416 research outputs found

    Vibration-based monitoring of civil infrastructure: challenges and successes

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    Author's manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s13349-011-0009-5© Springer-Verlag 2011Co -published with International Society for Structural Health Monitoring of Intelligent InfrastructureStructural health monitoring (SHM) is a relatively new paradigm for civil infrastructure stakeholders including operators, consultants and contractors which has in the last two decades witnessed an acceleration of academic and applied research in related areas such as sensing technology, system identification, data mining and condition assessment. SHM has a wide range of applications including, but not limited to, diagnostic and prognostic capabilities. However, when it comes to practical applications, stakeholders usually need answers to basic and pragmatic questions about in-service performance, maintenance and management of a structure which the technological advances are slow to address. Typical among the mismatch of expectation and capability is the topic of vibration-based monitoring (VBM), which is a subset of SHM. On the one hand there is abundant reporting of exercises using vibration data to locate damage in highly controlled laboratory conditions or in numerical simulations, while the real test of a reliable and cost effective technology is operation on a commercial basis. Such commercial applications are hard to identify, with the vast majority of implementations dealing with data collection and checking against parameter limits. In addition there persists an unhelpful association between VBM and 'damage detection' among some civil infrastructure stakeholders in UK and North America, due to unsuccessful transfer of technology from the laboratory to the field, and this has resulted in unhealthy industry scepticism which hinders acceptance of successful technologies. Hence the purpose of this paper is showcase successful VBM applications and to make the case that VBM does provide valuable information in real world applications when used appropriately and without unrealistic expectations. © 2011 Springer-Verlag

    Non-Contact bridge deflection measurement : application of laser Technology

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    Structural deflections represent a critical response parameter often measured for structural health monitoring. Traditional measurement sensor technologies such as DCDTs, LVDTs, etc., require attaching the device between the point of measurement and a reference point. Generally, this requires connecting the sensor to the ground or a temporary structure such as scaffolding. Use of the traditional sensors for highway bridge deflection measurement poses many challenges as most of them are over either a road or a waterway. Because of these challenges, they are not often used and deflection is calculated either from indirect data such as girder end rotation or the structural parameters that contribute to deflection which is derived from measurements such as strain and curvature. Strictly speaking, measured displacements provide the best means for understanding structural behavior. Aiming at addressing the challenges of direct measurements of bridge deflections, this article will address the capabilities of two state-of-the-art non-contact measurement technologies. These technologies are: Laser Tracker and Laser Scanner. Laser Tracker records position coordinates at few discrete points while the laser scanner captures point clouds representing deformed and undeformed shapes of a structure. These two remote technologies present distinctive advantages, capabilities, limitations, and several challenges for field applications. The article will present a case study where laser tracker and laser scanner was collaboratively used to measure the deflection of a highway bridge under static truck loads. Further, the capabilities, limitations, and several challenges for field applications of these technologies will be summarized

    Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations

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    Many Lynch syndrome (LS) carriers remain unidentified, thus missing early cancer detection and prevention opportunities. Tested probands should inform their relatives about cancer risk and options for genetic counselling and predictive gene testing, but many fail to undergo testing. To assess predictive testing uptake and demographic factors influencing this decision in LS families, a cross-sectional registry-based cohort study utilizing the Finnish Lynch syndrome registry was undertaken. Tested LS variant probands (1184) had 2068 children divided among three generations: 660 parents and 1324 children (first), 445 and 667 (second), and 79 and 77 (third). Of children aged 418 years, 801 (67.4%), 146 (43.2%), and 5 (23.8%), respectively, were genetically tested. Together, 539 first-generation LS variant carriers had 2068 children and grandchildren (3.84 per carrier). Of the 1548 (2.87 per carrier) eligible children, 952 (61.5%) were tested (1.77 per carrier). In multivariate models, age (OR 1.08 per year; 95% CI 1.06-1.10), family gene (OR 2.83; 1.75-4.57 for MLH1 and 2.59; 1.47-4.56 for MSH2 compared with MSH6), one or more tested siblings (OR 6.60; 4.82-9.03), no siblings (OR 4.63; 2.64-8.10), and parent under endoscopic surveillance (OR 5.22; 2.41-11.31) were independent predictors of having genetic testing. Examples of parental adherence to regular surveillance and genetically tested siblings strongly influenced children at 50% risk of LS to undergo predictive gene testing. High numbers of untested, adult at-risk individuals exist even among well-established cohorts of known LS families with good adherence to endoscopic surveillance.Peer reviewe

    Lay Perspectives on Receiving Different Types of Genomic Secondary Findings : a Qualitative Vignette Study

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    available at: https://rdcu.be/4BhDGenome-wide sequencing may generate secondary findings (SFs). It is recommended that validated, clinically actionable SFs are reported back to patients/research participants. To explore publics’ perspectives on the best ways to do this, we performed a vignette study among Finnish adults. Our aim was to explore how lay people react to different types of hypothetical genomic SFs. Participants received a hypothetical letter revealing a SF predisposing to a severe but actionable disease - cardiovascular disease (familial hypercholesterolemia, long QT syndrome) or cancer (Lynch syndrome, Li–Fraumeni syndrome). Participants (N=29) wrote down their initial reactions, and discussed (N=23) these in focus groups. Data were analyzed using inductive thematic analysis. Reactions to hypothetical SFs varied according to perceived severity and familiarity of the diseases. SFs for cancer were perceived as more threatening than for cardiovascular diseases, but less distressing than risk for psychiatric or neurological disorders, which participants spontaneously brought up. Illness severity in terms of lived experience, availability of treatment, stigma, and individual’s responsibility to control risk were perceived to vary across these disease types. In addition to clinical validity and utility, SF reporting practices need to take into account potential familiarity and lay illness representations of different diseases. Illness representations may influence willingness to receive SFs, and individuals’ reactions to this information.Peer reviewe

    A multiobjective model for passive portfolio management: an application on the S&P 100 index

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    This is an author's accepted manuscript of an article published in: “Journal of Business Economics and Management"; Volume 14, Issue 4, 2013; copyright Taylor & Francis; available online at: http://dx.doi.org/10.3846/16111699.2012.668859Index tracking seeks to minimize the unsystematic risk component by imitating the movements of a reference index. Partial index tracking only considers a subset of the stocks in the index, enabling a substantial cost reduction in comparison with full tracking. Nevertheless, when heterogeneous investment profiles are to be satisfied, traditional index tracking techniques may need different stocks to build the different portfolios. The aim of this paper is to propose a methodology that enables a fund s manager to satisfy different clients investment profiles but using in all cases the same subset of stocks, and considering not only one particular criterion but a compromise between several criteria. For this purpose we use a mathematical programming model that considers the tracking error variance, the excess return and the variance of the portfolio plus the curvature of the tracking frontier. The curvature is not defined for a particular portfolio, but for all the portfolios in the tracking frontier. This way funds managers can offer their clients a wide range of risk-return combinations just picking the appropriate portfolio in the frontier, all of these portfolios sharing the same shares but with different weights. An example of our proposal is applied on the S&P 100.García García, F.; Guijarro Martínez, F.; Moya Clemente, I. (2013). A multiobjective model for passive portfolio management: an application on the S&P 100 index. Journal of Business Economics and Management. 14(4):758-775. doi:10.3846/16111699.2012.668859S758775144Aktan, B., Korsakienė, R., & Smaliukienė, R. (2010). TIME‐VARYING VOLATILITY MODELLING OF BALTIC STOCK MARKETS. 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Financial Analysts Journal, 51(6), 75-80. doi:10.2469/faj.v51.n6.1952Corielli, F., & Marcellino, M. (2006). Factor based index tracking. Journal of Banking & Finance, 30(8), 2215-2233. doi:10.1016/j.jbankfin.2005.07.012Derigs, U., & Nickel, N.-H. (2004). On a Local-Search Heuristic for a Class of Tracking Error Minimization Problems in Portfolio Management. Annals of Operations Research, 131(1-4), 45-77. doi:10.1023/b:anor.0000039512.98833.5aDose, C., & Cincotti, S. (2005). Clustering of financial time series with application to index and enhanced index tracking portfolio. Physica A: Statistical Mechanics and its Applications, 355(1), 145-151. doi:10.1016/j.physa.2005.02.078Focardi, S. M., & Fabozzi 3, F. J. (2004). A methodology for index tracking based on time-series clustering. Quantitative Finance, 4(4), 417-425. doi:10.1080/14697680400008668Gaivoronski, A. A., Krylov, S., & van der Wijst, N. (2005). Optimal portfolio selection and dynamic benchmark tracking. 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V., & Stasytyte, V. (s. f.). Decision Making Strategies in Global Exchange and Capital Markets. Advances and Innovations in Systems, Computing Sciences and Software Engineering, 17-22. doi:10.1007/978-1-4020-6264-3_4Tabata, Y., & Takeda, E. (1995). Bicriteria Optimization Problem of Designing an Index Fund. Journal of the Operational Research Society, 46(8), 1023-1032. doi:10.1057/jors.1995.139Teresienė, D. (2009). LITHUANIAN STOCK MARKET ANALYSIS USING A SET OF GARCH MODELS. Journal of Business Economics and Management, 10(4), 349-360. doi:10.3846/1611-1699.2009.10.349-36

    Biodegradable, flexible silicon nanomembrane-based NO x gas sensor system with record-high performance for transient environmental monitors and medical implants

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    Abstract: A novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period of operation offers unprecedented opportunities for medical implants, environmental sensors, and other applications. Here, we describe a biodegradable, flexible silicon-based electronic system that detects NO species with a record-breaking sensitivity of 136 Rs (5 ppm, NO2) and 100-fold selectivity for NO species over other substances with a fast response (~30 s) and recovery (~60 s). The exceptional features primarily depend on not only materials, dimensions, and design layouts but also temperatures and electrical operations. Large-scale sensor arrays in a mechanically pliable configuration exhibit negligible deterioration in performance under various modes of applied loads, consistent with mechanics modeling. In vitro evaluations demonstrate the capability and stability of integrated NOx devices in severe wet environments for biomedical applications
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