Verification-based software-fault detection

Software is used in many safety- and security-critical systems. Software development is, however, an error-prone task. In this work new techniques for the detection of software faults (or software "bugs") are described which are based on a formal deductive verification technology. The described techniques take advantage of information obtained during verification and combine verification technology with deductive fault detection and test generation in a very unified way

Verification-based Software-fault Detection

Software is used in many safety- and security-critical systems. Software development is, however, an error-prone task. In this dissertation new techniques for the detection of software faults (or software "bugs") are described which are based on a formal deductive verification technology. The described techniques take advantage of information obtained during verification and combine verification technology with deductive fault detection and test generation in a very unified way

Mapping Tasks to Interactions for Graph Exploration and Graph Editing on Interactive Surfaces

Graph exploration and editing are still mostly considered independently and systems to work with are not designed for todays interactive surfaces like smartphones, tablets or tabletops. When developing a system for those modern devices that supports both graph exploration and graph editing, it is necessary to 1) identify what basic tasks need to be supported, 2) what interactions can be used, and 3) how to map these tasks and interactions. This technical report provides a list of basic interaction tasks for graph exploration and editing as a result of an extensive system review. Moreover, different interaction modalities of interactive surfaces are reviewed according to their interaction vocabulary and further degrees of freedom that can be used to make interactions distinguishable are discussed. Beyond the scope of graph exploration and editing, we provide an approach for finding and evaluating a mapping from tasks to interactions, that is generally applicable. Thus, this work acts as a guideline for developing a system for graph exploration and editing that is specifically designed for interactive surfaces.Comment: 21 pages, minor corrections (typos etc.

Unterstützung des Editierens von Graphen in Visuellen Repräsentationen

The goal of this thesis is to provide solutions for supporting the direct editing of graphs in visual representations for analyzing graphs. For that, a conceptual view on the user's tasks is established first. On this basis, several novel approaches to "visually edit" the different data aspects of graphs - the graph's structure and associated attribute values - are introduced. Thereby, different visual graph representations suitable for communicating the data are considered.Das Ziel der vorliegenden Dissertation ist, Lösungen zur Unterstützung des direkten Editierens von Graphen in visuellen Repräsentationen zur Analyse von Graphen bereitzustellen. Dafür wird zunächst eine konzeptuelle Sicht auf die Aufgaben des Nutzers entwickelt. Auf dieser Basis werden anschließend mehrere neue Verfahren eingeführt, welche das "visuelle Editieren" der verschiedenen Datenaspekte von Graphen - der Struktur sowie dazu assoziierte Attributwerte - ermöglichen. Dabei werden verschiedene visuelle Graphrepräsentationen berücksichtigt, welche die Daten in geeigneter Form kommunizieren

SymbioCity: Smart Cities for Smarter Networks

The "Smart City" (SC) concept revolves around the idea of embodying cutting-edge ICT solutions in the very fabric of future cities, in order to offer new and better services to citizens while lowering the city management costs, both in monetary, social, and environmental terms. In this framework, communication technologies are perceived as subservient to the SC services, providing the means to collect and process the data needed to make the services function. In this paper, we propose a new vision in which technology and SC services are designed to take advantage of each other in a symbiotic manner. According to this new paradigm, which we call "SymbioCity", SC services can indeed be exploited to improve the performance of the same communication systems that provide them with data. Suggestive examples of this symbiotic ecosystem are discussed in the paper. The dissertation is then substantiated in a proof-of-concept case study, where we show how the traffic monitoring service provided by the London Smart City initiative can be used to predict the density of users in a certain zone and optimize the cellular service in that area.Comment: 14 pages, submitted for publication to ETT Transactions on Emerging Telecommunications Technologie

Towards a novel bioelectrocatalytic platform based on "wiring" of pyrroloquinoline quinone-dependent glucose dehydrogenase with an electrospun conductive polymeric fiber architecture

Electrospinning is known as a fabrication technique for electrode architectures that serve as immobilization matrices for biomolecules. The current work demonstrates a novel approach to construct a conductive polymeric platform, capable not only of immobilization, but also of electrical connection of the biomolecule with the electrode. It is produced upon electrospinning from mixtures of three different highly conductive sulfonated polyanilines and polyacrylonitrile on ITO electrodes. The resulting fiber mats are with a well-retained conductivity. After coupling the enzyme pyrroloquinoline quinone-dependent glucose dehydrogenase (PQQ-GDH) to polymeric structures and addition of the substrate glucose an efficient bioelectrocatalysis is demonstrated. Depending on the choice of the sulfonated polyanilline mediatorless bioelectrocatalysis starts at low potentials;no large overpotential is needed to drive the reaction. Thus, the electrospun conductive immobilization matrix acts here as a transducing element, representing a promising strategy to use 3D polymeric scaffolds as wiring agents for active enzymes. In addition, the mild and well reproducible fabrication process and the active role of the polymer film in withdrawing electrons from the reduced PQQ-GDH lead to a system with high stability. This could provide access to a larger group of enzymes for bioelectrochemical applications including biosensors and biofuel cells

Elektrogesponnene Polymerfasern als neuartiges Material für die Bioelektrokatalyse des Enzyms Pyrrolochinolinchinon-abhängige Glucosedehydrogenase

Es wurde ein dreidimensionales Polymerfasernetzwerk aufgebaut, charakterisiert und anschließend daran das Enzym Pyrrolochinolinchinon-abhängige Glukosedehydrogenase (PQQ)GDH gebunden. Das Polymerfasernetzwerk wurde durch Elektrospinnen einer Mischung des Polymers Polyacrylnitril und verschiedener leitfähiger Polymere der Polyanilin-Familie auf Indium-Zinn-Oxid-Elektroden aufgebracht. Die so hergestellten Fasermatten erwiesen sich bei mikroskopischen Untersuchungen gleichförmig präpariert und die Faserdurchmesser bewegten sich im Bereich weniger hundert Nanometer. Das Redoxpaar Kaliumhexacyanoferrat (II/III) zeigte an diesen Polymer-Elektrodenstrukturen eine quasi-reversible Elektrochemie. Bei weitergehenden Untersuchungen an den enzymmodifizierten Fasern ((PQQ)GDH) konnten unter Substratzugabe (Glukose) bioelektrokatalytische Ströme nachgewiesen werden. Das Fasernetzwerk fungiert hier nicht nur als Immobilisierungsmatrix, sondern als auch als Teil des Signalwandlers.A three-dimensional polymeric electrode structure was developed, characterized and subsequently coupled with the enzyme pyrroloquinoline quinone-dependent Glucosedehydrogenase (PQQ)GDH. The polymeric fiber network is produced by means of electrospinning from mixtures of polyacrylonitrile (PAN) and three different sulfonated poylanilines on top of ITO electrodes. The mats are uniform in their overall appearance; average diameters of the fibers produced are in the range of a few hundred nanometers. These polymeric structures can be shown to allow electrochemical conversions as verified with the ferri-/ferrocyanide redox couple. In addition, application in bioelectrocatalysis can be demonstrated. For two of three selected blends of PAN with sulfonated polyanillines, a well-defined bioelectrochemical response is obtained upon covalent fixation of PQQ-GDH to the fiber network and subsequent addition of substrate glucose. The electrospun matrix does not only act here as an immobilization support, but at the same time as a transducing element

Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity

BACKGROUND: As in ulcerative colitis, there is an increased incidence of colorectal carcinoma in Crohn's disease. While carcinoma formation originating from ano-rectal fistulas is generally considered as a rare event there are different publications reporting on mucinous adenocarcinoma formation in association with a neovagina and rectovaginal fistulas. To the best of our knowledge this is the first description of a perianal mucinous adenocarcinoma arising in a patient after Crohn's disease proctocolectomy. CASE PRESENTATION: We report the case of a 50-year old female with a mucinous adenocarcinoma forming in the perineum eleven years after proctocolectomy for Crohn's disease. The patient was readmitted with perineal pain, leucocytosis and a perineal mass highly suspicious of abscess formation in the MRI-Scan. Histological examination revealed a mucinous adenocarcinoma. Exenteration including vagina, uterus and ovaries together with the coccygeal-bone was performed. CONCLUSION: Mucinous adenocarcinoma formation is a rare complication of Crohn's disease and so far unreported after proctocolectomy