Estructura y relato en diseño : el holograma como metáfora epistemológica y herramienta didáctica del diseño

La sobrevaloración del diseño como categoría formal evidencia una debilidad en cuanto a la comprensión y sensibilidad ante la capacidad expresiva del mismo, provocando un desequilibrio proyectual que sobreformaliza y banaliza al diseño. En efecto, se inicia un camino hacia la epistemología del diseño, con el objetivo de comprender al mismo como un sistema de configuración complejo que se visualiza como cuerpo, pero que inscribe en sí mismo estructuras virtuales de género y naturaleza variable, mostrándose dichas estructuras como aquella pulsión generativa del diseño que nos permite acercarnos al interior o alma de un proyecto, captando su naturaleza, su genotipo, para así permitir la emergencia del fenotipo como forma u objeto de diseño coherente al contexto sociocultural que se proyecta. Se trata de reivindicar y valorar al diseño como estructura y relato sociocultural, con la capacidad de proyectar el entorno con formas coherentes de acuerdo a intenciones y principios significativos.The over value of design as a formal category shows a debility regarding the comprehension and sensibility in which it expresses it self, provoking a disequilibrium that banalize and over formalize design. In Fact, it starts a road through the epistemology of design, with de objetive of comprehending it self as a complex configuration system that shows it self as body but inscribe inside virtual structures of gender and variable nature, these structures are shown through the generative impulse that allow us to get deep into the soul and meaning of a project capturing it's nature genotype and that way allow the emergence of the fenotype as a form or object that is coherent to the cultural context of interest. It's mentioned to give design the value as a structure and socioculural expression, capable of showing a space of coherent shapes in regard of it's intention and significant principles

Dibujo, imagen, tiempo, arquitectura

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Antroposfera : aprenentatge col·laboratiu i creativitat en la pràctica projectual del disseny

Aquest estudi de cas recull les reflexions al voltant d’un taller experimental on s’han aplicat estratègies didàctiques basades en el desconfort i la ficció amb els objectius d’avaluar l’eficàcia d’un marc d’aprenentatge construït a partir de la combinació de diferents contextos, considerar el procés projectual com a matèria d’especulació en sí mateix i intensificar la creativitat en la pràctica del disseny. A partir del plantejament estratègic del taller i del control del procés de disseny amb els ítems de ficció i desconfort durant el desenvolupament del taller, s'ha pogut traçar la incidència que cadascun d'ells té en l'assoliment de l'aprenentatge col·laboratiu del projecte

A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism

BACKGROUND: HIV protease inhibitor (PI) therapy results in the rapid selection of drug resistant viral variants harbouring one or two substitutions in the viral protease. To combat PI resistance development, two approaches have been developed. The first is to increase the level of PI in the plasma of the patient, and the second is to develop novel PI with high potency against the known PI-resistant HIV protease variants. Both approaches share the requirement for a considerable increase in the number of protease mutations to lead to clinical resistance, thereby increasing the genetic barrier. We investigated whether HIV could yet again find a way to become less susceptible to these novel inhibitors. METHODS AND FINDINGS: We have performed in vitro selection experiments using a novel PI with an increased genetic barrier (RO033-4649) and demonstrated selection of three viruses 4- to 8-fold resistant to all PI compared to wild type. These PI-resistant viruses did not have a single substitution in the viral protease. Full genomic sequencing revealed the presence of NC/p1 cleavage site substitutions in the viral Gag polyprotein (K436E and/or I437T/V) in all three resistant viruses. These changes, when introduced in a reference strain, conferred PI resistance. The mechanism leading to PI resistance is enhancement of the processing efficiency of the altered substrate by wild-type protease. Analysis of genotypic and phenotypic resistance profiles of 28,000 clinical isolates demonstrated the presence of these NC/p1 cleavage site mutations in some clinical samples (codon 431 substitutions in 13%, codon 436 substitutions in 8%, and codon 437 substitutions in 10%). Moreover, these cleavage site substitutions were highly significantly associated with reduced susceptibility to PI in clinical isolates lacking primary protease mutations. Furthermore, we used data from a clinical trial (NARVAL, ANRS 088) to demonstrate that these NC/p1 cleavage site changes are associated with virological failure during PI therapy. CONCLUSIONS: HIV can use an alternative mechanism to become resistant to PI by changing the substrate instead of the protease. Further studies are required to determine to what extent cleavage site mutations may explain virological failure during PI therapy

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

And she said: "I don't want to be a model"

Hay algo en los modelos arquitectónicos que al imitar o reproducirse limita las formas de ejercer la arquitectura y construir el espacio. Desde una perspectiva “queer”, al margen del discurso, el horizonte se amplia y el sentido de lo arquitectónico emerge

Estructura y relato en diseño : el holograma como metáfora epistemológica y herramienta didáctica del diseño

La sobrevaloración del diseño como categoría formal evidencia una debilidad en cuanto a la comprensión y sensibilidad ante la capacidad expresiva del mismo, provocando un desequilibrio proyectual que sobreformaliza y banaliza al diseño. En efecto, se inicia un camino hacia la epistemología del diseño, con el objetivo de comprender al mismo como un sistema de configuración complejo que se visualiza como cuerpo, pero que inscribe en sí mismo estructuras virtuales de género y naturaleza variable, mostrándose dichas estructuras como aquella pulsión generativa del diseño que nos permite acercarnos al interior o alma de un proyecto, captando su naturaleza, su genotipo, para así permitir la emergencia del fenotipo como forma u objeto de diseño coherente al contexto sociocultural que se proyecta. Se trata de reivindicar y valorar al diseño como estructura y relato sociocultural, con la capacidad de proyectar el entorno con formas coherentes de acuerdo a intenciones y principios significativos.The over value of design as a formal category shows a debility regarding the comprehension and sensibility in which it expresses it self, provoking a disequilibrium that banalize and over formalize design. In Fact, it starts a road through the epistemology of design, with de objetive of comprehending it self as a complex configuration system that shows it self as body but inscribe inside virtual structures of gender and variable nature, these structures are shown through the generative impulse that allow us to get deep into the soul and meaning of a project capturing it's nature genotype and that way allow the emergence of the fenotype as a form or object that is coherent to the cultural context of interest. It's mentioned to give design the value as a structure and socioculural expression, capable of showing a space of coherent shapes in regard of it's intention and significant principles

El futuro de la investigacion y la docencia en las escuelas de arquitectura en España:legislación y realidad

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