Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome

Metabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most important pathways of tumor dissemination, contributing to metastasis. Thus, our aim was to evaluate whether the expression of molecular biomarkers involved in angiogenic and lymphangiogenic processes influenced CC clinicopathological features and prognosis in patients with MS. Clinical and pathological data of 300 patients submitted to CC surgical resection at a single tertiary hospital were retrospectively retrieved from hospital records. Tumor tissue microarrays of archived paraffin-embedded blocks were used to assess CD31, VEGF-A and D2–40 tissue expression by immunohistochemistry. The percentage of stained area was quantified by computerized morphometric analysis. No association between tissue expression of angiogenesis and lymphangiogenesis biomarkers and tumor clinical and pathological characteristics was found. However, in subgroup analysis of patients with MS, dysglycemia was associated with lower D2–40 expression (p = 0.007) and high waist-circumference was associated with higher D2–40 (p = 0.0029) and VEGF-A expression (p = 0.026). In an adjusted Cox proportional hazard model CD31 expression was significantly associated with greater disease-free survival (HR=0.62; 95% CI: 0.41–0.95, p = 0.028). No association was found between D2–40 and VEGF-A expression and CC prognosis. Our data reinforces previous reports that suggest the potential use of CD31 as a CC prognostic biomarker. Additionally, our data further supports the evidence for an interplay between metabolic dysfunction, tumor microenvironment, and vascularization pathways.info:eu-repo/semantics/publishedVersio

SOROPREVALÊNCIA DA IMUNODEFICIÊNCIA E LEUCEMIA VIRAL FELINA NO HOSPITAL VETERINÁRIO SYLVIO BARBOSA CARDOSO/UECE

Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) are retroviruses of clinical importance for cats due to their immunosuppressive effects and with a prevalence of 12.32% for FIV and 5.8% for FeLV in the city of Fortaleza. Since there is only one study evaluating the seroprevalence of the pathologies in question in the region, the objective of the present study was to evaluate these data in felines treated at the Sylvio Barbosa Cardoso Veterinary Hospital (HVSBC) located at the State University of Ceará (UECE) in the city of Fortaleza, from March to December 2021, 75 screening tests were performed by immunochromatographic assays. Parameters such as gender, age, domicile status and clinical manifestations were evaluated. The results showed that 16% were positive for FIV, 9% for FeLV and 4% for coinfection (FIV/FeLV). The FIV or FeLV positive animals were mostly male, adult, semi-domiciled and symptomatic cats. The most common clinical manifestation observed in IVF patients was gingivitis. This study showed that 29% of the cats tested were positive and among these 86% were males, more than 50% semi-domiciled, 31% aged between 1 and 2 years old and 81% symptomatic. Epidemiological factors, such as gender, domicile status, age and clinical manifestation, are of paramount importance for the series of retroviruses in Fortaleza. The prevalence of the diseases in question observed in the present study is serious due to the consequences they can cause in affected animals and the potential chance of dissemination.O Vírus da Imunodeficiência Felina (FIV) e o Vírus da Leucemia Felina (FeLV) são retrovírus de importância clínica para os felinos devido seus efeitos imunossupressores e com prevalência de 12,32% para FIV e 5,8% para FeLV na cidade de Fortaleza. Objetivou-se com o estudo foi avaliar a soroprevalência destas doenças em felinos atendidos no Hospital Veterinário Sylvio Barbosa Cardoso (HVSBC) localizado na Universidade Estadual do Ceará (UECE) do município de Fortaleza, no período de março a dezembro de 2021, sendo realizados 75 testes de triagem por ensaios imunocromatográficos. Parâmetros como gênero, idade, estado de domiciliamento e manifestações clínicas foram   avaliados. Os resultados mostraram que 16% foram positivos para o FIV, 9% para o FeLV e 4% para a coinfecção (FIV/FeLV). Os animais FIV ou FeLV positivos eram na sua maioria gatos machos, adultos, semidomiciliados e sintomáticos. A manifestação clínica mais comum observada nos portadores de FIV foi gengivite. Este estudo demonstrou que 29% dos gatos testados foram positivos e entre esses 86% eram machos, mais de 50% semidomiciliados, 31% com idade entre 1 e 2 anos de idade e 81% sintomáticos. Fatores epidemiológicos, como sexo, estado de domiciliamento, idade e manifestação clínica, são de suma importância para a casuística das retroviroses em Fortaleza. A prevalência das doenças em questão observadas no presente estudo é grave devido as consequências que podem causar nos animais acometidos e a potencial chance de disseminação

Vivência na monitoria de anatomia humana: relato de experiência de discentes-monitores do curso de Fisioterapia

This article relates the importance of the experience of monitoring in life academic students-monitors on the Human Anatomy discipline of Physiotherapy course at the University of Pernambuco (UPE), Petrolina. The study is qualitative using experience report by studentsmonitors of discipline, from march 2013 to december 2014. The monitoring activities were developed in the laboratory of studies and researches in human anatomy on that university. In addition to aid the teacher in practical classes, the monitors were part of other activities promoted by the laboratory involving teaching, research and extension. The experiences of the monitors have allowed observing the importance of the relation between theoretical and practical, enabling the teaching and learning process and expanding their knowledge, academic and professional perspectives.ESTE ARTÍCULO REPORTA LA IMPORTANCIA DE LA EXPERIENCIA DE LA MONITORIA EN LA VIDA DE LOS ESTUDIANTES-MONITORES, DE LA DISCIPLINA DE ANATOMÍA HUMANA EN EL CURSO DE FISIOTERAPIA DE LA UNIVERSIDAD DE PERNAMBUCO (UPE), CAMPUS PETROLINA. EL ESTUDIO ES DEL TIPO CUALITATIVO A TRAVÉS DE RELATO EXPERIMENTADO POR ESTUDIANTES-MONITORES DE LA DISCIPLINA EN EL PERÍODO DE MARZO DE 2013 HASTA DICIEMBRE DE 2014. LAS ACTIVIDADES DE MONITORIA SE LLEVARON A CABO EN EL LABORATORIO DE ESTUDIOS Y INVESTIGACIONES EN ANATOMÍA HUMANA DE LA REFERIDA UNIVERSIDAD. MÁS ALLÁ DE LA AYUDA AL PROFESOR EN CLASES PRÁCTICAS, HICIERON PARTE DE OTRAS ACTIVIDADES PROMOVIDAS POR EL LABORATORIO ENVOLVIENDO LA ENSEÑANZA, LA INVESTIGACIÓN Y LA EXTENSIÓN. LAS EXPERIENCIAS DE LOS MONITORES PERMITE OBSERVAR LA IMPORTANCIA DE CONEXIÓN DE LA ENSEÑANZA TEÓRICO-PRÁCTICA, FACILITANDO EL PROCESO DE ENSEÑANZA-APRENDIZAJE Y LA AMPLIACIÓN DE SUS CONOCIMIENTOS Y PERSPECTIVAS ACADÉMICAS Y PROFESIONALES, PREPARANDO EL FUTURO FISIOTERAPEUTA PARA UNA BUENA RELACIÓN CON SUS PACIENTES, LO QUE LE PERMITE UNA ACCIÓN MÁS EFICAZ. PALABRAS CLAVES: ANATOMÍA. ENSEÑANZA. EXPERIENCIA. FORMACIÓNO presente artigo relata a importância da vivência da monitoria na vida acadêmica de discentes-monitores, da disciplina de Anatomia Humana, no curso de Fisioterapia da Universidade De Pernambuco (UPE) campus Petrolina. O estudo é de cunho qualitativo, utilizando o relato de experiência vivenciado por discentes-monitores da disciplina, no período de março de 2013 a dezembro de 2014. As atividades de monitoria foram desenvolvidas no laboratório de estudos e pesquisas em anatomia humana da referida universidade. Além do auxílio ao professor nas aulas práticas, os monitores fizeram parte de outras atividades promovidas pelo laboratório envolvendo o ensino, a pesquisa e a extensão. As experiências vivenciadas pelos monitores possibilitaram observar a importância da relação entre teoria e prática, viabilizando o processo de ensinoaprendizagem e ampliando os seus conhecimentos, perspectivas acadêmicas e profissionais

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Mammals in Portugal: a data set of terrestrial, volant, and marine mammal occurrences in Portugal

Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of the Azores and Madeira that includes 105,026 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used to collect the data were: live observations/captures (43%), sign surveys (35%), camera trapping (16%), bioacoustics surveys (4%) and radiotracking, and inquiries that represent less than 1% of the records. The data set includes 13 types of records: (1) burrows | soil mounds | tunnel, (2) capture, (3) colony, (4) dead animal | hair | skulls | jaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8), observation in shelters, (9) photo trapping | video, (10) predators diet | pellets | pine cones/nuts, (11) scat | track | ditch, (12) telemetry and (13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100 m (76%). Rodentia (n =31,573) has the highest number of records followed by Chiroptera (n = 18,857), Carnivora (n = 18,594), Lagomorpha (n = 17,496), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 7008). The data set includes records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus [n = 12,159], Monachus monachus [n = 1,512], and Lynx pardinus [n = 197]). We believe that this data set may stimulate the publication of other European countries data sets that would certainly contribute to ecology and conservation-related research, and therefore assisting on the development of more accurate and tailored conservation management strategies for each species. There are no copyright restrictions; please cite this data paper when the data are used in publications