Évaluation des ressources en eau de la Martinique : calcul spatialisé de la pluie efficace et validation à l’échelle du bassin versant

L’évaluation des différents termes du bilan hydrologique à l’échelle d’un bassin versant constitue l’un des points clés de la gestion des ressources en eau, et ce, tout particulièrement dans les régions montagneuses présentant de fortes variations spatiales de la pluviométrie et de l’évapotranspiration. Une méthodologie, basée sur le modèle classique de Thornthwaite, est proposée. Elle prend en compte les différents types de sols, l’occupation des sols ainsi que les effets topographiques et calcule les différents termes du bilan hydrologique (pluie, évapotranspiration, pluie efficace, etc.). L’approche a été mise en oeuvre à l’échelle du kilomètre carré, pour l’ensemble de l’île de la Martinique (1 080 km2), puis validée à l’échelle du bassin versant, en comparant les pluies efficaces calculées avec les débits mesurés aux stations de jaugeage. Malgré l’absence de calage des différents paramètres du modèle, les résultats sont très satisfaisants. Une surestimation de la pluie efficace est néanmoins observée pour la plupart des bassins versants utilisés pour la validation du modèle. Cet écart est attribué à une sous-estimation de l’évapotranspiration potentielle, la plupart des bassins versants comportant une composante forestière significative, non prise en compte dans le modèle.The assessment of the various components of the hydrologic budget at catchment scale represents a key challenge for water resources management. This is especially true for regions characterized by important spatial variability in rainfall or evapotranspiration due, for example, to topographical effects. A methodology, based on the classical Thornthwaite model, is proposed to account for soil types, land cover changes and topographical effects on the main components of the water cycle (rainfall, evapotranspiration and efficient rainfall). The approach is developed for the whole Martinique Island (French West Indies, 1080 km2) using a 1-km2 resolution and validated at catchment scale comparing computed efficient rainfall with measured discharge at several gauging stations. Despite the absence of any calibration of the model parameters, the results are satisfying. A slight overestimation of the efficient rainfall is generally observed for the validation watersheds. This discrepancy is interpreted as an underestimation of potential evapotranspiration as the classical Penman-Montheit formula for grass is used despite the presence of forested areas in most of the watersheds

Hydrogeological conceptual model of andesitic watersheds revealed by high-resolution heliborne geophysics

We conducted a multidisciplinary study at the watershed scale of an andesitic-type volcanic island in order to better characterize the hydrogeological functioning of aquifers and to better evaluate groundwater resources. A heliborne Time Domain ElectroMagnetic (TDEM) survey was conducted over Martinique in order to investigate underground volcanic structures and lithology, characterized by high lateral and vertical geological variability and resulting in a very high heterogeneity of their hydrogeological characteristics. Correlations were made on three adjacent watersheds between resistivity data along flight lines and geological and hydrogeological data from 51 boreholes and 24 springs, showing that the younger the formations, the higher their resistivity. Correlation between resistivity, geology and transmissivity data of three aquifers is attested: within the interval 10–100&thinsp;ohm&thinsp;m and within a range of 1 to 5.5&thinsp;Ma, the older the formation, the lower its resistivity, and the older the formation, the higher its transmissivity. Moreover, we demonstrate that the main geological structures lead to preferential flow circulations and that hydrogeological watersheds can differ from topographical watersheds. The consequence is that, even if the topographical watershed is small, underground flows from an adjacent watershed can add significant amounts of water to such a catchment. This effect is amplified when lava domes and their roots are situated upstream, as they present very high hydraulic conductivity leading to deep preferential groundwater flow circulations. We also reveal, unlike basaltic-type volcanic islands, that hydraulic conductivity increases with age in this andesitic-type volcanic island. This trend is interpreted as the consequence of tectonic fracturing associated with earthquakes in this subduction zone, related to andesitic volcanic islands. Finally, our approach allows characterization in detail of the hydrogeological functioning and identification of the properties of the main aquifer and aquitard units, leading to the proposition of a hydrogeological conceptual model at the watershed scale. This working scale seems particularly suitable due to the complexity of edifices, with heterogeneous geological formations presenting high lateral and vertical variability. Moreover, our study offers new guidelines for accurate correlations between resistivity, geology and hydraulic conductivity for volcanic islands. Finally, our results will also help stakeholders toward a better management of water resources.</p

Effect of volcanic dykes on coastal groundwater flow and saltwater intrusion : a field-scale multiphysics approach and parameter evaluation

Acknowledgments This research was primarily based on research grant‐aided by the Irish Department of Communications, Energy and Natural Resources under the National Geoscience Programme 2007–2013. It also benefited from complementary funding from the Scottish Alliance for Geoscience, Environment and Society (SAGES). We acknowledge the contribution in data acquisition of the MSc students in Environmental Engineering at Queen's University Belfast, the landowner for access to the inland fields and the Department of Geography, Archaeology and Paleoecology at QUB for provision of the tidal model of Belfast Lough. The data used are listed in the references, tables, and figures and are available from the corresponding author upon demand. We acknowledge the constructive comments by the Associate Editor and three reviewers, which helped in improving the final manuscript.Peer reviewedPublisher PD

Eradication of an outbreak of vancomycin-resistant Enterococcus (VRE): the cost of a failure in the systematic screening

BACKGROUND: Vancomycin-resistant enterococci (VRE) are still a concern in hospital units tending to seriously ill patients. However, the cost-effectiveness of active surveillance program to identify asymptomatically VRE colonized patient remains debatable. This work aims at evaluating the cost of a failure in the active surveillance of VRE that had resulted in an outbreak in a French University Hospital. FINDINGS: A VRE outbreak was triggered by a failure in the systematic VRE screening in a medico-surgical ward specialised in liver transplantation as a patient was not tested for VRE. This failure was likely caused by the reduction of healthcare resource. The outbreak involved 13 patients. Colonized patients were grouped in a dedicated part of the infectious diseases unit and tended by a dedicated staff. Transmission was halted within two months after discovery of the index case. The direct cost of the outbreak was assessed as the cost of staffing, disposable materials, hygiene procedures, and surveillance cultures. The loss of income from spare isolation beds was computed by difference with the same period in the preceding year. Payments were drawn from the hospital database. The direct cost of the outbreak (2008 Euros) was €60 524 and the loss of income reached €110 915. CONCLUSIONS: Despite this failure, the rapid eradication of the VRE outbreak was a consequence of the rapid isolation of colonized patient. Yet, eradicating even a limited outbreak requires substantial efforts and resources. This underlines that special attention has to be paid to strictly adhere to active surveillance program

A rewiring model of intratumoral interaction networks.

Intratumoral heterogeneity (ITH) has been regarded as a key cause of the failure and resistance of cancer therapy, but how it behaves and functions remains unclear. Advances in single-cell analysis have facilitated the collection of a massive amount of data about genetic and molecular states of individual cancer cells, providing a fuel to dissect the mechanistic organization of ITH at the molecular, metabolic and positional level. Taking advantage of these data, we propose a computational model to rewire up a topological network of cell-cell interdependences and interactions that operate within a tumor mass. The model is grounded on the premise of game theory that each interactive cell (player) strives to maximize its fitness by pursuing a rational self-interest strategy, war or peace, in a way that senses and alters other cells to respond properly. By integrating this idea with genome-wide association studies for intratumoral cells, the model is equipped with a capacity to visualize, annotate and quantify how somatic mutations mediate ITH and the network of intratumoral interactions. Taken together, the model provides a topological flow by which cancer cells within a tumor cooperate or compete with each other to downstream pathogenesis. This topological flow can be potentially used as a blueprint for genetically intervening the pattern and strength of cell-cell interactions towards cancer control

Développement d'un implant à géométrie variable pour le traitement des fractures du fémur proximal chez les personnes âgées

Les fractures du fémur proximal de la personne âgée sont généralement fixées par des dispositifs d ostéosynthèse. Pour les fractures particulières dites inter-trochantériennes, il est possible de fixer la fracture de manière intra-médullaire (à l intérieur de l os) ou de manière extra-médullaire (en dehors de l os). Pour chaque type de traitement, les hôpitaux sont équipés des deux systèmes de fixation. Les différences de morphologie des individus impliquent l existence de multiples références d implants et donc de surcoûts en termes d équipement. Dans ce travail de thèse, un implant original adaptable à la plupart des morphologies a été développé. Cet implant permettra non seulement d offrir aux chirurgiens une souplesse au cours des interventions chirurgicales mais aussi de réduire de manière significative les stocks d implants dans les hôpitaux. Le comportement mécanique de l implant est étudié dans différents cas de fractures par deux approches complémentaires, une méthode numérique par Éléments Finis et une approche expérimentale mettant en oeuvre des techniques de stéréo-corrélation à partir d images de caméras rapides. Les résultats des calculs numériques sont confrontés à ceux issus d essais réalisés sur des fémurs synthétiques, puis cadavériques en laboratoire d anatomie. Les comparaisons avec des implants existants montrent que ce nouveau concept d implant permet une fixation plus stable des fragments osseux et une bonne compression du foyer de fracture.Proximal femoral fractures in the elderly are generally fixed with osteosynthetic devices. For specific fractures called intertrochanteric, it is possible to fix the fracture in an intramedullary way (inside the bone) or in an extramedullary way (outside the bone). For each type of treatment, hospitals are equipped with the two fixing systems. The differences in physical characteristics between individuals imply the existence of multiple references implants and therefore additional costs in terms of equipment. In this thesis work,an original implant adaptable to most people has been developed. This implant will provide surgeons greater flexibility during surgery but also significantly reduce stocks implants in hospitals. The mechanical behavior of the implant is studied in different cases of fractures by two complementary approaches,a finite element analysis and an experimental study employing stereo-image correlation technique from images of high speed cameras. The results of the numerical calculation are compared with those derived from tests on synthetic femurs, then cadaver in anatomy laboratory. Comparisons with existing implants show that this new implant concept allows for a more stable fixation of bone fragments and a good compression of the fracture.SAVOIE-SCD - Bib.électronique (730659901) / SudocGRENOBLE1/INP-Bib.électronique (384210012) / SudocGRENOBLE2/3-Bib.électronique (384219901) / SudocSudocFranceF

Can Peto\u27s paradox be used as the null hypothesis to identify the role of evolution in natural resistance to cancer? A critical review

BACKGROUND: Carcinogenesis affects not only humans but almost all metazoan species. Understanding the rules driving the occurrence of cancers in the wild is currently expected to provide crucial insights into identifying how some species may have evolved efficient cancer resistance mechanisms. Recently the absence of correlation across species between cancer prevalence and body size (coined as Peto\u27s paradox) has attracted a lot of attention. Indeed, the disparity between this null hypothesis, where every cell is assumed to have an identical probability to undergo malignant transformation, and empirical observations is particularly important to understand, due to the fact that it could facilitate the identification of animal species that are more resistant to carcinogenesis than expected. Moreover it would open up ways to identify the selective pressures that may be involved in cancer resistance. However, Peto\u27s paradox relies on several questionable assumptions, complicating the interpretation of the divergence between expected and observed cancer incidences. DISCUSSIONS: Here we review and challenge the different hypotheses on which this paradox relies on with the aim of identifying how this null hypothesis could be better estimated in order to provide a standard protocol to study the deviation between theoretical/theoretically predicted and observed cancer incidence. We show that due to the disproportion and restricted nature of available data on animal cancers, applying Peto\u27s hypotheses at species level could result in erroneous conclusions, and actually assume the existence of a paradox. Instead of using species level comparisons, we propose an organ level approach to be a more accurate test of Peto\u27s assumptions. SUMMARY: The accuracy of Peto\u27s paradox assumptions are rarely valid and/or quantifiable, suggesting the need to reconsider the use of Peto\u27s paradox as a null hypothesis in identifying the influence of natural selection on cancer resistance mechanisms