Test of ID carbon-carbon composite prototype tiles for the SPIDER diagnostic calorimeter

Additional heating will be provided to the thermonuclear fusion experiment ITER by injection of neutral beams from accelerated negative ions. In the SPIDER test facility, under construction at Consorzio RFX in Padova (Italy), the production of negative ions will be studied and optimised. To this purpose the STRIKE (Short-Time Retractable Instrumented Kalorimeter Experiment) diagnostic will be used to characterise the SPIDER beam during short operation (several seconds) and to verify if the beam meets the ITER requirement regarding the maximum allowed beam non-uniformity (below \ub110%). The most important measurements performed by STRIKE are beam uniformity, beamlet divergence and stripping losses. The major components of STRIKE are 16 1D-CFC (Carbon matrix-Carbon Fibre reinforced Composite) tiles, observed at the rear side by a thermal camera. The requirements of the 1D CFC material include a large thermal conductivity along the tile thickness (at least 10 times larger than in the other directions); low specific heat and density; uniform parameters over the tile surface; capability to withstand localised heat loads resulting in steep temperature gradients. So 1D CFC is a very anisotropic and delicate material, not commercially available, and prototypes are being specifically realised. This contribution gives an overview of the tests performed on the CFC prototype tiles, aimed at verifying their thermal behaviour. The spatial uniformity of the parameters and the ratio between the thermal conductivities are assessed by means of a power laser at Consorzio RFX. Dedicated linear and non-linear simulations are carried out to interpret the experiments and to estimate the thermal conductivities; these simulations are described and a comparison of the experimental data with the simulation results is presented

Decoding neural responses to temporal cues for sound localization

The activity of sensory neural populations carries information about the environment. This may be extracted from neural activity using different strategies. In the auditory brainstem, a recent theory proposes that sound location in the horizontal plane is decoded from the relative summed activity of two populations in each hemisphere, whereas earlier theories hypothesized that the location was decoded from the identity of the most active cells. We tested the performance of various decoders of neural responses in increasingly complex acoustical situations, including spectrum variations, noise, and sound diffraction. We demonstrate that there is insufficient information in the pooled activity of each hemisphere to estimate sound direction in a reliable way consistent with behavior, whereas robust estimates can be obtained from neural activity by taking into account the heterogeneous tuning of cells. These estimates can still be obtained when only contralateral neural responses are used, consistently with unilateral lesion studies. DOI: http://dx.doi.org/10.7554/eLife.01312.001

Lost in the Mist: Acute Adrenal Crisis Following Intranasal Fluticasone Propionate Overuse

Introduction. Acute adrenal crisis in relation to nasal steroid overuse has been reported very scantly in English medical literature and remains an underdiagnosed condition. Case presentation. A 55 year-old male presented with altered mental status, retrograde amnesia, fluid refractory hypotension, abdominal pain, fever, and chest pain. Physical examination revealed amnesia, bradypsychia, tachycardia, decreased muscle tone and hyporeflexia. Overuse of nasal steroid was suspected by history. Random early morning cortisol level was < 0.2 mcg/dL. The patient was started on hydrocortisone and within 24 hours he had a full recovery. Conclusion. This one-of-a-kind case describes acute adrenal crisis secondary to withdrawal from inhaled nasal corticosteroids overuse in a patient with particular risk factors. Prevention and early recognition of this disorder can significantly reduce its morbidity and mortality

A resilience transition for sustainable urban development : a process design methodology to support participatory decision making

Actualmente, más del 50% de la población mundial vive en áreas urbanas (75% en EU), y las ciudades concentran entre un 60-80% del consumo energético global y el mismo porcentaje de las emisiones de GEI CO2. Así mismo, producen el 50% de residuos a nivel global, consumen 75% de los recursos naturales y concentran el 80% del PIB (UNEP-DTIE, 2013). -El cambio climático tiene el potencial de influir casi el total de los componentes del medio urbano y genera nuevos y complejos retos para la calidad de vida, la salud y la biodiversidad urbanas. Algunas ciudades experimentarán sequías y elevadas temperaturas. Otras podrían experimentar inundaciones. El cambio climático afectará muchos aspectos de la vida en una ciudad, desde la calidad del aire, hasta los patrones de consumo. La UE ha puesto en marcha ambiciosas políticas e iniciativas para promover soluciones sobre el terreno, entre las que se incluyen iniciativas para aumentar la resiliencia y promover tanto las energías renovables como las tecnologías de baja emisión de carbono. (EC, 2015). Las ciudades ya han comenzado a desarrollar políticas, planes y acciones específicas para la mitigación o la adaptación al cambio climático, y un relativamente pequeño pero creciente número de ellas, se encuentran liderando pioneros enfoques integrados basados en la resiliencia, que buscan responder a los retos presentados por la incertidumbre y la imprevisible naturaleza de los fenómenos que se abordan, lo cual se ve aunado a una falta de conocimiento especializado en cambio climático, en términos de investigación, evaluación, métodos, herramientas y habilidades de planeación. (EU, 2013). Haciendo una revisión en torno a los principios clave del desarrollo sostenible y a los retos clave a nivel urbano, tales como el cambio global ambiental y climático, aquí se presenta una metodología para el diseño de un proceso de transición hacia la resiliencia urbana. La metodología está basada en la amplia participación de los tomadores de decisiones, siguiendo los principios de co-diseño y co-evolución. El elemento más innovador de la metodología está relacionado con su contribución en términos de la teoría de la planeación y las prácticas para la resiliencia urbana a través de escalas tanto temporales como espaciales, lo cual se encuentra poco desarrollado actualmente. Además, el enfoque participativo del proceso de diseño redefine el rol de los planificadores aportando una perspectiva más amplia, no más como demiurgo, sino como un facilitador en los procesos de diseño y El objetivo original de la tesis, es el desarrollo de una metodología para la evaluación integrada del desarrollo urbano sostenible, expandido y ampliado para abordar la necesidad que existe, como se prueba tanto en la existencia de literatura científica como de documentos de políticas de la UE y de la ONU, de encontrar nuevas formas y métodos para la planeación en términos de resiliencia urbana, vista como un proceso dinámico y continuo de adaptación de la ciudad que permita un balance entre la necesidad de reducir el riesgo y la de innovar, todo ello para aumentar el bienestar de los ciudadanos a través de la co-evolución basada en procesos de planeación participativa. El resultado obtenido es una metodología de diseño de procesos completamente funcional para la transición hacia la resiliencia urbana, incluyendo un enfoque sistémico y un método de evaluación integrada de la sostenibilidad, el cual ha sido desarrollado desde su concepción a un Nivel de Preparación Tecnológica 7-8, finalmente incluyendo una demostración del prototipo del sistema en un ambiente operativo.Today over 50% of world population lives in urban areas (75% in EU), and cities account for 60-80% of global energy consumption and the same share of GHG CO2, producing 50% of global waste, consuming 75% of natural resources and producing 80% of global GDP. (UNEP-DTIE, 2013) ¿Climate change has the potential to influence almost all components of the urban environment and raises new, complex challenges for quality of urban life, health and urban biodiversity. Some cities will experience droughts and increased temperatures. Others may experience floods. Climate change will affect many aspects of urban living from air quality to consumption patterns. The EU has put in place ambitious policies and initiatives to promoting solutions on the ground. These include initiatives to increase resilience and promote renewable energies and low-carbon technologies. (EC, 2015) Cities have already started to develop specific mitigation or adaption or risk policies/plans/actions; and a relatively small but growing number of them are now pioneering an integrated approach urban resilience based, facing challenges related uncertainty and unpredictability of the phenomena they are addressing, and ultimately suffering for a lack of knowledge in terms of research, evaluation methods/tools and planning skills. (EU, 2013) Following a review of sustainable development principles and key urban challenges, as climate and global environmental changes, it is here presented a process design methodology for urban resilience transition. The methodology is based on broad stakeholders' participation, following co-design and co-evolution principles. The most innovative element of the process design methodology is related to the contribution in terms of planning theory and practices for urban resilience, cross-scale both in time and space, which is currently very little understood and developed. Furthermore the participatory process design approach re-define the role of planner in a wider perspective, not any longer as demiurges, but as facilitator of planning and design processes. The original objective of the thesis, to develop a methodology for integrated evaluation of sustainable urban development, was expanded and broadened to address the very needed request, as proven by both existence of scientific literature and EU/UN policy document, for new forms and methodology of planning addressing urban resilience, as a dynamic process of continuous adaptation of cities balancing between the need to reduce risk and to innovate, ultimately to increase well-being urban citizens, through co-evolution based participatory planning processes. The results is a fully working process design methodology for urban resilient transition, including the original system thinking approach and embedded with an integrated evaluation of sustainability system, which has been developed from inception to a Technology Readiness Level 7-8, finally including the system prototype demonstration in operational environment

Proteome analysis of vernix caseosa

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldVernix caseosa (vernix) is a white creamy substance covering the skin of the fetus during the last trimester of pregnancy. The function of vernix has long been debated but no consensus has been reached. We here report a proteome analysis of vernix using two-dimensional gel electrophoresis, matrix-assisted laser desorption/ionization mass spectrometry and liquid chromatography coupled to tandem mass spectrometry. We have identified 41 proteins, of which 25 are novel to vernix. Notably, 39% of the identified vernix proteins are components of innate immunity, and 29% have direct antimicrobial properties. These results form a substantial contribution to the knowledge of vernix composition and demonstrate that antimicrobial protection of the fetus and the newborn child is a major and important function of vernix

Mindsets for Green Innovation

Managers’ mindset about the sustainability construct and its triggers is the topic dealt with in the paper. The interviewed managers are all working in companies expressing a commitment on sustainability in their external communication. However, our findings reveal that their commitment is pursued from different business models, visions and ideas about the sustainability construct. We found that sustainability is not triggered, approached and practiced in accordance with one overall mindset. Four interrelated mindsets emerged - due to that sustainability is a learning process and thus formed and developed over time