Synthesis of Janus compounds for the recognition of G-U mismatched nucleobase pairs

The design and synthesis of two Janus-type heterocycles with the capacity to simultaneously recognize guanine and uracyl in G-U mismatched pairs through complementary hydrogen bond pairing is described. Both compounds were conveniently functionalized with a carboxylic function and efficiently attached to a tripeptide sequence by using solid-phase methodologies. Ligands based on the derivatization of such Janus compounds with a small aminoglycoside, neamine, and its guanidinylated analogue have been synthesized, and their interaction with Tau RNA has been investigated by using several biophysical techniques, including UV-monitored melting curves, fluorescence titration experiments, and 1H NMR. The overall results indicated that Janus-neamine/guanidinoneamine showed some preference for the +3 mutated RNA sequence associated with the development of some tauopathies, although preliminary NMR studies have not confirmed binding to G-U pairs. Moreover, a good correlation has been found between the RNA binding affinity of such Janus-containing ligands and their ability to stabilize this secondary structure upon complexation

Measurement of electroweak parameters from hadronic and leptonic decays of the Z 0

We have studied the reactions e + e − →hadrons, e + e − , μ + μ − and τ + τ − , in the energy range 88.2 GeV. A total luminosity of 5.5 pb −1 , corresponding to approximately 115000 hadronic and 10000 leptonic Z 0 decays, has been recorded with the L3 detector. From a simultaneous fit to all of our measured cross section data, we obtain assuming lepton universality:Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47890/1/10052_2005_Article_BF01475788.pd

Управление системой электрохимической защиты магистрального газопровода в условиях вечной мерзлоты

Объектом исследования подсистема коррозионного мониторинга электрохимической зашиты магистрального газопровода. Цель работы – проанализировать управление системой электрохимической зашиты магистрального газопровода в условиях вечной мерзлоты. В результате анализа установлено, что ПКМ-ТСТ-КонтКорр удовлетворяет требованиям системы управления техническим состоянием и целостностью площадных объектов организации.The object of study is the subsystem of corrosion monitoring of electrochemical protection of the main gas pipeline. The purpose of the work is to analyze the management of the system of electrochemical protection of the main gas pipeline in permafrost conditions. As a result of the analysis, it was established that PKM-TST-KontKorr satisfies the requirements of the system for managing the technical condition and integrity of the organization’s area facilities

Search for non-minimal Higgs bosons in Z 0 decays

We report on a search for the neutral and charged Higgs bosons predicted by models of spontaneous symmetry breaking with more than one Higgs doublet field. No signals are observed. We set model-independent limits on masses or branching ratios of singly and pair-produced neutral and charged Higgs bosons. In addition, we interpret our results in the framework of a general two-doublet Higgs model and the Minimal Supersymmetric extension of the Standard Model.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47892/1/10052_2005_Article_BF01474331.pd

Measurement of Z0 decays to hadrons, and a precise determination of the number of neutrino species

We have made a precise measurement of the cross section for e+e--->Z0-->hadrons with the L3 detector at LEP, covering the range from 88.28 to 95.04 GeV. From a fit to the Z0 mass, total width, and the hadronic cross section to be MZ0=91.160 +/- 0.024 (experiment) +/-0.030(LEP) GeV, [Gamma]Z0=2.539+/-0.054 GeV, and [sigma]h(MZ0)=29.5+/-0.7 nb. We also used the fit to the Z0 peak cross section and the width todetermine [Gamma]invisible=0.548+/-0.029 GeV, which corresponds to 3.29+/-0.17 species of light neutrinos. The possibility of four or more neutrino flavors is thus ruled out at the 4[sigma] confidence level.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28683/3/0000500.pd

A measurement of the Z0 leptonic partial widths and the vector and axial vector coupling constants

We have measured the partial widths of the Z0 into lepton pairs, and the forward-backward charge asymmetry for the process e+e--->[mu]+[mu]- using the L3 detector at LEP. We obtain an average [Gamma]ll of 83.0+/-2.1+/-1.1 MeV.From this result and the asymmetry measurement, we extract the values of the vector and axial vector couplings of the Z0 to leptons: grmv=-0.066-0.027+0.046 and grmA= -0.495-0.007+0.007.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28666/3/0000483.pd