Un espacio de culto rural romano en Montesa, comarca de La Costera, Valencia

Este estudio se centra en un yacimiento localizado en la partdida de El Canari de Montesa, en la comarca de La Costera, Valencia. Allí se han encontrado una serie de estructuras y niveles arqueológicos que pueden ser asimilados a un santuario rural romano en uso desde la segunda mitad del siglo II a.C. hasta mediados de siglo I d.C. Asimismo, en su entorno, se han encontrado otras estructuras relacionadas con el abancalado de campos para el cultivo

El Impacto de las habilidades sociales en el ámbito virtual enfocado a la negociación

En este trabajo se pretende analizar el desarrollo de la negociación, englobando aquí las habilidades sociales, dentro del ámbito virtual. Por ello analizamos primeramente el entorno donde se va a desarrollar la negociación, el ámbito virtual, en segundo lugar, la negociación, y, por último, trataremos las habilidades sociales, las cuales son indispensables para el correcto desarrollo de la negociación

El uso de la Inteligencia Artificial por parte de la Administración Tributaria

La Inteligencia Artificial (IA) se está convirtiendo en una parte cada vez más vital de la Administración Tributaria debido a su capacidad para procesar grandes cantidades de datos, detectar tendencias, incoherencias e irregularidades, así como automatizar diversas tareas manuales. Esto supone un ahorro de costes y una mejora de la eficacia. La IA es utilizada por la Administración Tributaria para diversas aplicaciones, como identificar estafas fiscales, calcular el riesgo fiscal, descubrir errores en los impuestos que se han presentado y clasificar a los contribuyentes en grupos según su riesgo fiscal. Además, la IA ayuda a mejorar el servicio al cliente y la experiencia del usuario mediante chatbots y ayudantes virtuales. Sin embargo, la utilización de la IA en la Administración Tributaria se enfrenta a dificultades y peligros como la necesidad de garantizar la privacidad y la seguridad de los datos, la comprensión y aplicación precisas de los resultados de la IA, y cómo garantizar la claridad y la imparcialidad al utilizar la IA. Es indispensable que la Administración Tributaria emplee la IA con principios éticos y responsabilidad. En resumen, la IA proporciona muchas formas de mejorar el rendimiento y la productividad de la Administración Tributaria, pero también presenta dificultades sustanciales que deben tratarse adecuadamente. La integración de la IA debe gestionarse e implementarse tácticamente, teniendo en cuenta las cuestiones morales y legales asociadas a su utilización

An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElevierResearch on pain following spinal cord injury (SCI) has revealed that patients not only experience several types of pain that could prove to be challenging to address, but also that each individual can interpret such pain in different subjective ways. In this paper we introduce a 3-D system for facilitating the efficient management of pain, and thus, supporting clinicians in overcoming the aforementioned challenges. This system was evaluated by a cohort of 15 SCI patients in a pilot study that took place between July and October 2010. Participants reported their experiences of using the 3-D system in an adapted version of the System Usability Scale (SUS) questionnaire. Statistically significant results were obtained with regards to the usability and efficiency of the 3-D system, with the majority of the patients finding it particularly useful to report their pain. Our findings suggest that the 3-D system can be an efficient tool in the efforts to better manage the pain experience of SCI patients

Yield response of seedless watermelon to different drip irrigation strategies under Mediterranean conditions

[EN] Water is an essential resource for food production, as agriculture consumes close to 70% of the total freshwater, and its shortage is becoming critical in arid and semiarid areas of the world. Therefore, it is important to use water more efficiently. The objectives of this project are to determine the productive response and the irrigation water use efficiency of seedless watermelon to three irrigation management strategies over two growing seasons. This was done by applying 100, 75 and 50% of the irrigation water requirements (IWR) the first year, in the second year added six additional treatments, of which three treatments were regulated deficit irrigation with 75% IWR during the vegetative growth, fruit development and fruit ripening stages, and the other three treatments were with 50% IWR during the same stages. The exposure of watermelon plants to severe deficit irrigation resulted in a reduction in dry biomass, total and marketable yield, average fruit weight, fruit number and harvest index, and without improvement of marketable fruit quality. The fruit ripening was the less sensitive stage to water deficits. Relative water content and cell membrane stability index decreased as the water deficit increased. Irrigation water use efficiency decreased to a lesser extend during the fruit ripening stage than when water restriction were applied during different growth stages. If water is readily available, irrigating with 100% of water requirements is recommended, but in the case of water scarcity, applying water shortage during fruit ripening stage would be advisable.Abdelkhalik, A.; Pascual-Seva, N.; Nájera, I.; Giner, A.; Baixauli Soria, C.; Pascual España, B. (2019). Yield response of seedless watermelon to different drip irrigation strategies under Mediterranean conditions. Agricultural Water Management. 212:99-110. https://doi.org/10.1016/j.agwat.2018.08.0449911021

Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease

[EN] Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen species. At the same time, both organelles are critical for the maintenance of a healthy redox balance in the cell. Consequently, failure in the function of both organelles is causally linked to oxidative stress and accelerated aging. However, it has become clear that peroxisomes and mitochondria are much more intimately connected both physiologically and structurally. Both organelles share common fission components to dynamically respond to environmental cues, and the autophagic turnover of both peroxisomes and mitochondria is decisive for cellular homeostasis. Moreover, peroxisomes can physically associate with mitochondria via specific protein complexes. Therefore, the structural and functional connection of both organelles is a critical and dynamic feature in the regulation of oxidative metabolism, whose dynamic nature will be revealed in the future. In this review, we will focus on fundamental aspects of the peroxisome-mitochondria interplay derived from simple models such as yeast and move onto discussing the impact of an impaired peroxisomal and mitochondrial homeostasis on ROS production, aging, and disease in humans.Work from the authors’ laboratory was supported by grants from Ministerio de Economía, Industria y Competitividad (BFU2016-75792-R) and from Ministerio de Economía y Competitividad (BFU2011-23326).Pascual-Ahuir Giner, MD.; Manzanares-Estreder, S.; Proft, M. (2017). Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity. (9860841). https://doi.org/10.1155/2017/9860841S986084

Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast

[EN] Sphingolipids are regulators of mitochondria-mediated cell death in higher eukaryotes. Here, we investigate how changes in sphingolipid metabolism and downstream intermediates of sphingosine impinge on mitochondrial function. We found in yeast that within the sphingolipid degradation pathway, the production via Dpl1p and degradation via Hfd1p of hexadecenal are critical for mitochondrial function and cell death. Genetic interventions, which favor hexadecenal accumulation, diminish oxygen consumption rates and increase reactive oxygen species production and mitochondrial fragmentation and vice versa. The location of the hexadecenal-degrading enzyme Hfd1p in punctuate structures all along the mitochondrial network depends on a functional ERMES (endoplasmic reticulum-mitochondria encounter structure) complex, indicating that modulation of hexadecenal levels at specific ER-mitochondria contact sites might be an important trigger of cell death. This is further supported by the finding that externally added hexadecenal or the absence of Hfd1p enhances cell death caused by ectopic expression of the human Bax protein. Finally, the induction of the sphingolipid degradation pathway upon stress is controlled by the Hog1p MAP kinase. Therefore, the stress-regulated modulation of sphingolipid degradation might be a conserved way to induce cell death in eukaryotic organisms.The authors thank Eulalia de Nadal, William Prinz, Benoit Kornmann, Stephen Manon, Benedikt Westermann, and Frank Madeo for the kind gift of yeast strains and plasmids. The authors thank Alba Calatayud for her help with Bax expression experiments and Benito Alarcon for his help with the confocal microscopy. This work was supported by the grants from the Ministerio de Economia y Competitividad (BFU2011-23326 and BFU2016-75792-R).Manzanares-Estreder, S.; Pascual-Ahuir Giner, MD.; Proft, M. (2017). Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast. Oxidative Medicine and Cellular Longevity. (2708345):1-15. https://doi.org/10.1155/2017/2708345S115270834

Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell

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