On relativistic approaches to the pion self-energy in nuclear matter

We argue that, in contrast to the non-relativistic approach, a relativistic evaluation of the nucleon--hole and delta-isobar--nucleon hole contributions to the pion self-energy incorporates the s-wave scattering, which requires a more accurate evaluation. Therefore relativistic approach containing only these diagrams does not describe appropriately the pion self-energy in isospin symmetric nuclear matter. We conclude that, a correct relativistic approach to the pion self-energy should involve a more sophisticated calculation in order to satisfy the known experimental results on the near-threshold behaviour of the pion-nucleon (forward) scattering amplitude.Comment: 7 pages,1 figur

One-loop corrections to the Drell-Yan process in SANC (I). The charged current case

Radiative corrections to the charged current Drell-Yan processes are revisited. Complete one-loop electroweak corrections are calculated within the automatic SANC system. Electroweak scheme dependence and the choice of the factorization scale are discussed. Comparisons with earlier calculations are presented.Comment: extended version submitted to EPJ

Isospin and symmetry energy effects on nuclear fragment production in liquid-gas type phase transition region

We have demonstrated that the isospin of nuclei influences the fragment production during the nuclear liquid-gas phase transition. Calculations for Au197, Sn124, La124 and Kr78 at various excitation energies were carried out on the basis of the statistical multifragmentation model (SMM). We analyzed the behavior of the critical exponent tau with the excitation energy and its dependence on the critical temperature. Relative yields of fragments were classified with respect to the mass number of the fragments in the transition region. In this way, we have demonstrated that nuclear multifragmentation exhibits a 'bimodality' behavior. We have also shown that the symmetry energy has a small influence on fragment mass distribution, however, its effect is more pronounced in the isotope distributions of produced fragments.Comment: 8 pages, 9 figures, accepted for publication in EPJ

Non-equilibrated post freeze out distributions

We discuss freeze out on the hypersurface with time-like normal vector, trying to answer how realistic is to assume thermal post freeze out distributions for measured hadrons. Using simple kinetic models for gradual freeze out we are able to generate thermal post FO distribution, but only in highly simplified situation. In a more advanced model, taking into account rescattering and re-thermalization, the post FO distribution gets more complicated. The resulting particle distributions are in qualitative agreement with the experimentally measured pion spectra. Our study also shows that the obtained post FO distribution functions, although analytically very different from the Juttner distribution, do look pretty much like thermal distributions in some range of parameters.Comment: 14 pages, 2 figures, EPJ style, submitted to EPJ

Leading-particle suppression in high energy nucleus-nucleus collisions

Parton energy loss effects in heavy-ion collisions are studied with the Monte Carlo program PQM (Parton Quenching Model) constructed using the BDMPS quenching weights and a realistic collision geometry. The merit of the approach is that it contains only one free parameter that is tuned to the high-pt nuclear modification factor measured in central Au-Au collisions at sqrt{s_NN} = 200 GeV. Once tuned, the model is coherently applied to all the high-pt observables at 200 GeV: the centrality evolution of the nuclear modification factor, the suppression of the away-side jet-like correlations, and the azimuthal anisotropies for these observables. Predictions for the leading-particle suppression at nucleon-nucleon centre-of-mass energies of 62.4 and 5500 GeV are calculated. The limits of the eikonal approximation in the BDMPS approach, when applied to finite-energy partons, are discussed.Comment: 28 pages, 14 figures, final version, accepted by Eur. Phys. J.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts from 51 samples of synovial tissue from patients with RA or osteoarthritis (OA). Utilizing an integrated strategy based on canonical correlation analysis of 5,265 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics revealed cell states expanded in RA synovia: THY1(CD90) + HLA-DRA hi sublining fibroblasts, IL1B + pro-inflammatory monocytes, ITGAX + TBX21 + autoimmune-associated B cells and PDCD1 + peripheral helper T (T PH ) cells and follicular helper T (T FH ) cells. We defined distinct subsets of CD8 + T cells characterized by GZMK + , GZMB + , and GNLY + phenotypes. We mapped inflammatory mediators to their source cell populations; for example, we attributed IL6 expression to THY1 + HLA-DRA hi fibroblasts and IL1B production to pro-inflammatory monocytes. These populations are potentially key mediators of RA pathogenesis

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the \u3e20 distinct compound classes is also reviewed, and commonalities are discussed

Designing Building Skins with Biomaterials

This chapter presents several successful examples of biomaterial facade design. It discusses facade function from aesthetical, functional, and safety perspectives. Special focus is directed on novel concepts for adaptation and special functionalities of facades. Analysis of the structure morphologies and aesthetic impressions related to the bio-based building facades is supported with photographs collected by authors in various locations. Finally, particular adaptations and special functionalities of bio-based facades going beyond traditional building envelope concept are supported by selected case studies