An ecolodge in Thailand: a site design based upon the local vernacular village

This thesis began from my interest in using indigenous architectural and dwelling patterns of fishing villages in coastal Thailand as a model for a new sustainable community. The provincial government has a policy promoting longstay tourism for affluent retirees from other countries, enabling them to experience the natural, historical, and cultural heritage of the area at an economical cost. To fulfill the local government\u27s policy and my intention to design such a facility, this thesis proposes to design an international ecolodge for a site near Yisan Village. The area is very peaceful yet it is not so far from downtown Samut Songkhram City. This thesis offers the design of a sustainable resort community as a guide to be adapted to other applications on the specific site using local vernacular building and dwelling patterns in a new situation

Pro-coagulant imbalance in patients with chronic liver disease

n/

Guidelines on fibrinogen assays

No abstract available

Hypercoagulability of COVID-19 patients in Intensive Care Unit: A Report of Thromboelastography Findings and other Parameters of Hemostasis

BACKGROUND: The severe inflammatory state secondary to Covid-19 leads to a severe derangement of hemostasis that has been recently described as a state of disseminated intravascular coagulation (DIC) and consumption coagulopathy, defined as decreased platelet count, increased fibrin(ogen) degradation products such as D-dimer as well as low fibrinogen. AIMS: Whole blood from 24 patients admitted at the intensive care unit because of Covid-19 was collected and evaluated with thromboelastography by the TEG point-of-care device on a single occasion and six underwent repeated measurements on two consecutive days for a total of 30 observations. Plasma was evaluated for the other parameters of hemostasis. RESULTS: TEG parameters are consistent with a state of hypercoagulability as shown by decreased R and K values, and increased values of K angle and MA. Platelet count was normal or increased, prothrombin time and activated partial thromboplastin time were near(normal). Fibrinogen was increased and D-dimer was dramatically increased. C-reactive protein was increased. Factor VIII and von Willebrand factor (n=11) were increased. Antithrombin (n=11) was marginally decreased and protein C (n=11) was increased. CONCLUSION: The results of this cohort of patients with Covid-19 are not consistent with acute DIC, rather they support hypercoagulability together with a severe inflammatory state. These findings may explain the events of venous thromboembolism observed in some of these patients and support antithrombotic prophylaxis/treatment. Clinical trials are urgently needed to establish the type of drug, dosage and optimal duration of prophylaxis

Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma

Background: The mechanisms responsible for the increased thrombotic risk associated with thalassemia are still unclear. They might be related to the effects of red blood cell or endothelial cell derangements, increased numbers of platelets as well as abnormal plasma coagulation. Design and Methods: To evaluate the relative role played by cells and plasma we investigated 169 patients with thalassemia by means of thromboelastometry and thrombin generation tests. Thromboelastometry measures indices of the viscoelastic properties of whole blood after activation of coagulation and is characterized by the clotting time, which may be considered as a conventional coagulation time, clot formation time, defined as the time needed for the clot to reach a fixed firmness, and the maximum clot firmness, defined as the maximal amplitude of the tracing. Results: All the thromboelastometry parameters determined in whole blood (including shortened clotting time and clot formation time, and increased maximum clot firmness), were consistent with hypercoagulability, especially in splenectomized patients. Conversely, thrombin generation as determined in platelet-poor plasma was not. Conclusions: These findings point to blood cells and/or platelets rather than to plasma abnormalities as the most important determinants of the thrombotic risk observed in thalassemic patients who had been splenectomized. These results might have important diagnostic and therapeutic implications

THE DEVELOPMENT OF A READING COMPREHENSION TEST IN ENGLISH FOR TERTIARY-LEVEL STUDENTS IN THAILAND

Master'sMASTER OF ART

Misura della proteina S e della resistenza alla proteina C attivata. Risultati della Valutazione Esterna di Qualit\ue0 (VEQ)-CISMEL*

Background. One of the aims of the External Quality Assurance Scheme (EQAS) is to provide information useful to standardize laboratory methods and to help choosing the most appropriate laboratory strategy to investigate clinical conditions. Methods. We looked at the results coming from the EQAS in coagulation organized by the CISMEL group in three different exercises where participants analyzed three well characterized plasmas for protein S and activated protein C resistance. Results. Three consecutive exercises showed that the functional anticoagulant assay for protein S is affected by the presence of the factor V Leiden mutation and that the method for the measurement of activated protein C resistance based on prediluiton of test plasma in factor V deficient plasma is highly specific for factor V Leiden. Conclusions. EQAS exercises carried out across the country with samples unknown to the participants confirm two important findings that may be used to design a diagnostic strategy for the investigation of patients with thrombophilia