Can the Brazilian caffeine expectancy questionnaires differentiate the CYP1A2 and ADORA2A gene polymorphisms? : an exploratory study with Brazilian athletes

This study investigated the ability of the Brazilian Caffeine Expectancy Questionnaire (CaffEQ-BR), full and brief versions, to differentiate genetic profiles regarding the polymorphisms of the CYP1A2 (rs 762551) and ADORA2A (rs 5751876) genes in a cohort of Brazilian athletes. Onehundred and fifty participants were genotyped for CYP1A2 and ADORA2A. After the recruitment and selection phase, 71 (90% male and 10% female, regular caffeine consumers) completed the CaffEQ-BR questionnaires and a self-report online questionnaire concerning sociodemographic data, general health status, and frequency of caffeine consumption. The order of completion of the CaffEQBR questionnaires was counterbalanced. The concordance between the full and brief versions of the CaffEQ-BR was analyzed using the intraclass correlation coefficient (ICC). To determine the discriminatory capacity of the questionnaires for genotype, the receiver operating characteristic (ROC) curve was applied for sensitivity and specificity (significance level of 5%). Mean caffeine intake was 244 161 mg day1. The frequency of AA genotypes for CYP1A2 was 47.9% (n = 34) and 52.1% (n = 37) for C-allele carriers (AC and CC). The frequencies of TT genotypes for ADORA2A were 22.7% (n = 15) and 77.3% (n = 51) for C-allele carriers (TC and CC). All CaffEQ-BR factors, for the full and brief versions, were ICCs > 0.75, except for factor 6 (anxiety/negative effects; ICC = 0.60), and presented ROC curve values from 0.464 to 0.624 and 0.443 to 0.575 for CYP1A2 and ADORA2A. Overall, the CaffEQ-BR (full and brief versions) did not show discriminatory capacity for CYP1A2 and ADORA2A gene polymorphisms. In conclusion, the CaffEQ-BR was not able to differentiate genotypes for the CYP1A2 or ADORA2A genes in this group of Brazilian athletes

Micropolíticas: devir, cooperação dissonante e experiência pura

This article traces the definition of the concept of micropolitics in a singular perspective of Critical Semiotics. It seeks supplements in the theories of Deleuze and Guattari to think of it as an underlying force to alliances that produce zones of becoming. Regarding the propositions of Rolnik and Guattari, it proposes the understanding of micropolitics as a process of dissonant cooperation among subjects positioned in distinct subjectivities, a process that makes these existential models deterritorialize themselves. Concerning the phenomenal characteristics of this process, it uses the thought of James and Lapoujade to understand that micropolitics is produced and intensified based on what these thinkers called pure experience.O artigo traça um percurso de definição do conceito de micropolítica em uma visada singular da Semiótica Crítica. Busca suplementos nas teorizações de Deleuze e Guattari para pensá-la enquanto força subjacente a alianças que produzem zonas de devir. Em relação às proposições de Rolnik e Guattari, projeta a compreensão da micropolítica enquanto processo de cooperação dissonante entre sujeitos posicionados em subjetividades distintas, processo que faz esses modelos existenciais desterritorializarem-se. Já considerando as características fenomênicas desse processo, recorre ao pensamento de James e de Lapoujade para compreender que a micropolítica é produzida e intensificada a partir do que esses filósofos chamaram de experiência pura

A aventura crítica da semiótica

The critical adventure of semiotics courses through the main theses about semiotics and communication that have been discussed during the first stage of the research Critical Semiotics: Towards a theory of materialities in communication. In it, the Semiotics and Communication Cultures Research Group (GPESC) discussed the potentialities and limits of a communicational perspective not only based on the founding works of semiotic research (Saussure, Peirce) and developed in its structuralist models (Jakobson, Barthes, Hjelmslev, Lotman), but also revisited by ideas that deconstructed structuralism through the postulates of this very structuralism (Derrida, Kristeva, Deleuze, Guattari). The paper presents this suggestion by means of ten deconstructions related to concepts and theoretical problems which are key to the debate around the materialities of communication: semiotics, communication, materialities, presence, phenomenon, representamen, mediums, sign and significant, structure and system. In so doing, it suggests a move from materialities towards the immanence of a micropolitical and post- human communication.A aventura crítica da semiótica percorre as principais teses sobre a semiótica e a comunicação conforme trabalhadas na primeira etapa da pesquisa Semiótica Crítica, denominada Por uma teoria das materialidades na comunicação. Nela, o Grupo de Pesquisa Semiótica e Culturas da Comunicação procurou discutir as potencialidades e limites de uma perspectiva comunicacional não somente fundamentada nos trabalhos fundadores da semiótica (Saussure, Peirce) e desenvolvida em seus modelos estruturalistas (como em Jakobson, Barthes, Hjelmslev e Lotman), mas também revisitada pelos textos que operaram uma desconstrução do estruturalismo pelo interior dos postulados deste próprio estruturalismo (Derrida, Kristeva, Deleuze, Guattari). O artigo apresenta esta proposta pelos modos como a pesquisa trabalhou com dez desconstruções ligadas a conceitos e problemas teóricos centrais ao debate das materialidades da comunicação: semiótica, comunicação, materialidades, presença, fenômeno, representâmen, meios, signo e significante, estrutura e sistema, sugerindo uma passagem das materialidades à imanência de uma comunicação micropolítica e pós-humana

A aventura crítica da semiótica

A aventura crítica da semiótica percorre as principais teses sobre a semiótica e a comunicação conforme trabalhadas na primeira etapa da pesquisa Semiótica Crítica, denominada Por uma teoria das materialidades na comunicação. Nela, o Grupo de Pesquisa Semiótica e Culturas da Comunicação procurou discutir as potencialidades e limites de uma perspectiva comunicacional não somente fundamentada nos trabalhos fundadores da semiótica (Saussure, Peirce) e desenvolvida em seus modelos estruturalistas (como em Jakobson, Barthes, Hjelmslev e Lotman), mas também revisitada pelos textos que operaram uma desconstrução do estruturalismo pelo interior dos postulados deste próprio estruturalismo (Derrida, Kristeva, Deleuze, Guattari). O artigo apresenta esta proposta pelos modos como a pesquisa trabalhou com dez desconstruções ligadas a conceitos e problemas teóricos centrais ao debate das materialidades da comunicação: semiótica, comunicação, materialidades, presença, fenômeno, representâmen, meios, signo e significante, estrutura e sistema, sugerindo uma passagem das materialidades à imanência de uma comunicação micropolítica e póshumana.The critical adventure of semiotics courses through the main theses about semiotics and communication that have been discussed during the first stage of the research Critical Semiotics: Towards a theory of materialities in communication. In it, the Semiotics and Communication Cultures Research Group (GPESC) discussed the potentialities and limits of a communicational perspective not only based on the founding works of semiotic research (Saussure, Peirce) and developed in its structuralist models (Jakobson, Barthes, Hjelmslev, Lotman), but also revisited by ideas that deconstructed structuralism through the postulates of this very structuralism (Derrida, Kristeva, Deleuze, Guattari). The paper presents this suggestion by means of ten deconstructions related to concepts and theoretical problems which are key to the debate around the materialities of communication: semiotics, communication, materialities, presence, phenomenon, representamen, mediums, sign and significant, structure and system. In so doing, it suggests a move from materialities towards the immanence of a micropolitical and posthuman communication

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Manejo reprodutivo da bovinocultura de leite nos assentamentos rurais do município de Ilha Solteira-SP

The study was conducted in 35 small properties located in rural settlements of the city of Ilha Solteira, SP, through technical visits and questionnaires in order to assess the reproductive management of dairy cattle, identifying the main limiting factors and proposing improvements for producers. Use of crossbred with breeds without dairy aptitude, poor adherence to reproductive biotechnology and absence of livestock control, were the most limiting factors found in relation to reproductive management in dairy cattle in the rural settlement of Ilha Solteira, SP.O trabalho foi desenvolvido em 35 pequenas propriedades situadas nos assentamentos rurais do município de Ilha Solteira, SP, através da realização de visitas técnicas e aplicação de questionários, com o intuito de avaliar o manejo reprodutivo do gado leiteiro, identificando os principais fatores limitantes e propondo melhorias para os produtores. O uso de animais cruzados com raças sem aptidão leiteira, baixa adesão à biotecnologia reprodutiva e ausência de controle zootécnico, foram os fatores limitantes mais encontrados, em relação ao manejo reprodutivo na bovinocultura de leite nos assentamento rurais do município de Ilha Solteira, SP

Avaliação do manejo nutricional do rebanho leiteiro nos assentamentos rurais do município de Ilha Solteira-SP

The study was conducted in 35 properties, located in Rural Settlements: Estrela da Ilha, Santa Maria da Lagoa and the Cinturão Verde district of Ilha Solteira-SP, in order to assess the nutritional management of dairy cows and identify the main limiting for milk production, through technical visits and interviews with producers. They were collected data on key forage species used, grazing management, food storage and supplementation used, among others. It might be considered that the main limiting for the production of milk, from the nutritional point of view, is the improper use of pastures and ineffective nutritional management.O trabalho foi conduzido em 35 propriedades, situadas nos Assentamentos Rurais: Estrela da Ilha, Santa Maria da Lagoa e no bairro Cinturão Verde, em Ilha Solteira-SP, com o intuito de avaliar o Manejo nutricional de vacas leiteiras e identificar os principais limitantes para a produção leiteira, através de visitas técnicas e entrevistas com os produtores. Foram levantados dados sobre as principais espécies forrageiras utilizadas, manejo de pastejo, estocagem de alimentos e suplementação utilizada, entre outros. Pôde-se considerar que os principais limitantes para a produção de leite, do ponto de vista nutricional, são o uso incorreto das pastagens e manejo nutricional ineficaz