Summary of experimentally determined facts concerning the behavior of the boundary layer and performance of boundary layer measurements

A summary report of boundary layer studies is presented. Preliminary results of experimental measurements show that: (1) A very thin layer (approximately 0.4 mm) of the boundary layer seems to be accelerated; (2) the static pressure of the outer flow does not remain exactly constant through the boundary layer; and (3) an oncoming boundary layer which is already turbulent at the suction point can again become laminar behind this point without being completely sucked off

Synthetic approach to epibatidine from 1-(phenylsulfonyl)pyrrole

The goal of this research was to synthesize the natural product epibatidine, a non-opiate analgesic and nicotinic acetylcholine agonist isolated from Epipedobates tricolor. A synthetic pathway utilizing a Diels-Alder cycloaddition of a 3-pyridyl substituted pyrrole and tosylacetylene was conceived based upon the original mass spectral fragmentation pathway of epibatidine determined by Daly. Although this pathway had been previously attempted using 1-(triisopropyl)-3-[5-(2-chloropyridyl)]pyrrole in the key Diels-Alder step, the lack of cycloadduct suggested that a pyrrole with a more electron withdrawing protecting group was required for this step. Therefore, synthesis of 1-(phenylsulfonyl)-3-[5-(2-chloropyridyl)]pyrrole via a palladium catalyzed cross-coupling reaction of 1-(phenylsulfonyl)-3-pyrroline and 2-chloro-5-iodopyridine was set as a synthetic goal and accomplished. The Diels-Alder reaction required further investigation to determine the extent to which 1-(phenylsulfonyl)pyrrole would undergo cycloaddition with dimethyl acetylenedicarboxylate and tosylacetylene. Once this was completed, the Diels-Alder reaction of 1-(phenylsulfonyl)-3-[5-(2-chloropyridyl)]pyrrole was attempted with tosylacetylene but the desired cycloadduct could not be found

Adapting an organic chemistry course for the visually impaired

https://scholarworks.moreheadstate.edu/student_scholarship_posters/1173/thumbnail.jp

Two new extensions to L1 adaptive control theory

This thesis introduces two new extensions to L1 adaptive control theory. The first is an L1 adaptive state feedback controller with generalized proportional adaptation law for a class of linear systems with input–gain uncertainties and unmatched nonlinear disturbances. The proportional adaptation law provides an adaptive estimate that is directly proportional to the error between the output of the system and the state predictor. One advantage of the new adaptive law is the additional phase margin in the estimation loop, allowing for accommodation of first order sensor dynamics in the state predictor. An additional benefit is the reduction of the required computational resources, since the error bounds reduce at a rate directly proportional to the adaptation gain as compared to the square root of the adaptation gain achieved by the L1 adaptive controllers using gradient descent adaptation laws. In addition, an L1 adaptive funnel controller and variable dependent adaptation law are provided as particular cases for the generalized proportional framework. Also presented is the connection between the generalized proportional feedback law and previous L1 switching controller. The second extension is an L1 adaptive controller for a class of uncertain systems in the presence of time and output dependent unknown nonlinearities and uncertain input matrix with performance specifications defined via a time–varying reference system using output feedback. It is shown that both extensions exhibit the standard characteristics of the L1 adaptive control theory: scaling of transient responses, a guaranteed time–delay margin at high adaptation rates, and the trade off between robustness and performance is determined by the design of a low pass filter

Pengembangan Situs Web Accelist Ticketing System pada PT Accelist Lentera Indonesia

Dewasa ini, perkembangan teknologi berlangsung secara pesat. Salah satu bidang yang terpengaruh dalam perkembangan teknologi adalah bidang teknologi informasi. Dalam pengerjaan projek pada perusahaan yang bergerak di bidang teknologi informasi umumnya dilakukan sesuai dengan kebutuhan pelanggan. Sejalan dengan perkembangan teknologi PT. Accelist Lentera Indonesia mengembangkan sebuah situs web untuk menunjang kebutuhan client atau pelanggan. Situs web tersebut adalah situs web ticketing system yang dapat digunakan oleh developer dan business analyst. Pengembangan dilakukan dengan menggunakan bahasa pemograman Typescript dengan framework Next.JS. Pada akhir pengembangan situs web dapat berjalan dengan baik dan menunjukkan tampilan yang sesuai dengan yang diharapkan. Hasil dari pengembangan telah diserahkan untuk dilakukan evaluasi dan pemeriksaan oleh project manager

Uji Daya Hambat Ekstrak Jintan Hitam (Nigella sativa) Terhadap Bakteri Acinetobacter baumannii Dengan Metode Dilusi Cair

Penggunaan bahan alam sebagai salah satu terapi pengobatan telah diterima secara luas hampir di seluruh dunia. Menurut World Health Organitation (WHO), negara-negara di Afrika, Asia, dan Amerika latin menggunakan obat herbal sebagai pelengkap pengobatan primer. Penggunaan tanaman obat juga ditujukan untuk menurunkan tingkat resistensi terhadap antibiotik. Resistensi terhadap penggunaan antibiotik merupakan masalah besar, maka solusinya adalah dengan memanfaatkan sumber daya alam yang ada karena sumber obat terbaik adalah obat alami. Tujuan Penelitian ini Untuk mengetahui daya hambat ekstrak jintan hitam (Nigella sativa) terhadap pertumbuhan bakteri Acinetobacter baumannii. Penelitian ini merupakan penelitian ekperimental laboratorik dengan metode dilusi cair. Sampel yang digunakan pada penelitian ini adalah jintan hitam (Nigella sativa) dengan cara konsentrasi bertingkat 256mg/mL, 128mg/mL, 64mg/mL, 32mg/mL, 16mg/mL, 8mg/mL, 4mg/mL, 2mg/mL, 1mg/mL, 0,5mg/mL, 0,25mg/mL, dan 0,125mg/mL, dan pemeriksaan di lakukan di Laboratorium Mikrobiologi Program Analis Kesehatan Universitas MH Thamrin Jakarta. Nilai konsentrasi hambat minimum (KHM/MIC) ekstrak jintan hitam yang di dapatkan pada konsentrasi 256 mg/mL pada amoxicillin konsentrasi 128 mg/mL terhadap bakteri Acinetobacter baumannii. Simpulan Ekstrak etanol jintan hitan (Nigella sativa) memiliki daya hambat antibakteri terhadap bakteri Acinetobacter baumanniiKata kunci : Ekstrak jintan hitam (Nigella sativa), Acinetobacter baumannii, amoxicilli

Comparing Narratives of Personal and Preferred Partner Characteristics in Online Dating Advertisements

This study explored online personal ads of 294 heterosexual and homosexual men and women in the United States through a qualitative analysis and comparison of participant-generated “personal” and “preferred partner” narratives. Nine characteristics were identified and combined into three overarching categories: physical, lifestyle, and personality characteristics. These three personal and preferred partner characteristics were examined for difference by gender, sexual orientation, age and desired relationship type of the advertisers. Main effects emerged for all four predictors, most notably for age and desired relationship type. Additionally, this study explored the possibility that personal and preferred partner narratives contained similar constellations of characteristics, finding significant correlations on all three variables, lending support for the matching hypothesis in dating partner characteristics

Northern and Southern variations on a theme: Notes on the Mandarin koiné of Qīng China

This paper examines two Qīng period records of the Guānhuà for what they reveal about the Mandarin koiné during that dynasty, especially with regard to Mandarin spoken in south China: the Kāngxī Dictionary and Gāo Jìngtíng's Zhèngyīn cuōyào. The Kāngxī Dictionary provides us with a Mandarin rime table that illustrates evidence for the prestige Mandarin pronunciation of the early Qīng, which turns out not to have been based on Beijing phonology. Gāo Jìngtíng's book was the first indigenous textbook of Mandarin and contains many passages that provide fascinating glimpses of language use in urban areas along the corridors of travel between Guǎngzhōu and Běijīng, as well as a rather detailed presentation of the phonology of the Mandarin of his day. Taken together, these two sources reveal much about the history of Mandarin in south during Qīng. They are witnesses that allow us to sketch out an outline of the phonology of Qīng Mandarin and identify its most salient characteristics

Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Post-exertional malaise (PEM) is the hallmark clinical feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PEM involves a constellation of substantially disabling signs and symptoms that occur in response to physical, mental, emotional, and spiritual over-exertion. Because PEM occurs in response to over-exertion, physiological measurements obtained during standardized exertional paradigms hold promise to contribute greatly to our understanding of the cardiovascular, pulmonary, and metabolic states underlying PEM. In turn, information from standardized exertional paradigms can inform patho-etiologic studies and analeptic management strategies in people with ME/CFS. Several studies have been published that describe physiologic responses to exercise in people with ME/CFS, using maximal cardiopulmonary testing (CPET) as a standardized physiologic stressor. In both non-disabled people and people with a wide range of health conditions, the relationship between exercise heart rate (HR) and exercise workload during maximal CPET are repeatable and demonstrate a positive linear relationship. However, smaller or reduced increases in heart rate during CPET are consistently observed in ME/CFS. This blunted rise in heart rate is called chronotropic intolerance (CI). CI reflects an inability to appropriately increase cardiac output because of smaller than expected increases in heart rate. The purposes of this review are to (1) define CI and discuss its applications to clinical populations; (2) summarize existing data regarding heart rate responses to exercise obtained during maximal CPET in people with ME/CFS that have been published in the peer-reviewed literature through systematic review and meta-analysis; and (3) discuss how trends related to CI in ME/CFS observed in the literature should influence future patho-etiological research designs and clinical practice