chon Hye Sook
- Chon Hye Sook
- Company Jesus Alarcon
- Congzhu Li
- Contreras Mejia Fernando
- Contreras Jessica Reyes
- Covens Allan
- Csoszi Tibor
- Da Costa Miranda Vanessa
- Danbo Wang
- De Cuypere Eveline
- De Guerke Lara
- De La Garza Joseph
- De Melo Andreia Cristina
- De Melo Andreia Cristina
- Debruyne Philip
- Del Rosario Paula Michelle
- Denys Hannelore
- Depasquale Stephen
- Devinder Paul
- Diaz Julian Rivera
- Disilvestro Paul
- Dominguez-andrade Adriana
- Donnelly Conor
- Edraki Babak
- Egger Eva
- Estevez-garcia Purificacion
- Fleming Evelyn
- Forget Frederic
- Fountzilas George
- Fox Jenny
- Frentzas Sophia
- Galvez Fernando
- Ganessan Kichendasse
- Gao Bo
- Garcia Yolanda
- Garza Joseph De La
- Ge Lou
- Gen-hai Zhu
- Gerson-cwilich Raquel
- Ghatage Prafull
- Gil-martin Marta
- Gil-martin Marta
- Gilbert Lucy
- Gold Michael
- Gold Michael A.
- Gordinier Mary
- Goyal Lovenish
- Grisan Karin
- Guedes Joao Daniel
- Guiling Li
- Gupta Sudeep
- Guy Michael
- Hamanishi Junzo
- Hartenbach Ellen
- Haygood Chisten
- Hernandez Angel Luis
- Hernandez Carlos Hernandez
- Hernandez Jesus Lopez
- Ho Wing Ming
- Hong Shi
- Hong Sook Hee
- Hong Zheng
- Hongwu Wen
- Honhon Brigitte
- Imai Yuichi
- Inciura Arturas
- Ji-hong Liu
- Jing Wang
- Jonuskiene Goda
- Joosens Eric
- Jordan Scott
- Joseph De Padua Charles Andree
- Kado Nobuhiro
- Kamiura Shoji
- Kang Sokbom
- Karageorgopoulou Sofia
- Kato Hienori
- Ke Wang
- Kilgore Larry
- Kim Byoung-gie
- Kim Jan-weon
- Kim Yong Man
- Kim Young
- Kirtbaya Dmitriy
- Klasa-mazurkiewicz Dagmara
- Klasa-mazurkiewicz Dagmara
- Kondo Eiji
- Kovel Svetlana
- Krabisch Petra
- Kreynina Julya
- Kubiatowski Tomasz
- Kudaka Wataru
- Kui Jiang
- Landherr Laszlo
- Lau Susie
- Lazaretti Nicolas
- Lee Jung-yun
- Lee Jung-yun
- Leibovici Anca
- Li Li
- Li Wang
- Lim Sheow Lei
- Lisyanskaya Alla
- Liu Ji-hong
- Liu Xiaochun
- Loen Chan Karen Kar
- Lopez Carolina Ortiz
- Lucci Joseph
- Makarova Yulia
- Martinez Lira Jose Luis
- Martinez Jeronimo
- Matsumoto Takashi
- Mattar Andre
- Mccollum Michael
- Mccollum Michael
- Mchale Michael
- Mcintyre Kristi
- Mcintyre Kristi
- Mejia Fernando Contreras
- Meniawy Tarek
- Messing Mark
- Mileshkin Linda
- Miller Eirwen
- Min Hao
- Moore Kathleen
- Moore Kathleen
- Mori Masahiko
- Moroney John
- Muller Andreas
- Naik Radheshyam
- Navarrete Aleman Jaime Esteban
- Nishikawa Tadaaki
- Nishikawa Tadaaki
- Nishio Shin
- Nishio Shin
- Novak Zoltan
- Novak Zoltan
- Nunes Joao Soares
- Okamoto Aikou
- Onstad Michaela
- Oppermann Kussler Christina Pimentel
- Orlova Rashida
- Ortiz Taylor
- Oza Amit
- Ozair Sobia
- Pacheco Carlos Javier
- Palmeiro Daniela Neves
- Papadimitriou Christos
- Papadimitriou Christos
- Papai Zsuzsanna
- Patil Tushar
- Pennington Kathryn
- Pennington Kathryn
- Pereira Jaime Rendon
- Perez Isaura Fernandez
- Pfaendler Krista
- Pirmagomedov Albert
- Poka Robert
- Potemski Piotr
- Priebe Anna
- Provencher Diane
- Psyrri Amanda
- Pustilnik Terri
- Qi Zhou
- Qinglei Gao
- Ramos Guette Pedro Luis
- Redondo-sanchez Andres
- Resnick Kimberly
- Richardson Gary
- Rom Joachim
- Roncolato Felicia
- Rose Peter
- Rosengarten Ora
- Rubini Liedke Pedro Emanuel
- Ryu Sang Young
- Saevets Valeria
- Safina Sufia
- Safra Tamar
- Salinas Erin
- Sehouli Jalid
- Sehouli Jalid
- Sekine Masayuki
- Shai Ayelet
- Shao Peng David Tan
- Sharma Sudarshan
- Sihai Liao
- Sikorska Magdalena
- Sipocz Istvan
- Skopin Pavel
- Sobol Urszula
- Soh Lay Tin
- Soliman Pamela
- Somashekhar S.p.
- Song Yong Jung
- Songling Zhang
- Sperfeld Antje
- Starks David
- Su Mien Lynette Ngo
- Sumi Toshiyuki
- Sundborg Michael
- Sundborg Michael
- Suso Juan Pablo
- Takano Hirokuni
- Takehara Kazuhiro
- Teplinsky Eleonora
- Thomes Pepin Jessica
- Thomes-pepin Jessica
- Tillmanns Todd
- Tillmanns Todd D.
- Tiscoski Katsuki Arima
- Torregroza Otero Marco Antonio
- Touhami Omar
- Tyulyandina Alexandra
- Van Nieuwenhuysen Els
- Van Nieuwenhuysen Els
- Vettus Elen
- Vieira Carolina Martins
- Villegas Tomas Sanchez
- Wang Ke
- Warshal David
- Weidong Zhao
- Westin Shannon N.
- Westin Shannon N.
- Wimberger Pauline
- Woliver Thomas
- Wu Xiaohua
- Wuliang Wang
- Yamagami Wataru
- Yin Rutie
- Ying Cheng
- Yu Zhang
- Yunokawa Mayu
- Zagour Florai
- Zhiqing Liang
- Zorr Andreas
- Publication venue
- American Society of Clinical Oncology (ASCO)
- Publication date
- 28/06/2024
- Field of study
PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer
Study of the B−→Λc+Λˉc−K− decay
- Author
- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Adlarson Patrik Harri
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Aiola Salvatore
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Ao Dong
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Atzeni Michele
- Audurier Benjamin
- Bachmann Sebastian
- Bachmayer Marie
- Back John
- Bailly-Reyre Aurelien
- Baladron Rodriguez Pablo
- Balagura Vladislav
- Baldini Wander
- Baptista de Souza Leite Juan
- Barbetti Matteo
- Barlow Roger
- Barsuk Sergey
- Barter William
- Bartolini Matteo
- Baryshnikov Fedor
- Basels Jan-Marc
- Bassi Giovanni
- Batsukh Baasansuren
- Battig Alexander
- Bay Aurelio
- Beck Anja
- Becker Maik
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Belavin Vladislav
- Belin Samuel
- Bellee Violaine
- Belous Konstantin
- Belov Ilia
- Belyaev Ivan
- Ben-Haim Eli
- Benane Gaya
- Bencivenni Giovanni
- Berezhnoy Alexander
- Bernet Andres Sergi
- Bernet Roland
- Berninghoff Daniel
- Bernstein Harris Conan
- Bertella Claudia
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bian Lingzhu
- Bieker Martin Stefan
- Biesuz Nicolo Vladi
- Bifani Simone
- Billoir Pierre
- Biolchini Alice
- Birch Matthew
- Bishop Fionn Caitlin Ros
- Bitadze Alexander
- Bizzeti Andrea
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blank Jonah Evan
- Blusk Steven
- Bobulska Dana
- Boelhauve Julian Alexander
- Boente Garcia Oscar
- Boettcher Thomas
- Boldyrev Alexey
- Bolognani Carolina
- Bolzonella Riccardo
- Bondar Nikolay
- Borgato Federica
- Borghi Silvia
- Borsato Martino
- Borsuk Jozef Tomasz
- Bouchiba Sonia Amina
- Bowcock Themistocles
- Boyer Alexandre
- Bozzi Concezio
- Bradley Matthew John
- Braun Svende
- Brea Rodriguez Alexandre
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brown James David
- Brundu Davide
- Buonaura Annarita
- Buonincontri Laura
- Burke Aodhan Tomas
- Burr Christopher
- Bursche Albert
- Butkevich Anatoly
- Butter Jordy Sebastiaan
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calefice Lukas
- Cali Stefano
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Campoverde Quezada Angel Fernando
- Capelli Simone
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carus Leon David
- Casais Vidal Adrian
- Caspary Rowina
- Casse Gianluigi
- Cattaneo Marco
- Cavallero Giovanni
- Cavallini Viola
- Celani Sara
- Cerasoli Jacopo
- Cervenkov Daniel
- Chadwick Abbie Jane
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chavez Barajas Carlos Alberto
- Chefdeville Maximilien
- Chen Chen
- Chen Shanzhen
- Chernov Aleksei
- Chernyshenko Serhii
- Chobanova Veronika
- Cholak Serhii
- Chrzaszcz Marcin
- Chubykin Aleksei
- Chulikov Vladimir
- Ciambrone Paolo
- Cicala Maria Flavia
- Cid Vidal Xabier
- Ciezarek Gregory
- Clarke Peter
- Clemencic Marco
- Cliff Harry
- Closier Joel
- Cobbledick John Leslie
- Coco Victor
- Coelho Joao A.B
- Cogan Julien
- Cogneras Eric
- Cojocariu Lucian
- Collins Paula
- Colombo Tommaso
- Congedo Liliana
- Contu Andrea
- Cooke Naomi
- Corredoira Imanol
- Corti Gloria
- Couturier Benjamin
- Craik Daniel Charles
- Cruz Torres Melissa Maria
- Currie Robert
- d'Ambrosio Carmelo
- d'Argent Philippe
- da Silva Cesar Luiz
- Dadabaev Shakhzod
- Dai Lingyun
- Dai Xinchen
- Dall'Occo Elena
- Dalseno Jeremy
- Daniel Jessy
- Danilina Anna
- Davies Jonathan Edward
- Davis Adam
- de Aguiar Francisco Oscar
- de Boer Jan
- de Bruyn Kristof
- de Capua Stefano
- de Cian Michel
- de Freitas Carneiro da Graca Ulisses
- de Lucia Erika
- de Miranda Jussara
- de Paula Leandro
- de Serio Marilisa
- de Simone Dario
- de Simone Patrizia
- de Vellis Fabio
- de Vries Jacco
- Dean Cameron Thomas
- Debernardis Francesco
- Decamp Daniel
- Dedu Vlad-George
- del Buono Luigi
- Delaney Blaise
- Dembinski Hans Peter
- Denysenko Vadym
- Deschamps Olivier
- Dettori Francesco
- Dey Biplab
- Di Nezza Pasquale
- Diachkov Igor
- Didenko Sergey
- Dieste Maronas Lorena
- Ding Shuchong
- Dobishuk Vasyl
- Dolmatov Aleksandr
- Dong Chenzhi
- Donohoe Amanda May
- Dordei Francesca
- dos Reis Alberto
- Douglas Lauren
- Downes Anthony Gavin
- Duda Piotr Jakub
- Dudek Maciej Wojciech
- Dufour Laurent
- Duk Viacheslav
- Durante Paolo
- Duras Maciej
- Durham John Matthew
- Dutta Deepanwita
- Dziurda Agnieszka
- Dzyuba Alexey
- Easo Sajan
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eirea Orro Caetano
- Eisenhardt Stephan
- Ejopu Enoch
- Ek-In Surapat
- Eklund Lars
- Ely Scott
- Ene Alexandru
- Epple Eliane
- Escher Stephan
- Eschle Jonas Nathanael
- Esen Sevda
- Evans Timothy
- Fabiano Federica
- Falcao Lucas
- Fan Yanting
- Fang Bo
- Fantini Lisa
- Faria Maria
- Farry Stephen
- Fazzini Davide
- Felkowski Lukasz Jerzy
- Feo Mauricio
- Fernandez Gomez Miguel
- Fernez Alex Daniel
- Ferrari Fabio
- Ferreira Lopes Lino
- Ferreira Rodrigues Fernando
- Ferreres Sole Silvia
- Ferrillo Martina
- Ferro-Luzzi Massimiliano
- Filippov Sergey
- Fini Rosa Anna
- Fiorini Massimiliano
- Firlej Miroslaw
- Fischer Kamil Leszek
- Fitzgerald Dillon Scott
- Fitzpatrick Conor
- Fiutowski Tomasz
- Fleuret Frederic
- Fontana Marianna
- Fontanelli Flavio
- Forty Roger
- Foulds-Holt Daniel
- Franco Lima Vinicius
- Franco Sevilla Manuel
- Frank Markus
- Franzoso Edoardo
- Frau Giulia
- Frei Christoph
- Friday David Anthony
- Fu Jinlin
- Fuehring Quentin
- Fulghesu Tommaso
- Gabriel Emmy
- Galati Giuliana
- Galati Maria Domenica
- Gallas Torreira Abraham
- Galli Domenico
- Gambetta Silvia
- Gan Yuyue
- Gandelman Miriam
- Gandini Paolo
- Gao Yang
- Gao Yuanning
- Garau Michela
- Garcia Martin Luis Miguel
- Garcia Moreno Paula
- Garcia Plana Beatriz
- Garcia Rosales Felipe Andres
- García Pardiñas Julián
- Garrido Lluis
- Gaspar Clara
- Geertsema Robbert Erik
- Gerick David
- Gerken Louis Lenard
- Gersabeck Evelina
- Gersabeck Marco
- Gershon Timothy
- Giambastiani Luca
- Gibson Valerie
- Giemza Henryk Karol
- Gilman Alexander Leon
- Giovannetti Matteo
- Gioventù Alessandra
- Gironella Gironell Pere
- Giugliano Carmen
- Giza Maciej Artur
- Gizdov Konstantin
- Gkougkousis Evangelos Leonidas
- Gligorov Vladimir
- Golobardes Elisabet
- Golubkov Dmitry
- Golutvin Andrey
- Gomes Alvaro
- Gomez Fernandez Sergio
- Goncalves Abrantes Fernanda
- Goncerz Mateusz
- Gong Guanghua
- Gorelov Igor Vladimirovich
- Gotti Claudio
- Grabowski Jascha Peter
- Grammatico Thomas
- Granado Cardoso Luis Alberto
- Graugés Eugeni
- Graverini Elena
- Graziani Giacomo
- Grecu Alexandru Tudor
- Greeven Lex Marinus
- Grieser Nathan Allen
- Grillo Lucia
- Gromov Sergey
- Gruberg Cazon Barak Raimond
- Gu Chenxi
- Guarise Marco
- Guittiere Manuel
- Gushchin Evgeny
- Guth Andreas
- Guz Yury
- Gys Thierry
- Göbel Carla
- Günther Paul Andre
- Hadavizadeh Thomas
- Haefeli Guido
- Haen Christophe
- Haimberger Jakob
- Haines Susan
- Halewood-Leagas Tabitha
- Halvorsen Marius Maehlum
- Hamilton Phoebe Meredith
- Hammerich Jan
- Han Qundong
- Han Xiaoxue
- Hansen Eva Brottmann
- Hansmann-Menzemer Stephanie
- Hao Lei
- Harnew Neville
- Harrison Thomas
- Hasse Christoph
- Hatch Mark
- He Jibo
- Heijhoff Kevin
- Henderson Conor
- Henderson Riley Dylan Leslie
- Hennequin Arthur Marius
- Hennessy Karol
- Henry Louis
- Herd James Daniel
- Heuel Johannes
- Hicheur Adlène
- Hill Donal
- Hilton Martha
- Hollitt Sophie
- Horswill Joshua Ethan
- Hou Ruiwen
- Hou Yingrui
- Hu Jiangqiao
- Hu Jifeng
- Hu Wenhua
- Hu Xiaofan
- Huang Wenqian
- Huang Xiaotao
- Hulsbergen Wouter
- Hunter Ross John
- Hushchyn Mikhail
- Hutchcroft David
- Ibis Philipp
- Idzik Marek
- Ilin Dmitrii
- Ilten Philip
- Inglessi Alexander
- Iniukhin Aleksandr
- Ishteev Artur
- Ivshin Kuzma
- Jacobsson Richard
- Jage Hendrik
- Jaimes Elles Sergio Javier
- Jakobsen Sune
- Jans Eddy
- Jashal Brij Kishor
- Jawahery Abolhassan
- Jevtic Vukan
- Jiang Emily Kaiyin
- Jiang Xiaojie
- Jiang Yi
- John Malcolm
- Johnson Daniel
- Jones Christopher
- Jones Thomas Peter
- Jost Beat
- Jurik Nathan
- Juszczak Izabela
- Kandybei Sergii
- Kang Youen
- Karacson Matthias
- Karpenkov Dmitrii
- Karpov Maksim
- Kautz Jacob William
- Keizer Floris
- Keller Dustin Michael
- Kenzie Matthew
- Ketel Tjeerd
- Khanji Basem
- Kharisova Anastasiia
- Kholodenko Sergei
- Khreich Gaelle
- Kirn Thomas
- Kirsebom Veronica Soelund
- Kitouni Ouail
- Klaver Suzanne
- Kleijne Nico
- Klimaszewski Konrad
- Kmiec Mateusz Rafal
- Koliiev Serhii
- Kondybayeva Almagul
- Konoplyannikov Anatoly
- Kopciewicz Pawel
- Kopecna Renata
- Koppenburg Patrick
- Korolev Mikhail
- Kostiuk Igor
- Kot Oleksander
- Kotriakhova Sofia
- Kozachuk Anastasiia
- Kravchenko Polina
- Kravchuk Leonid
- Krawczyk Rafal Dominik
- Kreps Michal
- Kretzschmar Sophie Katharina
- Krokovny Pavel
- Krupa Wojciech
- Krzemien Wojciech
- Kubat Jakub
- Kubis Sebastian Antoni
- Kucewicz Wojciech
- Kucharczyk Marcin
- Kudryavtsev Vasily
- Kupsc Andrzej
- Lacarrere Daniel
- Lafferty George
- Lai Adriano
- Lampis Andrea
- Lancierini Davide
- Landesa Gomez Clara
- Lane John Jake
- Lane Richard
- Lanfranchi Gaia
- Langenbruch Christoph
- Langer Jan
- Lantwin Oliver
- Latham Thomas
- Lazzari Federico
- Lazzaroni Massimo
- Le Gac Renaud
- Lee Sook Hyun
- Leflat Alexander
- Lefèvre Regis
- Legotin Sergey
- Leroy Olivier
- Lesiak Tadeusz
- Leverington Blake
- Li Anfeng
- Li Hengne
- Li Kechen
- Li Pei-Rong
- Li Peilian
- Li Shiyang
- Li Tiange
- Li Tianqi
- Li Yiming
- Li Zhuoming
- Liang Xixin
- Lin Chuangxin
- Lin Tai-Hua
- Lindner Rolf
- Lisovskyi Vitalii
- Litvinov Roman
- Liu Guoming
- Liu Huanhuan
- Liu Qian
- Liu Shuaiyi
- Lobo Salvia Aniol
- Loi Angelo
- Lollini Riccardo
- Lomba Castro Julian
- Longstaff Iain
- Lopes Jose
- Lopez Huertas Albert
- Lovell George Holger
- Lu Yu
- Lucarelli Chiara
- Lucchesi Donatella
- Luchuk Stanislav
- Lucio Martinez Miriam
- Lukashenko Valeriia
- Luo Yiheng
- Lupato Anna
- Luppi Eleonora
- Lusiani Alberto
- Lynch Kate
- Lyu Xiao-Rui
- López Soliño Saúl
- Ma Lishuang
- Ma Ruiting
- Maccolini Serena
- Machefert Frederic
- Maciuc Florin
- Mackay Innes
- Macko Vladimir
- Mackowiak Patrick
- Madhan Mohan Lakshan Ram
- Maevskiy Artem
- Maisuzenko Dmitrii
- Majewski Maciej Witold
- Malczewski Jakub Jacek
- Malde Sneha
- Malecki Bartosz
- Malinin Alexander
- Maltsev Timofei
- Manca Giulia
- Mancinelli Giampiero
- Mancuso Chiara
- Manuzzi Daniele
- Manzari Claudio Andrea
- Marangotto Daniele
- Marchand Jean François
- Marconi Umberto
- Mariani Saverio
- Marin Benito Carla
- Marks Jörg
- Marshall Alexander Mclean
- Marshall Phillip John
- Martelli Gabriele
- Martellotti Giuseppe
- Martinazzoli Loris
- Martinelli Maurizio
- Martinez Santos Diego
- Martinez Vidal Fernando
- Massafferri André
- Materok Marcel
- Matev Rosen
- Mathad Abhijit
- Matiunin Viacheslav
- Matteuzzi Clara
- Mattioli Kara Renee
- Mauri Andrea
- Maurice Emilie
- Mauricio Joan
- Mazurek Michal
- Mccann Michael
- Mcconnell Lucas
- Mcgrath Tamaki Holly
- Mchugh Niall Thomas
- Mcnab Andrew
- Mcnulty Ronan
- Mead James Vincent
- Meadows Brian
- Meier Gerwin
- Melnychuk Dmytro
- Meloni Simone
- Merk Marcel
- Merli Andrea
- Meyer Garcia Lucas
- Miao Dexing
- Mikhasenko Mikhail
- Milanes Diego Alejandro
- Millard Edward James
- Milovanovic Marko
- Minard Marie-Noelle
- Minotti Alessandro
- Miralles Tristan
- Mitchell Sara Elizabeth
- Mitreska Biljana
- Mitzel Dominik Stefan
- Mohammed Rizwaan Adeeb
- Moise Razvan-Daniel
- Mokhnenko Sergei
- Mombächer Titus
- Monk Matthew David
- Monroy Igancio Alberto
- Monteil Stephane
- Morandin Mauro
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- Wilkinson Michael K
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- Witek Mariusz
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- Wormser Guy
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- Wu Jie
- Wyllie Kenneth
- Xiang Zhiyu
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Jingyi
- Xu Li
- Xu Liangjun
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhihao
- Yang Di
- Yang Shuangli
- Yang Xueting
- Yang Youhua
- Yang Zhenwei
- Yang Zishuo
- Yeomans Lauren Emma
- Yeroshenko Vsevolod
- Yeung Ho Yin Dereck
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zenaiev Oleksandr
- Zeng Ming
- Zhang Chenjia
- Zhang Dongliang
- Zhang Liming
- Zhang Shulei
- Zhang Shunan
- Zhang Yanxi
- Zhang Yu
- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
- Zhou Tianwen
- Zhou Xiaokang
- Zhou Yixiong
- Zhovkovska Valeriia
- Zhu Xianglei
- Zhu Xiaoyu
- Zhu Zhanwen
- Zhukov Valery
- Zou Quan
- Zucchelli Stefano
- Zuliani Davide
- Zunica Gianluca
- Publication venue
- Publication date
- 02/11/2022
- Field of study
The decay B−→Λc+Λˉc−K− is studied
in proton-proton collisions at a center-of-mass energy of s=13 TeV
using data corresponding to an integrated luminosity of 5 fb−1
collected by the LHCb experiment. In the Λc+K− system, the
Ξc(2930)0 state observed at the BaBar and Belle experiments is
resolved into two narrower states, Ξc(2923)0 and Ξc(2939)0,
whose masses and widths are measured to be m(Ξc(2923)0)=2924.5±0.4±1.1MeV,m(Ξc(2939)0)=2938.5±0.9±2.3MeV,Γ(Ξc(2923)0)=0004.8±0.9±1.5MeV,Γ(Ξc(2939)0)=0011.0±1.9±7.5MeV, where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt Λc+K− sample. Evidence of a new Ξc(2880)0
state is found with a local significance of 3.8σ, whose mass and width
are measured to be 2881.8±3.1±8.5MeV and 12.4±5.3±5.8MeV, respectively. In addition, evidence of a new decay mode
Ξc(2790)0→Λc+K− is found with a significance of
3.7σ. The relative branching fraction of B−→Λc+Λˉc−K− with respect to the B−→D+D−K−
decay is measured to be 2.36±0.11±0.22±0.25, where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions R(D∗) and R(D0)
- Author
- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Adlarson Patrik Harri
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Ao Dong
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Atzeni Michele
- Audurier Benjamin
- Bachiller Perea Irene
- Bachmann Sebastian
- Bachmayer Marie
- Back John
- Bailly-Reyre Aurelien
- Baladron Rodriguez Pablo
- Balagura Vladislav
- Baldini Wander
- Baptista de Souza Leite Juan
- Barbetti Matteo
- Barlow Roger
- Barsuk Sergey
- Barter William
- Bartolini Matteo
- Baryshnikov Fedor
- Basels Jan-Marc
- Bassi Giovanni
- Batsukh Baasansuren
- Battig Alexander
- Bay Aurelio
- Beck Anja
- Becker Maik
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Belin Samuel
- Bellee Violaine
- Belous Konstantin
- Belov Ilia
- Belyaev Ivan
- Ben-Haim Eli
- Benane Gaya
- Bencivenni Giovanni
- Berezhnoy Alexander
- Bernet Andres Sergi
- Bernet Roland
- Berninghoff Daniel
- Bernstein Harris Conan
- Bertella Claudia
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bian Lingzhu
- Bieker Martin Stefan
- Biesuz Nicolo Vladi
- Billoir Pierre
- Biolchini Alice
- Birch Matthew
- Bishop Fionn Caitlin Ros
- Bitadze Alexander
- Bizzeti Andrea
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blank Jonah Evan
- Blusk Steven
- Bobulska Dana
- Boelhauve Julian Alexander
- Boente Garcia Oscar
- Boettcher Thomas
- Boldyrev Alexey
- Bolognani Carolina
- Bolzonella Riccardo
- Bondar Nikolay
- Borgato Federica
- Borghi Silvia
- Borsato Martino
- Borsuk Jozef Tomasz
- Bouchiba Sonia Amina
- Bowcock Themistocles
- Boyer Alexandre
- Bozzi Concezio
- Bradley Matthew John
- Braun Svende
- Brea Rodriguez Alexandre
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brown James David
- Brundu Davide
- Buonaura Annarita
- Buonincontri Laura
- Burke Aodhan Tomas
- Burr Christopher
- Bursche Albert
- Butkevich Anatoly
- Butter Jordy Sebastiaan
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calefice Lukas
- Cali Stefano
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- Calvo Gomez Miriam
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Campoverde Quezada Angel Fernando
- Capelli Simone
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- Cardini Alessandro
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- Casais Vidal Adrian
- Caspary Rowina
- Casse Gianluigi
- Cattaneo Marco
- Cavallero Giovanni
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- Celani Sara
- Cerasoli Jacopo
- Cervenkov Daniel
- Chadwick Abbie Jane
- Chahrour Ibrahim
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chavez Barajas Carlos Alberto
- Chefdeville Maximilien
- Chen Chen
- Chen Shanzhen
- Chernov Aleksei
- Chernyshenko Serhii
- Chobanova Veronika
- Cholak Serhii
- Chrzaszcz Marcin
- Chubykin Aleksei
- Chulikov Vladimir
- Ciambrone Paolo
- Cicala Maria Flavia
- Cid Vidal Xabier
- Ciezarek Gregory
- Cifra Pierfrancesco
- Clarke Peter
- Clemencic Marco
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- Cobbledick John Leslie
- Coco Victor
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- Cogan Julien
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- Davies Jonathan Edward
- Davis Adam
- de Aguiar Francisco Oscar
- de Boer Jan
- de Bruyn Kristof
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- de Cian Michel
- de Freitas Carneiro da Graca Ulisses
- de Lucia Erika
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- de Paula Leandro
- de Serio Marilisa
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- de Vellis Fabio
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- Dean Cameron Thomas
- Debernardis Francesco
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- del Buono Luigi
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- Yeroshenko Vsevolod
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- Yin Hang
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- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zeng Ming
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- Zhang Liming
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- Zhang Shunan
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- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
The ratios of branching fractions
R(D∗)≡B(Bˉ→D∗τ−νˉτ)/B(Bˉ→D∗μ−νˉμ) and R(D0)≡B(B−→D0τ−νˉτ)/B(B−→D0μ−νˉμ) are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb−1 of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
τ−→μ−ντνˉμ. The measured values are
R(D∗)=0.281±0.018±0.024 and
R(D0)=0.441±0.060±0.066, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is ρ=−0.43. Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
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- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
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- Chandrakumar Aberami
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- Chenna Srikanth
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- Hedstrom Amanda
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- Patel Krishna
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- Pawley Corinne
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- Wood Edith
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- Woodward Stephen
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- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
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- Baker Evelyn
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- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
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- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
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- Bauchmuller Kris
- Bayne Madeleine
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- Paramasivam Elankumaran
- Parekh Dhruv
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- van Amerongen Roosmarijn
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- Wittenberg Wendy
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- Wood Hannah
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- Woodward Robert
- Woolett Melissa
- Worner Ruth
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- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Aberami Chandrakumar
- Abhijit Mate
- Adam Hague
- Adam Webber
- Adrian Barry
- Adrian Bergin
- Adrian Blight
- Adrian Butler
- Adrian Parry-Jones
- Afaq Saulat
- Afaq Saulat
- Afnan Chaudhry
- Afraim Salek-Haddadi
- Aguilar
- Ahamad Hassan
- Ahmad Maatouk
- Ahmed Osman
- Aidan Hutchison
- Aileen McGrath
- Ailsa Fulton
- Aine Wallace
- Ajay Bhalla
- Ajmal Anversha
- Al-Shahi Salman
- Al-Shahi Salman
- Al-Shahi Salman
- Alda Remegoso
- Alex Blades
- Alex Ramshaw
- Alex Shah
- Alexandra Pitt-Ford
- Alfonso Tanate
- Ali Ali
- Ali James
- Alicia Rodgers
- Alison McLoughlin
- Alison Whitcher
- Alison Wiltshire
- Allan MacRaild
- Allan Walker
- Alpha Anthony
- Amanda Buck
- Amanda Hedstrom
- Amanda Hedstrom
- Amanda Smart
- Amber Siddiqui
- Amit Mistri
- Amy Ashton
- Amy Steele
- Anand Nair
- Andrea Hall
- Andrea Ingham
- Andrew Moores
- Andrew Sigsworth
- Andrew Smith
- Andrew Stanners
- Andrew Stone
- Andrew Young
- Anette David
- Angela Bell
- Angela Bowring
- Angela Chamberlain
- Angela Cook
- Angela Dodd
- Angela Stevens
- Angela Welch
- Angela Willberry
- Anita Goff
- Anja Ljubez
- Ann Deary
- Ann Needle
- Anna Verrion
- Anne Hardwick
- Anne Hayes
- Anne Nicolson
- Anne Oshodi
- Anne Suttling
- Annemarie Hunter
- Anoja Rajapakse
- Anthea Parry
- Anthony Byrne
- Anthony Hemsley
- Antony Kenton
- Anu Joyson
- Anwer Siddiqui
- Aparna Pusalkar
- Aravind Manoj
- Arindam Kar
- Arshad Majis
- Arshi Iqbal
- Arumugam Nallasivan
- Arun Singh
- Arunkumar Annamalai
- Aryelly Rodriguez
- Ashish Macaden
- Ashleigh Walters
- Ashraf Ahmed
- Ashraf Nasim
- Audrey Thomson
- Avani Shukla
- Azlisham Mohd Nor
- Azra Banaras
- Baigent
- Balakrishna Kumar
- Baljinder Rai
- Baljit Jagpal
- Bander Dallol
- Barbara Longland
- Barbara Madigan
- Barbara Williams-Yesson
- Barry Moynihan
- Basaam Aweid
- Becky Jupp
- Bejot
- Belinda Wroath
- Bella Richard
- Benjamin Hunt
- Benjamin Hyams
- Benjamin Jackson
- Benjamin Jelley
- Benjamin Tomlinson
- Bernard Esisi
- Bernard Esisi
- Beth Hazel
- Bethan Charles
- Bethan Morse
- Betty Mokoena
- Bev Maund
- Beverley McClelland
- Beverly MacLennan
- Bharath Kumar Cheripelli
- Bhavini Patel
- Biffi
- Biju Bhaskaran
- Bindu Gregory
- Bithi Rahman
- Breffni Keegan
- Brian Clarke
- Brian MacInnes
- Brigid Hairsine
- Brigitte Yip
- Bruno
- Carinna Vickers
- Carla Jordan
- Carmen Constantin
- Carol Denniss
- Carol Graham
- Carol Jeffs
- Carol Williams
- Carole Green
- Carole Hays
- Caroline Bagnall
- Caroline Blair
- Caroline Blair
- Caroline Clarke
- Caroline Clay
- Caroline Crosbie
- Caroline Davies
- Caroline Hogan
- Caroline Lambert
- Caroline Lovelock
- Caroline McGhee
- Caroline Roughan
- Caroline Watchurst
- Cassilda Peixoto
- Catherine Ovington
- Catherine Plewa
- Cathy Mason
- Catrin Blank
- Chakravarthi Rajkumar
- Champa Patel
- Chantel Cox
- Charde Naylor
- Charlotte Barr
- Charlotte Culmsee
- Charlotte Eglinton
- Charlotte Eglinton
- Charlotte Fox
- Charlotte Perkins
- Chelsea Causley
- Cherish Boxall
- Chloe Cox
- Chloe Hughes
- Chloe van Someren
- Chong
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- Christian Hansen
- Christina Dickinson
- Christine Dickson
- Christine Kamara
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- Christine Lerpiniere
- Christine Lerpiniere
- Christine McAlpine
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- Christopher Allen
- Christopher Matthews
- Chukwuka Orefo
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- Claire Cullen
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- Claire Nott
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- Claire Stephens
- Claire Sutton
- Claire Triscott
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- Clark
- CLM Sudlow
- Colin Baigent
- Colin Jenkins
- Connor McGill
- Corinne Pawley
- Counsell
- Damian McArdle
- Daniel Epstein
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- Danielle Gilmour
- David Broughton
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- Ding
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- Dipankar Dutta
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- Don Sims
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- Duke Phiri
- Duncan Bailey
- Duncan Wilson
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- Edith Wood
- Edward Littleton
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- Emmanuelle Owoyele
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- Sandra Leason
- Sandra Nelson
- Sankaranarayanan Ramachandran
- Santhosh Subramonian
- Sarah Board
- Sarah Brown
- Sarah Caine
- Sarah Crisp
- Sarah Cuddy
- Sarah Finlay
- Sarah Horton
- Sarah O'Toole
- Sarah Ross
- Sarah Stevenson
- Sarah Thomas
- Sarah Thornthwaite
- Sarah Trippier
- Sarah Wilson
- Sean Mcauley
- Senthil Raghunathan
- Seona Burgess
- Shagufta Khan
- Shahrzad Shahmehri
- Shanni McDonald
- Shannon Amoils
- Sharon Johnson
- Sharon Storton
- Sharon Tysoe
- Sheila Mashate
- Sheila Nyabadza
- Shelley Treadwell
- Shez Feerick
- Shrivakumar Krishnamoorthy
- Shuja Punekar
- Shuna Egerton
- Shyam Kelavkar
- Silvie Davies
- Simon Hervey
- Simon Sharpe
- Simon Smith
- Simone Ivatts
- Sindhu Rashmi
- Siobhan Kelly
- Sissy Ispoglou
- Skarlet Markova
- Skelton Miriam
- Sofia Dima
- Sonia Raj
- Sophie Newton
- Sreeman Andole
- Srikanth Chenna
- Stacey Valentine
- Stefan Schwarz
- Steiner
- Steinhubl
- Stephanie Jones
- Stephanie Lee
- Stephanie McCann
- Stephanie Stevens
- Stephen Duberley
- Stephen Woodward
- Steve Buckle
- Steve Buckle
- Stuart Maguire
- Stuart Symonds
- Sue Evans
- Sue Lyjko
- Suheil Ponnambath
- Suja Cherian
- Sujata Blane
- Sulaiman Sultan
- Susan Clayton
- Susan Crawford
- Susan Downham
- Susan Maiden
- Susan McDonald
- Susan O'Connell
- Susan Pound
- Susan Szabo
- Susan Thompson
- Susan Tucker
- Susan White
- Susannah Walker
- Suzanne Lucas
- Suzanne Ragab
- Suzanne Tauro
- Swapna Kunhunny
- Sweni Shah
- Syed Haider
- Tajammal Zahoor
- Talal Al-Mayhani
- Talat Anjum
- Tanya Ingram
- Tara Lawrence
- Tarn Nozedar
- Tatiana Garcia
- Tatjana Roganova
- Temi Adedoyin
- Teo
- Teresa Beaty
- Teresa Thompson
- Terry Jones
- Thayalini Loganathan
- Thomas Gattringer
- Thomas Harrison
- Tim Cassidy
- Timothy England
- Timothy Webster
- Toby Black
- Tolu Adesina
- Tom Hughes
- Tom Webb
- Tony Rudd
- Tracey Cosier
- Tracey Dobson
- Tracy Fuller
- Tracy Marsden
- Tressy Pitt-Kerby
- Una Poultney
- Ursula Schulz
- Usman Khan
- Uzma Khan
- Val Jones
- Valerie Gott
- Valerie Hogg
- van Asch
- Vanessa Pressly
- Varthi Sukdeo
- Vasileios Papavasileiou
- Venetia Vettimootal Johnson
- Vera Cvoro
- Vicky Taylor
- Victoria Adell
- Victoria Little
- Victoria O'Loughlin
- Victoria Sutton
- Victoria Tilley
- Vidya Baliga
- Vinh Nguyen
- Vinodh Krishnamurthy
- Wilma Smith
- WN Whiteley
- Wong
- Wood
- Xuya Huang
- Yasmin Harrington-Davies
- Yogish Joshi
- Yogish Pai
- Yolanda Baird
- Zhe Law
- Zin Naing
- Publication venue
- 'Elsevier BV'
- Publication date
- 21/05/2019
- Field of study
BACKGROUND: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events. METHODS: The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627). FINDINGS: Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29-146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0- 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25-1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39-1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65-1·60]; p=0·92). INTERPRETATION: These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention. FUNDING: British Heart Foundation
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