850 research outputs found
Approaching Fifth to Sixth Grade Flute Pedagogy Considering VARK Learning Styles Model
The benefits of learning an instrument for childhood development intersecting with the positive growth trend in homeschooled families generates increased demand in value for supporting resources. Creating resources that would include learning styles defined by the VARK model (Visual, Auditory, Read/Write, Kinesthetic) designed to engage students during their particular developmental stage enhances at-home music education. The compiled research surrounding VARK learning styles and flute specific pedagogy would provide a foundation for specialized flute exercises and activities for fifth to sixth grade students learning to play the flute in a homeschooled or private lesson setting. The structure of the thesis is as follows: a presentation of the purpose for this research, an examination of each learning style in the VARK model, general and critical observations of 10 existing flute method books, and the application of findings resulting in 10 pages of activities and exercises to engage young flutists
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CTLA-4: a negative regulator of autoimmune disease.
CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to examine the role of CTLA-4 in regulating autoimmune disease. Murine relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) is a demyelinating disease mediated by PLP139-151-specific CD4+ T cells in SJL/J mice. Anti-CTLA-4 mAbs (or their F(ab) fragments) enhanced in vitro proliferation and pro-inflammatory cytokine production by PLP139-151-primed lymph node cells. Addition of either reagent to in vitro activation cultures potentiated the ability of T cells to adoptively transfer disease to naive recipients. In vivo administration of anti-CTLA-4 mAb to recipients of PLP139-151-specific T cells resulted in accelerated and exacerbated disease. Finally, anti-CTLA-4 treatment of mice during disease remission resulted in the exacerbation of relapses. Collectively, these results suggest that CTLA-4 mediates the downregulation of ongoing immune responses and plays a major role in regulating autoimmunity
Climate Change and Idaho Agriculture: Is Farm Size a Determinate of Adaptive Capacity?
Determining how agriculture will be affected by climate change is not only a question biophysical change in crop production; it also depends on the adaptation of the farmer to these changing conditions. A flaw in models using nationally aggregated cross sectional data is that the adaptive capacity of unique farms is not captured in the analysis. In order to understand the local effect of climate change on welfare models must capture attributes specific to the study area. Factors that must be taken into consideration include farm characteristics local policy and institutional frameworks (Antle et al. 2004; Mendelsohn, Nordhaus, and Shaw 1994). This study looks at weather and crop characteristic specific to Idaho agriculture by utilizing county data over a fifty year period. This approach captures local conditions, although adaptation under climate change is hard to determine because of the prevalence of advanced adaptation techniques, such as irrigation and cultivation technology, across all farm sizes
Downsizing for the future: Whatcom County Adult Correction Facility and Sheriff\u27s headquarters environmental impact assessment
The purpose of this environmental impact assessment (EIA) is to determine the effects of constructing and operating the proposed Adult Corrections Facilities and Sheriffs Headquarters in Whatcom County, Washington. This EIA addresses the positive and negative impacts associated with the proposed action, alternative action and no action alternative
Optimal filter approximation by means of a phase-only filter with quantization
Approximate filters based on a phase-only filter for reliable recognition of objects are proposed. Good light efficiency and discrimination capability close to that of the optimal filter can be obtained. Computer simulation results are presented and discussed
Testing theoretical models of magnetic damping using an air track
Magnetic braking is a long-established application of Lenz's law. A rigorous
analysis of the laws governing this problem involves solving Maxwell's
equations in a time-dependent situation. Approximate models have been developed
to describe different experiences related to this phenomenon. In this paper we
present a new method for the analysis of the magnetic braking using a magnet
fixed to the glider of an air track. The forces acting on the glider, a result
of the eddy currents, can be easily observed and measured. As a consequence of
the air track inclination, the glider accelerates at the beginning, although it
asymptotically tends towards a uniform rectilinear movement characterized by a
terminal speed. This speed depends on the interaction between the magnetic
field and the conductivity properties of the air track. Compared with previous
related approaches, in our experimental setup the magnet fixed to the glider
produces a magnetic braking force which acts continuously, rather than over a
short period of time. The experimental results satisfactorily concur with the
theoretical models adapted to this configuration.Comment: 15 pages, 5 figure
Conversion Efficacy and Safety of Intravenous Ibutilide Compared With Intravenous Procainamide in Patients With Atrial Flutter or Fibrillation 11This study was sponsored by Pharmacia & Upjohn, Kalamazoo, Michigan.22See Appendix Afor a complete list of investigators and study sites.
AbstractObjectives. This multicenter study compared the efficacy and safety of ibutilide versus procainamide for conversion of recent-onset atrial flutter or fibrillation.Background. Ibutilide fumarate is an intravenous (IV) class III antiarrhythmic agent that has been shown to be significantly more effective than placebo in the pharmacologic conversion of atrial flutter and fibrillation to sinus rhythm. Procainamide is commonly used for conversion of recent-onset atrial fibrillation to normal sinus rhythm.Methods. One hundred twenty-seven patients (age range 22 to 92 years) with atrial flutter or fibrillation of 3 h to 90 days’ (mean 21 days) duration were randomized to receive either two 10-min IV infusions of 1 mg of ibutilide fumarate, separated by a 10-min infusion of 5% dextrose in sterile water, or three successive 10-min IV infusions of 400 mg of procainamide hydrochloride.Results. Of the 127 patients, 120 were evaluated for efficacy: 35 (58.3%) of 60 in the ibutilide group compared with 11 (18.3%) of 60 in the procainamide group had successful termination within 1.5 h of treatment (p < 0.0001). Seven patients were found to have violated the protocol and were not included in the final evaluation. In the patients with atrial flutter, ibutilide had a significantly higher success rate than procainamide (76% [13 of 17] vs. 14% [3 of 22], p = 0.001). Similarly, in the atrial fibrillation group, ibutilide had a significantly higher success rate than procainamide (51% [22 of 43] vs. 21% [8 of 38], p = 0.005). One patient who received ibutilide, which was found to be a protocol violation, had sustained polymorphic ventricular tachycardia requiring direct current cardioversion. Seven patients who received procainamide became hypotensive.Conclusions. This study establishes the superior efficacy of ibutilide over procainamide when administered to patients to convert either atrial fibrillation or atrial flutter to sinus rhythm. Hypotension was the major adverse effect seen with procainamide. A low incidence of serious proarrhythmia was seen with the administration of ibutilide occurring at the end of infusion
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