64 research outputs found
The skyrmion switch: turning magnetic skyrmion bubbles on and off with an electric field
Nanoscale magnetic skyrmions are considered as potential information carriers
for future spintronics memory and logic devices. Such applications will require
the control of their local creation and annihilation, which involves so far
solutions that are either energy consuming or difficult to integrate. Here we
demonstrate the control of skyrmion bubbles nucleation and annihilation using
electric field gating, an easily integrable and potentially energetically
efficient solution. We present a detailed stability diagram of the skyrmion
bubbles in a Pt/Co/oxide trilayer and show that their stability can be
controlled via an applied electric field. An analytical bubble model, with the
Dzyaloshinskii-Moriya interaction imbedded in the domain wall energy, account
for the observed electrical skyrmion switching effect. This allows us to unveil
the origin of the electrical control of skyrmions stability and to show that
both magnetic dipolar interaction and the Dzyaloshinskii-Moriya interaction
play an important role in the skyrmion bubble stabilization
EurOP2E â the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachers
Purpose
Sharing and developing digital educational resources and open educational resources has been proposed as a way to harmonize and improve clinical pharmacology and therapeutics (CPT) education in European medical schools. Previous research, however, has shown that there are barriers to the adoption and implementation of open educational resources. The aim of this study was to determine perceived opportunities and barriers to the use and creation of open educational resources among European CPT teachers and possible solutions for these barriers.
Methods
CPT teachers of British and EU medical schools completed an online survey. Opportunities and challenges were identified by thematic analyses and subsequently discussed in an international consensus meeting.
Results
Data from 99 CPT teachers from 95 medical schools were analysed. Thirty teachers (30.3%) shared or collaboratively produced digital educational resources. All teachers foresaw opportunities in the more active use of open educational resources, including improving the quality of their teaching. The challenges reported were language barriers, local differences, lack of time, technological issues, difficulties with quality management, and copyright restrictions. Practical solutions for these challenges were discussed and include a peer review system, clear indexing, and use of copyright licenses that permit adaptation of resources.
Conclusion
Key challenges to making greater use of CPT open educational resources are a limited applicability of such resources due to language and local differences and quality concerns. These challenges may be resolved by relatively simple measures, such as allowing adaptation and translation of resources and a peer review system
The challenges of prescription safety without marketing approvals : the example of baclofen in alcohol dependence
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Les enjeux de sĂ©curitĂ© de la prescription hors AMM : lâexemple du baclofĂšne dans lâalcoolodĂ©pendance
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Vaccination contre la pandémie grippale A(H1N1)v au cours de l'hiver 2009-2010 (suivi de pharmacovigilance d'une cohorte de femmes enceintes vaccinées dans le Nord Pas-de-Calais)
LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF
Contexte et problĂ©matiqueâ: La formation mĂ©dicale continue sur le mĂ©dicament constitue, Ă lâheure actuelle, un vrai challenge, notamment dans le contexte de lâavĂšnement des rĂ©seaux sociaux, et plus particuliĂšrement de TwitterÂź, qui ont rĂ©volutionnĂ© lâaccĂšs Ă lâinformation. ExĂ©gĂšseâ: Le compte TwitterÂź @Reseau_CRPV a Ă©tĂ© crĂ©Ă© par le RĂ©seau français des centres rĂ©gionaux de pharmacovigilance (RFCRPV) regroupant lâensemble des 31âcentres rĂ©gionaux de pharmacovigilance (CRPV) en France et dont une des missions est lâinformation sur le mĂ©dicament. Outre la diffusion dâinformation des agences officielles et une veille bibliographique, ce compte propose tous les vendredis un questionnaire Ă rĂ©ponse unique (le #PharmacoQuiz), en lien avec les mĂ©dicaments, et comportant quatre propositions. Les thĂ©matiques abordĂ©es sont vastes, des effets indĂ©sirables au bon usage des mĂ©dicaments en passant par lâaddictovigilance. La difficultĂ© des quiz est Ă©tablie grĂące Ă un systĂšme de gradation par Ă©toiles. La rĂ©ponse dĂ©taillĂ©e est publiĂ©e le lundi suivant, associĂ©e Ă la diffusion dâinformations provenant de la littĂ©rature scientifique en rĂ©fĂ©rence au quiz. Comme tout tweet, câest Ă©galement lâoccasion pour la communautĂ© scientifique dâĂ©changer et de dĂ©battre sur une problĂ©matique spĂ©cifique liĂ©e au mĂ©dicament. Par rapport aux mĂ©thodes traditionnelles de diffusion dâinformation ou dâenseignement, les mĂ©dias sociaux offrent une flexibilitĂ© importante et facilitent les interactions entre celui qui diffuse lâinformation et les pairs ou Ă©tudiants. Conclusionâ: Le #PharmacoQuiz constitue le premier exemple français dâĂ©valuation des connaissances dans le domaine de la pharmacologie via un rĂ©seau social. Câest un outil novateur et ludique de formation mĂ©dicale continue qui contribue pleinement aux missions de formation et dâinformation des CRPV
Pneumopathie interstitielle diffuse sous mésalazine : un effet indésirable sous diagnostiqué ?
Nous rapportons le cas dâune femme traitĂ©e par adalimumab
et mésalazine pour une maladie de Crohn depuis neuf ans qui présenta
une pneumopathie interstitielle diffuse (PID). Plusieurs Ă©tiologies
avaient été évoquées initialement : évolution de la maladie, effet
indĂ©sirable de lâadalimumab. Les troubles pulmonaires sâaggravaient nĂ©anmoins
malgrĂ© lâarrĂȘt de lâadalimumab et la mĂ©salazine Ă©tait finalement
arrĂȘtĂ©e 6 mois plus tard conduisant Ă une rĂ©gression complĂšte de
lâatteinte pulmonaire. Les PID sont bien connues lors de traitement
par mĂ©salazine mais sa responsabilitĂ© nâest pas forcĂ©ment envisagĂ©e
en prioritĂ© et le diagnostic peut donc ĂȘtre retardĂ©
Service Dogs and Persons with Disabilities: When COVID-19 Lockdown Changes Their Relationship
International audienceSimple Summary COVID-19 constitutes a major event with multiple consequences for our intra- and interspecific relationships. Persons with disabilities, who own service dogs, develop strong relationships with them. In the present study, we hypothesized that the COVID-19 lockdown would have influenced people with disabilities/service dog relationships. An online survey was conducted during the first COVID-19 lockdown in France, which included information on the general context prior to and during the COVID-19 lockdown. The results confirm that service dogs, like other pets, constituted a source of emotional support for people during the COVID-19 lockdown. However, it appears that the COVID-19 lockdown elicited a costlier relationship for service dog owners. Our study highlights that, in extreme situations, the characteristics of human-animal relationships can be exacerbated in positive and negative ways. These results are important for organizations providing service dogs to evaluate the support they provide to their recipients. Persons with disabilities, who own service dogs, develop strong relationships with them. Since the COVID-19 pandemic decreased the possibility of social contact and modified human relationships, we hypothesized that the COVID-19 lockdown would influence people with disabilities-service dog relationships. An online survey was conducted during the first COVID-19 lockdown in France and included information (e.g., MONASH score) both in the general context prior to and during the COVID-19 lockdown. Seventy owners participated. Compared to the general context, scores for the Perceived Emotional Closeness and Perceived Costs subscales were significantly higher during the COVID-19 lockdown, while scores for the Dog-Owner Interaction subscale were significantly lower during the COVID-19 lockdown. Our study confirmed that service dogs, like other pets, were a source of emotional support for their owners during the COVID-19 lockdown. However, people with disabilities found their relationship with their service dog costlier (e.g., my dog makes too much mess). Our study highlights that, in extreme situations, characteristics of a human-animal relationship can be exacerbated in both positive and negative ways
Comment les plateformes de lâĂ©conomie collaborative sâassurent-elles de la fidĂ©lisation de leurs utilisateurs, au travers de stratĂ©gies de contrĂŽle de la qualitĂ© du service proposĂ©, et de recherche de satisfaction des utilisateurs ? : Case study
Marketin
Clomiphene citrate and neural tube defects: a metaâanalysis of controlled observational studies
International audienceAt the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0.76-1.51). Since then, additional studies have been published and the risk of NTDs associated with periconceptional CC exposure may have changed
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