Non‐pharmacological interventions for managing delirium in hospitalised patients

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the effectiveness of single or multicomponent non‐pharmacological interventions in reducing the symptoms, duration or severity of an established episode of delirium in hospitalised people outside intensive care settings

Myriad: Design and implementation of a federated database prototype

This paper describes our experiences in the design and implementation of Myriad, and in the project management. Special emphasis is given to discussing design alternatives and their impact on Myriad. This paper also presents the software engineering principles and the project management techniques we used in developing Myriad and the lessons we learned. We believe these lessons would be useful for practitioners who wish to develop a similar syste

Viruses in extreme environments

The original publication is available at www.springerlink.comInternational audienceThe tolerance limits of extremophiles in term of temperature, pH, salinity, desiccation, hydrostatic pressure, radiation, anaerobiosis far exceed what can support non-extremophilic organisms. Like all other organisms, extremophiles serve as hosts for viral replication. Many lines of evidence suggest that viruses could no more be regarded as simple infectious ‘‘fragments of life'' but on the contrary as one of the major components of the biosphere. The exploration of niches with seemingly harsh life conditions as hypersaline and soda lakes, Sahara desert, polar environments or hot acid springs and deep sea hydrothermal vents, permitted to track successfully the presence of viruses. Substantial populations of double-stranded DNA virus that can reach 109 particles per milliliter were recorded. All these viral communities, with genome size ranging from 14 kb to 80 kb, seem to be genetically distinct, suggesting specific niche adaptation. Nevertheless, at this stage of the knowledge, very little is known of their origin, activity, or importance to the in situ microbial dynamics. The continuous attempts to isolate and to study viruses that thrive in extreme environments will be needed to address such questions. However, this topic appears to open a new window on an unexplored part of the viral world