Exploring the Intersection of Designing for Crime and the Future of the Public Forum

As more public spaces are under the influence of private stakeholders in cities, it is important to consider the role, both financial and social, that these stakeholders have on the design of the physical space and the users of the space. This analysis will utilize a qualitative methodological approach to understand the contested redevelopment of a public park in Richmond, Virginia as it transitioned from a city-owned space to a public-private partnership. By gaining a better understanding of the major spheres of influence involved in the redevelopment, namely the large public university and the corporations adjacent to the space, it is understood that the public spaces in question take on forms that are less public and more exclusionary in nature. Upon the conclusion of this analysis, I provide suggestions and recommendations for the future of the public forum and the role that private stakeholders might have in public spaces going forward

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury.

AbstractMorphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions. Despite its widespread use and effectiveness, one of the major drawbacks of morphine is its relatively short half-life of approximately 4 h. This short half-life often necessitates multiple administrations of the drug each day, which may contribute to both dependence and tolerance to morphine. Here, we tested the analgesic properties of a new polymer form of morphine known as PolyMorphine. This polymer has monomeric units of morphine incorporated into a poly(anhydride-ester) backbone that has been shown to hydrolyze into free morphine in vitro. Using an animal model of chronic pain, the spared nerve injury surgery, we showed that PolyMorphine is able to block spared nerve injury-induced hypersensitivity in mice for up to 24-h post-administration. Free morphine was shown to only block spared nerve injury-induced hypersensitivity for up to 2-h post-injection. PolyMorphine was also shown to act through the mu opioid receptor due to the ability of naloxone (a mu opioid receptor antagonist) to block PolyMorphine-induced analgesia in spared nerve injury animals pretreated with PolyMorphine. Additionally, we observed that PolyMorphine causes similar locomotor and constipation side effects as free morphine. Finally, we investigated if PolyMorphine had any effects in a non-evoked pain assay, conditioned place preference. Pretreatment of spared nerve injury mice with PolyMorphine blocked the development of conditioned place preference for 2-methyl-6-(phenylethynyl)pyridine (MPEP), a short-lasting mGluR5 antagonist with analgesic-like properties. Free morphine does not block the development of preference for MPEP, suggesting that PolyMorphine has longer lasting analgesic effects compared to free morphine. Together, these data show that PolyMorphine has the potential to provide analgesia for significantly longer than free morphine while likely working through the same receptor

Libbie & Grove Urban Design Plan

This plan was created for the City of Richmond Department of Planning and Development Review to serve as a recommendation for urban design improvements and suggested changes to zoning ordinances for the Libbie and Grove commercial area located in the Westhampton neighborhood. To begin, an in-depth demographic analysis was conducted for the Westhampton neighborhood. Special attention was paid to socioeconomic factors and trends in census tracts directly surrounding the Libbie and Grove commercial corridor. Based on these analyses and new development occurring in the Libbie and Grove commercial corridor, we were able to allocate six sites or “study areas” as candidates for redevelopment. All of these sites represent valuable areas within the Libbie and Grove commercial corridor. The sites were selected and designed with different intentions, but aim to create a complete streetscape for the commercial area. Based on this analysis and study, it is our recommendation that a new zoning code be implemented for the Libbie and Grove commercial area in order to codify form based design requirements in order to preserve and enhance a village feel at Grove and Libbie and promote compatible future development

Examining ‘good’ mothering and value transmission: how British-born South Asian mothers seek generational change

Sociological literature has begun to examine how mothers occupying non-normative positions negotiate the transmission of cultural capital and habitus, and how the norms of good mothering shape this process. However, less is known about second-generation mothers’ experiences, despite evidence of changing gender relations within ethnic minority communities. Drawing on interviews with British-born South-Asian mothers who held upwardly mobile aspirations, we highlight several forms of departure from intensive, middle-class mothering. Informants face additional responsibilities for transmitting cultural and religious capital, pursuing the ideal of the child as ‘skilled cultural navigator’, enabling their children to negotiate hybridised identities. They reinterpret the norms of intensive mothering, pushing against key tropes including expert-dependence, self-sacrifice, and overprotection. These findings extend knowledge of the mother’s role in creating a reflexive habitus, by showing how second-generation mothers socialise their children with reflexively chosen cultural and religious practices, based on egalitarian gender norms

Pensions and Wages: An Hedonic Price Theory Approach

This paper examines whether a tradeoff exists between the level of pension benefits and wages for comparably skilled workers. The 1983 survey of Consumer Finances is used to match detailed information on pension plans to detailed personal characteristics of a random sample of the population. The pension wage tradeoff is estimated using both a life-tine or contractual model of the labor market and the spot market model used in previous studies. The results indicate a large negative tradeoff in the contractual model but only a negligible tradeoff in the spot market model. Results from estimating the underlying structural supply and demand equation for pensions are also presented.

Diasporas and secessionist conflicts : the mobilization of the Armenian, Albanian and Chechen diasporas

This article examines the impact of diasporas on secessionist conflicts, focusing on the Albanian, Armenian and Chechen diasporas and the conflicts in Kosovo, Karabakh and Chechnya during the 1990s. How do diasporas radicalize these conflicts? I argue that despite differences in diaspora communal characteristics and the types of the secessionist conflicts, a common pattern of mobilization develops. Large-scale diasporic support for secessionism emerges only after independence is proclaimed by the local elites. From that point onwards diasporas become engaged in a conflict spiral, and transnational coalitions are formed between local secessionist and diaspora groups. Depending on the organizational strength of the local strategic centre and the diasporic institutions, these coalitions endure or dissipate. Diasporas exert radicalization influences on the conflict spiral on two specific junctures – when grave violations of human rights occur in the homeland and when local moderate elites start losing credibility that they can achieve the secessionist goal

Stereoscopic Vision in Unmanned Aerial Vehicle Search and Rescue

Search and rescue operations are challenging due to the hazards imposed on the rescue teams. Team ARM IT has developed a virtual reality interface that controls a mounted camera payload on an unmanned aerial vehicle (UAV) through a head mounted display. This allows rescuers to manipulate a UAV to assist search and rescue missions safely and effectively through telepresence and enhanced situational awareness. The team tested these hypotheses by prototyping, testing, and refining individual components of the system through the use of flight simulation software and on-site volunteer testing. By providing a realistic sense of the UAV environment enhanced with relevant information, Team ARM IT’s project reduces the danger to the rescuers and provide cognitively natural situational awareness

Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations

Smooth muscle dysfunction syndrome (SMDS) due to heterozygous ACTA2 arginine 179 alterations is characterized by patent ductus arteriosus, vasculopathy (aneurysm and occlusive lesions), pulmonary arterial hypertension, and other complications in smooth muscle-dependent organs. We sought to define the clinical history of SMDS to develop recommendations for evaluation and management. Medical records of 33 patients with SMDS (median age 12 years) were abstracted and analyzed. All patients had congenital mydriasis and related pupillary abnormalities at birth and presented in infancy with a patent ductus arteriosus or aortopulmonary window. Patients had cerebrovascular disease characterized by small vessel disease (hyperintense periventricular white matter lesions; 95%), intracranial artery stenosis (77%), ischemic strokes (27%), and seizures (18%). Twelve (36%) patients had thoracic aortic aneurysm repair or dissection at median age of 14 years and aortic disease was fully penetrant by the age of 25 years. Three (9%) patients had axillary artery aneurysms complicated by thromboembolic episodes. Nine patients died between the ages of 0.5 and 32 years due to aortic, pulmonary, or stroke complications, or unknown causes. Based on these data, recommendations are provided for the surveillance and management of SMDS to help prevent early-onset life-threatening complications

Genetic effects on gene expression across human tissues

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of diseas