The IJsselcog project:from excavation to 3D reconstruction

The 15th-century IJsselcog was lifted in 2016 from the river IJssel near Kampen (the Netherlands). From stern to bow and from starboard to portside about 70% of the original wooden hull is preserved. The combined approach of analogue documentation and photogrammetry enabled the research team to reconstruct the original ship in 2D and 3D, followed by a comprehensive study of its nautical characteristics. The hull volume and height were maximized by the shipbuilders using previously unknown construction elements in cogs, such as wales and vertical riders; shipbuilding traits that are generally applied to 16th- and 17th-century carvel-built cargo ships. (C) 2019 The Author

Pectins from various sources inhibit galectin-3-related cardiac fibrosis

Purpose of the study: A major challenge in cardiology remains in finding a therapy for cardiac fibrosis. Inhibition of galectin-3 with pectins attenuates fibrosis in animal models of heart failure. The purpose of this study is to identify pectins with the strongest galectin-3 inhibitory capacity. We evaluated the in vitro inhibitory capacity, identified potent pectins, and tested if this potency could be validated in a mouse model of myocardial fibrosis. Methods: Various pectin fractions were screened in vitro. Modified rhubarb pectin (EMRP) was identified as the most potent inhibitor of galectin-3 and compared to the well-known modified citrus pectin (MCP). Our findings were validated in a mouse model of myocardial fibrosis, which was induced by angiotensin II (Ang II) infusion. Results: Ang II infusion was associated with a 4–5-fold increase in fibrosis signal in the tissue of the left ventricle, compared to the control group (0•22±0•10 to 1•08±0•53%; P < 0•001). After treatment with rhubarb pectin, fibrosis was reduced by 57% vs. Ang II alone while this reduction was 30% with the well-known MCP (P = NS, P < 0•05). Treatment was associated with a reduced cardiac inflammatory response and preserved cardiac function. Conclusion: The galectin-3 inhibitor natural rhubarb pectin has a superior inhibitory capacity over established pectins, substantially attenuates cardiac fibrosis, and preserves cardiac function in vivo. Bioactive pectins are natural sources of galectin-3 inhibitors and may be helpful in the prevention of heart failure or other diseases characterized by fibrosis. Funding: Dr. Meijers is supported by the Mandema-Stipendium of the Junior Scientific Masterclass 2020-10, University Medical Center Groningen and by the Netherlands Heart Foundation (Dekkerbeurs 2021)Dr. de Boer is supported by the Netherlands Heart Foundation (CVON SHE-PREDICTS-HF, grant 2017-21; CVON RED-CVD, grant 2017-11; CVON PREDICT2, grant 2018-30; and CVON DOUBLE DOSE, grant 2020B005), by a grant from the leDucq Foundation (Cure PhosphoLambaN induced Cardiomyopathy (Cure-PLaN), and by a grant from the European Research Council (ERC CoG 818715, SECRETE-HF)

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

A triple isotope approach (Sr-O-C) to assess human mobility dynamics in the Lower Germanic limes borderscape (40–470 CE)

The intention of the Roman administration to develop the Lower Germanic limes region into a military zone must have been a catalyst for (long-distance) human and faunal mobility in the course of the 1st century CE. A triple isotope approach (Sr-O-C) has been used on a total of 21 cremations (bone and pars petrosa) and 21 inhumations (dental elements) from the Dutch Lower Germanic limes borderscape region to study the demographic dynamics between 150 and 500 CE. The dental enamel 87Sr/86Sr range from 0.7086 to 0.7158. The variability in Sr within the cremated remains is more limited: 0.7089 to 0.7103. The δ18OPDB data range from −7.6 ‰ to −4.3 ‰. All but one individual dating to the Early and Middle Roman period exhibit Sr ratios that are consistent with the expected local (0.7088–0.7092) or regional (up to ± 0.7110) 87Sr/86Sr signature. The population dynamics drastically change in the subsequent Late Roman period. Fifty percent (6/12) of the investigated Late Roman population (partially) spent part of their childhood away from the Dutch river system or even the Batavian civitas. The cremated long bone 87Sr/86Sr possibly point towards residential stability during the last few years of life: all data are compatible with the expected regional Sr signature. The δ13CPDB data vary between −16.0 ‰ and −8.7 ‰: the latter was indicative of a diet rich in C4 food, which was not a staple in the Roman diet in the Lower Germanic limes region. Although more research is essential to better understand the population dynamics in the limes borderscape, it is clear that the isotope data reflect the political-military status of the Lower Germanic limes region, especially during the transition to a militarized zone in the later Roman period. Identifying possible regions of provenance is a challenge. Another proxy for provenance, namely the cultural artefacts associated with the excavated people, did not show a specific relationship between cultural background and geographical origin

A monumental burial ground from the Funnel Beaker Period at Oosterdalfsen (the Netherlands)

In 2015 a rescue excavation took place at Oosterdalfsen (municipality of Dalfsen, Overijssel, the Netherlands) yielded traces of a burial ground, an earthen monument and a house plan, all dating from the Funnel beaker period. In total c. 137 graves were found. In several burial pits a corps silhouette was still visible indicating that these deceased were positioned in Hocker position. In total 123 pots were found in the graves. The decorated pots can be dated in Brindleyhorizon 4–7 (c. 3200 – 2700 BC). One large structure consisted of a ditch with a proximal length of 30 m and width of 4 m. Because the presence of a central grave is not ascertained we do not interpret this ditch system as the remnants of a monumental grave, but rather as an ditch-delimited arena for burial rituals. The house was two-aisled in construction, similar to the ones found at Flögeln 1 and Penningbüttel. The Oosterdalfsen community seems to have created amonumental expression in earth – the ditched feature. The large number of burials allows defining both norm and variation in burial rites in a meaningful way. The analysis of the pots, in combination with spatial analysis, will perhaps allow us to better understand the social built-up of the community that used the site for their burial rites