Yüksek binaların aerodinamik performansı: rüzgâr geçiş ve yatay perde duvar katları arasındaki ilişki üzerine bir çalışma.

Numbers of slender tall buildings, particularly “super-slenders”, are increasing rapidly due to the quest for maximizing the leasable space in plan or being iconic or both. With their relatively short structural depth in plan, limiting the top drift, in other words, satisfying the serviceability limit is usually the governing constraint in their design. Using multi-level outriggers, tuned mass dampers and distinctive aerodynamic modifications such as wind flow openings together is rather mandatory to realization of such designs. However, there is a trade-off between outrigger system and wind escape floor if they are located at the same level. The outriggered-frame structural system gives the building its stiffness whereas openings as wind escape floors are aerodynamic modifications for decreasing the wind load acting on building. This study evaluates the interrelation of outriggers and wind escape floors arranged at the same floor level in terms of several structural response parameters. The relationship between openings as aerodynamic modifications for mitigating the wind loads and outriggers (including virtual outriggers) in slender tall buildings have been investigated with the aim of improving the building performance in the context of top drift limitation and reduced wind loads. The research question is the possibility of having less number of outrigger floors by taking the advantage of wind escapes which have located at the outrigger floors without sacrificing occupant comfort. In other words, if the top drift of a building which has a certain type and number of outriggers organized with wind openings can be kept less than the top drift of a building having more outrigger floors with closed façades, then the architects and engineers may prefer the combined use of outrigger floors with wind escape floors to increase leasable plan area. An existing super-slender building having both outriggers and wind flow openings at mechanical floor levels has been selected and alternative outrigger and wind flow opening configurations have been modelled on this sample building. Then comparisons have been made to scrutinize the optimum use of outriggers with wind openings. Top drift, story shear and moment, particularly core moment, have been used as demand parameters in this study. The results showed that the optimum use of wind openings with certain type of outriggers can yield better structural response to wind loads compared to closed façade building having more number of outriggers. Code based wind loading without vortex shedding effects can be counted as limitations of the study. Thus, wind tunnel testing of promising outrigger wind escape floor arrangements identified in this study can be conducted as future remarks.M.S. - Master of Scienc

Yatay Perdeli Narin Yüksek Yapılarda Rüzgâr Kaçış Katlarının Optimizasyonu

Narin yüksek binalarda cephe ve kütlenin aerodinamik tasarımına ek olarak yapı cephesinde oluşturulan açıklıklar (rüzgâr kaçış katları) ile binadaki yatay ötelenme kontrol edilebilir. Ancak bu durum yapıdaki kullanılabilir alanı azaltmaktadır. Benzer şekilde yüksek yapılarda rijitliğin arttırılması (örn. yapının taşıyıcı elemanlarının boyutunun büyümesi) kullanılabilir alanların veya panoramik görüşün azalması gibi tasarımcılar tarafından arzu edilmeyen sonuçlar ortaya çıkarabilir. Bu çalışmada, rüzgar kaçış katları ve yatay perde duvarların (sanal yatay perdeler de dâhil) bir arada kullanılması ile yapıdaki kullanılabilir katların sayısının ve binanın rüzgar performansının (maksimum tepe ötelenmesi ve taban moment değerleri) optimizasyonu hedeflenmektedir. Bu çalışma kapsamında rüzgar açıklıklarının sayısı ve konumu, narin yüksek bir yapıda kullanılamayan kat sayısını düşürmek amacıyla irdelenecektir

Examining of Consumers Social and Environmental Susceptibility, Attitudes, Behaviors, Consciousness And Purchasing Preferences Against Social And Environmental Activities Made By Enterprises

Ülkemizde yaşanan çevresel ve sosyal sorunlar, her geçen gün artarak, gerek sosyal medya, gerek sivil toplum örgütleri ve dernekler ve gerekse de bireyler tarafından yoğun rağbet gösterilen gündemler olarak karşımıza çıkmaktadır. Hem hükümet yetkilileri hem de gönüllü işletmeler aracılığıyla sosyal ve çevresel konular içerikli faaliyet, olay ve reklamlara sık sık maruz kalmaktayız. Kimi zaman bu aktivitelerden habersiz kalmakta kimi zaman ise bu aktivitelerin içinde kendimizi dahil bulmaktayız. İş dünyası bu konular üzerine sürekli dikkati çekmekte ve tüm işletmelerin sosyal ve çevresel duyarlılıklarını destekleyici yeni rekabet mecraları yaratmaktadırlar. Tüketiciler sadece birer birey olarak düşünülmemelidir. Toplumun sosyal bir varlığı olarak da tüketiciler tatmin edilmeli ve her bakımdan kapsamlı olarak yaratılacak firma imajında bu konular gözden kaçırılmamalıdır. Tüketicilerin duyarlı oldukları sosyal ve çevresel sorunlar ve bu sorunlarla ilgili yasalardan haberdarlıkları ile işletmelerin bu konularda yapmış oldukları faaliyetlere karşı tutumlarını ve davranışlarını ortaya koyarak işletmelerin daha etkili sosyal ve çevresel faaliyetler gösterebilmeleri ve bunları etkili bir şekilde tanıtabilmeleri adına önerilerde bulunulması bakımından araştırmamızın önemli katkı sağlayabileceği düşünülmektedir. Araştırmada, Düzce İlinde ikamet etmekte olan ve rastgele seçilen 401 kişi üzerinde yüz yüze anket uygulaması yapılmıştır. Veriler SPSS 15.0 programında One-Way ANOVA ve Tukey testleri ile değerlendirilmiştir.The environmental and social problems occurring in our country are seemed as highly rated agendas by social media, non-governmental organizations, foundations and individuals. We are exposed frequently to advertisements, activities and events concerning environmental and social issues through governments and voluntary enterprises. Sometimes we live uninformed about these applications, sometimes we found ourselves inside of them. Business world creates new competition means supporting social and environmental sensibilities of businesses. Consumers usually considered as only single individuals, however, they have to be seemed also as the members of the society. The firms also have to take this situation of the individuals into consideration. The contribution of our study to the social sciences literature would be stated as: the awareness of consumers about social and environmental issues and legislation concerning those problems; awareness of consumers about activities made by private enterprises concerning social and environmental issues; and recommendations to the enterprises about realizing and advertising their activities concerning social and environmental issues more efficiently. In this study, questionnaires were conducted face to face to randomly chosen 401 citizens inhabiting in Düzce province. The data have been analyzed by SPSS 15.0 program through One-Way ANOVA and Tuchey tests

The use of complementary and alternative medicine by the stem cell transplantation patients

Çalışma 2006 yılında 32. Ulusal Türk Hematoloji Kongresi’ nde sözel bildiri olarak sunulmuş olup, ‘Genç Katılımcı Ödülü’ almıştır.Bu çalışma kök hücre nakli yapılan hastaların nakil öncesi ya da nakil sonrası TAT uygulamalarının değerlendirilmesi amacıyla tanımlayıcı olarak yapılmıştır. Veriler Ankara’da bulunan 5 hastanede tedavi gören 153 hastadan toplanmıştır. Veri toplama formu sosyo-demografik özellikler ve geçen ve bir önceki yıllardaki ilik nakillerinde TAT kullanımına ilişkin bilgileri kapsamaktadır. Hastaların TAT rak %48.4’ünün şifalı bitkisel ürünleri, %28.1’inin dini aktiviteleri (dualar) kullandığı belirlenmiştir. Hastaların sıklıkla bitkisel ürün olarak ısırgan otunu (%69.0) ,hayvansal ürün olarak ise kaplumbağa kanını kullandığı saptandı. Hastalar çoğunlukla tedavi edici, gevşetici ve manevi güç olarak TAT kullandığını belirtmiştir. Hastaların %79.0’u doktorları ile TAT kullanımlarına ilişkin tartışmadıklarını/danışmadıklarını belirtmiştir. Bu çalışmanın bulgularının diğer çalışmalardakilerle benzer olduğu saptanmıştır.The aim of this descriptive study was to investigate the types and prevalence of complementary and alternative medicine (CAM) use among patients with malignancy who have undergone bone marrow transplantation (before and after). A demographic questionnaire was completed with 153 patients at five hospitals located in Ankara. Data has been collected from a face-to-face interview performed by a nurse. The most common types of CAM used were herbs (%48.4) and pray (%28.1). The most frequently used herb was stinging nettle (%69.0) and animal product was blood of turtle. Common reasons for using CAM were that it is “curative", it gives "relaxation" and evokes "spiritual wellbeing”. Majority of the patients using CAM (%79.0) did not discuss the use of these therapies with their primary physicians. This study revealed that most findings in this study are similar to the results of other studies

Sperm quality and oxidative stress in chub Squalius orientalis and Padanian barbel Barbus plebejus (Teleostei: Cyprinidae) after in vitro exposure to low doses of bisphenol A.

In an aquatic environment, the presence of Bisphenol A (BPA) adversely affects reproduction, biology, behavior, gonads, and early larval development of fish due to being endocrine-disrupting compound. In addition, the detected concentration of BPA in water bodies is reported to be higher than 0.41 μg/L. As an alternative tool, sperm cells are used in toxicological assays for the reliable and practical assessment. For these reasons, we examined the effects of in vitro exposure of BPA on sperm quality of chub Squalius oriantalis and Padanian barbel Barbus plebejus. Spermatozoa were exposed to lower concentrations (0, 0.5, 1.25, 2.5, and 5 µg/L) of BPA for 2 h. The enzymatic activities [glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD)] and lipid peroxidation (MDA) were evaluated in spermatozoa. The results demonstrated that BPA exposure significantly decreased activities of SOD and GSH-Px but increased CAT activity and lipid peroxidation (MDA). Compared to control, the percentage and duration of sperm motility significantly decreased. Overall, spermatozoa clearly showed the sensitivity to lower concentrations of BPA

A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha-Amanitin-Induced Hepatotoxicity

Amanita phalloides species mushrooms containing alpha-amanitin (-AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of -AMA-induced hepatotoxicity. We investigated the effects of resveratrol on -AMA-induced hepatotoxicity and compared with silibinin, a known antidote using in vivo and in vitro toxicity models. In the in vivo protocol, resveratrol (30 mg/kg) was given simultaneously with -AMA (-AMA + SR) or 12 (-AMA + 12R) or 24 (-AMA + 24R) hr after -AMA administration. Silibinin (5 mg/kg) (-AMA + Sil) and normal saline (-AMA + NS) were given simultaneously with -AMA. We found that liver transaminase levels in -AMA + SR and -AMA + 12R groups and histomorphologic injury score in the -AMA + SR, -AMA + 12R, -AMA + 24R and -AMA + Sil groups were significantly lower than that of the -AMA + NS group. Resveratrol decreased mononuclear cell infiltration, necrosis and active caspase-3 immunopositivity in the liver. In the in vitro protocol, the effects of resveratrol and silibinin were evaluated in a reduction in cell viability induced by -AMA in THLE-2 and THLE-3 hepatocytes. Neither resveratrol nor silibinin was found to be effective in increasing cell viability decreased by -AMA + NS. As a conclusion, resveratrol was found to be effective in -AMA-induced hepatotoxicity with its anti-inflammatory properties in in vivo conditions. It is a promising compound with the potential for use in the treatment of hepatotoxicity associated with Amanita phalloides type mushroom poisonings

Comparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases

Comparative in vitro activity of plazomicin and 4 older aminoglycosides was evaluated with broth microdilution in 714 blood isolates from 14 hospitals in Turkey

Can we predict patients that will not benefit from invasive mechanical ventilation? A novel scoring system in intensive care: the IMV mortality prediction score (IMPRES)

KUCUK, Ahmet Oguzhan/0000-0002-6993-0519; Kirakli, Cenk/0000-0001-6013-7330; KUCUK, Mehtap PEHLIVANLAR/0000-0003-2247-4074; Aksoy, Iskender/0000-0002-4426-3342WOS: 000504051300010PubMed: 31655511Background/aim: The present study aimed to define the clinical and laboratory criteria for predicting patients that will not benefit from invasive mechanical ventilation (IMV) treatment and determine the prediction of mortality and prognosis of these critical ill patients. Materials and methods: The study was designed as an observational, multicenter, prospective, and cross-sectional clinical study. It was conducted by 75 researchers at 41 centers in intensive care units (ICUs) located in various geographical areas of Turkey. It included a total of 1463 ICU patients who were receiving invasive mechanical ventilation (IMV) treatment. A total of 158 parameters were examined via logistic regression analysis to identify independent risk factors for mortality; using these data, the IMV Mortality Prediction Score (IMPRES) scoring system was developed. Results: The following cut-off scores were used to indicate mortality risk: 8, very high risk. There was a 26.8% mortality rate among the 254 patients who had a total IMPRES score of lower than 2. The mortality rate was 93.3% for patients with total 1M PRES scores of greater than 8 (P < 0.001). Conclusion: The present study included a large number of patients from various geographical areas of the country who were admitted to various types of ICUs, had diverse diagnoses and comorbidities, were intubated with various indications in either urgent or elective settings, and were followed by physicians from various specialties. Therefore, our data are more general and can be applied to a broader population. This study devised a new scoring system for decision-making for critically ill patients as to whether they need to be intubated or not and presents a rapid and accurate prediction of mortality and prognosis prior to ICU admission using simple clinical data