Follicular thyroid carcinoma invades venous rather than lymphatic vessels

Follicular thyroid carcinoma (FTC) tends to metastasize to remote organs rather than local lymph nodes. Separation of FTC from follicular thyroid adenoma (FTA) relies on detection of vascular and/or capsular invasion. We investigated which vascular markers, CD31, CD34 and D2-40 (lymphatic vessel marker), can best evaluate vascular invasion and why FTC tends to metastasize via blood stream to remote organs. Thirty two FTCs and 34 FTAs were retrieved for evaluation. The average age of patients with FTA was 8 years younger than FTC (p = 0.02). The female to male ratio for follicular neoplasm was 25:8. The average size of FTC was larger than FTA (p = 0.003). Fourteen of 32 (44%) FTCs showed venous invasion and none showed lymphatic invasion, with positive CD31 and CD34 staining and negative D2-40 staining of the involved vessels. The average number of involved vessels was 0.88 ± 1.29 with a range from 0 to 5, and the average diameter of involved vessels was 0.068 ± 0.027 mm. None of the 34 FTAs showed vascular invasion. CD31 staining demonstrated more specific staining of vascular endothelial cells than CD34, with less background staining. We recommended using CD31 rather than CD34 and/or D2-40 in confirming/excluding vascular invasion in difficult cases. All identified FTCs with vascular invasions showed involvement of venous channels, rather than lymphatic spaces, suggesting that FTCs prefer to metastasize via veins to distant organs, instead of lymphatic vessels to local lymph nodes, which correlates with previous clinical observations

Assessing recent trends in high-latitude Southern Hemisphere surface climate

Understanding the causes of recent climatic trends and variability in the high-latitude Southern Hemisphere is hampered by a short instrumental record. Here, we analyse recent atmosphere, surface ocean and sea-ice observations in this region and assess their trends in the context of palaeoclimate records and climate model simulations. Over the 36-year satellite era, significant linear trends in annual mean sea-ice extent, surface temperature and sea-level pressure are superimposed on large interannual to decadal variability. However, most observed trends are not unusual when compared with Antarctic paleoclimate records of the past two centuries. With the exception of the positive trend in the Southern Annular Mode, climate model simulations that include anthropogenic forcing are not compatible with the observed trends. This suggests that natural variability likely overwhelms the forced response in the observations, but the models may not fully represent this natural variability or may overestimate the magnitude of the forced response

Southern Hemisphere climate variability forced by Northern Hemisphere ice-sheet topography

The presence of large Northern Hemisphere ice sheets and reduced greenhouse gas concentrations during the Last Glacial Maximum fundamentally altered global ocean–atmosphere climate dynamics1. Model simulations and palaeoclimate records suggest that glacial boundary conditions affected the El Niño–Southern Oscillation2,3, a dominant source of short-term global climate variability. Yet little is known about changes in short-term climate variability at mid- to high latitudes. Here we use a high-resolution water isotope record from West Antarctica to demonstrate that interannual to decadal climate variability at high southern latitudes was almost twice as large at the Last Glacial Maximum as during the ensuing Holocene epoch (the past 11,700 years). Climate model simulations indicate that this increased variability reflects an increase in the teleconnection strength between the tropical Pacific and West Antarctica, owing to a shift in the mean location of tropical convection. This shift, in turn, can be attributed to the influence of topography and albedo of the North American ice sheets on atmospheric circulation. As the planet deglaciated, the largest and most abrupt decline in teleconnection strength occurred between approximately 16,000 years and 15,000 years ago, followed by a slower decline into the early Holocene

A regime shift in seasonal total Antarctic sea ice extent in the twentieth century

In stark contrast to the Arctic, there have been statistically significant positive trends in total Antarctic sea ice extent since 1979. However, the short and highly variable nature of observed Antarctic sea ice extent limits the ability to fully understand the historical context of these recent changes. To meet this challenge, we have created robust, observation-based reconstruction ensembles of seasonal Antarctic sea ice extent since 1905. Using these reconstructions, here we show that the observed period since 1979 is the only time all four seasons demonstrate significant increases in total Antarctic sea ice in the context of the twentieth century and that the observed increases are juxtaposed against statistically significant decreases throughout much of the early and middle twentieth century. These reconstructions provide reliable estimates of seasonally resolved total Antarctic sea ice extent and are skilful enough to better understand aspects of air–sea–ice interactions within the Antarctic climate system

The characteristic variability and connection to the underlying synoptic activity of the Amundsen-Bellingshausen Seas Low

© 2012 American Geophysical Unio

Evolution of the Southern Annular Mode during the past millennium

International audienceThe Southern Annular Mode (SAM) is the primary pattern of climate variability in the Southern Hemisphere1,2, influencing latitudinal rainfall distribution and temperatures from the subtropics to Antarctica. The positive summer trend in the SAM over recent decades is widely attributed to stratospheric ozone depletion2; however, the brevity of observational records from Antarctica1\textemdashone of the core zones that defines SAM variability\textemdashlimits our understanding of long-term SAM behaviour. Here we reconstruct annual mean changes in the SAM since AD 1000 using, for the first time, proxy records that encompass the full mid-latitude to polar domain across the Drake Passage sector. We find that the SAM has undergone a progressive shift towards its positive phase since the fifteenth century, causing cooling of the main Antarctic continent at the same time that the Antarctic Peninsula has warmed. The positive trend in the SAM since ~AD 1940 is reproduced by multimodel climate simulations forced with rising greenhouse gas levels and later ozone depletion, and the long-term average SAM index is now at its highest level for at least the past 1,000 years. Reconstructed SAM trends before the twentieth century are more prominent than those in radiative-forcing climate experiments and may be associated with a teleconnected response to tropical Pacific climate. Our findings imply that predictions of further greenhouse-driven increases in the SAM over the coming century3 also need to account for the possibility of opposing effects from tropical Pacific climate changes