Un breve análisis de la mortalidad del Covid-19 en países de América Latina

In early the 2020, the world faced a pandemic caused by Covid-19, which created crises in the health systems and economy of all nations. In Latin America, 1,246,190 cases and 65,228 deaths were recorded during the first four months of that year. Therefore, this study analyzed the data from report 101 of the World Health Organization, with the intention of identifying the countries in Latin America most affected by this crisis. With the use of the Pareto diagram tool, it could be shown that, the sum of positive cases in the countries of Brazil, Peru, Ecuador and Mexico represent approximately 80% of the total report of contagions in Latin America, the number of most alarming cases was recorded in Brazil with more than 70000 and the number of contagions does not exceed 0.1% of the total population of each government, with the exception of Ecuador, which surpassed it. However, this virus was not fatal in the first quarter of 2020 in Latin American countries  A principios del año 2020, el mundo enfrentó una pandemia ocasionada por el Covid-19, lo cual generó crisis en la salud y en la economía de todas las naciones. En América Latina, se registraron 1 246 190 casos y 65 228 muertes durante los cuatro primeros meses de ese año. Por lo tanto, en este estudio se analizaron los datos del informe 101 de la organización mundial de la salud, con la intensión de identificar los países de América Latina más afectados por esta crisis. Con la utilización de la herramienta diagrama de Pareto, se pudo evidenciar que, la sumatoria de casos positivos en los países de Brasil, Perú, Ecuador y México representan aproximada el 80% del reporte total de contagiados en América latina, el número de casos más alarmante se registró en Brasil con más de 70000 y el número de contagios no supera el 0,1% de la población total de cada gobierno, a excepción de Ecuador el cual lo superó. No obstante, este virus no fue mortal en el primer cuatrimestre del 2020 en los países de Latino América

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Un breve análisis de la mortalidad del Covid-19 en países de América Latina

In early the 2020, the world faced a pandemic caused by Covid-19, which created crises in the health systems and economy of all nations. In Latin America, 1,246,190 cases and 65,228 deaths were recorded during the first four months of that year. Therefore, this study analyzed the data from report 101 of the World Health Organization, with the intention of identifying the countries in Latin America most affected by this crisis. With the use of the Pareto diagram tool, it could be shown that, the sum of positive cases in the countries of Brazil, Peru, Ecuador and Mexico represent approximately 80% of the total report of contagions in Latin America, the number of most alarming cases was recorded in Brazil with more than 70000 and the number of contagions does not exceed 0.1% of the total population of each government, with the exception of Ecuador, which surpassed it. However, this virus was not fatal in the first quarter of 2020 in Latin American countries &nbsp;A principios del año 2020, el mundo enfrentó una pandemia ocasionada por el Covid-19, lo cual generó crisis en la salud y en la economía de todas las naciones. En América Latina, se registraron 1 246 190 casos y 65 228 muertes durante los cuatro primeros meses de ese año. Por lo tanto, en este estudio se analizaron los datos del informe 101 de la organización mundial de la salud, con la intensión de identificar los países de América Latina más afectados por esta crisis. Con la utilización de la herramienta diagrama de Pareto, se pudo evidenciar que, la sumatoria de casos positivos en los países de Brasil, Perú, Ecuador y México representan aproximada el 80% del reporte total de contagiados en América latina, el número de casos más alarmante se registró en Brasil con más de 70000 y el número de contagios no supera el 0,1% de la población total de cada gobierno, a excepción de Ecuador el cual lo superó. No obstante, este virus no fue mortal en el primer cuatrimestre del 2020 en los países de Latino América