4,085 research outputs found
Staggered-spin contribution to nuclear spin-lattice relaxation in two-leg antiferromagnetic spin-1/2 ladders
We study the nuclear spin-lattice relaxation rate in the two-leg
antiferromagnetic spin-1/2 Heisenberg ladder. More specifically, we consider
the contribution to from the processes with momentum transfer
. In the limit of weak coupling between the two chains, this
contribution is of activation type with gap at low temperatures
( is the spin gap), but crosses over to a slowly-decaying temperature
dependence at the crossover temperature . This crossover
possibly explains the recent high-temperature NMR results on ladder-containing
cuprates by T. Imai et al.Comment: 6 pages, 2 figures, REVTeX, uses eps
Feigned Consensus: Usurping the Law in Shaken Baby Syndrome/Abusive Head Trauma Prosecutions
Few medico-legal matters have generated as much controversy--both in the medical literature and in the courtroom--as Shaken Baby Syndrome (SBS), now known more broadly as Abusive Head Trauma (AHT). The controversies are of enormous significance in the law because child abuse pediatricians claim, on the basis of a few non-specific medical findings supported by a weak and methodologically flawed research base, to be able to âdiagnoseâ child abuse, and thereby to provide all of the evidence necessary to satisfy all of the legal elements for criminal prosecution (or removal of children from their parents). It is a matter, therefore, in which medical opinion claims to fully occupy the legal field. As controversies flare up increasingly in the legal arena, child abuse pediatricians and prosecutors now respond by claiming both that there is actually no real controversy about SBS/AHT, and that it is a purely medical âdiagnosisâ and not a legal conclusion, so testimony in support of the SBS hypothesis should not be challenged in court. This article, coauthored by four law professors, two physicians, and a physicist, demonstrates that there is very much a live controversy about the SBS/AHT hypothesis and maintains that, under traditional principles of evidence law, physicians should not be permitted to âdiagnoseâ abuse in court (as opposed to identifying specific symptoms or medical findings)
The Replication Argument for Incompatibilism
In this paper, I articulate an argument for incompatibilism about moral responsibility and determinism. My argument comes in the form of an extended story, modeled loosely on Peter van Inwagenâs ârollback argumentâ scenario. I thus call it âthe replication argument.â As I aim to bring out, though the argument is inspired by so-called âmanipulationâ and âoriginal designâ arguments, the argument is not a version of either such argumentâand plausibly has advantages over both. The result, I believe, is a more convincing incompatibilist argument than those we have considered previously
Zero mode quantization of multi-Skyrmions
A zero mode quantization of the minimal energy SU(2) Skyrmions for nucleon
numbers four to nine and seventeen is described. This involves quantizing the
rotational and isorotational modes of the configurations. For nucleon numbers
four, six and eight the ground states obtained are in agreement with the
observed nuclear states of Helium, Lithium and Beryllium. However, for nucleon
numbers five, seven, nine and seventeen the spins obtained conflict with the
observed isodoublet nuclear states.Comment: 37 pages, LaTeX, 4 figures. More careful treatment of double covers,
reference adde
Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. METHODS: Parallel studies were conducted in Tanzania, in which patients obtaining artemether-lumefantrine (AL) at 40 randomly selected public health facilities and 37 accredited drug dispensing outlets (ADDOs) were visited at home and questioned about doses taken. The effect of sector on adherence, controlling for potential confounders was assessed using logistic regression with a random effect for outlet. RESULTS: Of 572 health facility patients and 450 ADDO patients, 74.5% (95% CI: 69.8, 78.8) and 69.8% (95% CI: 64.6, 74.5), respectively, completed treatment and 46.0% (95% CI: 40.9, 51.2) and 34.8% (95% CI: 30.1, 39.8) took each dose at the correct time ('timely completion'). ADDO patients were wealthier, more educated, older, sought care later in the day, and were less likely to test positive for malaria than health facility patients. Controlling for patient characteristics, the adjusted odds of completed treatment and of timely completion for ADDO patients were 0.65 (95% CI: 0.43, 1.00) and 0.69 (95% CI: 0.47, 1.01) times that of health facility patients. Higher socio-economic status was associated with both adherence measures. Higher education was associated with completed treatment (adjusted OR = 1.68, 95% CI: 1.20, 2.36); obtaining AL in the evening was associated with timely completion (adjusted OR = 0.35, 95% CI: 0.19, 0.64). Factors associated with adherence in each sector were examined separately. In both sectors, recalling correct instructions was positively associated with both adherence measures. In health facility patients, but not ADDO patients, taking the first dose of AL at the outlet was associated with timely completion (adjusted OR = 2.11, 95% CI: 1.46, 3.04). CONCLUSION: When controlling for patient characteristics, there was some evidence that the adjusted odds of adherence for ADDO patients was lower than that for public health facility patients. Better understanding is needed of which patient care aspects are most important for adherence, including the role of effective provision of advice
Closing the compliance gap in marine protected areas with human behavioural sciences
Advocates, practitioners and policy-makers continue to use and advocate for marine protected areas (MPAs) to meet global ocean protection targets. Yet many of the worlds MPAs, and especially no-take MPAs, are plagued by poaching and ineffective governance. Using a global dataset on coral reefs as an example, we quantify the potential ecological gains of governing MPAs to increase compliance, which we call the âcompliance gapâ. Using ecological simulations based on model posteriors of joint Bayesian hierarchical models, we demonstrate how increased compliance in no-take MPAs could nearly double target fish biomass (91% increases in median fish biomass), and result in a 292% higher likelihood of encountering top predators. Achieving these gains and closing the compliance gap necessitates a substantial shift in approach and practice to go beyond optimizing enforcement, and towards governing for compliance. This will require engaging and integrating a broad suite of actors, principles, and practices across three key domains: (i)) harnessing social influence, (ii) integrating equity principles, and (iii) aligning incentives through market-based instruments. Empowering and shaping communication between actor groups (e.g., between fishers, practitioners, and policy-makers) using theoretically underpinned approaches from the behavioural sciences is one of the most essential, but often underserved aspects of governing MPAs. We therefore close by highlighting how this cross-cutting tool could be further integrated in governance to bolster high levels of compliance in MPAs
From high temperature supercondutivity to quantum spin liquid: progress in strong correlation physics
This review gives a rather general discussion of high temperature
superconductors as an example of a strongly correlated material. The argument
is made that in view of the many examples of unconventional superconductors
discovered in the past twenty years, we should no longer be surprised that
superconductivity emerges as a highly competitive ground state in systems where
Coulomb repulsion plays a dominant role. The physics of the cuprates is
discussed, emphasizing the unusual pseudogap phase in the underdoped region. It
is argued that the resonating valence bond (RVB) picture, as formulated using
gauge theory with fermionic and bosonic matter fields, gives an adequate
physical understanding, even though many details are beyond the powers of
current calculational tools. The recent discovery of quantum oscillations in a
high magnetic field is discussed in this context. Meanwhile, the problem of the
quantum spin liquid (a spin system with antiferromagnetic coupling which
refuses to order even at zero temperature) is a somewhat simpler version of the
high problem where significant progress has been made recently. It is
understood that the existence of matter fields can lead to de-confinement of
the U(1) gauge theory in 2+1 dimensions, and novel new particles (called
fractionalized particles), such as fermionic spinons which carry spin and no charge, and gapless gauge bosons can emerge to create a new critical
state at low energies. We even have a couple of real materials where such a
scenario may be realized experimentally. The article ends with answers to
questions such as: what limits if pairing is driven by an electronic
energy scale? why is the high problem hard? why is there no consensus?
and why is the high problem important?Comment: Submitted as "Key Issue" essay for Report of Progress in Physics; v2:
References are added and typos correcte
Amisulpride augmentation in clozapine-unresponsive schizophrenia: A double-blind, placebo-controlled, randomised trial of clinical and cost-effectiveness.
BACKGROUND: When treatment-refractory schizophrenia shows an insufficient response to a trial of clozapine, clinicians commonly add a second antipsychotic, despite the lack of robust evidence to justify this practice. OBJECTIVES: The main objectives of the study were to establish the clinical effectiveness and cost-effectiveness of augmentation of clozapine medication with a second antipsychotic, amisulpride, for the management of treatment-resistant schizophrenia. DESIGN: The study was a multicentre, double-blind, individually randomised, placebo-controlled trial with follow-up at 12 weeks. SETTINGS: The study was set in NHS multidisciplinary teams in adult psychiatry. PARTICIPANTS: Eligible participants were people aged 18-65 years with treatment-resistant schizophrenia unresponsive, at a criterion level of persistent symptom severity and impaired social function, to an adequate trial of clozapine monotherapy. INTERVENTIONS: Interventions comprised clozapine augmentation over 12 weeks with amisulpride or placebo. Participants received 400âmg of amisulpride or two matching placebo capsules for the first 4 weeks, after which there was a clinical option to titrate the dosage of amisulpride up to 800âmg or four matching placebo capsules for the remaining 8 weeks. MAIN OUTCOME MEASURES: The primary outcome measure was the proportion of 'responders', using a criterion response threshold of a 20% reduction in total score on the Positive and Negative Syndrome Scale. RESULTS: A total of 68 participants were randomised. Compared with the participants assigned to placebo, those receiving amisulpride had a greater chance of being a responder by the 12-week follow-up (odds ratio 1.17, 95% confidence interval 0.40 to 3.42) and a greater improvement in negative symptoms, although neither finding had been present at 6-week follow-up and neither was statistically significant. Amisulpride was associated with a greater side effect burden, including cardiac side effects. Economic analyses indicated that amisulpride augmentation has the potential to be cost-effective in the short term [net saving of between ÂŁ329 and ÂŁ2011; no difference in quality-adjusted life-years (QALYs)] and possibly in the longer term. LIMITATIONS: The trial under-recruited and, therefore, the power of statistical analysis to detect significant differences between the active and placebo groups was limited. The economic analyses indicated high uncertainty because of the short duration and relatively small number of participants. CONCLUSIONS: The risk-benefit of amisulpride augmentation of clozapine for schizophrenia that has shown an insufficient response to a trial of clozapine monotherapy is worthy of further investigation in larger studies. The size and extent of the side effect burden identified for the amisulpride-clozapine combination may partly reflect the comprehensive assessment of side effects in this study. The design of future trials of such a treatment strategy should take into account that a clinical response may be not be evident within the 4- to 6-week follow-up period usually considered adequate in studies of antipsychotic treatment of acute psychotic episodes. Economic evaluation indicated the need for larger, longer-term studies to address uncertainty about the extent of savings because of amisulpride and impact on QALYs. The extent and nature of the side effect burden identified for the amisulpride-clozapine combination has implications for the nature and frequency of safety and tolerability monitoring of clozapine augmentation with a second antipsychotic in both clinical and research settings. TRIAL REGISTRATION: EudraCT number 2010-018963-40 and Current Controlled Trials ISRCTN68824876. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 21, No. 49. See the NIHR Journals Library website for further project information
Gamma Ray Bursts as Probes of the Distant Universe
We review recent results on the high-redshift universe and the cosmic
evolution obtained using Gamma Ray Bursts (GRBs) as tracers of high-redshift
galaxies. Most of the results come from photometric and spectroscopic
observations of GRB host galaxies once the afterglow has faded away but also
from the analysis of the GRB afterglow line of sight as revealed by absorptions
in their optical spectrum.Comment: 20 pages, 4 figures. To appear in a special issue of Comptes Rendus
Physique "GRB studies in the SVOM era", Eds. F. Daigne, G. Dubu
Life After Succession in the Family Business: Is It Really the End of Problems?
The succession processes in family business are well chronicled in the business literature. Most of the research focuses on the process of transferring power within the business-family. What has not been as closely examined is the after-succession environment that exists when the management and leadership of the family business are passed on to the next generation. This article addresses that organizational climate and the potential for additional problems in the business-family if post-succession issues are not identified and addressed and suggests some steps that will be helpful in producing complete succession success.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
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