Association of Oral Contraceptives use with Breast Cancer and Hormone Receptor Status in Iraqi Women

BACKGROUND: Worldwide, there is a significant concern regarding the association of breast cancer risk and oral contraceptives use. Differences in demographical and pathological breast cancer characteristics in Iraqi patients have been reported compared to other western countries; however, studies addressing the risk of breast cancer among oral contraceptive users in Iraq and subsequent correlation with hormonal receptor status are lacking. AIM: The aim of the study was to evaluate association of breast cancer risk and oral contraceptives use in patients visiting tertiary oncology center and to correlate hormone receptor status with history of oral contraception use in breast cancer patients. PATIENTS AND METHODS: Two hundred women with breast cancer were compared regarding patterns of oral contraceptives use with 300 age-matched healthy female controls by personal interview and questionnaire. Patient’s records were reviewed for hormone receptor status. RESULTS: A significantly higher proportion (49%) of women with breast cancer reported a positive history of combined oral contraceptives use as compared with (35.7%) healthy controls. Ever oral contraceptives users had a significantly increased risk of breast cancer (odds ratio [OR] = 1.73; 95%, confidence interval = 1.2–2.5, p = 0.003), with the highest risk was seen in early use before the age of 20 (OR = 6.62, p = 0.02); whereas increased duration of use did not significantly increase the risk of breast cancer. There was no significant association between estrogen and progesterone receptors expression profile in breast cancer patients and combined oral contraceptive use. CONCLUSION: In Iraqi women, the risk of breast cancer increases with oral contraceptives intake particularly when starts early before the age of 20 years. The hormonal receptor status of breast cancer patients is not significantly affected by combined oral contraceptives use

Nonexistence of nonzero derivations on some classes of zero-symmetric 3-prime near-rings

We give some classes of zero-symmetric 3-prime near-rings such that every member of these classes has no nonzero derivation. Moreover, we extend the concept of “3-prime” to subsets of near-rings and use it to generalize Theorem 1.1 due to Fong, Ke, and Wang concerning the transformation near-rings M o (G) by using a different technique and a simpler proof.Наведено дєякі класи 3-простих майже-кілець з нульовою симєтрією таких, що будь-який елемент цих класів не має ненульової похідної. Крім того, поняття „3-простих" узагальнено на підмножини майже-кілець i застосовано, щоб узагальнити теорему 1.1 Фонга, Ке i Ванга про трансформацію майже-кілець M o (G) за допомогою іншої техніки та більш простого доведення

A modified empirical model for estimating the wetted zone dimensions under drip irrigation

Drip irrigation system has become one of the most common irrigation systems especially in arid and semi-arid regions due to its advantages in saving water. One of the most essential considerations in designing these systems is the dimensions of the wetted soil volume under emitters. These dimensions are significant in choosing the proper emitter spacing along the laterals and the suitable distance between laterals. In this study, a modified empirical equations for estimating the horizontal and vertical extend of the wetted zone under surface emitters were suggested. Data from published papers includes different conditions of soil properties and emitter discharge were used in deriving the empirical model using the nonlinear regression. The developed model has high value for coefficient of determination, R2. The results from the developed model were compared with results of other empirical models derived by other researchers. Some statistical criteria were used to evaluate the model performance which are the mean error ME, root mean square error RMSE, and model efficiency EF. The results revealed that the modified model showed good performance in predicting the wetted zone dimensions and it can be used in design and management of drip irrigation systems

The Use of Talc Powder in Bleaching Cotton Fibers

It is known that the use of sodium silicate (Na2 Si2 O3) in bleaching has some disadvantages such as its high cost, harsh handle of the bleached fabric, and the reduction of the tensile strength of the fabric.Talc Powder is used in the bleaching of woven cotton fabrics as a stabilizer for hydrogen peroxide (H2O2) instead of using sodium silicate. Many experiments were carried out using talc powder at variable condi-tions such as temperature and pH. The same experiments were carried out using sodium silicate stabilizer. Several experiments were carried out on fabrics without a stabilizer.The bleached samples were tested for whiteness, absorbence, and tensile strength. The untreated samples were tested for comparison. The results of the tested samples were recorded and analysed using statistical methods.The study proved that very good whiteness and higher absorbence were obtained when using talc powder, besides that the loss in tensile strength is relatively low. Also it was observed that the softness and handle of fabrics were improved

Morphological Variation between Life and Death Gastropod Populations in the Nile Delta: A Pollution-Induced Evolution

Wetland ecosystems of the Nile Delta face severe threats due to natural climatic changes and anthropogenic activities. Life and death assemblage comparisons can be implemented as a historical record to detect anthropogenic-induced environmental changes in the past few decades. A geometric morphometric approach was applied to quantify the pollution-induced morphological variation between life and death populations of the gastropod Melanoides tuberculata. The results indicated that life populations differ significantly from the death ones, where the first tend to be much smaller, more globular, and with a depressed aperture and whorl section. In addition, the phenetic diversity of the life populations was also decreased, and the allometric growth was shifted. These morphological changes in the life populations are well-known adaptations for reducing the cost of shell maintenance in polluted water. No distinct morphospace was found between life populations from different habitats, suggesting that habitats have no significant role in the current pollution-induced evolution.This work is funded by the Researchers Supporting Project number (RSP2023R455), King Saud University, Riyadh, Saudi Arabia

Placental pouch closure: a novel, safe and effective surgical procedure for conservative management of placenta accreta

Background: Placenta accreta spectrum (PAS) has become a global problem secondary to the high rate of cesarean delivery (CD). The current study presents an effective surgical procedure (placental pouch closure) for uterine preservation in patients with PAS. Methods: We applied this procedure in sixty cases at a tertiary university hospital between September 2017 and January 2019. We included women who were diagnosed as PAS based on preoperative ultrasound and Doppler evaluation, and who had the desire for uterine preservation. Results: The procedure was successful in almost all cases; the uterus was conserved 98.33 % of participants, with no associated severe maternal morbidities or mortality. In all cases, no additional surgical procedures were needed. The mean blood loss was 1263 ml, and the mean number of units of blood required for transfusion was 2.31 units. Conclusion: Identifying and meticulously closing the placental pouch is a novel surgical procedure for conservative management of PAS. In well-selected cases with the availability of facilities and expertise, the technique could have a place as a safe and effective surgical technique in women presenting with placenta accreta who desire uterine preservation. Trial registration number: NCT03241849. Registered on August 8, 201

High-Pressure Metal-Free Catalyzed One-Pot Two-Component Synthetic Approach for New 5-Arylazopyrazolo[3,4-b]Pyridine Derivatives

An appropriate and efficient Q-tube-assisted ammonium acetate-mediated protocol for the assembly of the hitherto unreported 5-arylazopyrazolo[3,4-b]pyridines was demonstrated. This methodology comprises the cyclocondensation reaction of 5-amino-2-phenyl-4H-pyrazol-3-one with an assortment of arylhydrazonals in an NH$_4$OAc/AcOH buffer solution operating a Q-tube reactor. This versatile protocol exhibited several outstanding merits: easy work-up, mild conditions, scalability, broad substrate scope, safety (the Q-tube kit is simply for pressing and sealing), and a high atom economy. Consequently, performing such reactions under elevated pressures and utilizing the Q-tube reactor seemed preferable for achieving the required products in comparison to the conventional conditions. Diverse spectroscopic methods and X-ray single-crystal techniques were applied to confirm the proposed structure of the targeted compounds

Examining the impacts of 12 weeks of low to moderate-intensity aerobic exercise on depression status in patients with systolic congestive heart failure - A randomized controlled study

OBJECTIVES: Psychiatric depression disorder is common in patients with systolic congestive heart failure (HF), and both conditions share underlying pathophysiological mechanisms. The incidence rate of depression disorder has clearly increased with the increase in HF manifestations in recent decades. Depression disorder is considered an independent predisposing factor for hospitalization, disturbed functional performance, and high rates of morbidity and mortality in HF patients. This randomized controlled study was designed to examine the impacts of low- to moderate-intensity aerobic exercise training on depression status in patients with systolic congestive HF. METHODS: A total of 46 systolic congestive HF patients with depression (40-60 years of age) were randomized to receive twelve weeks of mild- to moderate-intensity aerobic exercise plus standard medical treatment (exercise group) or standard medical treatment without any exercise intervention (control group). Depression status was examined using the validated Patient Health Questionnaire-9 (PHQ9) pre- and post-intervention at the end of the study program. RESULTS: No significant differences were observed between the exercise and control groups in demographic data or clinical characteristics (p40.05). Both study groups showed a significant reduction in depression status at the end of the 12-week intervention (po0.05). The comparison between the mean values of the depression scores showed significant differences between the two groups after 6 and 12 weeks of the intervention, indicating a greater reduction in depression scores in the exercise group than in the control group (po0.05). CONCLUSIONS: Twelve weeks of a low- to moderate-intensity aerobic exercise program was safe and effective for reducing depression severity in patients with systolic congestive HF. Low- to moderate-intensity aerobic training should be recommended for cardiac patients, particularly those with HF-related depression

Paratuberculosis: The Hidden Killer of Small Ruminants

Paratuberculosis (PTB) is a contagious and chronic enteric disease of ruminants and many non-ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), and is characterised by diarrhoea and progressive emaciation with consequent serious economic losses due to death, early culling, and reduced productivity. In addition, indirect economic losses may arise from trade restrictions. Besides being a production limiting disease, PTB is a potential zoonosis; MAP has been isolated from Crohn’s disease patients and was associated with other human diseases, such as rheumatoid arthritis, Hashimoto’s thyroiditis, Type 1 diabetes, and multiple sclerosis. Paratuberculosis in sheep and goats may be globally distributed though information on the prevalence and economic impact in many developing countries seem to be scanty. Goats are more susceptible to infection than sheep and both species are likely to develop the clinical disease. Ingestion of feed and water contaminated with faeces of MAP-positive animals is the common route of infection, which then spreads horizontally and vertically. In African countries, PTB has been described as a “neglected disease”, and in small ruminants, which support the livelihood of people in rural areas and poor communities, the disease was rarely reported. Prevention and control of small ruminants’ PTB is difficult because diagnostic assays demonstrate poor sensitivity early in the disease process, in addition to the difficulties in identifying subclinically infected animals. Further studies are needed to provide more insight on molecular epidemiology, transmission, and impact on other animals or humans, socio-economic aspects, prevention and control of small ruminant PTB