10 research outputs found

    Força de gestão de recursos humanos: exploração teórica e validação empírica no setor hoteleiro

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    A Gestão Estratégica de Recursos Humanos coloca a tónica na forma como o sistema de GRH é crítico para a eficácia organizacional. Apesar dos estudos teóricos e empíricos sobre o potencial da GRH no aumento do desempenho e eficácia das organizações, ainda há uma significativa falta de conhecimento no que respeita ao funcionamento dessa associação. Atendendo a esta problemática, Bowen e Ostroff (2004) introduziram o conceito de sistemas de GRH fortes. Estes sistemas comunicam mensagens claras e não ambíguas sobre o conteúdo da GRH, que orientam o comportamento dos colaboradores para o alcance dos objetivos organizacionais. São propostos nove atributos, agrupados em três clusters: distintividade, consistência e consenso. Com base em entrevistas semiestruturadas a diretores de recursos humanos de sete grandes cadeias hoteleiras situadas em Portugal, analisou-se a forma como estas empresas encaram a GRH, mais especificamente se nestas empresas a GRH pode ser considerada forte. Os dados foram comparados com as proposições teóricas de Bowen e Ostroff (2004), e verificou-se que dos nove atributos propostos pelos autores, apenas alguns têm apoio empírico. Os atributos que menos se evidenciam são: compreensibilidade, validade, e justiça. Conclui-se que estas empresas ainda têm um papel importante a desenvolver sobretudo no que respeita a estes aspetos menos valorizados.info:eu-repo/semantics/publishedVersio

    À conquista de um sistema forte de gestão de recursos humanos

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    Força de gestão de recursos humanos: exploração teórica e validação empírica no setor hoteleiro

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    A Gestão Estratégica de Recursos Humanos coloca a tónica na forma como o sistema de GRH é crítico para a eficácia organizacional.Apesar dos estudos teóricos e empíricos sobre o potencial da GRH no aumento do desempenho e eficácia das organizações, ainda há uma significativa falta de conhecimento no que respeita ao funcionamento dessa associação. Atendendo a esta problemática, Bowen e Ostroff (2004) introduziram o conceito de sistemas de GRH fortes. Estes sistemas comunicam mensagens claras e não ambíguas sobre o conteúdo da GRH, que orientam o comportamento dos colaboradores para o alcance dos objetivos organizacionais. São propostos nove atributos, agrupados em três clusters: distintividade, consistência e consenso. Com base em entrevistas semiestruturadas a diretores de recursos humanos de sete grandes cadeias hoteleiras situadas em Portugal, analisou-se a forma como estas empresas encaram a GRH, mais especificamente se nestas empresas a GRH pode ser considerada forte. Os dados foram comparados com as proposições teóricas de Bowen e Ostroff (2004), e verificou-se que dos nove atributos propostos pelos autores, apenas alguns têm apoio empírico. Os atributos que menos se evidenciam são: compreensibilidade, validade, e justiça. Conclui-se que estas empresas ainda têm um papel importante a desenvolver sobretudo no que respeita a estes aspetos menos valorizados.info:eu-repo/semantics/publishedVersio

    Anti-glutamic acid decarboxylase encephalitis presenting with choreo‐dystonic movements and coexisting electrographic seizures

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    © 2019 International Parkinson and Movement Disorder SocietyGlutamic acid decarboxylase (GAD) antibodies (ab) have been associated with rare disorders, such as Stiff-person syndrome, limbic encephalitis, cerebellar ataxia, and temporal lobe epilepsy. Other systemic autoimmune disorders have been linked to antiGAD ab, among them, diabetes mellitus (DM).info:eu-repo/semantics/publishedVersio

    Presentation1_PreEpiSeizures: description and outcomes of physiological data acquisition using wearable devices during video-EEG monitoring in people with epilepsy.pdf

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    The PreEpiSeizures project was created to better understand epilepsy and seizures through wearable technologies. The motivation was to capture physiological information related to epileptic seizures, besides Electroencephalography (EEG) during video-EEG monitorings. If other physiological signals have reliable information of epileptic seizures, unobtrusive wearable technology could be used to monitor epilepsy in daily life. The development of wearable solutions for epilepsy is limited by the nonexistence of datasets which could validate these solutions. Three different form factors were developed and deployed, and the signal quality was assessed for all acquired biosignals. The wearable data acquisition was performed during the video-EEG of patients with epilepsy. The results achieved so far include 59 patients from 2 hospitals totaling 2,721 h of wearable data and 348 seizures. Besides the wearable data, the Electrocardiogram of the hospital is also useable, totalling 5,838 h of hospital data. The quality ECG signals collected with the proposed wearable is equated with the hospital system, and all other biosignals also achieved state-of-the-art quality. During the data acquisition, 18 challenges were identified, and are presented alongside their possible solutions. Though this is an ongoing work, there were many lessons learned which could help to predict possible problems in wearable data collections and also contribute to the epilepsy community with new physiological information. This work contributes with original wearable data and results relevant to epilepsy research, and discusses relevant challenges that impact wearable health monitoring.</p

    Fish Oil Nanoemulsion Supplementation Attenuates Bleomycin-Induced Pulmonary Fibrosis BALB/c Mice

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    Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, when associated with a lipid nanoemulsion in an experimental pulmonary inflammatory model. Pulmonary fibrosis is a disease associated with excessive extracellular matrix deposition. We determined to investigate the morphophysiological mechanisms in mice that were pretreated after induction with bleomycin (BLM). The pretreatment was for 21 days with saline solution, sunflower oil (SO), fish oil (FO), and fish oil nanoemulsion (NEW3). The animals received a daily dose of 50 mg/Kg of docosahexaenoic acid DHA and 10 mg/Kg eicosapentaenoic (EPA) (100 mg/Kg), represented by a daily dose of 40 µL of NEW3. The blank group was treated with the same amount daily (40 µL) during the 21 days of pretreatment. The animals were treated with SO and FO, 100 mg/Kg (containing 58 mg/Kg of polyunsaturated fats/higher% linoleic acid) and 100 mg/Kg (50 mg/Kg of DHA and 10 mg/Kg EPA), respectively. A single dose of 5 mg/mL (50 μL) bleomycin sulfate, by the intratracheal surgical method in BALB/cAnNTac (BALB/c). NEW3 significantly reduced fibrotic progression, which can be evidenced by the protection from loss of body mass, increase in respiratory incursions per minute, decreased spacing of alveolar septa, decreased severity of fibrosis, and changes in the respiratory system. NEW3 attenuated the inflammatory changes developed in the experimental model of pulmonary fibrosis, while group SO showed a significant increase in inflammatory changes. This concluded that the presented results demonstrated that is possible to positively modulate the immune and inflamamtory response to an external agressor, by changing the nutitional intake of specific fatty acids, such as omega-3 placed in fish oil. Moreover, these benefits can be improved by the nanoencapsulation of fish oil in lipid nanoemulsions

    Characterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus

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    Eight new peptides were isolated from the skin secretion of the frog Leptodactylus pustulatus and their amino acid sequences determined by de novo sequencing and by cDNA cloning. Structural similarities between them and other antimicrobial peptides from the skin secretion of Leptodactylus genus frogs were found. Ocellatins-PT1 to -PT5 (25 amino acid residues) are amidated at the C-terminus, while ocellatins-PT6 to -PT8 (32 amino acid residues) have free carboxylates. Antimicrobial activity, hemolytic tests, and cytotoxicity against a murine fibroblast cell line were investigated. All peptides, except for ocellatin-PT2, have antimicrobial activity against at least one Gram negative strain. Ocellatin-PT8 inhibited the growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Salmonella choleraesuis strains with MICs in the 60−240 μM range. No significant effect was observed in human erythrocytes and in a murine fibroblast cell line after exposure to the peptides at MICs. A comparison between sequences obtained by both direct HPLC-MS de novo sequencing and cDNA cloning demonstrates the secretion of mature peptides derived from a pre-pro-peptide structure

    Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

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    © 2020 British Journal of AnaesthesiaBackground: Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache (PDPH). We aimed to describe management practices and outcomes after PDPH treated by epidural blood patch (EBP) or no EBP. Methods: Following ethics committee approval, patients who developed PDPH after accidental dural puncture were recruited from participating countries and divided into two groups, those receiving EBP or no EBP. Data registered included patient and procedure characteristics, headache symptoms and intensity, management practices, and complications. Follow-up was at 3 months. Results: A total of 1001 patients from 24 countries were included, of which 647 (64.6%) received an EBP and 354 (35.4%) did not receive an EBP (no-EBP). Higher initial headache intensity was associated with greater use of EBP, odds ratio 1.29 (95% confidence interval 1.19–1.41) per pain intensity unit increase. Headache intensity declined sharply at 4 h after EBP and 127 (19.3%) patients received a second EBP. On average, no or mild headache (numeric rating score≤3) was observed 7 days after diagnosis. Intracranial bleeding was diagnosed in three patients (0.46%), and backache, headache, and analgesic use were more common at 3 months in the EBP group. Conclusions: Management practices vary between countries, but EBP was more often used in patients with greater initial headache intensity. EBP reduced headache intensity quickly, but about 20% of patients needed a second EBP. After 7 days, most patients had no or mild headache. Backache, headache, and analgesic use were more common at 3 months in patients receiving an EBP

    Management practices for postdural puncture headache in obstetrics : a prospective, international, cohort study

    No full text
    Background: Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache (PDPH). We aimed to describe management practices and outcomes after PDPH treated by epidural blood patch (EBP) or no EBP. Methods: Following ethics committee approval, patients who developed PDPH after accidental dural puncture were recruited from participating countries and divided into two groups, those receiving EBP or no EBP. Data registered included patient and procedure characteristics, headache symptoms and intensity, management practices, and complications. Follow-up was at 3 months. Results: A total of 1001 patients from 24 countries were included, of which 647 (64.6%) received an EBP and 354 (35.4%) did not receive an EBP (no-EBP). Higher initial headache intensity was associated with greater use of EBP, odds ratio 1.29 (95% confidence interval 1.19-1.41) per pain intensity unit increase. Headache intensity declined sharply at 4 h after EBP and 127 (19.3%) patients received a second EBP. On average, no or mild headache (numeric rating score <= 3) was observed 7 days after diagnosis. Intracranial bleeding was diagnosed in three patients (0.46%), and backache, headache, and analgesic use were more common at 3 months in the EBP group. Conclusions: Management practices vary between countries, but EBP was more often used in patients with greater initial headache intensity. EBP reduced headache intensity quickly, but about 20% of patients needed a second EBP. After 7 days, most patients had no or mild headache. Backache, headache, and analgesic use were more common at 3 months in patients receiving an EBP
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